TY - JOUR ID - 9571 TI - Methylprednisolone Versus Dexamethasone for Control of Vertigo in Patients with Definite Meniere's Disease: A Randomized Clinical Trial JO - Iranian Journal of Otorhinolaryngology JA - IJORL LA - en SN - 2251-7251 AU - Masoumi, Elham AU - Dabiri, Sasan AU - Khorsandi Ashtiani, Mohammad Taghi AU - Erfanian, Reza AU - Sohrabpour, Saeed AU - Yazdani, Nasrin AU - Safaee, Alireza AU - Firouzifar, Mohammadreza AD - Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran AD - Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AD - Otorhinolaryngology Research Center, Tehran University of Medical Siences, Tehran, Iran AD - otorhinolaryngology research center, Tehran University of Medical Sciences, Tehran , Iran Y1 - 2017 PY - 2017 VL - 29 IS - 6 SP - 341 EP - 346 KW - Dexamethasone KW - Intratympanic injection KW - Meniere disease KW - Methylprednisolone KW - vertigo DO - 10.22038/ijorl.2017.23762.1779 N2 - Introduction: Definite Meniere's diseaseis associated with two or more definitive periods of vertigo along with hearing loss, plus tinnitus or aural fullness or both. This study aimed to compare the effect of intratympanic dexamethasone and methylprednisolone on the functional-level scale of pure-tone audiometry (PTA), and class outcome measures of vertigo.  Materials and Methods: In this clinical study, 69 patients with definite Meniere's disease, referred to the tertiary otolaryngology center, were randomly assigned to two groups: 36 patients were treated with intratympanic dexamethasone (4mg/dl) and 33 patients were treated with intratympanic methylprednisolone (40mg/dl). Each group received three weekly injections. After a follow-up of 1 and 6 months, PTA changes and vertigo control were evaluated.  Results: There was no statistically significant difference between the two groups with regard to control of vertigo (P=0.866, P=0.879 for 1 and 6 months post injection, respectively). PTA improvement was statistically significantly higher in the methylprednisolone group (P=0.006).  Conclusion: In summary, intratympanic corticosteroid is an effective treatment for Meniere's disease and can prevent other invasive treatments. Intratympanic methylprednisolone can improve hearing level to a greater extent than intratympanic dexamethasone, but the two groups were similarly beneficial in controlling vertigo. However, there was a trend toward a more sustained benefit with methylprednisolone. UR - https://ijorl.mums.ac.ir/article_9571.html L1 - https://ijorl.mums.ac.ir/article_9571_93a369ffa2221d7c7bb07ecc505d3576.pdf ER -