ORIGINAL_ARTICLE
Utility of the Atopy Patch Test in the Diagnosis of Allergic Rhinitis
Introduction: The diagnostic work-up of allergic rhinitis (AR) is first and foremost based on the combination of clinical history data and results of skin prick tests (SPT). Other tests, including specific IgE measurement, nasal challenge, and, as a third option, component resolved diagnosis or basophil activation test, may be useful when the diagnosis is difficult because of polysensitization or when negative results of SPT are observed despite a suggestive history for allergy. The atopy patch test (APT) that assesses the type 4 delayed hypersensitivity allergy is currently not sufficiently used. The data obtained in recent studies on the diagnostic utility of the APT in patients with AR was reviewed. Data Sources: Review of the literature. Conclusion: The data from available studies show that the APT is frequently positive in patients with AR, especially when there is a positive history for atopic dermatitis. Very often, APT is the only positive test and therefore performing only SPT or in vitro IgE measurement may lead to an erroneous diagnosis of nonallergic rhinitis. Recent data suggest a role for APT not only for diagnosis but also in epidemiological investigation on respiratory allergy.
https://ijorl.mums.ac.ir/article_6829_24483cd642e0f8200b93d2cf6e9074ca.pdf
2016-05-01
169
175
10.22038/ijorl.2016.6829
Allergic Rhinitis
Allergens
Atopy patch test
Diagnostic tests
Sensitization
Nicola
Fuiano
fuiano50@tin.it
1
Pediatric Allergy Service, San Severo, Italy.
LEAD_AUTHOR
Cristoforo
Incorvaia
cristoforo.incorvaia@gmail.com
2
Pulmonary Rehabilitation, ICP
Hospital, Via Bignami 1, 20137 Milan, Italy.
AUTHOR
1. Mims JW. Epidemiology of allergic rhinitis. Int Forum Allergy Rhinol. 2014;4(S2):S18–S20.
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2. Grabenhenrich LB, Keil T, Reich A, Gough H, Beschorner J, Hoffmann U,et al. Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years. J Allergy Clin Immunol 2015; 136(4): 932-40.e12.
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3. Frati F, Dell’Albani I, Passalacqua G, Bonini S, Rossi O, Senna G, et al. A survey of clinical features of allergic rhinitis in adults. Med Sci Monit 2014;20:2151-6.
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4. Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc 2007;28(1):3–9.
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5. Reed SD, Lee TA, McCrory DC. The economic burden of allergic rhinitis: a critical evaluation of the literature. Pharmacoeconomics 2004;22(6):345-61.
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6. Ryan MW. Asthma and rhinitis: Comorbidities. Otolaryngol Clin North Am 2008;41(2):283-95.
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7. Bousquet J, Heinzerling L, Bachert C, Papadopoulos NG, Bousquet PJ, Burney PG, et al. Global Allergy and Asthma European Network; Allergic Rhinitis and its Impact on Asthma. Practical guide to skin prick tests in allergy to aeroallergens. Allergy 2012;67:18-24.
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8. Dion GR, Weitzel EK, McMains KC. Current approaches to diagnosis and management of rhinitis. South Med J. 2013;106 (9):526-31.
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13. Migueres M, Dávila I, Frati F, Azpeitia A, Jeanpetit Y, Lhéritier-Barrand M, et al. Types of sensitization to aeroallergens: definitions, prevalences and impact on the diagnosis and treatment of allergic respiratory disease. Clin Transl Allergy. 2014;4:16.
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14. Moreno C, Justicia JL, Quiralte J, Moreno-Ancillo A, Iglesias-Cadarso A, Torrecillas M, et al. Olive, grass or both? Molecular diagnosis for the allergen immunotherapy selection in polysensitized pollinic patients. Allergy 2004;69(10):1357-63.
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15. Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, et al. Wao-Aria-Ga2len Task Force. A Wao- Aria- Ga2len consensus document on molecular-based allergy diagnostics. World Allergy Organ J 2013;6:17.
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16. Incorvaia C, Mauro M, Ridolo E, Makrì E, Montagni M, Ciprandi G. A pitfall to avoid when using an allergen microarray: the incidental detection of IgE to unexpected allergens. J Allergy Clin Immunol Pract. 2015;3(6):879-82.
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17. Rondón C, Campo P, Galindo L, Blanca-López N, Cassinello MS, Rodriguez-Bada JL, et al. Prevalence and clinical relevance of local allergic rhinitis. Allergy. 2012;67(10):1282-8
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18. Rondón C, Doña I, López S, Campo P, Romero JJ, Torres MJ, et al. Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response. Allergy 2008; 63(10):1352-8.
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19. Marcucci F, Sensi L. A new method for IgE detection in nasal mucosa. Clin Exp Allergy 1989;19(2):157-62.
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20. Fuiano N, Fusilli S, Passalacqua G, Incorvaia C. Allergen-specific immunoglobulin E in the skin and nasal mucosa of symptomatic and asymptomatic children sensitized to aeroallergens. J Investig Allergol Clin Immunol 2010; 20(5):425-30.
20
21. Incorvaia C, Fuiano N, Canonica GW. Seeking allergy when it hides: which are the best fitting tests? World Allergy Organ J 2013;6(1):11.
21
22. Ring J, Kunz B, Bieber T, Przybilla B. The “atopy patch test” with aeroallergens in atopic eczema. J Allergy Clin Immunol 1989;82:195.
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23. Sager N, Feldmann A, Schilling C, Kreitsch P, Neumann C. House dust mite specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J Allergy Clin Immunol 1992; 89(4):801-10.
23
24. Wistokat-Wülfing A, Schmidt P, Darsow U, Ring J, Kapp A, Werfel T. Atopy patch test reactions are associated with T lymphocyte-mediated allergen-specific immune responses in atopic dermatitis. Clin Exp Allergy 1999;29(4):513-21.
24
25. Kerschenlohr K, Decard S, Przybilla B, Wollenberg A. Atopy patch test reactions show a rapid influx of inflammatory dendritic epidermal cells(IDEC) in patients with extrinsic atopic dermatitis and patients withintrinsic atopic dermatitis patients. J Allergy Clin Immunol 2003; 111(4):869-74.
25
26. Kerschenlohr K, Decard S, Darsow U, Ollert M, Wollenberg A. Clinical and immunologic reactivity to aeroallergens in “intrinsic” atopic dermatitis patients. J Allergy Clin Immunol 2003; 111:195-97.
26
27. Darsow U, Laifaoui J, Kerschenlohr K, Wollenberg A, Przybilla B, Wüthrich B, et al. The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study. Allergy 2004; 59(12):1318-25.
27
28. Guler N, Kirerleri E, Tamay Z, Ones U. Atopy patch testing in children with asthma and rhinitis symptoms allergic to house dust mite. Pediatr Allergy Immunol 2006; 17(5): 346-50.
28
29. Fuiano N, Incorvaia C, Prodam F, Procaccini DA, Bona G. Relationship between the atopy patch test and clinical expression of the disease in children with atopic eczema/dermatitis syndrome and respiratory symptoms. Ann Allergy Asthma Immunol 2008; 101(2):174-8.
29
30. Sprecher E, Leung DY. Atopic dermatitis: scratching through the complexity of barrier dysfunction. J Allergy Clin Immunol. 2013; 132: 1130-1.
30
31. Fuiano N, Fusilli S, Incorvaia C. House dust mite-related allergic diseases: role of skinprick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy. Eur J Pediatr 2010;169(7):819-24.
31
32. Fuiano N, Incorvaia C. The atopy patch test: is it time to redefine its significance? Ann Allergy Asthma Immunol 2011;106(4):278-82.
32
33. Fuiano N, Diddi G, Delvecchio M, Incorvaia C. Diagnostic performance of the atopy patch test with inhalant allergens. J Investig Allergol Clin Immunol 2015; 25(1):34-9
33
34. Zhao J, Li LF. Atopy patch test to Dermatophagoides mix in a self-selected population in Beijing. Dermatitis 2013;24(2): 82-4.
34
35. Fuiano N, Diddi G, Delvecchio M, Incorvaia C. Prevalence of positive atopy patch test in an unselected pediatric population. Clin Mol Allergy2013; 24(2):82-4.
35
ORIGINAL_ARTICLE
Ocular Motor Function in Patients with Bilateral Vestibular Weakness
Introduction: Patients with bilateral weakness (BW) have many difficulties in gaze stability that interfere with their normal function. The aim of this study was to evaluate ocular motor functions in patients with BW to better understand the problem of gaze instability in these patients. Materials and Methods: Patients were referred from the Otolaryngology Department for Vestibular Assessment to our clinic between November 2014 and March 2015. We assessed ocular motor function (gaze, saccade, and smooth pursuit) in patients over the age of 18 years with BW, as verified by a caloric test. Results: Seventy-eight patients completed all the tests. The mean age of patients was 51.9 (±15.9) years, and 47 (60%) were female. Abnormal results were found in five (6.4%), 32 (41%), and seven (9%) patients with respect to gaze, smooth pursuit, and saccade, respectively. There were positive but relatively weak relationships between age and ocular motor results. Conclusion: Patients with BW suffer from dizziness and unsteadiness. These patients have abnormal function in ocular motor (especially smooth pursuit) tests. The ocular motor dysfunction is responsible for gaze instability in static positions such as standing.
https://ijorl.mums.ac.ir/article_6849_346283f42217fb1f388cd83be834be9c.pdf
2016-05-01
177
181
10.22038/ijorl.2016.6849
Gaze stability
Ocular motor
vertigo
Seyyed Amir Hossein
Ghazizadeh Hashemi
yaazalnoor@gmail.com
1
Department of ENT, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Sadegh
Jafarzadeh
jafarzadehs@mums.ac.ir
2
Department of Audiology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Majid
Haddadi Aval
majd1240@yahoo.com
3
Department of Audiology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Reza
Hosseinabadi
reza.hoseinabadi@gmail.com
4
Department of Audiology, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
1. Ramaioli C, Colagiorgio P, Saglam M, Heuser F, Schneider E, Ramat S, et al. The effect of vestibulo-ocular reflex deficits and covert saccades on dynamic vision in opioid-induced vestibular dysfunction. PloS one. 2014;9(10):e110322.
1
2. Guinand N, Pijnenburg M, Janssen M, Kingma H. Visual acuity while walking and oscillopsia severity in healthy subjects and patients with unilateral and bilateral vestibular function loss. Archives of otolaryngology head and neck surgery. 2012;138(3):301-6.
2
3. Ward BK, Agrawal Y, Hoffman HJ, Carey JP, Della Santina CC. Prevalence and impact of bilateral vestibular hypofunction: results from the 2008 US National Health Interview Survey. JAMA otolaryngology-head & neck surgery. 2013; 139(8):803-10.
3
4. Huh YE, Kim JS. Bedside evaluation of dizzy patients. Journal of clinical neurology (Seoul, Korea). 2013;9(4):203-13.
4
5. Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke. A journal of cerebral circulation. 2009;40(11):3504-10.
5
6. Oh SY, Kim DH, Yang TH, Shin BS, Jeong SK. Clinical classification and neuro-vestibular evaluation in chronic dizziness. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology. 2015;126(1):180-6.
6
7. Ross RG, Olincy A, Harris JG, Radant A, Adler LE, Compagnon N, et al. The effects of age on a smooth pursuit tracking task in adults with schizophrenia and normal subjects. Biological psychiatry. 1999;46(3):383-91.
7
8. Klein C, Fischer B, Hartnegg K, Heiss WH, Roth M. Optomotor and neuropsychological performance in old age. Experimental brain research. 2000;135(2):141-54.
8
9. Irving EL, Steinbach MJ, Lillakas L, Babu RJ, Hutchings N. Horizontal saccade dynamics across the human life span. Investigative ophthalmology & visual science. 2006;47(6):2478-84.
9
10. Roeser R, Valente M, Hosford-Dunn H. Audiology diagnosis, second edition,. new York: thieme, . 2007, Page 551.
10
11. Katz J, chasin M, English K, Hood L, Tillery K. Handbook of clinical audiology, seventh edition, Philadelphia, Wolters Kluwer. 2015, page 414.
11
12. Herdman SJ, Tusa RJ, Blatt P, Suzuki A, Venuto PJ, Roberts D. Computerized dynamic visual acuity test in the assessment of vestibular deficits. The American journal of otology. 1998;19(6):790-6.
12
13. Niemann T, Lappe M, Buscher A, Hoffmann KP. Ocular responses to radial optic flow and single accelerated targets in humans. Vision research. 1999;39(7):1359-71.
13
14. Dowiasch S, Marx S, Einhauser W, Bremmer F. Effects of aging on eye movements in the real world. Frontiers in human neuroscience. 2015;9:46.
14
15. Buttner-Ennever JA, Buttner U. Neuroanatomy of the ocular motor pathways. Bailliere's clinical neurology. 1992;1(2):263-87.
15
16. Tilikete C, Pelisson D. Ocular motor syndromes of the brainstem and cerebellum. Current opinion in neurology. 2008;21(1):22-8.
16
17. Strupp M, Hufner K, Sandmann R, Zwergal A, Dieterich M, Jahn K, et al. Central oculomotor disturbances and nystagmus: a window into the brainstem and cerebellum. Deutsches Arzteblatt international. 2011;108(12):197-204.
17
18. Ajrezo L, Wiener-Vacher S, Bucci MP. Saccades improve postural control: a developmental study in normal children. PloS one. 2013; 8(11):e81066.
18
19. Whitney SL, Marchetti GF, Pritcher M, Furman JM. Gaze stabilization and gait performance in vestibular dysfunction. Gait & posture. 2009; 29(2): 194-8.
19
20. Strupp M, Brandt T. Diagnosis and treatment of vertigo and dizziness. Deutsches Arzteblatt international. 2008;105(10):173-80.
20
21. Guinand N, Boselie F, Guyot JP, Kingma H. Quality of life of patients with bilateral vestibulopathy. The Annals of otology, rhinology, and laryngology. 2012;121(7):471-7.
21
ORIGINAL_ARTICLE
Is Daycare Tonsillectomy Safe?
Introduction: Tonsillectomy is one of the most common procedures performed by Ear, Nose, and Throat surgeon. Usually, the procedure is carried out as an inpatient surgery. With the increasing need to reduce healthcare costs, spare precious hospital beds, and shorten elective surgery lists, there is currently a trend towards performing tonsillectomy on a daycare basis. Materials and Methods: A prospective review of all tonsillectomies performed at the University Malaya Medical Center was undertaken for the year 2013. Demographic details, qualifying indications, and complication rates were evaluated. Results: There was no incidence of primary hemorrhage among the 96 tonsillectomies performed. There was no significant correlation in terms of secondary hemorrhage between inpatient and day-case tonsillectomy (P=0.54). Only two patients required revision surgery to stop post-tonsillectomy bleeding. None of the patients required blood transfusion, and there were no mortalities. Conclusion: Daycare tonsillectomy is safe as long as the patient is carefully selected. Both medical and social aspects should be taken into consideration. A post-operative observation period of at least 6 to 8 hours is important. The surgeon should personally review the patient post-operatively and decides if he or she should be hospitalized for observation, or safe for discharge.
https://ijorl.mums.ac.ir/article_6825_5c6047b76f388654908c1453de6fa4a6.pdf
2016-05-01
183
188
10.22038/ijorl.2016.6825
Daycare
Hemorrhage
Post-tonsillectomy bleeding
Tonsillectomy
Hui Tong
Wong
whtong83@gmail.com
1
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur,
Malaysia.
LEAD_AUTHOR
Sien Hui
Tan
sienic@yahoo.com
2
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur,
Malaysia.
AUTHOR
Aun Wee
Chong
aw_chong@um.edu.my
3
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur,
Malaysia.
AUTHOR
1. Carithers JS, Gebhart DE, Williams JA. Postoperative risks of pediatric tonsilloadeno- idectomy. The Laryngoscope 1987; 97(4): 422–9.
1
2. Fujihara K, Koltai PJ, Hayashi M, Tamura S, Yamanaka N. Cost-effectiveness of tonsillectomy for recurrent acute tonsillitis. Ann Otol Rhinol Laryngol 2006; 115(5):365–9.
2
3. Paradise JL, Bluestone CD, Colbom DK, Bernard BS, Rockette HE, Kiirs-Lasky M. Tonsillectomy and adenolonsillectomy for recurrent throat infection in moderately affected children. Pediatrics 2002;110(1):7–15.
3
4. Pickering AE, Bridge HS, Nolan J, Stoddart PA. Double blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children.Br J Anaesth 2002; 88(1):72–7.
4
5. Raymond CA. Study Questions Safety Economic Benefits of Outpatient Tonsil/Adenoid Surgery. JAMA1986; 256(3):311–2.
5
6. Reiner SA, Sawyer WP, Clark KF, Wood MW. Safety of outpatient tonsillectomy and adenoidectomy. Otolaryngol Head Neck Surg 1990; 102(2):161–8.
6
7. Maniglia AJ, Kushner H, Cozzi L. Adenotonsillectomy-A Safe Outpatient Procedure. Arch Otolaryngol Head Neck Surg.1989;115(1):92–4.
7
8. Guida RA, Mattucci KF. Tonsillectomy and Adenoidectomy: An Inpatient or Outpatient Procedure. Laryngoscope.1990; 100(5):491–493.
8
9. Tewary AK. Day-case tonsillectomy: a review of the literature. J Laryngol Otol. 1993; 107(8):703–5.
9
10. Laureyns G, Lemkens P, Jorissen M. Tonsillectomy as a day-case surgery: a safe procedure? B-ENT. 2006; 2(3):109–16.
10
11. Nurliza I, Norzi G, Azlina A, Hashimah I, Sabzah MH. Daycare tonsillectomy: a safe outpatient procedure. Hospital Sultanah Bahiyah, Alor Setar Malaysia experience. Med J Malaysia. 2011;66(5): 474–8.
11
12. Bluestone CD. Status of tonsillectomy and adenoidectomy. Laryngoscope. 1977; 87(8):1233–43.
12
13. Ranjit S, Brett RH, Lu PK, Aw CY. The incidence and management of post-tonsillectomy haemorrhage: a Singaporean experience. Singapore Med J 1999; 40(l0):622–6.
13
14. Ahmad R, Abdullah K, Amin Z, Rahman JA. Predicting safe tonsillectomy for ambulatory surgery. Auris Nasus Larynx. 2010;37(2):185–9.
14
15. Chee NW, Chan KO. Clinical audit on tonsils and adenoid surgery. Is day surgery a reasonable option. Ann Acad Med Singapore 1996; 25:245–50.
15
16. Postma DS, Folsom F. The case of outpatient "approach" for all pediatric tonsillectomies and/or adenoidectomies: a 4-year review of 1419 cases at a community hospital. Otolaryngol Head Neck Surg 2002;127:101–8.
16
17. Ross AT, Kazahaja K, Tom LW. Revisiting outpatient tonsillectomy in young children. Otolaryngol Head Neck Surg 2003;128(3):326–31.
17
18. Granell J, Gete P, Villagruela M, Bolanos C, Vicent JJ. Safety of outpatient tonsillectomy in children: a review of 6 years in a tertiary hospital experience. Otolaryngol Head Neck Surg 2004; 131:383–7.
18
19. Masoom A, Akhtar S, Humayun HN, Ikram M. Daycare adeno-tonsillectomy: is it safe in developing countries? J Pak Med Assoc. 2012; 62:458–60.
19
20. Tewary AK. Day-case tonsillectomy: A review of the literature. J Laryngol Otol 1993; 107:703–5.
20
21. Gabalski EC, Mattucci KF, Setzen M, Moleski P. Ambulatory tonsillectomy and adenoidectomy. Laryngoscope. 1996; 106(1 Pt 1):77–80.
21
22. Moralee SJ, Murray JA. Would day-case adult tonsillectomy be safe? J Laryngol Otol. 1995;109 (12): 1166–7.
22
23. Bennett AMD, Clark AB, Bath AP, Montgomery PQ. Meta-analysis of the timing of haemorrhage after tonsillectomy: an important factor in determining the safety of performing tonsillectomy as a day case procedure. Clin Otolaryngol 2005; 30:418–23.
23
ORIGINAL_ARTICLE
Is Sudden Hearing Loss Associated with Atherosclerosis?
Introduction: Sudden sensorineural hearing-loss (SSNHL) patients constitute approximately 2–3% of referrals to ear, nose and throat (ENT) clinics. Several predisposing factors have been proposed for this condition; one of which is vascular disorders and perfusion compromise. In this research the atherosclerotic changes and their known risk factors are studied in SSNHL patients. Materials and Methods: Thirty SSNHL patients and 30 controls were evaluated with regard to cardiovascular risks including history, heart examination, blood pressure, body mass index, waist circumference, electrocardiogram, blood sugar, triglycerides, cholesterol, high-sensitivity C-reactive protein (HSCRP); also, carotid artery color Doppler study was undertaken to measure intima media thickness(IMT). Results: IMT and HSCRP showed an increased risk in the case group compared with the controls (P= 0.005 & P=0.001). However, waist circumference, history of smoking, fasting blood sugar, lipid profile, and electrocardiogram revealed no significant difference between the two groups. Interestingly, blood pressure and body mass index were higher in the controls in this study. Conclusion: Sudden sensorineural hearing loss may be associated with subclinical atherosclerosis.
https://ijorl.mums.ac.ir/article_6851_d7a959cd59a52d020e40b17acdab5b7a.pdf
2016-05-01
189
195
10.22038/ijorl.2016.6851
Atherosclerosis
Risk factors
Carotid intima-media thickness
Doppler C-reactive protein
Ultrasonography
Sudden sensorineural hearing loss
Mohsen
Rajati
rajatim@mums.ac.ir
1
Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mahmoud Reza
Azarpajooh
azarpajoohmr@mums.ac.ir
2
Department of Neurology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mohsen
Mouhebati
mohebatim@mums.ac.ir
3
Department of Cardiology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mostafa
Nasrollahi
mehbakhsh@gmail.com
4
Department of Otorhinolaryngology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Maryam
Salehi
salehim@mums.ac.ir
5
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Ehsan
Khadivi
khadivie@mums.ac.ir
6
Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Navid
Nourizadeh
nourizadehn@mums.ac.ir
7
Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Firoozeh
Hashemi
8
Department of Otorhinolaryngology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mehdi
Bakhshaee
mehbakhsh@yahoo.com
9
Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
1. Whitaker S. Idiopathic sudden hearing loss. Otology & Neurotology. 1980;1(3):180-3.
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2. Wilson W. The relationship of the herpesvirus family to sudden hearing loss: a prospective clinical study and literature review. The Laryngoscope. 1986;96(8):870.
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4. Stokroos R, Albers F, Van Cauwenberge P. Diagnosis and treatment of idiopathic sudden sensorineural hearing loss (ISSHL). A survey in The Netherlands and Flanders. Acta oto-rhino-laryngologica belgica. 1996;50(3):237.
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5. Rajati M, Bakhshaee M, Naghavi E, Hoseinnejad F, Rouhi HR, Movahhed R. Studying VEMP in sudden sensorineural hearing loss. Iranian Journal of Otorhinolaryngology. 2011;23(64):60-74.
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6. Zhang K, Wang F, Zhang Y, Li M, Shi X. Anatomic investigation of the labyrinthine artery. Zhonghua er bi yan hou ke za zhi. 2002;37(2):103.
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7. A AH. Sensorineural hearing loss in adults. In: Flint PW HB, Lund VJ, Niparko JL, et al, editor. Cumming’s otolaryngology head and neck surgery
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5th ed. Philadelphia: Elsevier Mosby; 2010. 2127-30
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8. Arastou S, Tajedini A, Borghei P. Combined Intratympanic and Systemic Steroid Therapy for Poor-Prognosis Sudden Sensorineural Hearing Loss. Iranian Journal of Otorhinolaryngology 2013; 25(70):23-8.
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9. Rauch SD. Idiopathic sudden sensorineural hearing loss. New England Journal of Medicine. 2008;359(8):833-40.
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10. Wong ND. Epidemiological studies of CHD and the evolution of preventive cardiology. Nature Reviews Cardiology. 2014;11: 276–89
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11. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto Jr AM, Kastelein JJ, et al. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. The Lancet. 2009;373(9670):1175-82.
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12. Vainas T, Lubbers T, Stassen FR, Herngreen SB, van Dieijen-Visser MP, Bruggeman CA, et al. Serum C-reactive protein level is associated with abdominal aortic aneurysm size and may be produced by aneurysmal tissue. Circulation. 2003; 107(8):1103-5.
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13. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson Jr SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. New England Journal of Medicine. 1999; 340(1): 14-22.
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14. Takinami Y. Evaluation of effectiveness of stellate ganglion block (SGB) treatment of sudden hearing loss. Acta oto-laryngologica. 2012; 132(1): 33-8.
15
15. Lin RJ, Krall R, Westerberg BD, Chadha NK, Chau JK. Systematic review and meta‐analysis of the risk factors for sudden sensorineural hearing loss in adults. The Laryngoscope. 2012;122(3): 624-35.
16
16. Drobinski G, Evans J, Eugène M, Laurenceau J, Huberman J, Bèjean-Lebuisson A, et al. Assessment of the degree of severity of aortic stenosis. Clinical, mechanographic, echographic and hemodynamic study of 22 cases]. Archives des maladies du coeur et des vaisseaux. 1981;74(1):21.
17
17. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation. 1986;74(6):1399-406.
18
18. Głowińska-Olszewska B, Tołwińska J, Urban M. Interrelationship between endothelial dysfunction, IMT of the carotid arteries and adhesion molecules in obese hypertensive children and adolescents. Pediatric endocrinology, diabetes, and metabolism. 2007;13(1):7.
19
19. Crouse III JR. Predictive value of carotid 2-dimensional ultrasound. The American journal of cardiology. 2001;88(2):27-30.
20
20. Melling M, Koos W. Abnormality of the labyrinthine artery and its topographical relation to the abducent nerve. Cells Tissues Organs. 1996; 156(2):151-4.
21
21. Ciccone MM, Cortese F, Pinto M, Di Teo C, Fornarelli F, Gesualdo M, et al. Endothelial function and cardiovascular risk in patients with Idiopathic Sudden Sensorineural Hearing Loss. Atherosclerosis. 2012; 225(2):511-6.
22
22. Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H, et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otology & Neurotology. 2012; 33(7): 1142-50.
23
23. Pearson T A., Mensah G A., Alexander R. W, Anderson J L., Cannon III R O., Criqui M, et al. Markers of inflammation and cardiovascular disease application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association. Circulation. 2003; 107(3):499-511.
24
24. Nichols WW, Pepine CJ, O’Rourke MF. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke. N Engl J Med. 1999;340(22):1762-3.
25
ORIGINAL_ARTICLE
Investigating the Prevalence of Human Papilloma Virus in Squamous Cell Carcinoma of the Larynx and Its Correlation with Disease Prognosis
Introduction: The human papilloma virus (HPV) can play a role in the development of head and neck squamous cell carcinoma (SCC). Our aim was to assess the prevalence of HPV DNA in SCC of the larynx. The impact of HPV infection on patient survival was also evaluated. Materials and Methods: This case-control study was performed in 44 patients with SCC of the larynx (case group), while the control group comprised samples obtained from cadavers with no previous history of malignancy. A preliminary pathologic evaluation was performed on all samples in the control group (36 samples) to ensure the absence of dysplasia or malignancy. Polymerase chain reaction (PCR) was used to detect HPV DNA. After completing the treatment protocol, patients were followed to assess the impact of HPV infection on overall survival (OS). Results: PCR evaluation in the case group showed that HPV DNA was successfully isolated from 11 (25%) samples, while only two (5.6%) HPV DNA-positive were obtained from cadavers. According to these results, a significant difference was obtained in the prevalence of HPV DNA and laryngeal SCC between cases and controls (P=0.031). No statistically significant difference was observed in the OS of patients with or without HPV infection in the case group (P=0.235). Conclusion: Based on these results, we suggest that the prevalence of HPV infection is higher in laryngeal SCC subjects compared with healthy individuals. Although a longer OS was seen in HPV-positive patients, survival analysis did not show a significant difference in the comparison of HPV-positive and negative findings in SCC patients.
https://ijorl.mums.ac.ir/article_6854_5ef0baf1b332b1714ee68bc201ee50ef.pdf
2016-05-01
197
202
10.22038/ijorl.2016.6854
Human Papilloma Virus (HPV)
Larynx
Survival
Squamous cell carcinoma
Risk
Saeid
Atighechi
saeidatighechi@yahoo.com
1
Otorhinolaryngology Research Center, Department of Otorhinolaryngology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Mojtaba
Meybodian
dr.meybodian2015@gmail.com
2
Otorhinolaryngology Research Center, Department of Otorhinolaryngology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
LEAD_AUTHOR
Mohammad Hossein
Dadgarnia
drdadgarnia@yahoo.com
3
Otorhinolaryngology Research Center, Department of Otorhinolaryngology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Mohammad Hossein
Baradaranfar
baradaranf@yahoo.com
4
Otorhinolaryngology Research Center, Department of Otorhinolaryngology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Nasim
Behniafard
nbehniafard@gmail.com
5
Otorhinolaryngology Research Center, Department of Otorhinolaryngology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA: a cancer journal for clinicians. 2007;57(1):43-66.
1
2. Vigneswaran N, Williams MD. Epidemiologic trends in head and neck cancer and aids in diagnosis. Oral and maxillofacial surgery clinics of North America. 2014;26(2):123-41.
2
3. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiology Biomarkers & Prevention. 2005;14(2):467-75.
3
4. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. Journal of the National Cancer Institute. 2000;92(9):709-20.
4
5. Syrjänen K, Syrjänen S, Lamberg M, Pyrhönen S, Nuutinen J. Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis. International journal of oral surgery. 1983;12(6): 418-24.
5
6. Mehanna H, Beech T, Nicholson T, El‐Hariry I, McConkey C, Paleri V, et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta‐analysis of trends by time and region. Head & neck. 2013;35(5):747-55.
6
7. Hobbs C, Sterne J, Bailey M, Heyderman R, Birchall M, Thomas S. Human papillomavirus and head and neck cancer: a systematic review and meta‐analysis. Clinical Otolaryngology. 2006; 31(4): 259-66.
7
8. O’rorke M, Ellison M, Murray L, Moran M, James J, Anderson L. Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis. Oral oncology. 2012;48(12):1191-201.
8
9. Gillison M, Lowy D. A causal role for human papillomavirus in head and neck cancer. The Lancet. 2004;363(9420):1488-9.
9
10. .Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Eckel HE, Pfister HJ, et al. Human papillomavirus-positive tonsillar carcinomas: a different tumor entity? Medical microbiology and immunology. 2003;192(3):129-32.
10
11. Gillison ML. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Seminars in oncology 2004;31(6):744-54.
11
12. Cattani P, Hohaus S, Bellacosa A, Genuardi M, Cavallo S, Rovella V, et al. Association between cyclin D1 (CCND1) gene amplification and human papillomavirus infection in human laryngeal squamous cell carcinoma. Clinical cancer research. 1998;4(11):2585-9.
12
13. Flaitz C, Hicks M. Molecular piracy: the viral link to carcinogenesis. Oral oncology. 1998;34(6):448-53.
13
14. Dahlstrand H, Näsman A, Romanitan M, Lindquist D, Ramqvist T, Dalianis T. Human papillomavirus accounts both for increased incidence and better prognosis in tonsillar cancer. Anticancer research. 2008;28(2B):1133-8.
14
15. Näsman A, Attner P, Hammarstedt L, Du J, Eriksson M, Giraud G, et al. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma? International Journal of Cancer. 2009; 125(2):362-6.
15
16. Ryerson AB, Peters ES, Coughlin SS, Chen VW, Gillison ML, Reichman ME, et al. Burden of potentially human papillomavirus‐associated cancers of the oropharynx and oral cavity in the US, 1998–2003. Cancer. 2008;113(S10):2901-9.
16
17. Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Kolligs J, Jungehuelsing M, et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer. 2001; 92(11):2875-84.
17
18. Strome SE, Savva A, Brissett AE, Gostout BS, Lewis J, Clayton AC, et al. Squamous Cell Carcinoma of the Tonsils A Molecular Analysis of HPV Associations. Clinical Cancer Research. 2002; 8(4):1093-100.
18
19. Herrero R, Castellsagué X, Pawlita M, Lissowska J, Kee F, Balaram P, et al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. Journal of the National Cancer Institute. 2003;95(23):1772-83.
19
20. Zhang ZY, Sdek P, Cao J, Chen WT. Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa. International journal of oral and maxillofacial surgery. 2004; 33(1):71-4.
20
21. Rees L, Birchall M, Bailey M, Thomas S. A systematic review of case–control studies of human papillomavirus infection in laryngeal squamous cell carcinoma. Clinical Otolaryngology & Allied Sciences. 2004;29(4):301-6.
21
22. Laskaris S, Sengas I, Maragoudakis P, Tsimplaki E, Argyri E, Manolopoulos L, et al. Prevalence of Human Papillomavirus Infection in Greek Patients with Squamous Cell Carcinoma of the Larynx. Anticancer research. 2014;34(10):5749-53.
22
23. Roshan NM, Jafarian A, Ayatollahi H, Ghazvini K, Tabatabaee SA. Correlation of laryngeal squamous cell carcinoma and infections with either HHV-8 or HPV-16/18. Pathology Research and Practice. 2014;210(4):205-9.
23
24. Rodrigo JP, Hermsen MA, Fresno MF, Brakenhoff RH, García-Velasco F, Snijders PJ, et al. Prevalence of human papillomavirus in laryngeal and hypopharyngeal squamous cell carcinomas in northern Spain. Cancer epidemiology. 2015;39(1): 37-41.
24
25. Hoffmann M, Görögh T, Gottschlich S, Lohrey C, Rittgen W, Ambrosch P, et al. Human papillomaviruses in head and neck cancer: 8 year-survival-analysis of 73 patients. Cancer letters. 2005; 218(2):199-206.
25
ORIGINAL_ARTICLE
Audiological Evaluation of Patients Taking Kanamycin for Multidrug Resistant Tuberculosis
Introduction: The incidence of multidrug resistant tuberculosis is increasing in developing countries. Aminoglycosides are an integral part of second-line drugs, however ototoxicity is a major limitation for their use. This study aims to determine the extent of hearing loss in patients taking one of the commonly prescribed drugs for Multidrug resistant tuberculosis (MDR-TB), Kanamycin, at a Government Medical College, Patiala, Punjab, India, which is a 1200 bed tertiary care hospital. Materials and Methods: A total of 100 patients (68 males and 32 females) with confirmed diagnosis of MDR-TB were included in this study conducted between January 2012 and February 2014. Subjects were between 15 to 60 years of age, with a mean age of 37.46 ± 10.1. Pure tone audiometry (PTA) was performed before the start of the therapy, as a baseline, and was repeated after 1 week and 6 weeks of Kanamycin use to assess hearing loss as an effect of therapy. Results: Of the 100 patients examined, ototoxicity was found in 18 subjects post therapy. Incidence of high frequency hearing loss was 2% at week 1, and 12% after 6 weeks of follow up. However, 4% of the cases developed flat loss at week 6. The hearing loss was bilateral in 13 patients and unilateral in 5 patients. Ototoxicity was more common in males (66.67%) compared to females (33.3%). Maximum cases were found in the age group of 36 to 45 years (36.8%), the majority being from a rural background (83.3%). The association with socioeconomic status (P=0.024) and co-morbid conditions like diabetes and hypertension (P=0.001) reached statistical significance. Conclusion: Lack of specific guidelines to monitor patients taking aminoglycosides makes ototoxicity a major adverse effect of their use in MDR-TB. More studies are mandated to study the risk factors associated with the development of ototoxicity and for the development of alternate drugs for the treatment of MDR-TB.
https://ijorl.mums.ac.ir/article_6845_4d5cab5a96fae6527896bd1532e6931f.pdf
2016-05-01
203
208
10.22038/ijorl.2016.6845
Co-morbidity
Kanamycin
Ototoxicity
MDR-TB
Pure tone audiometry
Socioeconomic status
Vishal
Sharma
drvishalsharma2@gmail.com
1
Department of Otorhinolaryngology, Government Medical College, Patiala, Punjab, India.
AUTHOR
Sanjeev
Bhagat
sbent224@gmail.com
2
Department of Otorhinolaryngology, Government Medical College, Patiala, Punjab, India.
LEAD_AUTHOR
Ravinder
Singh
rsingh7373@gmail.com
3
Department of Otorhinolaryngology, Government Medical College, Patiala, Punjab, India.
AUTHOR
Bhimsain
Verma
bhimsain.verma@gmail.com
4
Department of Otorhinolaryngology, Government Medical College, Patiala, Punjab, India.
AUTHOR
Surinderpal
Singh
spsingh@gmail.com
5
Department of Otorhinolaryngology, Government Medical College, Patiala, Punjab, India.
AUTHOR
Shelja
Wadhwa
dr.sheljawadhwa.dsw@gmail.com
6
Department of Pulmonary Medicine, Government Medical College, Patiala, Punjab, India.
AUTHOR
1. World Health Organization, Geneva, Switzerland. Global tuberculosis control.WHO/HTM/TB/2011: 16.
1
2. Sande MA, Mandell GL. Antimicrobial agents. The aminoglycosides. In: Gilman. The Pharmacological Basis of Therapeutics. 8th ed. Pergamon Press: New York; 1990:1098–116.
2
3. Wu WJ, Sha SH, Schacht J. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiol. Neuro-otol 2002; 7: 171–4.
3
4. Brummett R E, Fox K E. Aminoglycoside-induced hearing loss in humans. Antimicrob Agents Chemother 1989; 33: 797–800.
4
5. American Speech-Language-Hearing Association audiologic management of individuals receiving cochleotoxic drug therapy. Guidelines for audiologic management of individuals receiving cochleotoxic drug therapy. ASHA 1994;34(12): 11-9.
5
6. Duggal P, Sarkar M. Audiologic monitoring of multidrug-resistant tuberculosis patients on aminoglycoside treatment with long term follow-up. BMC Ear, Nose and Throat Disorders 2007; 7: 1-7.
6
7. Campbell KC. Audiologic monitoring for ototoxicity. In: Roland P, Rutka J.Ototoxicity.B C Decker; 2004: 153-60.
7
8. Fausti SA, Helt WJ, Gordon JS, Reavis KM, Philips DS, Konard DL. Audiologic monitoring for ototoxicity and patient management. In: KCM Campbell. Pharmacology and ototoxicity for audiologists. New York: Thomson Delmar Learning; 2007, 1st ed, Ch. 17.
8
9. Javadi MR, Abtahi B, Gholami K, Moghadam BS, Tabarsi P, Salamzadeh J. The Incidence of Amikacin Ototoxicity in Multidrug-Resistant Tuberculosis Patients.Iranian Journal of Pharmaceutical Research 2011; 10 (4): 905-911.
9
10. de Jager P, Altena RV. Hearing loss and nephrotoxicity in long-term aminoglycoside treatment in patients with tuberculosis. Int J Tuberc Lung Dis 2002; 6(7):622–7.
10
11. Harris T, Bardien S, Schaaf HS, Petersen L, de Jong G, Fagan JJ. Aminoglycoside-induced hearing loss in HIV-positive and HIV-negative multidrug-resistant tuberculosis patients. S Afr Med J 2012; 102(6):363-6.
11
12. Moore RD, Smith CR, Lietman PS. Risk factors for the development of auditory toxicity in patients receiving aminoglycosides.J Infect Dis 1984;149:23-30.
12
13. Gatell J M, Ferran F, Araujo V, Bonet M, Soriano E, Traserra J et al. Univariate and multivariate analyses of risk factors predisposing to auditory toxicity in patients receiving aminoglycosides. Antimicrob Agents Chemother 1987; 31: 1383–7.
13
14. Gulbay BE, Gurkan OU, Yildiz OA, Onen ZP, Erkekol FO, Baccioglu, A et al. Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized patients for tuberculosis.Respiratory Medicine 2006;100:1834-42.
14
15. Bainbridge K, Hoffman H, Cowie C. Diabetes and hearing impairment in the United States: Audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004. Annals of Internal Medicine, 2008; 149, 1–10.
15
16. Seddon JA, Thee S, Jacobs K, Ebrahim A, Hesseling AC, Schaaf HS. Hearing loss in children
16
treated for multidrug resistant Tuberculosis. J Infect 2013; 66(4):320-9.
17
ORIGINAL_ARTICLE
Comparison of Tympanoplasty Results in Dry and Wet Ears
Introduction: Tympanoplasty is the standard and well established procedure for closure of tympanic membrane perforations .This paper compares the results of tympanoplasty in terms of hearing improvement and graft incorporation in patients with chronic perforation of the tympanic membrane between two groups with and without active drainage at the time of surgery. Materials and Methods: Sixty referring patients to specialty and subspecialty clinics between the age 15 to 60 years-old were selected. All patients suffered from Chronic Otitis Media and they were categorized into two groups: a) those with wet ears and b) those with dry ears. Tympanoplasty surgery was performed through the use of embedding technique of temporalis fascia graft and in medial position (Medial Graft Technique). Finally, the data about the level of hearing improvement and the repair of tympanic membrane were analyzed. Results: Although there was hearing improvement in both groups - with wet or dry ear - no statistically significant difference was observed between two groups. Following the surgery, tympanic membrane in two patients with wet ear and one with dry ear was not repaired, however according to the statistical analysis this difference was not significant. Conclusion: The results of this study showed that in contrast to the common perception that tympanoplasty results in the patients with wet ear is poorer than those with dry ear, there was little difference in the results of the operations performed on two groups.
https://ijorl.mums.ac.ir/article_6069_251c862705a333b673184f6fb800f56b.pdf
2016-05-01
209
214
10.22038/ijorl.2016.6069
Tympanoplasty
Wet Ear
Dry Ear
Audiometric Result
Nikzad
Shahidi
nikzadsh@yahoo.com
1
Department of Otorhinolaryngology Head and Neck Surgery, Imam Reza Hospital, Tabriz, Iran.
LEAD_AUTHOR
Masoud
Naderpoor
naderpoorm@yahoo.com
2
Department of Otorhinolaryngology Head and Neck Surgery, Imam Reza Hospital, Tabriz, Iran.
AUTHOR
Taghi
Hemmatjoo
ta_1348@yahoo.com
3
Department of Otorhinolaryngology Head and Neck Surgery, Imam Reza Hospital, Tabriz, Iran.
AUTHOR
1. Cummings CW. Otolaryngology Head & Neck Surgery.5th ed. USA: Mosby; 2010.
1
2. Albra R, ferrero V, Lacilla M, canale A. tympanic reperforation in Myringoplasty Evaluation of Prognostic factors. Annals of otology,rhinology and laryngology 2006;115(12):875-9.
2
3. Shaikh A A, Onali M A S, Shaikh S M, Rafi T.Outcome of Tympanoplasty Type - I by Underlay Technique.JLUMHS 2009; 08(01):80-4.
3
4. Vijayendra H, Rangam Chetty K, Sangeeta R. comparative study of tympanoplasty in wet perforation v/s totally dry perforation in tubotympanic disease. Indian Journal of Otolaryngology and Head and Neck Surgery 2006; 58(2):165-7.
4
5. Nagle S K, Jagade M V, Gandhi S R, Pawar P V. Comparative study of outcome of type I tympanoplasty in dry and wet ear. Indian J Otolaryngol Head Neck Surg 2009;61(2):138-40.
5
6. Hosney S, El-Anwar M, Abdelhady M, Khazbak A, El-Feky A. Outcome of myringoplasty in wet and dry ears.Int adv otol 2014;10(3),256-9.
6
ORIGINAL_ARTICLE
Outcomes of Autologous Fat Injection Laryngoplasty in Unilateral Vocal Cord Paralysis
Introduction: Unilateral vocal cord paralysis (UVCP) is not an uncommon finding. Several procedures are available to manage glottal insufficiency. We conducted a clinical trial to evaluate the outcome of fat injection laryngoplasty. Materials and Methods: Liposuctioned lower abdomen fat was injected for augmentation of paralyzed vocal cord in 20 patients with UVCP. Autologous fat was harvested with an 18G needle and a 20-ml disposable syringe using a liposuction technique. Clinical follow-up after the injection was carried out from 1 to 6–21 months Results: Voice and glottal protective function were significantly improved after the surgery. Vocal elements were immediately improved after the surgery, and after 1 year of follow-up. Conclusion: Fat injection laryngoplasty by liposuction is simple, safe, effective and has a low cost for patients with UVCP with aspiration and breathy voice dysphonia.
https://ijorl.mums.ac.ir/article_6858_7dcddd51c67010a337ffd80a90052059.pdf
2016-05-01
215
219
10.22038/ijorl.2016.6858
Autologous Fat
Laryngoplasty
Vocal Cord paralysis
Ehsan
Khadivi
khadivie@mums.ac.ir
1
Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mohammad
Akbarian
2
Department of Otorhinolaryngology, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
kamran
Khazaeni
khazaenik@mums.ac.ir
3
Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Maryam
Salehi
salehi@gmail.com
4
Department of Epidemiology, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
1. Myssiorek D. Recurrent laryngeal nerve paralysis: Anatomy andetiology. Otolaryngol Clin N Am 2004; 37:25–44.
1
2. Sulica L, Cultrara A, Blitzer A. Vocal fold paralysis: Causes, outcomes and clinical aspects. 1th ed. Springer; 2006.
2
3. Flint P, Haughey B, Lund V, Niparko K, Richardson M, et al. Cummings Otolaryngology - Head and Neck Surgery. 5th ed. Mosby; 2010.
3
4. Rakel R. Textbook of Family Medicine. 8th ed. Saunders; 2011.
4
5. Umeno MH, Shirouzu H, Chitose S, Nakashima T. Analysis of voice function following autologous fat injection for vocal fold paralysis. Otolaryngol Head Neck Surg. 2005; 132: 103–7.
5
6. Sasai HM, Watanabe Y, Muta H, Yoshida J, Hayashi I, Ogawa M, et al. Long-term histological outcomes of injected autologous fat into human vocal folds after secondary laryngectomy. Otolaryngol Head Neck Surg. 2005;132:685–8.
6
7. Fang TJ LH, Gliklich RE, Chen YH, Wang PC, Chuang HF. Outcomes of fat injection laryngoplasty in unilateral vocal cord paralysis. Arch Otolaryngol Head Neck Surg. 2010; 136(5):457-62.
7
8. Mikus JL, Koufman JA, Kilpatrick SE. Fate of liposuctioned and purified autologous fat injection in the canine vocal fold. Laryngoscope 1995; 105: 17–27.
8
9. Tucker HM. Direct Autogenous Fat Implantation for Augmentation of the Vocal Folds. J Voice 2001;15:565–9.
9
10. Umeno H CS, Sato K, Ueda Y, Nakashima T. Long-term postoperative vocal function after thyroplasty type I and fat injection laryngoplasty. Ann Otol Rhinol Laryngol. 2012;121(3):185–91.
10
11. Illouz YG. Present results of fat injection. Aesthetic Plast Surg 1988;12:175–181.
11
12. Chajchir A, Benzaquen I, Waxter E, et al. Fat injection. Aesthetic Plast Surg 1990;14:127–136.
12
ORIGINAL_ARTICLE
Use of Intrathecal Fluorescein in Recurrent Meningitis after Cochlear Implantation-A Case Report
Introduction: Congenital anomalies of the cochlea and labyrinth can be associated with meningitis and varying degrees of hearing loss or deafness. Despite antibiotics, meningitis remains a life threatening complication. Case Report: We report a case of recurrent meningitis following episodes of otitis media in a cochlear implantee child with bilateral vestibulocochlear malformation, due to fistula in the stapes footplate. Intrathecal fluorescin was used to identify the leak site. Conclusion: Recurrent meningitis can indicate for possible immunological or anatomical abnormalities as well for chronic parameningeal infections. Intraoperative use of intrathecal fluorescin is an ideal investigative tool to demonstrate cerebrospinal fluid (CSF) leak site in patients in whom other investigations fail to do so.
https://ijorl.mums.ac.ir/article_6060_4dd29c5461b6ab4413e47faa5f566a21.pdf
2016-05-01
221
226
10.22038/ijorl.2016.6060
Cochlear Implant
Inner ear malformations
Intrathecal fluorescin
Recurrent meningitis
Swati
Tandon
drswatitandon86@gmail.com
1
Department of Otorhinolaryngology, Sir Ganga Ram Hospital, Delhi, India.
LEAD_AUTHOR
Satinder
Singh
satindersingh123@rediffmail.com
2
Department of Otorhinolaryngology, Sir Ganga Ram Hospital, Delhi, India.
AUTHOR
Shalabh
Sharma
drshalabh68@yahoo.co.in
3
Deputy Director, Cochlear Implant Services, Sir Ganga Ram Hospital Delhi, India.
AUTHOR
Asish
Lahiri
lasish@yahoo.co.uk
4
Deputy Director, Cochlear Implant Services, Sir Ganga Ram Hospital Delhi, India.
AUTHOR
1. Tebruegge M, Curtis N. Epidemiology, etiology, pathogenesis, and diagnosis of recurrent bacterial meningitis. Clin Microbiol Rev 2008;21(3):519-37.
1
2. Sergez A, Martinez. Meningitis after cochlear implantation in Mondini malformation.Otolaryngol Head and Neck Surgery1997;116:104-6.
2
3. Shucknet HF. Mondini dysplasia: a clinical and pathological study. Ann Oto Rhino Laryngol 1980; 89(1 Pt 2): 1-23.
3
4. Sennaroglu L, Saatci I. A new classification for cochleovestibular malformations. Laryngoscope 2002; 112(12):2230-41.
4
5. Muranjan MN, Bharucha BA, Kirtane MV, Deshmukh CT. Mondini dysplasia of inner ear with CSF leak-Arare cause of recurrent meningitis. Indian Paediatrics. 1999; 36(4):401-6.
5
6. Mohamed E, Ibrahim AA, Ihab EA, Elwany S, Hassab MH, Khamis HM. Evaluation of the Role of High Resolution Computed Tomography and Magnetic Resonance Cisternography in Preoperative Identification of Skull Base Defect in Cases of Cerebrospinal Fluid Rhinorrhea. The International Medical Journal of Malaysia Dec 2012;11(2):3-9.
6
7. Felisati G, Bianchi A, Lozza P, Portaleone S. Italian multicentre study on intrathecal fluorescein for craniosinusal fistulae. Acta Otorhinolaryngol Ital. 2008 Aug; 28(4):159–163.
7
8. LueA J. Intrathecal fluorescin to localize cerebrospinal fluid leakage in bilateral mondini
8
dysplasia. Otol Neurol 2004; 25(1):50-2
9
9. WoolleyAL et al.Cochlear implantation in children with middle ear malformations.Ann Otol Rhino Laryngol 1998; 107(6):492-500
10
10.Rajati M, Ghassemi MM, Alipour M, Bakhshaee M, Shahabi A, Naseri Sadr M. Differentiation between CSF Otorrhea and Rhinorrhea in an Obscure Case of Recurrent Meningitis. Iran J Otorhinolaryngol. 2014 Apr; 26(75): 119-23.
11
11. Melek Kezban Gurbuz et al. Recurrent Meningitis due to Non-implanted Ear in Cochlear Implant Patient with Bilateral Inner Ear Abnormality: A case report. Int. Adv. Otol. 2011; 7:(2) 257-62.
12
12. Craig Herther, San Francisco, Robert A. Schindler. Mondini’s dysplasia with recurrent meningitis. Laryngoscope 1995; June 1985; 95(6): 655-8.
13
ORIGINAL_ARTICLE
Random Pattern Vertically Oriented, Partial Thickness Buccinator Myomucosal Flap for Intraoral Reconstruction: A Report of Two Cases
Introduction: Reconstruction of the oral cavity witha flap design containing the buccal mucosa and buccinator muscle but excluding the facial artery and vein is the topic of these case reports. Case Reports: This article uses random pattern vertically oriented partial thickness buccinator myomucosal flap for intraoral reconstruction in two cases. The first was for lining the mandibular anterior vestibule in a trauma patient. The second was for oral side coverage of bone graft in special cleft patient. In both patients, this flap survived and good bone coverage with non-keratinized mucosa was obtained. Conclusion: Thin long buccal myomucosal flap not including facial artery and vein can survive.
https://ijorl.mums.ac.ir/article_6831_0e1396f7ca9662151addd4c39d3092a9.pdf
2016-05-01
227
231
10.22038/ijorl.2016.6831
Artery
Flap
Mandibular Reconstruction
Amin
Rahpeyma
rahpeymaa@mums.ac.ir
1
Oral and Maxillofacial Diseases Research Center, Oral and Maxillofacial Surgery ,School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Saeedeh
Khajehahmadi
khajehahmadis@mums.ac.ir
2
Dental Research Center ,Oral and Maxillofacial Pathology , School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
1. Pribaz J, Stephens W, Crespo L, Gifford G. A new intraoral flap: facial artery musculomucosal (FAMM) flap. Plast Reconstr Surg 1992; 90(3): 421-9.
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2. Joshi A, Rajendraprasad JS, Shetty K. Reconstruction of intraoral defects using facial artery musculomucosal flap. Br J Plast Surg 2005; 58(8):1061-6.
2
3. Zhao Z, Li S, Yan Y, Li Y, Yang M, Mu L, et al. New buccinator myomucosal island flap: anatomic study and clinical application. Plast Reconstr Surg 1999;104(1):55-64.
3
4. Bianchi B, Ferri A, Ferrari S, Copelli C, Sesenna E. Myomucosal cheek flaps: applications in intraoral reconstruction using three different techniques. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 ;108(3):353-9
4
5. Rahpeyma A, Khajehahmadi S. Buccinator-based myomucosal flaps in intraoral reconstruction: A review and new classification. Natl J Maxillofac Surg 2013;4(1):25-32.
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6. Dupoirieux L, Plane L, Gard C, Penneau M. Anatomical basis and results of the facial artery musculomucosal flap for oral reconstruction. Br J Oral Maxillofac Surg 1999;37(1):25-8.
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7. O'Leary P, Bundgaard T. Good results in patients with defects after intraoral tumour excision using facial artery musculo-mucosal flap. Dan Med Bull 2011 ;58(5):A4264.
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8. Rossell-Perry P, Arrascue HM. The nasal artery musculomucosal cutaneous flap in difficult palatal fistula closure. Craniomaxillofac Trauma Reconstr 2012;5(3):175-84.
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9. Oberna F1, Takácsi-Nagy Z, Réthy A, Pólus K, Kásler M. Buccal mucosal transposition flap for reconstruction of oropharyngeal-oral cavity defects: an analysis of six cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(5):550-3.
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10. Rivera-Serrano CM, Oliver CL, Sok J, Prevedello DM, Gardner P, Snyderman CH, et al. Pedicled facial buccinator (FAB) flap: a new flap for reconstruction of skull base defects. Laryngoscope 2010;120(10):1922-30.
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11. Zhou XT. Effects of tissue expansion on the ratio of length to width of random-pattern skin flaps. Zhonghua Wai Ke Za Zhi 1989;27(7):417- 8, 445.
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ORIGINAL_ARTICLE
Synovial Sarcoma-A Rare Tumor of the Larynx
Introduction: Malignant mesenchymal tumors of the larynx are rare. One type of malignant mesenchymal tumor is synovial sarcoma with unknown histogenesis, which occurs predominantly in the lower extremities of young adults. The head and neck region is a relatively rare location. There are few cases of malignant mesenchymal tumors with laryngeal localization in literature. Case Report: In this report, a new case in a 23-year-old man, which was referred with increasing hoarseness for eight months, and dysphagia, odynophagia, and dyspnea since nearly one year ago, is reported. Indirect laryngoscopy revealed a laryngeal submucosal mass. The patient was operated and the histopathological diagnosis of synovial sarcoma was confirmed by IHC (Immunohistochemisry). Conclusion: Synovial sarcoma occurs predominantly in the lower extremities of young adults. Because very few cases of laryngeal synovial sarcoma are reported, every new case will bring some new information about diagnosis and therapy. It is of utmost importance to get to know new aspects and therapeutical modalities of this rare tumor.
https://ijorl.mums.ac.ir/article_6857_1fd08fcf3d62ce61c1d124b7605fccb8.pdf
2016-05-01
233
236
10.22038/ijorl.2016.6857
Synovial sarcoma
Larynx
Malignant mesenchymal tumors
Ghodrat
Mohammadi
mohammadig@yahoo.co.nz
1
Department of Otorhinolaryngology, Tabriz university of Medical Science, Tabriz, Iran.
LEAD_AUTHOR
Arezu
khansarinia
2
Department of Otorhinolaryngology, Tabriz university of Medical Science, Tabriz, Iran.
AUTHOR
1. Dei Tos AP, Sciot R, Giannini C, Furlanetto A,Rinaldo A, Dal Cin P, et al. Synovial sarcoma of the larynx and hypopharynx. Ann Otol Rhinol Laryngol 1998; 107(12):1080-5.
1
2. Bilgic B, Mete Ö, Öztürk AS, Demiryont M, Keles N, Basaran M. Synovial Sarcoma: a Rare Tumor of Larynx. Pathology Oncology Research 2003;9(4):242-5.
2
3. Abou Zeid HA, Arab SA, Al-Ghamdi AM, Al-Qurain AA, okhazy KM. Airway management of a rare huge-size supraglottic mass. Saudi Med J 2006; 27(5): 711-3.
3
4. Morland B, Cox G, Randall C, Ramsay A, Radford M. Synovial sarcoma of the larynx in a child: case report and histological appearances. Med Pediatr Oncol 1994; 23(1): 64-68.
4
5. Bao YY, Wang QY, Zhou Sh H , Zhao K, Ruan LX, Yao HT. Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma Radiol Oncol 2013; 47(2): 111–18. 6. Gatti WM, Strom CG, Orfei E. Synovial sarcoma of the laryngopharynx. Arch Otolaryngol. 1975; 101(10):633-6.
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7. Ferlito A, Caruso G. Endolaryngeal synovial sarcoma: An update on diagnosis and treatment. ORL, J Otorhinolaryngol Relat Spec 1991;53: 116-19.
6
8. Garenstein A, Neel HB 3rd, Weiland LH, et al: Sarcomas of the larynx. Arch Otolaryngol 1980;106: 8-12,
7
9. Weiss SW, Goldblum JR.Malignant soft tissue tumors of uncertain type. In: Enzinger and Weiss’s Soft Tissue Tumors, 4th Ed.
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10. Ishiki H, Miyajima C, Nakao K, Asakage T, Sugasawa M, Motoi T. Synovial sarcoma of the head and neck: rare case of cervical metastasis. J Head and neck .2009; 31(1):131-5.
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11. Bhandari A, Shrama MP, Bapna AS. Synovial Sarcoma of the larynx. IJO & HNS 1998; 50(3); 304-6.
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ORIGINAL_ARTICLE
Kimura’s Disease – An Unusual Presentation
Introduction: Kimura’s disease is a rare chronic inflammatory disease of unknown etiology, presenting as painless subcutaneous nodules with lymphadenopathy and peripheral eosinophilia, mainly disturbing the head and neck region. It mainly affects Asian males in their 2nd to 4th decade of life. One such case of Kimura’s disease, which is uncommon in Indian natives, is reported. Case Report: A male patient presented with an insidious onset of a progressive painless disfiguring swelling over his nose since four years, which was associated with nasal obstruction and postaural swelling with a history of an inconclusive incisional biopsy. Clinical examination showed a bilobed subcutaneous swelling present over the nose and a collapsed nasal valve area on anterior rhinoscopy. FNAC was non-diagnostic and CT scan showed a mildly enhancing mass lesion over the external nose. Complete surgical excision was performed. Diagnosis was confirmed upon postoperative histopathology. During his 2nd week follow up, the patient had a small nasal recurrence, which was treated medically with oral steroids, cetirizine, and pentoxyphylline for 4 weeks. The patient was disease free for 6 months. Conclusion: Kimura’s disease, although difficult to diagnosis clinically, should be considered in the differential diagnosis of patients who have a primary lymphadenopathy with eosinophilia with or without subcutaneous nodules. It should be investigated accordingly as the disease has an indolent course and good prognosis
https://ijorl.mums.ac.ir/article_6853_610b889175d0a70388bb32db50d131be.pdf
2016-05-01
237
240
10.22038/ijorl.2016.6853
Kimura’s
Lymphadenopathy
Subcutaneous mass
Candida
Eosinophilia
IgE
Praveer
Banerjee
drpraveerk@gmail.com
1
Department of Otorhinolaryngology, JLN Hospital & RC, Sector-9, Bhilai-490009, Chattisgarh, India.
AUTHOR
abhineet
jain
abhineetjn@gmail.com
2
Department of Otorhinolaryngology, JLN Hospital & RC, Sector-9, Bhilai-490009, Chattisgarh, India.
LEAD_AUTHOR
Manjunath
D
drmanjud@gmail.com
3
Department of Otorhinolaryngology, Karnataka Institute of Medical Sciences, Hubli-(karnataka), India.
AUTHOR
1. Li TJ, Chen XM, Wang SZ, Fan MW, Semba I, Kitano M. Kimura's disease. A clinicopathologic study of 54 Chinese patients. Oral Surgery, Oral Medicine, Oral Pathology 1996; 82(5):549–55.
1
2. Ranka SR, Rajput A, Kantharia CV. Kimura's disease.Indian Journal of Otolaryngology and Head and Neck Surgery 2004; 56(1): 43–5.
2
3. Kimura T, Yoshimura S, Ishikawa E. On the unusual granulation combined with hyperplastic changes of lymphatic tissue. Trans. Soc. Pathol Japan 1948; 37: 179-80
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4. Atar S, Oberman AS, Ben-Izak O, Flatau E. Recurrent Nephrotic syndrome associated with Kimuras disease in a young non-oriental male. Nephron 1994;68(2):259-61
4
5. Rajpoot DK, Pahl M, Clark J. Nephrotic syndrome associated with Kimura disease. Pediatric Nephrology 2000; 14 (6): 486–8.
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6. Armstrong WB, Allison G, Pena F, Kim JK. Kimura's disease: two case reports and a literature review. Annals of Otology, Rhinology and Laryngology 1998; 107(12):1066–71
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7. Day TA, Abreo F, Hoajsoe DK, Aarstad RF, Stucker FJ. Treatment of Kimura's disease: a therapeutic enigma. Otolaryngology Head and Neck Surgery 1995; 112 (2): 333–7.
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8. Aoki A, Shiiki K, Naito H, Ota Y. Cytokine levels and the effect of prednisolone on Kimura's disease: report of a case. Journal of Oral and Maxillofacial Surgery 2001; 59 (10):1238–41.
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9. Hareyama M, Oouchi A, Nagakura H, Asakura K, Saito A, Satoh M, et al. Radiotherapy for Kimura's disease: the optimum dosage. International Journal of Radiation Oncology Biology Physics 1998; 40 (3):647–51.
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10. Hongcharu W, Baldassano M, TaylorCR. Kimura's disease with oral ulcers: response to pentoxifylline.Journal of the American Academy of Dermatology 2000; 43(5):905–7.
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