%0 Journal Article %T Serum 25-Hydroxy Vitamin D in Chronic Rhinosinusitis with and Without Nasal Polyposis: A Case-Control Study in Northern Iran %J Iranian Journal of Otorhinolaryngology %I Mashhad University of Medical Sciences (MUMS) %Z 2251-7251 %A Faghih Habibi, Ali %A Gerami, Hooshang %A Banan, Rahmatollah %A Kazemnejad, Ehsan %A Khoshkhat, Parsa %A Alaie, Hooman %A Nemati, Shadman %D 2019 %\ 01/01/2019 %V 31 %N 1 %P 19-24 %! Serum 25-Hydroxy Vitamin D in Chronic Rhinosinusitis with and Without Nasal Polyposis: A Case-Control Study in Northern Iran %K Chronic %K Nasal Polyps %K Rhinitis %K Sinusitis %K Vitamin D %R 10.22038/ijorl.2018.32081.2055 %X Introduction: Chronic rhinosinusitis (CRS) with and without nasal polyposis is a chronic inflammatory disease of the sinuses and nasal mucosa. Recent evidence has indicated a relationship between serum 25-hydroxyl vitamin D (OH-VitD) deficiency and CRS. Regarding this, the present study aimed to compare the serum level of 25-OH-VitD in CRS patients with and without nasal polyposis and control groups. Materials and Methods: This study was conducted on 117 adult subjects in three groups of CRS with nasal polyposis (CRSwNP; n=32), CRS without nasal polyposis (CRSsNP; n=35), and healthy controls (n=50). The mean level of serum 25-OH-VitD in the three groups was measured by means of enzyme- linked immunosorbent assay. The data were analyzed using SPSS software (version 18). Results: Mean serum levels of 25-OH-VitD in CRSwNP, CRSsNP, and control groups were 12.52, 15.54, and 22.04 ng/ml, respectively. There was a significant difference between the case and control groups in terms of 25-OH-VitD level (P=0.0001). However, no significant difference was observed between the CRSwNP and CRSsNP groups in this regard (P=0.464). The women had a VitD deficiency odds ratio (OR) of 2.47, compared with men (OR=2.47, 95% CI=1.04-5.86). The OR of VitD deficiency with aging was obtained as 0.957 (95% CI=0.925-0.989). In this regard, older patients had a lower probability of VitD deficiency, compared to younger patients. Conclusion: As the findings indicated, serum 25-OH-VitD was significantly lower in CRS patients, compared with that in the non-CRS subjects. %U https://ijorl.mums.ac.ir/article_12093_90ffcf1bbc0b36a26f2f036cb9fc07e9.pdf