%0 Journal Article %T Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity %J Iranian Journal of Otorhinolaryngology %I Mashhad University of Medical Sciences (MUMS) %Z 2251-7251 %A Zand, Vahid %A Baradaranfar, Mohammadhossein %A Vaziribozorg, Sedighe %A Mandegari, Mohammad %A Mansourimanesh, Mahzad %A Saeidieslami, Nasir %D 2020 %\ 01/01/2020 %V 32 %N 1 %P 35-41 %! Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity %K CRS w NP %K Lund-Mackay Scale %K Vitamin D %K SNOT-22 %R 10.22038/ijorl.2019.31926.2050 %X AbstractIntroduction:The present study was conducted to investigate the association between the serum vitamin D levels and severity of disease in chronic rhino sinusitis (CRS) patients.Materials and Methods:This prospective cross-sectional study was conducted on a total of 93 patients suffering from chronic rhino sinusitis with nasal polyposis (CRS w NP). Serum level of 25-hydroxyvitamin D was detected using a simple blood test. A22-item questionnaire, namely the sinonasal outcome test-22 (SNOT-22), was used to assess the subjective disease severity and patients' quality of life. In addition, the radiographic signs of the disease severity were evaluated using the Lund-Mackay Scale (LMS).Results:The mean age and serum vitamin D level of the patients were measured at 37.7±13.6 years and 24.6±16.9 ng/ml, respectively. Moreover, the mean of LMS and SNOT-22 scores were calculated at 14.2±11.2 and 40.8±17.6, respectively. There was a negative correlation between the SNOT-22 and serum levels of vitamin D (P=0.034). Similarly, LMS and serum vitamin D levels were correlated negatively (P=0.027). Furthermore, the results revealed a direct relationship between LMS and SNOT-22 (P<0.0001).Conclusion:According to the obtained results, there was a significant relationship between the serum vitamin D levels and severity of disease in patients with CRS w NP. Therefore, serum vitamin D levels could be added to the routine workup of the patients suffering from CRS w NP. %U https://ijorl.mums.ac.ir/article_14223_efbeacee6fa8da41e95667d6ee146391.pdf