@article { author = {Arshi, Saba and Dehghani-Firouzabadi, Fatemeh and Ghalehbaghi, Babak and Dehghani-Firouzabadi, Ali and Jalali, Farhad and Shekarabi, Mehdi and Sirous, Reza and Dehghani-Firouzabadi, Mohammad}, title = {Otitis Media with Effusion in Children and the Impact of Risk Factors on Serum Cytokine Levels}, journal = {Iranian Journal of Otorhinolaryngology}, volume = {29}, number = {2}, pages = {75-81}, year = {2017}, publisher = {Mashhad University of Medical Sciences (MUMS)}, issn = {2251-7251}, eissn = {2251-726X}, doi = {10.22038/ijorl.2017.14410.1513}, abstract = {Introduction:To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME) Materials and Methods:We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls. Results:Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (P=0.009). However, after adjusting for confounding variables, there was no significant difference in serum levels of IL-13, IL-4, IFN-γ, or TNF-α between the two groups (P=0.287, P=0.627, P=0.793, and P=0.217, respectively) Conclusions:The findings of this study suggest that in comparison with the control group, serum IL-5 levels were elevated in OME cases.}, keywords = {Interleukins,Inflammatory cytokines,Otitis media with effusion,Pediatrics}, url = {https://ijorl.mums.ac.ir/article_8299.html}, eprint = {https://ijorl.mums.ac.ir/article_8299_f14da28b593ab4ae656fc412836ff6a1.pdf} }