Value of Platelet to Lymphocyte Ratio in Nasopharyngeal Carcinoma Various Stages

Document Type : Original

Authors

Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine Padjadjaran University/ Dr. Hasan Sadikin General Hospital Bandung, Indonesia.

10.22038/ijorl.2024.75070.3523

Abstract

Introduction:
Nasopharyngeal Carcinoma (NPC) is among the most common head and neck cancer, significantly affecting the growth of human tumors. Therefore, this study aimed to investigate platelet-to-lymphocyte ratio (PLR) as a measure of inflammation in patients with various stages of NPC.
Materials and Methods:
This retrospective case-control study was conducted on patients diagnosed with NPC between 2016 and 2020 in Dr. Hasan Sadikin Bandung Hospital, Indonesia. Based on NPC classification criteria, patients were classified into early and advanced groups. Subsequently, the PLR ratio was calculated as the number of platelet divided by the absolute number of lymphocytes in the two groups, and the results were statistically analyzed using Unpaired T-test, Pearson, and Chi-square test.
Results:
A total of 102 patients with an age range of 40 to 49 years were included in this study. A slight correlation of 0.272 (P<0.001) was observed between PLR and clinical stage, while NPC patients with PLR value > 188 had a 2.7 times higher risk of advanced stage (RR=2.702).
Conclusion:
The PLR was significantly related to the clinical stage of NPC cancer.

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Iranian Journal of Otorhinolaryngology
Volume 36, Issue 3
May and June 2024
Pages 467-473

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