ORIGINAL_ARTICLE
Hair Color and Hearing Loss: A Survey in a Group of Military Men
Introduction:
It has been shown that low levels of pigmentation increase susceptibility to noise-induced hearing loss in humans. For this reason, white populations develop more pronounced noise- induced hearing loss in comparison to black populations. Similarly, blue-eyed individuals exhibit greater temporary threshold shift than brown-eyed subjects; still, no strong correlation has been verified between the lightness of hair color and susceptibility to noise-induced hearing loss. This study was performed with the purpose of investigating a possible association between hair color and the degree of hearing loss due to firing noise. Study Design: Prospective observational study. Setting: A tertiary referral center with an accredited otorhinolaryngology-head & neck surgery department.
Materials and Methods:
A total of 57 military recruits were divided into two groups; light-colored (blond and light brown) and dark-colored hair (dark brown and black). The two groups were matched based on history of firing noise exposure (number of rounds; type of weapon) and the level of hearing loss at 2, 3, 4, 6 and 8 kHz sound frequencies was compared between them.
Results:
The results showed that the mean level of hearing loss of light-colored hair individuals (20.5±17dB) was significantly greater than that of dark-haired subjects (13.5±11dB), (P=0.023).
Conclusion:
The results indicate that hair color (blond versus black) can be used as an index for predicting susceptibility to noise-induced hearing loss in military environments. Therefore, based on the individual's hair color, upgraded hearing conservation programs are highly recommended.
https://ijorl.mums.ac.ir/article_193_70b86125bcfe14e2c427a024e1f898be.pdf
2012-10-01
155
160
10.22038/ijorl.2011.193
Hair color
Hearing Loss
Noise-induced
pigmentation
Disease Susceptibility
Amir Hossain
Ghazizadeh
1
Department of otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Mehdi
Bakhshaee
mehbakhsh@yahoo.com
2
Ear, Nose, Throat, Head and Neck surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ebrahim
Mahdavi
3
Audiologist, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Rahman
Movahhed
4
Department of otorhinolaryngology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
ORIGINAL_ARTICLE
Evaluation of Tissue Expression and Salivary Levels of HER2/neu in Patients with Head and Neck Squamous cell Carcinoma
Introduction:
HER2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. The purpose of this study was to determine the salivary levels and tissue expression of HER2/neu in patients with head and neck squamous cell carcinoma (HNSCC) and their correlation with clinicopathologic parameters.
Materials and Methods:
Enzyme-linked immunosorbent assays (ELISA) were used to evaluate the salivary levels of HER2/neu and immunohistochemistry was used to measure tissue expression of HER2/neu in 28 patients with HNSCC and 25 healthy control subjects.
Results:
The salivary levels of HER2/neu in patients with HNSCC were not significantly higher compared to healthy control subjects. There was no apparent correlation between salivary HER2/neu levels and clinicopathological features such as age, sex, tumor grade, tumor size and nodal status. All HNSCC specimens were positive (membranous or/and cytoplasmic) for HER2/neu, except one sample. Only one HNSCC specimen showed staining purely in the tumor-cell cytoplasm. All control specimens were also positive for both membranous and cytoplasmic HER2/neu but there was a significant difference between the level of cytoplasmic staining in the HNSCC specimens and in the control specimens (P<0.05).
Conclusion:
In our study, no overexpression of HER2/neu was observed. Thus, identification of HER2/neu levels plays no role in differentiating between normal and squamous cell carcinoma tissues or detecting the carcinogenesis process. Our findings suggest that the use of HER2/neu as a salivary marker of HNSCC is not recommended, because no significant preoperative elevation and no association with clinicopathological features were found.
https://ijorl.mums.ac.ir/article_668_b706dce7bea8b8f23e9327611db6360d.pdf
2012-10-01
161
170
10.22038/ijorl.2012.668
Carcinoma
HER2/neu
salivary gland
Squamous cell of head and neck
Tissue expression
Soheil
Pardis
1
Department of Oral and MaxillofacialPathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Yasaman
Sardari
2
Department of Oral and MaxillofacialPathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Mohammad Javad
Ashraf
3
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Azadeh Andisheh
Tadbir
4
Department of Oral and MaxillofacialPathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Hooman
Ebrahimi
5
Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Sara
Purshahidi
6
Department of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Bijan
Khademi
khademib@sums.ac.ir
7
Department of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Mohammad Javad
Fattahi
8
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Marzieh
Hamzavi
9
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
ORIGINAL_ARTICLE
A Study of the Etiology of Referred Otalgia
Introduction:
Otalgia is one of the complaints which may occur at any age. The etiology of the pain may be in the ear, structures around the ear or other head and neck structures. This is caused by the complex nervous connections in the head and neck areas, the ear, the pharynx and the nose. Since understanding the etiologies of referred otalgia can help in the assessment and treatment of the disease, this research was conducted to identify the etiologies of referred otalgia in patients visiting the ENT Clinic in Gorgan, Iran.
Materials and Methods:
This prospective research was conducted on patients who visited the ENT Clinic with an earache, but in initial assessments the ear was normal. Patients’ data consisting of sex, age, complaint, the inflicted side, physical findings in the ear, the nose, the throat and head and neck were recorded in a questionnaire. These data were then analyzed with SPSS software.
Results:
Of 770 patients with otalgia, 94 patients (12.2%) had referred otalgia. Of these patients 27.7% were men and 72.3% were women. The most common etiology of referred otalgia was dental problems (62.8%), and one patient who was being treated for pharyngitis had carcinoma of the base of the tongue. In 47.8% of cases the pain was in the left ear, in 43.4% in the right ear, and in 8.7% it was bilateral.
Conclusion:
In view of the fact that a significant proportion of the patients who complained of otalgia had no pathologies in the ear, thorough physical examination in adjacent structures especially teeth should be performed and malignancies should be considered as a possible etiology of otalgia.
https://ijorl.mums.ac.ir/article_195_0c34e7399f8afb7836e18905110c09c2.pdf
2012-10-01
171
176
10.22038/ijorl.2011.195
Cases
Earache
Pain
Referred
Mohammad Hosein
Taziki
1
Department of Otorhinolaryngology, Golestan University of Medical Sciences, Gorgan, Iran.
AUTHOR
Nasser
Behnampour
2
Hematology & Oncology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
AUTHOR
ORIGINAL_ARTICLE
Complications Requiring Cochlear Reimplantation
Introduction:
Otalgia is one of the complaints which may occur at any age. The etiology of the pain may be in the ear, structures around the ear or other head and neck structures. This is caused by the complex nervous connections in the head and neck areas, the ear, the pharynx and the nose. Since understanding the etiologies of referred otalgia can help in the assessment and treatment of the disease, this research was conducted to identify the etiologies of referred otalgia in patients visiting the ENT Clinic in Gorgan, Iran.
Materials and Methods:
This prospective research was conducted on patients who visited the ENT Clinic with an earache, but in initial assessments the ear was normal. Patients’ data consisting of sex, age, complaint, the inflicted side, physical findings in the ear, the nose, the throat and head and neck were recorded in a questionnaire. These data were then analyzed with SPSS software.
Results:
Of 770 patients with otalgia, 94 patients (12.2%) had referred otalgia. Of these patients 27.7% were men and 72.3% were women. The most common etiology of referred otalgia was dental problems (62.8%), and one patient who was being treated for pharyngitis had carcinoma of the base of the tongue. In 47.8% of cases the pain was in the left ear, in 43.4% in the right ear, and in 8.7% it was bilateral.
Conclusion:
In view of the fact that a significant proportion of the patients who complained of otalgia had no pathologies in the ear, thorough physical examination in adjacent structures especially teeth should be performed and malignancies should be considered as a possible etiology of otalgia.
https://ijorl.mums.ac.ir/article_196_d41d8cd98f00b204e9800998ecf8427e.pdf
2012-10-01
177
180
10.22038/ijorl.2011.196
Cochlear Implantation
Reimplantation
Revision surgery
Seied Basir
Hashemi
1
Department of Otolaryngology and Head and Neck Surgery, Khalili Hospital, Shiraz University of Medical Science, Shiraz, Iran
AUTHOR
Hajar
Bahrani fard
2
Department of Otolaryngology and Head and Neck Surgery, Khalili Hospital, Shiraz University of Medical Science, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Otological Findings Ten Years after Myringotomy with Tympanostomy Tube Insertion
Introduction:
To study the long-term complications of tympanostomy tube insertion in young children 10 years after surgery.
Materials and Methods:
In September 2011, the medical records of all patients who had undergone myringotomy with tympanostomy tube insertion between February 2000 and March 2001 at the two general hospitals of Isfahan University of Medical Sciences were studied. Of the 98 patients who fulfilled the inclusion criteria, 82 patients agreed to participate and were enrolled in the study. The complications of the operation were evaluated in these patients.
Results:
Of the 164 ears that were operated on, myringosclerosis was found in 17.1%, atrophy of the tympanic membrane in 1.2%, permanent perforation of the tympanic membrane in 0.6% and tympanic membrane atelectasis in 0.6%. None of the patients developed cholesteatoma as a complication of tympanostomy tube insertion.
Conclusion:
Considering the low risk of serious complications after 10 years, tympanostomy tube insertion is a safe and effective treatment option in the treatment of otitis media with effusion.
https://ijorl.mums.ac.ir/article_197_6f31876f1d5e5a84285a5f661aecfeea.pdf
2012-10-01
181
186
10.22038/ijorl.2011.197
Myringotomy
Myringosclerosis
Otitis media with effusion
perforation
Tympanostomy tube
Behrouz
Barati
1
Department of Otorhinolaryngology and Head and Neck Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Seyed Mostafa
Hashemi
2
Department of Otorhinolaryngology and Head and Neck Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
AUTHOR
Ali
Goljanian Tabrizi
3
Department of Otorhinolaryngology and Head and Neck Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
ORIGINAL_ARTICLE
Maternal Risk Factors for Oral Clefts: A Case-Control Study
Introduction:
A cleft lip with or without a cleft palate is one of the major congenital anomalies observed in newborns. This study explored the risk factors for oral clefts in Gorgan, Northern Iran.
Materials and Methods:
This hospital-based case-control study was performed in three hospitals in Gorgan, Northern Iran between April 2006 and December 2009. The case group contained 33 newborns with oral clefts and the control group contained 63 healthy newborns. Clinical and demographic factors, including date of birth, gender of the newborns, type of oral cleft, consanguinity of the parents, parental ethnicity, and the mother's parity, age, education and intake of folic acid were recorded for analysis.
Results:
A significant association was found between parity higher than 2 and the risk of an oral cleft (OR= 3.33, CI 95% [1.20, 9.19], P> 0.02). According to ethnicity, the odds ratio for oral clefts was 0.87 in Turkmens compared with Sistani people (CI 95% [0.25, 2.96]) and 1.11 in native Fars people compared with Sistani people (CI 95% [0.38, 3.20]). A lack of folic acid consumption was associated with an increased risk of oral clefts but this was not statistically significant (OR = 1.42, CI 95% [0.58, 3.49]). There were no significant associations between sex (OR boy/girl = 0.96, CI 95% [0.41, 2.23]), parent familial relations (OR = 1.07, CI 95% [0.43, 2.63]), mother's age and oral clefts.
Conclusions:
The results of this study indicate that higher parity is significantly associated with an increased risk of an oral cleft, while Fars ethnicity and a low intake of folic acid increased the incidence of oral clefts but not significantly.
https://ijorl.mums.ac.ir/article_198_652c2b9e65c76c58faa4790c579b1e6e.pdf
2012-10-01
187
192
10.22038/ijorl.2011.198
Cleft lip
Cleft palate
Consanguinity
Ethnicity
folic acid
Parity
Mohammad Jafar
Golalipour
mjgolalipour@yahoo.com
1
Gorgan congenital malformations research center, Golestan university of Medical sciences, Gorgan, Iran.
AUTHOR
Nafiseh
Kaviany
2
Gorgan congenital malformations research center, Golestan university of Medical sciences, Gorgan, Iran.
AUTHOR
Mostafa
Qorbani
3
Department of Epidemiology, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Elham
Mobasheri
4
Department of Gynecology, Gorgan Congenital Malformations Research Center, Golestan University of Medical, Sciences, Gorgan, Iran.
AUTHOR
ORIGINAL_ARTICLE
Multiple Congenital Epulis of the Mandibular Ridge:
A Case Report
Congenital epulis is a very rare benign soft-tissue tumor of uncertain histogenesis, which is also known as “gingival granular cell tumor of the newborn”. It occurs almost exclusively as a single tumor along the alveolar ridge of the maxilla in newborn females. Although congenital epulis is strikingly similar to the more common adult granular cell tumor histologically, in contrast to the latter congenital epulis cells are negative for S-100 protein. This case report describes a 15-day-old female infant with multiple congenital epulis of the mandibular alveolar ridge.
https://ijorl.mums.ac.ir/article_199_240f180d8ca179439f71eecdeaa13282.pdf
2012-10-01
193
196
10.22038/ijorl.2011.199
Congenital epulis
Congenital gingival granular cell tumor
Mandible
Mehran
Hiradfar
mhiradfar@gmail.com
1
Department of Pediatric Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Nona
Zabolinejad
2
Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mohammad
Gharavi
3
Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Sadaf
Sebt
4
Medical Student, Islamic Azad University of Mashhad, Iran.
AUTHOR
ORIGINAL_ARTICLE
Platelet-Rich Fibrin: An Autologous Fibrin Matrix in Surgical Procedures: A Case Report and Review of Literature
Introduction:
The healing process after surgery is a challenging issue for surgeons. Various materials and techniques have been developed to facilitate this process and reduce its period. Fibrin adhesives are often used in cardiothoracic and vascular surgery to seal diffuse microvascular bleeding and in general and plastic surgery to seal wound borders. This Case report and literature review will introduce the various usages of platelet-rich fibrin in different surgical procedures and the method of producing the matrix.
Case Report:
A 24-year old man with periorbital skin avulsion treated with PRF membrane has been reported and discussed in this paper.
Conclusion:
Platelet-rich fibrin is a natural autologous fibrin matrix, which can be produced with a simple blood sample and a table centrifuge. The material has been used in a wide range of surgical procedures to shorten the healing period and reduce post-surgical complications.
https://ijorl.mums.ac.ir/article_200_1b3e02af209825a8a9b46b7f61a953b5.pdf
2012-10-01
197
202
10.22038/ijorl.2011.200
Blood sample
Fibrin matrix
Healing
Platelet-rich fibrin
Surgery
Majid
Eshghpour
eshghpourm@mums.ac.ir
1
Department Of maxillofacial surgery,Maxillofacial research committee, Mashhad Dental faculty, Mashhad, Iran
AUTHOR
Mohammad Reza
Majidi
majidimr@mums.ac.ir
2
Ear, Nose, Throat, Head and Neck surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Amir Hossein
Nejat
3
Member of Student Research Committee, Mashhad dental faculty, Mashhad, Iran
AUTHOR
ORIGINAL_ARTICLE
A Broken Metallic Tracheostomy Tube
https://ijorl.mums.ac.ir/article_201_60620d375ca9792bfd9db437b03a680d.pdf
2012-10-01
203
203
10.22038/ijorl.2011.201
Mohammad
Naeimi
1
Ear, Nose, Throat, Head and Neck surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohsen
Rajati
rajatim@mums.ac.ir
2
Ear, Nose, Throat, Head and Neck surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Tirzad
Fooladvand
3
2Department of otorhinolaryngology, Qhaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR