Effects of Curcumin in Workers with Noise-Induced Hearing Loss: Preliminary Report

Articles in Press

Document Type : Original

Authors

1 Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur No. 5 Medan, 20155, INDONESIA

2 Faculty of Public Health, Universitas Sumatera Utara, Jl. Universitas No. 21, Medan, 20155, INDONESIA.

3 Malaysian Agricultural Research and Development Institute (MARDI), MARDI Headquarters, Persiaran MARDI-UPM, 43400 Serdang, Selangor, Malaysia.

10.22038/ijorl.2026.89875.4010

Abstract

Introduction:
Prolonged loud noise exposure causes sensorineural hearing loss through cochlear oxidative stress, requiring heat shock protein 70 (HSP70) for protection. Curcumin boosts antioxidant expression and safeguards the cochlea. Pure tone audiometry (PTA) measures the type of hearing loss and otoacoustic emission (OAE) detects early auditory issues. This study evaluated the impact of Curcumin on noise-exposed workers via PTA, OAE, and HSP70.
Materials and Methods:
This preliminary study included 54 noise-exposed workers with hearing thresholds ≥26 dB and SNR values <6 dB. Participants were randomized into three noise-exposed groups: placebo (positive control), 500 mg Curcumin, or 1,000 mg Curcumin for 4 weeks. A negative control group of 18 non-exposed workers with normal hearing who received no treatment, served as an external reference only. HSP70 levels, PTA, and OAE were measured before and after intervention in all groups.
Results:
PTA showed a significant worsening of hearing threshold in the positive control group (p=0.001), significant improvement in Curcumin 500 mg group (p=0.046), in the Curcumin 1,000 mg (p=0.059). OAE revealed substantial worsening of SNR in the positive control group (p<0.001) and significant increase in the Curcumin 500 mg (p<0.05) at 4, 7, 8, and 9 kHz, and in the 1,000 mg groups (p<0.05) at 5, 8, and 9 kHz. HSP70 levels significantly increased in the positive control group (p=0.021), both Curcumin groups showed a non-significant increase.
Conclusion:
Curcumin was associated with improved hearing thresholds and favorable SNR changes in noise-exposed workers. Changes in HSP70 levels were minimal and not statistically significant in the curcumin groups.

Keywords

Main Subjects

References

  1. Pisani A, Paciello F, Montuoro R, Rolando R, Galli J. Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experi- mental Models to Clinic. Life. 2023; 13(1035): 1-16.
  2. Graydon K, Waterworth C, Miller H, Gunasekera H. Global burden of hearing impairment and ear disease. J Laryngol Otol. 2019;133:18-25.
  3. Purnami N, Putri MSP. The Association of Reactive Oxygen Species Levels on Noise Induced Hearing Loss of High Risk Workers in Dr. Soetomo General Hospital Surabaya, Indonesia. Indian J Otolaryngol Head Neck Surg. 2019;71(1):86-89.
  4. Juwarna W, Adnan A, Haryuna TSHH. Noise Induced Hearing Loss in Begerpang Palm Oil Mill Workers. Int J Otorhinolaryngol Clin. 2018; 10(2): 56-60.
  5. Natarajan N. Batts S, Stankovic KM. Noise-Induced Hearing Loss. J Clin Med. 2023; 12(2347):1-34.
  6. Fetonia AR, Paciello F, Rolesia R, Paludetti G, Troiani. Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling. Free Radic Biol Med. 2019; 135:46–59.
  7. Schmitt H, Roemer A, Zeilinger C, Salcher R, Durisin M, Staecker H, Lenarz T, Warnecke A. Heat Shock Proteins in Human Perilymph: Implications for Cochlear Implantation. Otol Neurotol. 2017; 39(1): 37-44.
  8. Chen KH, Su SB, Chen KT. The Role of Genetic Variants in the Susceptibility of Noise-Induced Hearing Loss. Front Cell Neurosci. 2022; 16:946206.
  9. Lee BJ, Sukri NM, Ogden H, Vine C, Thake CD. A comparison of two commercially available ELISA methods for the quantification of human plasma heat shock protein 70 during rest and exercise stress. Cell Stress and Chaperones. 2015;20:917-926.
  10. Pratiwi FE, Haryuna TSH, Adriztina I, Khalid K. Correlation of SNR Value on DPOAE Examination with HSP70 Levels in Blood and HSP70 Expression in Cochlea of Noise Model Rattus norvegicus as an Indicator of Inner Ear Damage. Adv Life Sci. 2024; 11(2):322-328.
  11. Cameron I, McBain C. Occupational Noise Induced Hearing Loss and Audiometry. Kolling Institute of Medical Research 2019.
  12. Crowson MG, Hertzano R, Tucci D. Emerging Therapies for Sensorineural Hearing Loss. Otol Neurotol. 2017;38(xx):792-803.
  13. Osakabe N, Modafferi S, Ontario ML, Rampulla F, Zimbone V, Migliore MR. Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics. Medicina. 2023; 9(2045):1-25.
  14. Maiti P, Dunbar GL. Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegen- erative Diseases. Int J Mol Sci. 2018; 9(1637): 1-42.
  15. Haryuna TSH, Amellya D, Munir D, Zubaidah TSH. The Benefits of Curcuminoid to Expression Nuclear Factor Erythroid 2 Related Factor 2 (NRF2) and Signal to Noise Ratio (SNR) Value in the Noise Exposed Organ of Corti of Rattus Norvegicus. Rep Biochem Mol Biol. 2021;10(3):373-379.
  16. Walker JJ, Cleveland LM, Davis JL, Seales JS. Audiometry Screening and Interpretation. AFP. 2013; 87(1):41-48.
  17. Ismail H, Idris A, Hoong DCC, Ahmad H, Baharudin H, Reffin N, Jamaludin HH, Aris NA, Shen HZ. Noise-induced hearing loss among manufacturing factory workers in Kuching, Sarawak: Prevalence and associated risk factors. Med J Malaysia. 2023;78(5):559-565.
  18. Nurrokhmawati Y, Nataliningrum DM, Anggraeny D. Noise induced hearing loss among furniture factory workers PT Chitose Cimahi. AMHS. 2022;1(1):10-18.
  19. Chen KH, Su SB, Chen KT. An overview of occupational noise-induced hearing loss among workers: epidemiology, pathogenesis, and preventive measures. Environ Health Prev Med. 2020;25(65):1-10.
  20. Shuster BZ, Depireux DA, Mong JA, Hertzano R. Sex differences in hearing: Probing the role of estrogen signaling. J Acoust Soc Am. 2019; 145(6): 3656-3663.
  21. Nyarubeli IP, Tungu AM, Moen BE, Bråtveit M. Prevalence of Noise-Induced Hearing Loss Among Tanzanian Iron and Steel Workers: A Cross-Sectional Study. Int J Environ Res Public Health. 2019; 16(1367):1-13.
  22. Soltanzadeh A, Ebrahimi H, Fallahi M, Kamalinia M, Ghassemi S, Golmohammadi R. Noise Induced Hearing Loss in Iran: (1997-2012): Systematic Review Article. Iranian J Publ Health. 2014;43(12):1605-1615.
  23. Edward M, Manohar S, Somayaji G, Kallikkadan HH. Prevalence, awareness, and preventive practices of noise‑induced hearing loss in a plywood industry. Indian J Otol. 2016;22(1):14-18.
  24. Meng ZL, Chen F, Zhao F, Gu HL, Zheng Y. Early detection of noise-induced hearing loss. World J Clin Cases. 2022;10(6):1815-1825.
  25. Le TN, Straatman LV, Lea J, Westerberg B. Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options. J Otolaryngol-Head N. 2017;46(41):1-15.
  26. Atchariyasathian V, Chayarpha S, Saekhow S. Evaluation of Noise-Induced Hearing Loss with Audiometer and Distortion Product Otoacoustic Emissions.J Med Assoc Thai.2008;91(7):1066-1071.
  27. Tajdini A, Yazdi A K, Ravand H, Sahebi L. The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients. Iran J Otorhinolaryngol. 2023; 35(4): 207-215.
  28. Alizadeh M, Kheirouri S. Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials. BioMed. 2019; 9:10-22
  29. Gomes TLN, Zenha RSS, Antunes AH, Faria FR, Rezende KR, Souza E, et al. Evaluation of the Impact of Different Doses of Curcuma longa L. on Antioxidant Capacity: A Randomized, Double-Blind, Crossover Pilot Trial. Biomed Res Int. 2021;2021: 1-6.
  30. Soyalıç H, Gevrek F, Karaman S. Curcumin protects against acoustic trauma in the rat cochlea. Int J Pediatr Otorhinolaryngol. 2017;99(xx):100-106.
  31. Yamaguchi T, Yoneyama M, Onaka Y, Imaizumi A, Ogita K. Preventive effect of Curcumin and its highly bioavailable preparation on hearing loss induced by single or repeated exposure to noise: A comparative and mechanistic study. J Pharmacol Sci. 2017; xxx:1-9.
  32. Emekli ZI, Senturk F, Bahadir O. Protective Effects of Curcumin and N-Acetyl Cysteine Against Noise-Induced Sensorineural Hearing Loss: An Experimental Study. Indian J Otolaryngol Head Neck Surg. 2020;74(Suppl 1): S467-S471.
  33. Soares M, Santosa AB, Weicha TM, Mânica GG, Junior PIHB, Ludwig MS, HTG. Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status. Braz J Otorhinolaryngol. 2020; 86(6):703-710.
  34. Haryuna TSH, Lutan R, Purnami N, Ma’at S, Riawan W. The effect of curcuminoid to noise exposure viewed from the expression of heat shock protein-70 (HSP-70) in cochlear fibroblasts of Rattus norvegicus. IJLPR. 2013; 3(4): 29-35.
  35. Farounzafar F, Barreto G, Majeed M, Sahebkar A. Modulatory effects of curcumin on heat shocks protein in cancer: A promising therapeutic approach. BioFactors. 2019:1-10.
  36. Garde R, Dea A, Herwig MF, Ali A, Pincus D. Feedback control of the heat shock response by spatiotemporal regulation of HSP70. JCB. 2024; 223(12):1-16.
  37. Silva LS, Catalão CHR, Tocchini T. Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis. Pharm Biol. 2015; 55(1): 269-276.
  38. Qu B, Jia Y, Liu Y, Wang H, Ren G, Wang H. The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review. Cell Stress and Chaperones. 2015;20(x):885–892.

 

 

 

 

Iranian Journal of Otorhinolaryngology

Articles in Press, Corrected Proof
Available Online from 26 May 2026

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