eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
241
248
10.22038/ijorl.2016.7033
7033
Original
CenoDerm vs. Fascia lata for the Prevention of Dorsal Nasal Irregularities in Rhinoplasty
Alireza Mohebbi
mohebbidr@gmail.com
1
Roghayeh Hamidian
hamidian.r@gmail.com
2
Seyed Behzad Poosti
sb_pousti@yahoo.com
3
Seyedeh Simindokht Hosseini
simindokht_hosseini@yahoo.com
4
Otolaryngology Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Department of Otolaryngology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Otolaryngology Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Dorsal nasal irregularity is a complication of rhinoplasty surgery, mostly seen in patients with thin skin. Acellular dermis (CenoDerm) and homologous fascia lata covering the nasal bone cartilage structure have been used to achieve a smooth surface. In this study, we aimed to investigate clinical outcomes using these two materials. Materials and Methods: After a standard rhinoplasty procedure, a layer of the acellular dermis or homologous fascia lata was placed in the pocket of the dorsum. Patients were evaluated for clinical outcomes at 3, 6, and 12 months after the procedure. Results: Forty-two of 68 patients completed the follow-up period. Patient satisfaction was higher in the homologous fascia lata group. Similarly, nasal dorsum inspection and palpation results were better in the homologous fascia lata group compared with the CenoDerm group but was significant in palpation (P=0.00). There was no complete absorption in the homologous fascia lata group 6 months after surgery (P= 0.04 vs. CenoDerm) but no significant difference was observed at 12 months. Conclusion: Homologous fascia lata is better than acellular dermis in preventing dorsal nasal irregularity after rhinoplasty in thin-skinned patients.
https://ijorl.mums.ac.ir/article_7033_4f5e1150039efea54516ee23e14b96df.pdf
Acellular dermis
Fascia lata
Rhinoplasty
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
249
254
10.22038/ijorl.2016.7040
7040
Original
Effects of Steroids and Curcumin on Prevention of Laryngeal Stenosis Secondary to Trauma
Kamyar Iravani
iravanika@sums.ac.ir
1
Zahra Babaie
mahtab_169@yahoo.com
2
Mohammad Javad Ashraf
ashrafm@sums.ac.ir
3
Nader Tanided
tanifehn@gmail.com
4
Department of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
Stem cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: The aim of this study was to compare the preventive effects of corticosteroids and curcumin on subglottic stenosis in an animal model. Materials and Methods: Twenty-one male German Shepherd dogs were used for this study. After standardized trauma to the subglottic area, the dogs were divided into three groups. Group A received curcumin (450 mg/ day) for 15 days; Group B received beclomethasone (2 puffs/day, 50 µg/dose) for 15 days; Group C received saline spray only. At 6 weeks after the injury, the larynx specimens were examined histopathologically to assess epithelialization, inflammation, and fibrosis. Results: Complete epithelial covering of the steroid-treated group was significantly less than that of the control group. Despite inflammation and fibrosis, there was no significant difference between the steroid and control groups. In the curcumin-treated group, there was no significant difference between the groups. Conclusion: Topically applied steroid decreases epithelialization after induced subglottic injury. It is recommended that further studies be conducted in order to investigate the effects of the two drugs on airway stenosis prevention.
https://ijorl.mums.ac.ir/article_7040_25e1f75834fb2b8eb91c6ccf5e7ab093.pdf
Corticosteroids
Curcumin
Laryngeal stenosis
Laryngeal scar
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
255
260
10.22038/ijorl.2016.7034
7034
Original
Facial Nerve Monitoring During Parotidectomy: A Two-Center Retrospective Study
Stanislas Ballivet de Régloix
stanbdr@msn.com
1
Julia Grinholtz Haddad
jg@hotmail.fr
2
Olga Maurin
om@hotmail.fr
3
Louise Genestier
lh@hotmail.fr
4
Quentin Lisan
ql@hotmail.fr
5
Yoann Pons
yp@gmail.fr
6
Department of Otorhinolaryngology – Head and Neck Surgery, Military Training Hospital Percy 101, avenue Henri Barbusse 92140 Clamart, France.
Department of Otorhinolaryngology – Head and Neck Surgery, Versailles Hospital Center, André Mignot Hospital 177, rue de Versailles 77157 Le Chesnay cedex, France.
Department of Otorhinolaryngology – Head and Neck Surgery, Military Training Hospital Percy 101, avenue Henri Barbusse 92140 Clamart, France.
Department of Otorhinolaryngology – Head and Neck Surgery, Military Training Hospital Val de Grâce74, boulevard de Port Royal 75005 Paris, France.
Department of Otorhinolaryngology – Head and Neck Surgery, Military Training Hospital Percy 101, avenue Henri Barbusse 92140 Clamart, France.
Department of Otorhinolaryngology – Head and Neck Surgery, Military Training Hospital Percy 101, avenue Henri Barbusse 92140 Clamart, France.
Introduction: We present a retrospective two-center study series and discussion of the current literature to assess the benefits of facial nerve monitoring during parotidectomy. Materials and Methods: From 2007 to 2012, 128 parotidectomies were performed in 125 patients. Of these, 47 procedures were performed without facial nerve monitoring (group 1) and 81 with facial nerve monitoring (group 2). The primary endpoint was the House-Brackmann classification at 1 month and 6 months. Facial palsy was determined when the House-Brackmann grade was 3 or higher. Results: In group 1, 15 facial palsies were noted; 8 were transient and 7 were definitive. In group 2, 19 facial palsies were noted; 12 were transient and 7 were definitive. At both one and six months after parotidectomy, the rate of facial palsy in reoperation cases was significantly higher in group 1 than in group 2. Conclusion: Facial nerve monitoring is a simple, effective adjunct method that is available to surgeons to assist with the functional preservation of the facial nerve during parotid surgery. Although it does not improve the facial prognosis in first-line surgery, it does improve the facial prognosis in reoperations.
https://ijorl.mums.ac.ir/article_7034_ed5a3e11119c0cc1084d59688836dae7.pdf
Facial Nerve
Facial paralysis
Intraoperative Monitoring
Parotid gland
Reoperation
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
261
266
10.22038/ijorl.2016.7049
7049
Original
HLA-Cw Allele Frequency in Definite Meniere’s Disease Compared to Probable Meniere’s Disease and Healthy Controls in an Iranian Sample
Sasan Dabiri
sasan.dabiri@gmail.com
1
Fatemeh Ghadimi
fatemeh.ghadimi@gmail.com
2
mohammadreza Firouzifar
link2mrfs@gmail.com
3
Nasrin Yazdani
n_yazdani@tums.ac.ir
4
Mahsa Mohammad Amoli
amolimm@tums.ac.ir
5
Varasteh Vakili
vari_01@yahoo.com
6
Zahra Mahvi
z.mahvi69@gmail.com
7
Otorhinolaryngology Research Center, AmirAlam Hospital, Tehran University of Medical Sciences, Tehran, Iran
Otorhinolaryngology Research Center, AmirAlam Hospital, Tehran University of Medical Sciences, Tehran, Iran
Otorhinolaryngology Research Center, AmirAlam Hospital, Tehran University of Medical Sciences, Tehran, Iran
Otorhinolaryngology Research Center, AmirAlam Hospital, Tehran University of Medical Sciences, Tehran, Iran
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Otorhinolaryngology Research Center, AmirAlam Hospital, Tehran University of Medical Sciences, Tehran, Iran
Otorhinolaryngology Research Center, AmirAlam Hospital, Tehran University of Medical Sciences, Tehran, Iran
Introduction Several lines of evidence support the contribution of autoimmune mechanisms in the pathogenesis of Meniere’s disease. The aim of this study was determining the association between HLA-Cw Alleles in patients with definite Meniere’s disease and patients with probable Meniere’s disease and a control group. Materials and Methods: HLA-Cw genotyping was performed in 23 patients with definite Meniere’s disease, 24 with probable Meniere’s disease, and 91 healthy normal subjects, using sequence specific primers polymerase chain reaction technique. The statistical analysis was performed using stata 8 software. Results: There was a significant association between HLA-Cw*04 and HLA-Cw*16 in both definite and probable Meniere’s disease compared to normal healthy controls. We observed a significant difference in HLA-Cw*12 frequencies between patients with definite Meniere’s disease compared to patients with probable Meniere’s disease (P=0.04). The frequency of HLA-Cw*18 is significantly higher in healthy controls (P=0.002). Conclusion: Our findings support the rule of HLA-Cw Alleles in both definite and probable Meniere’s disease. In addition, differences in HLA-Cw*12 frequency in definite and probable Meniere’s disease in our study’s population might indicate distinct immune and inflammatory mechanisms involved in each condition.
https://ijorl.mums.ac.ir/article_7049_c6a914fc1276b690a662cdc71114792f.pdf
HLA-Cw
Immunogenetics
Meniere’s disease
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
267
274
10.22038/ijorl.2016.7036
7036
Original
Analysis of Epstein Barr Virus Encoded RNA Expression in Nasopharyngeal Carcinoma in North-Eastern India: A Chromogenic in Situ Hybridization Based Study
Anjan Saikia
anjanamch14@gmail.com
1
Vandana Raphael
raphaellyngdoh@gmail.com
2
N. Brian Shunyu
drnbshunyu@yahoo.com
3
Yookarin Khonglah
yookarink@gmail.com
4
Jaya Mishra
jayamishraxyz@gmail.com
5
Ankit Jitani
ankitjitani@gmail.com
6
Jayanta Medhi
jm_17f@rediffmail.com
7
Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.
Department of Otorhinolaryngology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.
Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.
Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.
Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.
Department of Otorhinolaryngology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.
Introduction: Nasopharyngeal carcinoma (NPC) is a common cancer in the North-East region of India. Though the role of environmental contributors of NPC in the North-Eastern part of India is firmly established, EBV as an etiological agent in the region remains unexplored. Material and Methods: Fifty-one patients, who presented at the department of ENT, NEIGRIHMS and were confirmed as NPC upon histopathological examination, were included in the study. Chromogenic in-situ hybridization (CISH) was used for the evaluation of EBER (Epstein Barr Virus Encoded RNA). Presence of nuclear signals was taken as positive for EBER expression. EBER status was correlated with various clinicopathological parameters like age, sex, dietary habits, histological types of NPC, and ethnicity of the patients. Results: The age range of the study group was 25 to 70 years with a mean age of 44.64 years and a male:female ratio of 3:2. Non-keratinizing undifferentiated type of NPC was the most common histological type. EBV was positive in 59% (30/51) of our cases. It showed a statistically significant correlation with the Naga community (P=0.01), with consumption of smoked food (P=0.02), and cigarette smoking (P=0.02). There was no correlation of EBV with age, sex, lymph node metastasis, stage, and histology. Conclusion: Our result indicates that EBV may be an additional risk factor in the pathogenesis of NPC in this region of India. So apart from lifestyle modification, a future study for a screening test for EBV viral load even in asymptomatic patients may be considered, for determination of disease susceptibility, early diagnosis, and proper management.
https://ijorl.mums.ac.ir/article_7036_db6e8feb02ddabcbde086f57b0df239c.pdf
EBV
EBER
Nasopharynx
nasopharyngeal cancer
CISH
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
275
280
10.22038/ijorl.2016.7046
7046
Original
Asthma in Rhinosinusitis: A Survey from Iran
Mehdi Bakhshaee
bakhshaeem@mums.ac.ir
1
Mohamad Reza Majidi
majidimr@mums.ac.ir
2
Vahideh Gharavi
v_gharavi@yahoo.com
3
Fatemeh Sadat Alavizadeh
moghimant921@mums.ac.ir
4
Rahman Movahed
rahmanmovahhed@gmail.com
5
Parasto Asnaashari
6
Amir Mohammad hashem Asnaashari
am_asnaashari@yahoo.com
7
Sinus and Surgical Endoscopic Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sinus and Surgical Endoscopic Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Otorhinolaryngology, Mashhad University of Medical Sciences, Mashhad, Iran.
COPD Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Otorhinolaryngology, Mashhad University of Medical Sciences, Mashhad, Iran.
COPD Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
COPD Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Introduction: The coexistence of asthma and chronic rhinosinusitis (CRS) is more common than expected given their individual prevalence in the general population and may affect patient’s quality of life. The aim of this study was to evaluate the prevalence of asthma in chronic rhinosinusitis in Mashhad, Northeast Iran. Materials and Methods: This study was performed in two university hospital from November 2012 for 12 months. In total, 153 patients with chronic rhinosinusitis were enrolled and referred to a particular pulmonologist for asthma evaluation. Results: The mean age of participants was 40.54±13.11 years, and 41.8% were male. In total, 63.4% of patients had the polypoid form of CRS. The proportion of patients in this study with asthma was 41.8%, compared with a general asthma prevalence in this region of 13.5%. Conclusion: There is a high prevalence of asthma among patients with CRS, but it often remains undiagnosed. Asthma in CRS patients should be diagnosed and treated in order to improve patient’s quality of life. We recommend an evaluation of the lower airways in all of these patients as well as further studies in this field.
https://ijorl.mums.ac.ir/article_7046_20f9074bd7697588433f34bebed51aed.pdf
Asthma
Sinusitis
Spirometry
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
281
285
10.22038/ijorl.2016.7037
7037
Sclerosing Mucoepidermoid Carcinoma of the Parotid Gland
Farahnaz Bidari Zerehpoosh
farahnazbidari@yahoo.com
1
Bijan Naghibzadeh
naghibzadehb@yahoo.com
2
Elena Jamali
elena.jamali@yahoo.com
3
Moein Jamali
moein.jamali@gmail.com
4
Amirali Mafi
amirali.mafi@gmail.com
5
Hooman Bahrami Motlagh
hoomanbahrami@gmail.com
6
Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Otorhinolaryngology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Radiology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction: Mucoepidermoid carcinoma represents one of the most common malignant salivary gland tumors.However, the sclerosing morphologic variant is extremely rare with only 23 reported cases in the English-language literature since it was discovered in 1987. Case Report: Herein, we describe another case that was diagnosed in a 25-year-old woman presenting with a posterior auricular mass, as well as a review of the literature, which demonstrates that this is an extremely rare malignancy with no strict protocol for treatment. Conclusion: Pathologists must be aware of recognizing low grade sclerosing mucoepidermoid carcinoma which has metastatic potential and is frequently misdiagnosed as a benign lesion.
https://ijorl.mums.ac.ir/article_7037_de0bdb5927f25e004f391e2f413976c7.pdf
Mucoepidermoid carcinoma
Sclerosing
Parotid gland
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
287
290
10.22038/ijorl.2016.7038
7038
Intraparotid Neurofibroma of the Facial Nerve: A Case Report
Ahmed Nofal
dr.ahmed.nofal@gmail.com
1
Mohammad El-Anwar
mwenteg@yahoo.com
2
Department of Otorhinolaryngology , Faculty of Medicine, Zagazig University, Egypt.
Department of Otorhinolaryngology , Faculty of Medicine, Zagazig University, Egypt.
Introduction: Intraparotid neurofibromas of the facial nerve are extremely rare and mostly associated with neurofibromatosis type 1 (NF1). Case Report: This is a case of a healthy 40-year-old man, which underwent surgery for a preoperatively diagnosed benign parotid gland lesion. After identification of the facial nerve main trunk, a single large mass (6 x 3 cm) incorporating the upper nerve division was observed. The nerve portion involved in the mass could not be dissected and was inevitably sacrificed with immediate neuroraphy of the upper division of the facial nerve with 6/0 prolene. The final histopathology revealed the presence of a neurofibroma. Complete left side facial nerve paralysis was observed immediately postoperatively but the function of the lower half was returned within 4 months and the upper half was returned after 1 year. Currently, after 3 years of follow up, there are no signs of recurrence and normal facial nerve function is observed. Conclusion: Neurofibroma should be considered as the diagnosis in a patient demonstrating a parotid mass. In cases where it is diagnosed intraoperatively, excision of part of the nerve with the mass will be inevitable though it can be successfully repaired by end to end anastomosis.
https://ijorl.mums.ac.ir/article_7038_a769955bb396df9b6d4a78668dc0f6c2.pdf
Facial Nerve
Parotid gland
Neurofibroma
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
291
296
10.22038/ijorl.2016.7039
7039
Unusually Giant Sublingual Epidermoid Cyst: A Case Report
Chintan Nishar
stars.chin@gmail.com
1
Atish Gujrathi
stars_chin@yahoo.co.in
2
Vijayalaxmi Ambulgekar
hodent.gmcn@gmail.com
3
Pravin Chavan
pravin_4155@yahoo.co.in
4
Department of Otorhinolaryngology, Dr. Shankarrao Chavan Govt. Medical College, Nanded, India.
Department of Otorhinolaryngology, Dr. Shankarrao Chavan Govt. Medical College, Nanded, India.
Department of Otorhinolaryngology, Dr. Shankarrao Chavan Govt. Medical College, Nanded, India.
Department of Otorhinolaryngology, Dr. Shankarrao Chavan Govt. Medical College, Nanded, India.
Introduction: Epidermoid cysts are rare, slow‑growing, benign, developmental cysts, which are derived from abnormally situated ectodermal tissue. Epidermoid cysts of the floor of the mouth represent <0.01% of all oral cysts. So far, only a few cases have been reported. Case Report: Hereby, we present a case of a giant sublingual epidermoid cyst, which was completely asymptomatic upon presentation. However, due to its large size, it pushed the epiglottis posteriorly and created difficulty during intubation. The patient developed respiratory distress after its surgical excision and extubation, requiring tracheostomy post operatively. The patient recovered well and a successful weaning of tracheostomy was performed, giving the patient a healthy life. Conclusion: Epidermoid cyst is a rare differential diagnosis of sublingual swelling that should be kept in mind for large asymptomatic swellings in this region. The only symptom it can cause might be respiratory distress due to its large size. This can happen not only pre-operatively but also post-operatively and the surgeon should be ready for immediate tracheostomy.
https://ijorl.mums.ac.ir/article_7039_fd10706e4873f3ca8944521b82f6b83a.pdf
Epidermal Cyst
Intubation
Sublingual
Surgery
Tracheostomy
eng
Mashhad University of Medical Sciences (MUMS)
Iranian Journal of Otorhinolaryngology
2251-7251
2251-726X
2016-07-01
28
4
297
302
10.22038/ijorl.2016.7043
7043
Treatment Approach for Maxillary Hypoplasia in Cleft Patients: Class III Elastics with Skeletal Anchorage (Report of Two Cases)
Arezoo Jahanbin
jahanbina@mums.ac.ir
1
Mojgan Kazemian
kazemianm@mums.ac.ir
2
Iman Saeedi Pouya
dr.saeedipouya@gmail.com
3
Neda Eslami
eslamin@mums.ac.ir
4
Hooman Shafaee
shafaeeh@mums.ac.ir
5
Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
Oral and Maxillary Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Orthodontics, Mashhad University of Medical Sciences, Mashhad, Iran.
Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Introduction: Treatment ofcleft lip and palate patients requires a multidisciplinary plan. These patients usually have a hypoplastic maxilla due to the prior surgical scars. Orthognathic surgery to advance the maxilla in these patients is not very efficient; therefore, orthopedic interventions during an appropriate age seems to be essential. Case Report: In this article, two cleft lip and palate patients have been treated with Class III elastics anchored to the maxillary posterior and mandibular anterior miniplates in order to induce maxillary advancement. Conclusion: Both cases showed a significant improvement in their profiles with minimal dentoalveolar compensations. A counterclockwise rotation of the mandible occurred.
https://ijorl.mums.ac.ir/article_7043_7f3030fd6b1baf05dd3fb6b54d7a3b08.pdf
Cleft lip and palate
Skeletal anchorage
Maxillary advancement