TY - JOUR ID - 13018 TI - The Effect of Gelfoam Impregnated With Botulinum Toxin on Allergic Rhinitis Symptoms JO - Iranian Journal of Otorhinolaryngology JA - IJORL LA - en SN - 2251-7251 AU - Zand, Vahid AU - Baradaranfar, Mohammadhossein AU - Dadgarnia, Mohammadhossein AU - Meybodian, Mojtaba AU - Vaziribozorg, Sedighe AU - Mandegari, Mohammad AU - Behniafard, Nasrin AU - Dehghani, Amrollah AD - Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Allergy and Clinical Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Y1 - 2019 PY - 2019 VL - 31 IS - 4 SP - 203 EP - 208 KW - Allergic Rhinitis KW - Botulinum toxin KW - Gelfoam DO - 10.22038/ijorl.2018.31884.2046 N2 - Introduction: This study evaluated the effect of gelfoam impregnated with botulinum toxin on the symptoms induced by allergic rhinitis. Materials and Methods: In total, 30 patients with allergic rhinitis who did not respond to common therapies were included in this clinical trial study. All patients were treated with intranasal gelfoam impregnated with botulinum toxin type a (40 unit in each side) placed in the middle meatus of each nostril. The main symptoms of allergic rhinitis were scored from zero to three by the patients. Symptoms recorded and compared before and two months after the treatment. Result: The mean age of patients was 31.03±6.9 years. The mean score for sneezing was 2.23 before the treatment which significantly decreased to 1.06 after the treatment (P<0.05). The mean scores of rhinorrhea, nasal congestion, and nasal itching were 2.53, 2.03, and 1.93, respectively, before the treatment which significantly decreased to 0.93, 1, and 0.8 after the treatment (P<0.05). No reported side effects was observed in this study. Conclusion: According to the results, treatment with gelfoam impregnated with botulinum toxin is an effective and safe method in patients who have not responded to common therapies for allergic rhinitis. Accordingly, it is recommended to relieve symptoms in patients with seasonal allergic rhinitis in order to maintain the effectiveness of this treatment at least 8 weeks. UR - https://ijorl.mums.ac.ir/article_13018.html L1 - https://ijorl.mums.ac.ir/article_13018_b0b776c7ee9db943f564c21ca5d66024.pdf ER -