Otolaryngology Research Centre, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
10.22038/ijorl.2026.93656.4108
Abstract
Introduction Post-tonsillectomy hemorrhage is one of the most common and potentially life-threatening complications of tonsillectomy in adults and may result in readmission or reoperation. Adults are known to have a higher bleeding risk compared with children due to increased inflammation, comorbid factors, and surgical complexity. Identification of factors associated with postoperative bleeding is essential for optimizing surgical technique, postoperative care, and patient counseling. Materials and Methods This retrospective case–control study included adult patients (≥18 years) who underwent bilateral tonsillectomy at two tertiary referral hospitals between March 2021 and March 2023. Patients who developed post-tonsillectomy hemorrhage were compared with a matched control group without bleeding. Demographic characteristics, surgical indications, operative variables, and surgeon-related factors were evaluated. Post-tonsillectomy hemorrhage was defined as any postoperative pharyngeal bleeding confirmed by an otolaryngologist. Results Among 350 adult tonsillectomies, post-tonsillectomy hemorrhage occurred in 54 patients (15.4%), predominantly secondary bleeding. In multivariate analysis, halitosis (p<0.001), chronic recurrent tonsillitis (p=0.001), sleep disturbances (p=0.001), use of sutures during the primary procedure (p=0.002), and surgeon experience (p=0.013) were independently associated with post-tonsillectomy hemorrhage. Tonsillolith showed a borderline association (p=0.054), while body mass index was not significant (p=0.748). No significant differences were observed in age, sex, smoking status, tonsillar hypertrophy grade, or operative duration (p>0.05). Most bleeding episodes occurred spontaneously (59.3%), and bleeding resolved without surgical intervention in 66.7% of cases. Conclusion Several patient- and surgery-related factors were associated with post-tonsillectomy hemorrhage in adults. Recognition of these associations may aid in perioperative risk assessment and postoperative management.
Galindo Torres BP, De Miguel García F, Whyte Orozco J. Tonsillectomy in adults: Analysis of indications and complications. Auris Nasus Larynx. 2018;45(3):517-21.
Chen D, Afzal N, Sohn S, Habermann EB, Naessens JM, Larson DW, et al. Postoperative bleeding risk prediction for patients undergoing colorectal surgery. Surgery. 2018;164(6):1209-16.
Faramarzi A, Heydari ST. Prevalence of Post-tonsillectomy Bleeding as Day-case Surgery with Combination Method; Cold Dissection Tonsillectomy and Bipolar Diathermy Hemostasis. Iran J Pediatr. 2010;20(2):187-92.
Inuzuka Y, Mizutari K, Kamide D, Sato M, Shiotani A. Risk factors of post-tonsillectomy hemorrhage in adults. Laryngoscope Investig Otolaryngol. 2020;5(6):1056-62.
Kim J, Bhattacharjee R, Dayyat E, Snow AB, Kheirandish-Gozal L, Goldman JL, et al. Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apnea. Pediatr Res. 2009;66(4):423-8.
Stoodley P, Debeer D, Longwell M, Nistico L, Hall-Stoodley L, Wenig B, et al. Tonsillolith: not just a stone but a living biofilm. Otolaryngol Head Neck Surg. 2009;141(3):316-21.
Caldas MP, Neves EG, Manzi FR, de Almeida SM, Bóscolo FN, Haiter-Neto F. Tonsillolith--report of an unusual case. Br Dent J. 2007;202(5):265-7.
Hsueh WY, Hsu WC, Ko JY, Yeh TH, Lee CH, Kang KT. Postoperative hemorrhage following tonsillectomy in adults: Analysis of population-based inpatient cohort in Taiwan. Auris Nasus Larynx. 2019;46(3):397-406.
Mueller J, Boeger D, Buentzel J, Esser D, Hoffmann K, Jecker P, et al. Population-based analysis of tonsil surgery and postoperative hemorrhage. Eur Arch Otorhinolaryngol. 2015; 272(12):3769-77.
Fushimi K, Gyo K, Okunaka M, Watanabe M, Sugihara A, Tsuzuki K. Analysis of risk factors for post-tonsillectomy hemorrhage in adults. Auris Nasus Larynx. 2023;50(3):389-94.
Patel SD, Daher GS, Engle L, Zhu J, Slonimsky G. Adult tonsillectomy: An evaluation of indications and complications. Am J Otolaryngol. 2022; 43(3): 103403.
Seyhun N, Dizdar SK, Çoktur A, Bektaş ME, Albuz O, Erol ZN, et al. Risk factors for post-tonsillectomy hemorrhage in adult population: Does smoking history have an impact? Am J Otolaryngol. 2020;41(1):102341.
Manimaran V, Mohanty S, Jayagandhi SK, Umamaheshwaran P, Jeyabalakrishnan S. A Retrospective Analysis of Peroperative Risk Factors Associated with Posttonsillectomy Reactionary Hemorrhage in a Teaching Hospital. Int Arch Otorhinolaryngol. 2019;23(4):e403-e7.
Aldrees T, Alzuwayed A, Majed A, Alzamil A, Almutairi M, Aloqaili Y. Evaluation of Secondary Post-Tonsillectomy Bleeding among Children in Saudi Arabia: Risk Factor Analysis. Ear Nose Throat J. 2022;101(3):Np135-np42.
Peça R, Correia M, Rosa C, Correia-Rodrigues P, Luís L. Adult tonsillectomy: Risk factors for postoperative complications. Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço. 2024;62(1):49-56.
Xu B, Jin HY, Wu K, Chen C, Li L, Zhang Y, et al. Primary and secondary postoperative hemorrhage in pediatric tonsillectomy. World J Clin Cases. 2021;9(7):1543-53.
Williamson A, Coleman H, Douglas C. Does infection play a role in post-tonsillectomy haemorrhage? A narrative review. J Laryngol Otol. 2023;137(7):710-7.
Articles in Press, Corrected Proof Available Online from 26 May 2026
Janipour, M. , Keshavarz, F. and Babaei, A. (2026). Evaluation of Factors Associated with Post-Tonsillectomy Bleeding in Adults. Iranian Journal of Otorhinolaryngology, (), 189-196. doi: 10.22038/ijorl.2026.93656.4108
MLA
Janipour, M. , , Keshavarz, F. , and Babaei, A. . "Evaluation of Factors Associated with Post-Tonsillectomy Bleeding in Adults", Iranian Journal of Otorhinolaryngology, , , 2026, 189-196. doi: 10.22038/ijorl.2026.93656.4108
HARVARD
Janipour, M., Keshavarz, F., Babaei, A. (2026). 'Evaluation of Factors Associated with Post-Tonsillectomy Bleeding in Adults', Iranian Journal of Otorhinolaryngology, (), pp. 189-196. doi: 10.22038/ijorl.2026.93656.4108
CHICAGO
M. Janipour , F. Keshavarz and A. Babaei, "Evaluation of Factors Associated with Post-Tonsillectomy Bleeding in Adults," Iranian Journal of Otorhinolaryngology, (2026): 189-196, doi: 10.22038/ijorl.2026.93656.4108
VANCOUVER
Janipour, M., Keshavarz, F., Babaei, A. Evaluation of Factors Associated with Post-Tonsillectomy Bleeding in Adults. Iranian Journal of Otorhinolaryngology, 2026; (): 189-196. doi: 10.22038/ijorl.2026.93656.4108