Effect of Adenotonsillectomy on Serum Levels of Total Antioxidant-A Prospective Cohort Study

Document Type: Original


Department of Otolaryngology Head and Neck Surgery, Hamadan University of Medical Science, Hamadan, Iran.


Antioxidants are essential elements in reducing the harmful effects of free radicals. The aim of this study was to compare the serum levels of total antioxidant before and after adenotonsillectomy procedure.
Materials and Methods:
This study was conducted on 41 children with the age range 3-12 who underwent adenotonsillectomy. The total level of antioxidants was measured before and two months after adenotonsillectomy.
The mean±SD level of serum antioxidants raised significantly from 11.17 (15.36) before surgery to 22.19 (10.87) IU/mL after surgery (P<0.001). The mean value was increased from 15.50 (17.97) to 24.89 (12.66) and 6.62 (10.67) to 19.36 (7.98) IU/ml among males and females, respectively.
Adenotonsillectomy can efficiently increase the serum levels of total antioxidant among children with adenotonsillar hypertrophy. Moreover, it can improve the immune system against free radicals.


Main Subjects

1. Shirley WP,Woolley AL,Wiatrak BJ. Pharyngitis and adenotonsillar disease. In: FLint PW, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robins KT, et al editors. Cummings otolaryngology head & neck surgery. 5th ed. Philadelphia: Mosby Elsevier; 2015. p. 2782-802.

2. Ahmadi MS, Amirhassani S, Poorolajal J. The effect of adenotonsillectomy on pediatric nocturnal enuresis: a prospective cohort study.Iranian Journal of Otorhinolaryngology. 2013;25(1):55-60.

3. Kaygusuz I, Ilhan N, Karlidag T, Keles E, Yalcin S, Cetiner H. Free radicals and scavenging enzymes in chronic tonsillitis.Otolaryngology head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2003; 129(3):265-8.

4. Yilmaz T, Kocan EG, Besler HT. The role of oxidants and antioxidants in chronic tonsillitis and adenoid hypertrophy in children.Int J Pediatr Otorhinolaryngol.2004;68(8):1053-8.

5. Kalayci O,Besler T,Kilinc K, Sekerel BE, Saraclar Y. Serum levels of antioxidant vitamins (alpha tocopherol,beta carotene,and ascorbic acid) in children with bronchial asthma.The Turkish journal of pediatrics.2000;42(1):17-21.

6. Cvetkovic T, Vlahovic P, Todorovic M, Stankovic M. Investigation of oxidative stress in patients with chronic tonsillitis.Auris, nasus, larynx. 2009; 36(3):340-4.

7. Kowalska M, Kowalska H, Zawadzka-Glos L, Debska M, Szerszen E,Chmielik M, et al. Dysfunction of peripheral blood granulocyte oxidative metabolism in children with recurrent upper respiratory tract infections.Int J Pediatr Otorhinolaryngol.2003;67(4):365-71.

8. Shukla GK,Garg A, Bhatia N, Pandey S, Kaur G, Shukla RN, et al.Significance of free radicals in chronic tonsillitis.Bollettino chimico farmaceutico. 2000;139(2):103-5.

9. Helmut S, physiology E. Oxidative stress: Oxidants and antioxidants.Exp Physiol. 1997; 82(2):291-5.

10. Yılmaza T, Koçana EG, Besler HT. The role of oxidants and antioxidants in chronic tonsillitis and adenoid hypertrophy in children.Int J Pediatr Otorhinolaryngol.2004;68:1053-58.

11. Dogruer ZN, Unal M, Eskandari G, Pata YS, Akbas Y, Cevik T, et al. Malondialdehyde and antioxidant enzymes in children with obstructive adenotonsillar hypertrophy.Clinical biochemistry. 2004; 37(8):718-21.

12. Kiroglu AF, Noyan T, Oger M, Kara T. Oxidants and antioxidants in tonsillar and adenoidal tissue  in chronic adenotonsillitis and adenotonsillar hypertrophy in children.Int J Pediatr Otorhinolaryngol. 2006;70(1):35-8.

13. Shishegar M, Ashraf AM. Assessment of oxidant and antioxidant serum levels in children                      with chronic tonsillitis before and after tonsillectomy. Indian journal of basic and applied medical research. 2015; 221-6.

14. Hoon Cho J,D.Sub J,WonKim Y, Hong S,Kook Kim J. Reduction in oxidative stress biomarkers after adeno tonsillectomy. International journal of pediatric otorhinolaryngology  september 2015, 1408-11.