Synchronous Parotid and Homolateral Submandibular Gland Pleomorphic Adenoma

Document Type: Case Report

Authors

1 Department of Otolaryngology and Head and Neck Surgery, Medanta- The Medicity, Gurugram, India.

2 Department of Pathology, Medanta- The Medicity, Gurugram, India.

Abstract

Introduction:
Pleomorphic adenomas are benign neoplasms of salivary glands. The simultaneous homolateral occurrence of these tumors in salivary glands is exceedingly rare.
 
Case Report:
An adult female presenting to our OPD with the swelling of right-sided preauricular and submandibular regions was diagnosed with the pleomorphic adenoma based on fine needle aspiration cytology. The patient was subjected to the excision of both swellings under general anesthesia. Postoperative facial nerve functions were within normal limits and final histopathology confirmed pleomorphic adenoma involving both the sites. A pertinent detailed literature review of English and non-English studies was indicative of only nine such cases.
 
Conclusion:
Simultaneously occurring pleomorphic adenoma involving homolateral parotid and submandibular glands is a rare phenomenon that should be kept in mind when examining the swelling of the unifocal salivary gland.

Keywords

Main Subjects


1. Robert L. Peel, Raja R. Seethala. Pathology of Salivary Gland Disease. In: Eugene N. Myers, Robert L. Ferris, editors. Salivary gland disorders. Springer-Verlag:Berlin Heidelberg;  2007. 1st ed : p-45.

2. Miliauskas JR, Hunt JL. Primary Unilateral Multifocal Pleomorphic Adenoma of the Parotid Gland: Molecular Assessment and Literature Review. Head Neck Pathol. 2008;2(4):339-42.

3. Keldahl ML, Zarif A, Gattuso P. Bilateral synchronous pleomorphic adenoma diagnosed by fine-needle aspiration. Diagn Cytopathol. 2004; 30(5):356–8.

4. Silva SJ, Costa Junior GT, Brant Filho AC, Faria PR, Loyola AM. Metachronous bilateral pleomorphic adenoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3):333–8.

5. Lenson N, Strong MS. Multiple mixed tumors of salivary glands. N Engl J Med 1956;254:1231-3.

6. Gates GA, Ritter FN, Mesara BW. Multiple primary mixed tumors of the salivary gland. A case report. Arch. Otolaryngol. 1966;84:329-31.

7. Yajin K, Harada Y, Omura R, Sera K, Hirakawa K, Sato S, et al. Simultaneous pleomorphic adenomas of the right parotid and ipsilateral submandibular glands. Auris Nasus Larynx 1987; 14(1):47–55.

8. Nagler RM, Laufer D. Synchronous pleomorphic adenomas of the major salivary glands: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87(6):735–7.

9. Taki M, Syogaki K, Shimada T, Hisa Y, Shinomiya T, Kimura T, et al. Pleomorphic Adenomas in Parotid Gland and Submandibular Gland of the Other Side- A Case Report. Practica Oto-Rhino-Laryngologica. 2001;94(5):437-41.

10. Keberle M, Ströbel P, Relic A. Synchronous pleomorphic adenoma of the parotid and submandibular glands. Rofo. 2005;177(3):436-8.

11. Dell’aquila A, Vitiello G, D’anna E, Battista F. Synchronous pleomorphic adenoma of parotid and submandibular glands. A case report. Italian Journal of Maxillofacial Surgery. 2010;21(1):
49-51.

12. Pingarrón-Martín L, Arias- Gallo LJ, Demaría-Martínez G. Remarkable Triple Pleomorphic Adenoma Affecting both Parotid and Submandibular Glands. CraniomaxillofacTraumaReconstr.  2015; 8(2):129-31.

13. Loh D, Galloway S, Slavin J, Nguyen K, Wei B. Synchronous contralateral pleomorphic adenoma of the parotid gland and submandibular gland. Pathology. 2017;49(1):92-4.

14. Alshagroud R, Kamoh A, Popat SR, Weber MB, Aguirre A. Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature. Head Neck Pathol. 2017;11(4):487-93.

15. Turnbull AD, Frazell EL. Multiple tumours of the major salivary gland. Am.J.Surg1969;118:787-9.

16. Frazell EL. Clinical aspects of tumours of major salivary glands. Cancer. 1954;7:637.

17. Foote FW Jr, Frazell EL. Tumors of the major salivary glands. Cancer. 1953;6(6):1065–133.

18. McGrath MH. Malignant transformation in concurrent benign mixed tumors of the parotid and submaxillary glands. Plast Reconstr Surg.  1980; 65: 676–8.

19. Ochal-Choińska AJ, Osuch-Wójcikiewicz E. Particular aspects in the cytogenetics and molecular biology of salivary gland tumours - Current review of reports. Contemp Oncol (Pozn). 2016;20:281–6.

20. Shinohara M, Ikebe T, Nakamara S, Takenoshita Y, Oka M, Mori M. Multiple pleomorphic adenomas arising in the parotid and submandibular lymph nodes. Brit J Oral Maxillofac Surg. 1996;34:515.