Basaloid Squamous Cell Carcinoma: An Unusual Ball-Valve Laryngeal Obstruction

Document Type: Case Report

Authors

1 Department of Otorhinolaryngology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

2 Department of Pathology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Abstract

Introduction:
A rare case of basaloid squamous cell carcinoma (BSCC) of the larynx, which has not been previously reported, is described.
Case Report:
A 60-year-old man was presented to the Otolaryngology Department with progressive dyspnoea and dysphagia to solids for over a period of 1 week. Direct laryngoscopy revealed a tumour at the laryngeal aspect of the epiglottis, which prolapsed into the laryngeal inlet each time the patient inspired. This resulted in an inspiratory stridor despite adequate glottic opening and normal mobility of the vocal cords.
 
Conclusion: 
Therefore, in cases where a ball-valve lesion causes intermittent life-threatening airway obstruction, BSCC of the larynx, though rare, must be considered as a differential diagnosis.

Keywords

Main Subjects


1.Wain SL, Kier R, Vollmer RT, Bossen EH. Basaloid-squamous carcinoma of the tongue, hypopharynx and larynx: report of 10 cases. Hum Pathol 1986; 17(11):1158-66.

2. Akyol MU, Seckin S, Albayrak L, Ozdem C. Basaloid squamous cell carcinoma of the larynx. Eur Arch Otorhinolaryngol 1995; 252: 485–87.
3. Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A, Doglioni C. Basaloid squamous cell carcinoma of the head and neck: clinicopathologic features and differential diagnosis. Ann Otol Rhinol Laryngol 1996; 105:75–82.

4. Paulino AF, Singh B, Shah JP, Huvos AG. Basaloid squamous cell carcinoma of the head and neck. Laryngoscope 2000;110:1479–82.

5. Bahar G, Feinmesser R, Popovtzer A, Ulanovsky D, Nageris B, Marshak G, et al. Basaloid squamous carcinoma of the larynx. Am J Otolaryngol 2003; 24: 204–8.

6.  Soriano E, Faure C, Lantuejoul S, Reyt E, Bolla M, Brambilla E, et al. Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case control study of 62 patients. Eur J Cancer 2008;44:244–50.

7. Suster S, Rosai J. Thymic carcinoma: a clinicopathologic study of 60 cases. Cancer 1991;67:1025–32.

8. Ereno C, Gaafar A, Garmendia M, Bilbao FJ, López JI. Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature. Head Neck Pathol 2008;2:83-91.

9. Banks ER, Frierson Jr HF, Mills SE, George E, Zarbo RJ, Swanson PE. Basaloid squamous cell carcinoma of the head and neck: a clinicopathologic and immunohistochemical study of 40 cases. Am J Surg Pathol 1992;16:939–46.

10. Wieneke JA, Thompson LDR, Wenig BM. Basaloid squamous cell carcinoma of the sinonasal tract. Cancer 1999;85:841–54.

11. Wan SK, Chan JK, Lau WH, Yip TT. Basaloid-squamous carcinoma of the nasopharynx. An Epstein-Barr virus-associated neoplasm compared with morphologically identical tumors occurring in other sites. Cancer 1995;76(10):1689-93.

12. Kleist B, Bankau A, Lorenz G, Jager B, Poetsch M. Different risk factors in basaloid and common head and neck cancer. Laryngoscope 2004; 114(6):1063-8.

13. Cardesa A, Zidar N, Ereno C. Basaloid squamous cell carcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D,editors. Pathology and genetics of head and neck tumours. Lyon, France: IARC Press;2005:124-5.

14. Luna MA, El Naggar A, Parichatikanond P, Weber RS, Batsakis JG. Basaloid squamous carcinoma of the upper aerodigestive tract. Cancer 1990;66:537–42.

15. Fritsch VA, Lentsch EJ. Basaloid squamous cell carcinoma of the larynx: Analysis of 145 cases with comparison to conventional squamous cell carcinoma. Head Neck 2014;36(2):164-70.