ORIGINAL_ARTICLE
Common Mutations of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in Non-Syndromic Cleft Lips and Palates Children in North-West of Iran
Introduction: Cleft lips and cleft palates are common congenital abnormalities in children. Various chromosomal loci have been suggested to be responsible the development of these abnormalities. The present study was carried out to investigate the association between the suspected genes (methylenetetrahydrofolate reductase [MTHFR] A1298C and C677T) that might contribute into the etiology of these disorders through application of molecular methods. Materials and Methods: This cross-sectional and explanatory study was carried out on a study population of 65 affected children, 130 respective parents and 50 healthy individuals between 2009 and 2012 at Tabriz University of Medical Sciences, IR Iran. After DNA extraction, amplification refractory mutation system–polymerase chain reaction (ARMS-PCR) and restriction fragment length polymorphism (RFLP)-PCR were used respectively to investigate the C677T and A1298C mutations for the MTHFR gene. Results: There was a significant difference in the rates of the C677T mutation when affected patients and their fathers were compared with the control group (odds ratio [OR]=0.44) (OR=0.64). However, there was no significant difference observed in the rate of this mutation between the patients’ mothers and the control group (OR=1.35). In addition, the abnormality rate was higher in patients with the A1298C mutation and their parents, when compared with the control group. This abnormality rate was higher for the affected children and their fathers in comparison with their mothers (Fathers, OR=0.26; Mothers, OR=0.65; Children, OR=0.55). No significant difference was seen in the rate of the polymorphism C677T in its CC, when the affected children and their parents were compared with the control group. However, there was a significant difference in the A1298C mutation. Conclusion: An association was seen between the A1298C mutation and cleft lip and cleft palate abnormalities in Iran. However, there seems to be a stronger relationship between the C67TT mutation and these abnormalities in other countries, which could be explained by racial differences. Moreover, this association was more notable between the affected children and their fathers than their mothers. The findings in this study may be helpful in future studies and screening programs.
https://ijorl.mums.ac.ir/article_3224_3467fff086d2f3c0f9e3b2d4416022dd.pdf
2015-01-01
7
14
10.22038/ijorl.2015.3224
A1298C mutation
Cleft lip
Cleft palate
C677T mutation
MTHFR
Shahin
Abdollahi-Fakhim
abdollahi_sh@yahoo.com
1
Department of Pediatric Otorhinolaryngology, Children’s Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Mehrdad
Asghari Estiar
asghari_ms@yahoo.com
2
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Parizad
Varghaei
3
Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Mahdi
Alizadeh Sharafi
shaeafi_al@hotmail.com
4
Tabriz Genetic Analysis Center (TGAC), Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Masoud
Sakhinia
masoud.sakhinia@yahoo.com
5
Faculty of Medicine, University of Liverpool, Liverpool, United Kingdom.
AUTHOR
Ebrahim
Sakhinia
asghari_ms@razi.tums.ac.ir
6
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
LEAD_AUTHOR
1. Tanabe A, Taketani Sh, Endo-Ichikava Y, Tokunaga R, Ogawa Y, Hiramatos M. Analysis of the candidate genes responsible for non-syndromic cleft lip and palate in Japanese people. Clinical Science 2000; 99(2):105-111.
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2. Jones MC. Etiology of facial clefts. Prospective evaluation of 428 patients. Cleft Palate J 1988; 25 (1):16-20.
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3. Cummings CW, Haughey BH, Thomas JR, Harker LA, Flint PW. Cummings Otolaryngology: Head and Neck Surgery, 4st ed. Mosby, USA; 2004:2907-95.
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4. Johansson B, Ringsberg KC. Parents' experiences of having a child with cleft lip and palate. Journal of Advanced Nursing 2004; 47(2):165-173.
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5. Spritz RA. The genetics and epigenetics of orofacial clefts. Curr Opin Pediatr 2001;13(6):556-60.
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6. Lowry RB, Trimble BK. Incidence rates for cleft lip and palate in British Columbia 1951-1971 for North American Indian Japanese, Chinese and total populations: Secular trends over twenty years. Teratology 1977;16(3):277-83.
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7. Gorlin RY, Cohen MM, Hannekam R. Syndromes of the head and neck, 4st ed. Oxford University Press: Newyork; 2011:413-15.
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8. Rajabian MH, Sherkat M. An epidemiologic study of oral clefts in Iran: Analysis of 1669 cases. Cleft Palate Craniofac J 2000; 37(2):191-6.
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9. Taher AA. Cleft lip and palate in Tehran. Cleft Palate Craniofac J 1992; 29 (1): 15-6.
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10. Wysznsky DF, Beaty TH. Review the role of potential teratogens in the origin of human non-syndromic oral clefts.Teratology 1996;53(5):309-17.
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11. Lammer EJ, Chen DT, Hoar RM. Retinoic acid embryopathy. N Engl J Med 1985; 313(14):837-41.
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12. Murray JC. Gene/environment causes of cleft lip and/or palate. Clin Genet 2002; 61(4):248-56.
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13. Fogh-Andersen P. Inheritance of harelip and cleft palate. Nyt Nordisk Forlag 1942; 10(2):39-45.
13
14. Marazita ML, Goldstein AM, Smalley SL. Cleft lip with or without cleft palate: reanalyasis of three generation family study in England. Genet Epidemiol 1986; 3(5):335-42.
14
15. Sozen MA, Tolarova MM, Spritz RA. The common MTHFR C677T and A1298C variants are not associated with the risk of non-syndromic cleft lip/palate in northern Venezuella. J Genet Genomics 2009; 36(5):283-8.
15
16. Jencks DA, Mathews RG. Allosteric inhibition of Methylenetetrahydrofolate reductase by adenosylme- thionine. Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium. J Biol Chem 1987; 262 (6): 2485-93.
16
17. Goyette P, Summer JS, Milos R, Duncan AM, Rosenblatt DS, Matthews RG, et al. Human methylenetetra- hydrofolate reductase: Isolation of cDNA, Maping and mutation identification. Nat Genet 1994; 7(2):195-200.
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18. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: A common mutation in methy- lenetetrahydrofolate reductase. Nat Genet 1995; 510(14):111-13.
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19. Blanton SH, Kolle BS, Hecht JT, Mulliken JB, Martin ER. No evidence supporting MTHFR as a risk factor in the development of familial NSCLP. Am J Med Genet 2000; 92(5): 370-1.
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20. Shaw GM, Rozen R, Finnell RH, Todorof K, Lammer EJ. Infant C677T mutation in MTHFR gene, maternal periconceptional vitamin use, and cleft lip. Am J Med Genet 1998;80(3):196-8.
20
21. Martinelli M, Scapoli L, Pezzeti F, Carinci F, Carinci P, Baciliero U, et al. Suggestive linkage between markers on chromosome 19q13.2 and nonsyndromic orofacial cleft information. Genomics
21
1998; 51(2):177-81.
22
22. Brandalize AP, Bandinelli E, Borba JB, Felix TM, Roisenberg I, Schuler Faccini I. Polymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip/palate in South Brazil. Braz J Med Biol Res 2007; 40(6):787-91.
23
23. Van Rooij IA, Vermeij-Keers C, Kluijtmans LA, Ocke MC, Zielhuis GA, Goorhuis-Brouwer SM, et al. Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate? Am J Epidemiol 2003; 157 (7): 583-91.
24
24. Verkleij-Hagoort A, Bliek J, Sayed-Tabatabaei F, Ursen N, Steegers E, Steegers-Theunissen R. Hyperhomocysteinemia and MTHFR polymer- phisms in association with orofacial clefts and congenital heart defects: a meta-analysis. Am J Med Genet A 2007; 143A (9):952-60.
25
25. Talarova MM, Cervenka J. Classification and birth prevalence of orofacial clefts. Amer J Med Genet 1998; 75(2):126-37.
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26. Mills JL, Kirke PN, Molloy AM, Burke H, Conley MR, Lee YJ, et al. Methyenetetrahydrofolate reductase thermolabile variant and oral clefts. Am J Med Genet 1999; 86(1):71-4.
27
27. Pezzetti F, Martinelli M, Scapoli L, Carinci F, Palmieri A, Marchesini J. Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate. Hum Mutat 2004; 24(1):104-105.
28
28. ShotelersukV, Ittiwut EJ, Siriwan P, Angspatt A. Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip. J Med Genet2003; 40(5):e64.
29
29. Prescott NJ, Winter RM, Malcolm S. Maternal MTHFR genotypecontributes to the risk of non-syndromic cleft lip and palate. J Med Genet 2002; 39(5):368-9.
30
30. Jugessur A, Wilcox AJ, Lie RT, Murray JC, Taylor JA, Ulvik A, et al. Exploring the effects of methyenetetrahydrofolate reductase gene variants
31
C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads. Am J Epidemiol 2003; 157(12):1083-91.
32
31. Blanton SH, Patel S, Hecht JT, Mulliken JB. MTHFR is not a risk factor in the development of isolated nonsyndromic cleft lip and palate. Am J Med Genet 2002; 110(4):404-5.
33
32. Van der put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Med Genet 1998;62(5):1044-51.
34
33. Friso S, Girelli D, Trabetti E, Stranieri C, Olivieri O, Tinnazi E, et al. A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocystein/folate metabolism. Clin Exp Med 2002; 2(1):7-12.
35
ORIGINAL_ARTICLE
Corrosive Injury of the Upper Gastrointestinal Tract: Review of Surgical Management and Outcome in 14 Adult Cases
Introduction: Caustic ingestion is responsible for a spectrum of upper gastrointestinal tract injury from self-limited to perforation. This study conducted to evaluate clinical characteristics as well as surgical outcomes in patients with caustic ingestion. Materials and Methods: Between Nov1993 to march 2011, 14 adults with a clinical evidence of corrosive ingestion were admitted into our institutions (Omid and Ghaem hospitals). Patients evaluated for etiology of erosion, location, type of surgery, morbidity and mortality after surgery. Results: 14 patients (10men and 4 women) with a age range between18-53 years were evaluated. In 6 patients, the injury was accidental and in 8 patients ingestion was a suicide attempt. Ingested agent included nitric acid in 4 patients, hydrochloric acid in 7 patients, sulfuric acid in 2 patients and strong alkali in one patient. The location and extent of lesion varied included esophagus in 13 cases, stomach in 7 cases and the pharynx in 3 cases. Acute abdomen was developed In 2 patients and a procedure of total gasterectomy and blunt esophagectomy was performed. In the remaining patients, substernal esophageal bypass in 2 patients, esophageal resection and replacement surgery in 9 patients and gastroenterostomy in one patient performed to relieve esophageal stricture. Two patients died of mediastinitis after esophageal replacement surgery. Postoperative strictures were developed in 2 survived patients with hypopharyngeal reconstruction that was managed by per oral bougienage in one patient and KTP Laser and stenting in the other patient. Conclusion: Esophageal resection with replacement was safe and good technique for severe corrosive esophageal stricture with low mortality and morbidity.
https://ijorl.mums.ac.ir/article_3419_ecdcc25a35afb0373de8990bd4877c2b.pdf
2015-01-01
15
21
10.22038/ijorl.2015.3419
Caustic ingestion
Esophageal replacement
Esophageal stricture
Mohammad Taghi
Rajabi
1
Endoscopic & Minimally Invasive Surgery Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Ghodratollah
Maddah
maddahgh@mums.ac.ir
2
Cardio- Thoracic Surgery & Transplant Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Reza
Bagheri
bagherir@mums.ac.ir
3
Cardio- Thoracic Surgery & Transplant Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mostafa
Mehrabi
4
Surgical Oncology Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Hossein
Shabahang
5
Endoscopic & Minimally Invasive Surgery Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Farjad
Lorestani
6
Endoscopic & Minimally Invasive Surgery Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
1. Hugh B, Thomas Kelly D. Michael Corrosive ingestion and the surgeon J Am Coll Surg 1999; 189(5): 508-22.
1
2. Wu Ming-Ho, lai Wu-wei. Esophageal reconstruction for esophageal strictures or resection after corrosive injury. Ann Thoracic Surg 1992; 53(5): 798-802.
2
3. Browne Y, Dale, Thompson N. James. Caustic ingestion in the book of pediatric otolaryngology head & neck surgery edited by Charles W. Cummings, John M. Fredrickson, Lee A. Richardson, David E. Schuller, 3th edition, volume 5 Mosby-year book Inc 1998: 366-76.
3
4. Spiegel Joseph R, Sataloff Robert Thayer. Caustic injury of the esophagus in the book of the esophagus edited by D.O. Castell, J. E. Richter 3th ed. Lippincott Williams & Wilkins Philadelphia 1999: 564-77.
4
5. Thomas Arthur N, Dedo Herbert H, Lim Robert C Jr, Steele Muriel. Pharngoesophageal caustic stricture. Treatment by pharyngogastrostomy compared to colon interposition combined with free bowel graft. Am J Surg 1976; 132(2): 195-203.
5
6. Doolin Edward J. Composite reconstruction of the Esophagus and hypopharynx after severe caustic injury. Ann Otorhinol Laryngol 1994; 103: 36-40.
6
7. Panieri E, Rode H, Millar AJW, Cywes S. Oesophageal replacement in the management of corrosive strictures: when is surgery indicated? Pediatr Surg Int 1998; 13: 336-40.
7
8. Postlethwait RW. Colon interposition for esophageal substitution. Surg, Gynecol & Obstet 1983; 156(3): 377-83.
8
9. Nicosia Jon F, Thornton Joseph P, Folk Frank A, Saletta John D. Surgical management of corrosive gastric injuries. Annals of Surgery 1974; 180(2): 139-43.
9
10. Estrera Aaron, Taylor Wayne, Millis Lawrence. J. Corrosive burns of the Esophagus and stomach: A recommendation for an aggressive surgical approach. Annal Thorac Surg 1986; 41(3): 276-83.
10
11. Jeng Long Bin Benjamin, Chen Hoang-Yang, Chen Shin - Chen, Hwang Tsann-Long, Jan Yi-Yin, Wang Chia-Siu, Chen Miin-Fu. Upper gastrointestinal ablation for patients with extensive injury after ingestion of strong acid. Arch Surg 1994; 129(10): 1086-90.
11
12. Ashcraft Keith W. Chemicals Esophageal injuries in the book of pediatric surgery edited by Ashcraft, Murphy, Sharp, Sigalet, Synder 3th edition W. B Saunders Company 2000; 325-347.
12
13. Dilawari JB, Singh Surjit, Rao PN, Anand BS. Corrosive acid ingestion in man-a clinical and endoscopic study. GUT 1984; 25(10): 183-7.
13
14. Ferguson Mark K, Marcello Migliore, Staszak M. RN, Little Alex.G. Early evaluation and therapy for caustic esophageal injury. Am J Surg 1989; 157(1): 116-20.
14
15. Peters Jeffrey H, Demeester Tom R. Caustic injury in the principles of surgery edited by Schwartz, Shires, Spencer, Daly, Fischer, Galloway volume ΙΙ 7th edi McGraw-Hill 1999; 1158-61.
15
16. Ho-Wu Ming, Lai Wu-Wei, Lin Mu-Yen, Chou Nan-Song. Prevention and management of strictures after hypopharyngocolostomy or esophagocolostomy. Ann Thoracic Surgery 1994; 58(1): 108-11.
16
17. Brun JG, Koskas F, Dubost C. Blunt thorax oesophageal stripping: Am emergency procedure for caustic ingestion. Br J Surg 1984; 71(9): 698-700.
17
18. Horvath Ors P. Tiborolah, Gabriella Zentai. Emergency Esophagogastrectomy for treatment of hydrochloric acid. Ann Thorac Surg 1991; 52(1): 98-101.
18
19. Cebeci Hayrettin, Paksoy Melih, Kaytaz Asim, Unal Ethem. Cololaryngostomy procedure in caustic esophageal burns. Eur J Cardio-Thorac Surg 2002; 21(1): 136-9.
19
20. Howu Ming, Tseng Yau-Lin, Lin Mu-Yen, Lai Wu-Wei. Esophageal reconstruction for hypopharyn- goesophageal strictures after corrosive injury. European J Cardio-Thoracic Surg 2001; 19: 400-5.
20
21. Ferguson Mark. K. the colon as a reconstructive organ In the book of reconstructive surgery of the esophagus edited by Mark K. Ferguson Futura publishing Company inc. 2002; 161-3.
21
22. Harlak A, Yigit T, Coskun K, Ozer T, Mentes O, Gülec B, Kozak O. Surgical treatment of caustic esophageal strictures in adults. Int J Surg. 2013; 11(2):164-8.
22
ORIGINAL_ARTICLE
Mastoid Cavity Obliteration with Combined Palva Flap and Bone pâté
Introduction: This study was designed to evaluate the usefulness of mastoid cavity obliteration with combined bone pâté and Palva flap in the prevention of problematic mastoid cavities after canal wall down mastoidectomy. Materials and Methods: In a prospective longitudinal study with a mean follow-up of 28 months conducted between 2008–2012, a series of 56 ears in 48 patients with chronic otitis media due to a cholesteatoma underwent canal wall down mastoidectomy that their mastoid cavity obliterated with combined bone pâté and Palva flap. Seventeen (30%) ears were managed via revision surgery, with the reminder via primary surgery. Data included mastoid cavity status, results at second-look surgery with ossiculoplasty, and postoperative complications. Results: All patients underwent second-look surgery. Forty-six (82%) ears maintained a very small, dry and healthy mastoid cavity. Seven (13%) ears had occasional otorrhea, and three (5%) ears had small granulation tissue. Seven (12.5%) ears had residual cholesteatoma pearl in the middle ear at second-look surgery. Four (7%) ears exhibited wound infection. Conclusion: Canal wall down mastoidectomy and mastoid cavity obliteration with combined bone pâté and Palva flap is a effective option for the complete removal of cholesteatoma and prevention of postoperative mastoid cavity problems.
https://ijorl.mums.ac.ir/article_3223_019511dc7ee49b07025b9558db7956a8.pdf
2015-01-01
23
28
10.22038/ijorl.2015.3223
Bone pâté
Chronic otitis media
Cholesteatoma
Mastoidectomy
Mastoid obliteration
Palva flap
Samad
ghiasi
ghiasis2000@yahoo.com
1
Department of Otorhinolaryngology, Tabriz University of Medical Sciences, Tabriz, Iran.
LEAD_AUTHOR
1. Gantz BJ, Wilkinson EP, Hansen MR. Canal wall reconstruction tympanomastoidectomy with mastoid obliteration. Laryngoscope 2005; 115: 1734–40.
1
2. Cho SW, Cho Y, Cho H. Mastoid obliteration with Silicone blocks after canal wall down mastoidectomy. Clinical and Experimental Otorhinolaryngol 2012; 1:23–27.
2
3. Yanagihara N, Komori M, Hinohira Y. Total mastoid obliteration in staged canal-up tympanoplasty for cholesteatoma facilitates tympanic aeration. Otology & Neurotology 2009; 30: 766–70.
3
4. Lee WS, Choi JY, Song MH, Son EJJung SH, Kim SH. Mastoid and epitympanic obliteration in canal wall up mastoidectomy for prevention of retraction pocket. Otology & Neurotology 2005; 26: 1107–11.
4
5. Moffat DA, Gray RF, Irving RM. Mastoid obliteration using bone pâté. Clin Otolaryngol Allied Sci 1994; 19:149–57.
5
6. Estrem SA, Highfill G. Hydroxyapatite canal wall reconstruction/mastoid obliteration. Otolaryngol Head Neck Surg 1999; 120:345–49.
6
7. Chan CY, Chan YM. Mastoid obliteration and reconstruction: A review of techniques and results. Proceeding of Singapore Healthcare 2012;21:23–29.
7
8. Palva T. Surgical treatment of chronic middle ear disease. II. Canal wall up and canal wall down procedures. Acta Otolaryngol 1987;104:487–94.
8
9. Maniu A, Cosgarea M. Mastoid obliteration with concha cartilage graft and temporal muscle fascia.ORL J Otorhinolaryngol 2012;74(3):141–15.
9
10. Lasisi OA, Lawal HA. Deep temporalis fascia in tympanomastoid reconstruction. Afr J Med Med Sci 2007; 36(2):183–87.
10
11. Takahashi H, Iwanaga T, Kaieda S, Fukuda T, Kumagami H, Takasaki K et al. Mastoid obliteration combined with soft-wall reconstruction of posteriorear canal. Eur Arch Otorhinolaryngol 2007; 264: 867–71.
11
12. Silvola JT. Mastedoctomy oblitration with bioactive glass: A Pilot study. Otolaryngol Head Neck Surg 2012; 147(1): 119–126.
12
13. Hung T, Leung N, van Hasselt A, Kwok CL, Tong M. Long-term outcome of the Hong Kong vascularized, pediceled temporalis fascia flap in reconstruction of mastoid cavity. Laryngoscope 2007; 117(8):1403–07.
13
14. Singh V, Atlas M. Obliteration of the persistently discharging mastoid cavity using the middle temporal artery flap. Otolaryngol Head Neck Surg 2007; 137:433–38.
14
15. Cheney ML, Megerian CA, Brown MT, McKenna MJ, Nadol JB. The use of the temporoparietal fascial flap in temporal bone reconstruction. Am J Otol 1996; 17(1):137–42.
15
16. Olson KL, Manolidis S. The pedicled superficial temporalis fascia flap: a new method for reconstruction in otologic surgery. Otolaryngol Head Neck Surg 2002; 126(5):538–47.
16
17. Ramsey MJ, Merchant SN, McKenna MJ. Postauricular periosteal-pericranial flap for mastoid obliteration and canal wall down tympanomasto- idectomy. Otol Neurotol 2004; 25(6):87–78.
17
18. Goel A. Extended vascularized temporalis muscle-fascia flap. Br J Neurosurg 1994;8(6)731–3.
18
19. Kahramanyol M, Ozunlu A, Pabuscu Y. Fascioperiosteal flap and neo-osteogenesis in radical mastoidectomy: long-term results. Ear Nose Throat J 2000; 79(7):524–26.
19
20. Farrior JB. Postauricular myocutaneous flap in otologic surgery. Otolaryngol Head Neck Surg 1998; 118(6):743–46.
20
21. Uçar J. Canal wall reconstruction and mastoid obliteration with composite multi-fractured osteoperiostealflap. Eur Arch Otorhinolaryngol 2006; 263: 1082–86.
21
22. Bonding P, Henrichen J. Results of modified canal wall up technique with obliteration in cholesteatoma. In: Tos M et al (eds) Cholesteatoma and mastoid surgery. Amsterdam; Kugler and Ghedini; 1989. P. 871–73.
22
23. Takahashi S, Nozaki M, Urano M, Nakano Y. Problems of the open cavity (in Japanese). Pract Otorhinolarngol 1994; 87: 317–23.
23
ORIGINAL_ARTICLE
Surgical Outcomes of Cerebellopontine angle Tumors in 50 Cases
Introduction: To report our experience with a large series of surgical procedures for removal of cerebellopontine angle (CPA) tumors using different approaches. Materials and Methods: This was a retrospective analysis of 50 patients (mean age, 49 years) with CPA tumors (predominantly acoustic neuroma) who underwent surgical removal using appropriate techniques (principally a translabyrinthine approach) during a 4-year period. Results: One death occurred during this study. There were nine cases (18%) of cerebrospinal fluid leak, and five patients (10%) were diagnosed as having bacterial meningitis. Complete gross tumor removal was not achieved in four patients (8%). Facial nerve function as measured by the House Brackmann system was recorded in all patients 1 year following surgery: 32% had a score of 1 or 2; 26% had a score of 3 or 4; and 8% had a score of 5 or 6. Other complications included four cases of wound infection. Conclusion: The translabyrinthine approach was predominantly used in our series of CPA tumors, and complication rates were comparable with other large case series.
https://ijorl.mums.ac.ir/article_3436_0181dc7789a160d9511d1dca4e2e206e.pdf
2015-01-01
29
34
10.22038/ijorl.2015.3436
acoustic neuroma
translabyrinthine approach
retrosigmoid approach
cerebellopontine angle tumours
faramarz
memari
memari1@gmail.com
1
Department of Otorhinolaryngology Head and Neck Surgery, Hazrate Rasul Medical Center, Iran University of Medical Sciences. Tehran, Iran.
AUTHOR
Fatemeh
Hassannia
fatimahassannia@yahoo.com
2
Department of Otorhinolaryngology Head and Neck Surgery, Hazrate Rasul Medical Center, Iran University of Medical Sciences. Tehran, Iran.
LEAD_AUTHOR
Seyedhamid
Abtahi
shrabtahi@yahoo.com
3
Department of Otorhinolaryngology Head and Neck Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
AUTHOR
2. Tos M, Thomasen J, Harmsen A. Results of translabyrinthine removal of 300 acoustic neuroma related to tumor size. Acta Otolaryngol Sppl. 1988; 452: 38-51.
1
3. Shelton C. Unilateral acoustic tumors: how often do they recur after translabyrinthine removal? Laryngoscope 1995; 105(9): 958-66.
2
4. Briggs RJ, Luxford WM, Atkins JS Jr, Hitselberger WE. Translabyrinthine removal of large acoustic neuromas. Neurosurgery 1994; 34 (5):785-90.
3
5. Celikkanat S, Saleh E, Khashaba A, Taiba A, Russo A, Mazzoni A, et al. Cerebrospinal fluid leak after translabyrinthine Acoustic neuromas surgery. Otolaryngol Head Neck Surg 1995; 112: 654-8.
4
6. Rodgers J, Luxford W. factors affecting the development of cerebrospinal fluid leak and meningitis after acoustic tumor surgery. Laryngoscope 1993; 103(9): 959-62.
5
7. Hoffman R. Cerebrospinal fluid leak following acoustic neuroma removal. Laryngoscope 1994; 104: 40-58.
6
8. Iwai Y, Yamanka K, Ishiguro T. Surgery combined with radiosurgery of large acoustic neuromas. Surg Neurol 2003; 59(4): 283-91.
7
9. Mass SC, Weit RJ, Dinces E. Complications of the translabyrinthine approach for the removal of acoustic neuromas. Arch Otolaryngol Head Neck Surg 1999; 125(7): 801-4.
8
10. Chen Ling, Chen Li-hua, Ling Feng, LIU Yun-sheng, Madjid Samii, Amir Samii. Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy. Chin Med J 2010; 123(3): 274-80.
9
11. Ashfaq UI Hassan, Ghulam Hassan, Zahida Rasool. Vestibular schoannoma: anatomical, medical and surgical perspective. Int J Med Sci 2013; 1(3): 78-182.
10
ORIGINAL_ARTICLE
Cleft lip and Palate: A 30-year Epidemiologic Study in North-East of Iran
Introduction: Cleft lip and palate are among the most common congenital anomalies worldwide. This study was conducted in order to explore the incidence and related factors of cleft lip and/or palate (CL/P) among live births in Mashhad, North-Eastern Iran. Materials and Methods: In this cross-sectional study, records of 28,519 infants born between March 1982 and March 2011 at three major hospitals in Mashhad were screened for oral clefts. Clinical and demographic factors relating to diagnosed cases, including birth date, gender, birth weight, maternal age, number of pregnancies, type and side of cleft and presence of other congenital anomalies were recorded for analysis. Results: The overall incidence of CL/P was 1.9 per 1,000 live births. Cleft lip associated with cleft palate (CLP) was the most prevalent type of cleft (50%), followed by isolated cleft lip (35.2%) and isolated cleft palate (14.8%). A total of 92.6% of oral clefts were bilateral and 5.5% were located on the right side. In addition, clefts were found to be more common in male than female births (male/female ratio=2.3). The rate of associated congenital anomalies in CL/P newborns was 37%. No significant differences were observed in the incidence of oral clefts across three decades of study; except for CLP which was significantly more prevalent between 2002–2011 (P=0.027). There were no significant differences with regard to season of birth, associated anomalies or maternal age of affected newborns in the three time periods of the study. Furthermore, maternal age and number of pregnancies were not significantly different among the three types of cleft (P=0.43 and P=0.91, respectively). Although the mean birth weight of patients affected with isolated cleft palate was considerably lower than that of the other two types of cleft, the difference was not statistically significant (P=0.05). Conclusion: This study indicates a frequency of CL/P close to the findings in East Asian countries and higher than some previous reports from Iran, European and American countries. Ethnicity-related genetic factors may have a role in the conflicting results obtained from different populations.
https://ijorl.mums.ac.ir/article_3221_931dd2a98c58c120e05a2eb5149e013c.pdf
2015-01-01
35
41
10.22038/ijorl.2015.3221
Cleft lip
Cleft palate
incidence
Epidemiology
Iran
Hamid Reza
Kianifar
kianifarhr@mums.ac.ir
1
Department of Pediatrics,Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Nadia
Hasanzadeh
hasanzadeh.nadia@gmail.com
2
Dental Material Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Arezoo
Jahanbin
jahanbina@mums.ac.ir
3
Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Atefeh
Ezzati
ati_ezzati@yahoo.com
4
Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Homa
Kianifar
dr_kianifar@yahoo.com
5
Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
AUTHOR
1. Souza J, Raskin S. Clinical and epidemiological study of orofacial clefts. J Pediatr (Rio J) 2013; 89 (2):137-44.
1
2. Lei RL, Chen HS, Huang BY, Chen YC, Chen PK, Lee HY et al. Population-based study of birth prevalence and factors associated with cleft lip and palate in Taiwan 2002-2009. PLoS One 2013; 8(3): e58690.
2
3. Eslami N, Majidi MR, Aliakbarian M, Hasanzadeh N. Oral health-related quality of life in children with cleft lip and palate. J Craniofac Surg 2013 Jul; 24(4):e340-3.
3
4. Wehby GL, Cassell CH. The impact of orofacial clefts on quality of life and healthcare use and costs. Oral diseases 2010;16(1):3-10.
4
5. Hasanzadeh N, Omidkhoda M, Jahanbin A, Vatankhah M. Coping strategies and psychological distress among mothers of patients with nonsyndromic cleft lip and palate and the family impact of this disorder. J Craniofac Surg 2014, In press.
5
6. Croen LA, Shaw GM, Wasserman CR, Tolarová MM. Racial and ethnic variations in the prevalence of orofacial clefts in California, 1983-1992. Am J Med Genet 1998;79:42–47.
6
7. Mossey PA, Little J. Epidemiology of oral clefts: an international perspective. In: Wyszynski DF editors. Cleft lip and palate: from origin to treatment. New York: Oxford University Press; 2002:127–158.
7
8. Mossey PA, Modell B. Epidemiology of oral clefts 2012:an international perspective. Front Oral Biol 2012; 16:1-18.
8
9. Tolarová MM, Cervenka J. Classification and birth prevalence of orofacial clefts. Am J Med Genet 1998;75(2):126-37.
9
10. Manyama M, Rolian C, Gilyoma J, Magori CC, Mjema K, Mazyala E, et al. An assessment of orofacial clefts in Tanzania. BMC Oral Health 2011; 11:11-5.
10
11. Wang W, Guan P, Xu W, Zhou B. Risk Factors for Oral Clefts: a Population-Based Case-Control Study in Shenyang, China. Paediatr Perinat Epidemiol 2009; 23: 310–20.
11
12. Tanaka SA, Mahabir RC, Jupiter DC, Menezes JM. Updating the epidemiology of cleft lip with or without cleft palate. Plast Reconstr Surg 2012; 129(3):511e-8e.
12
13. IPDTOC Working Group. Prevalence at birth of cleft lip with or without cleft palate: Data from the International Perinatal Database of Typical Oral Clefts (IPDTOC). Cleft Palate Craniofac J. 2011; 48(1):66-81.
13
14. Khazaei S, Shirani AM, Khazaei M, Najafi F. Incidence of cleft lip and palate in Iran. A meta-analysis. Saudi Med J 2011; 32(4):390-3.
14
15.Golalipour MJ, Mirfazeli A, Behnampour N. Birth prevalence of oral clefting in northern Iran. Cleft Palate Craniofac J 2007; 44(4):378-80.
15
16. Yassaei S, Mehrgerdy Z, Zareshahi G. Prevalence of cleft lip and palate in births from 2003 - 2006 in Iran. Community Dent Health 2010; 27(2):118-21.
16
17.Zandi M, Heidari A. An epidemiologic study of orofacial clefts in hamedan city, iran: a 15-year study. Cleft Palate Craniofac J 2011; 48(4):483-9.
17
18. Farhud DD, Walizadeh GR, Kamali MS. Congenital malformations and genetic diseases in Iranian infants. Hum Genet 1986;74(4):382-5.
18
19. Rajabian MH, Sherkat M. An epidemiologic study of oral clefts in Iran: analysis of 1,669 cases. Cleft Palate Craniofac J 2000; 37(2):191-6.
19
20. Rajabian MH, Aghaei S. Cleft lip and palate in southwestern Iran: an epidemiologic study of live births. Ann Saudi Med 2005; 25(5):385-8.
20
21. Jalili D, Fathi M, Jalili C. Frequency of cleft lip and palate among live births in Akbar Abadi Hospital. Acta Med Iran 2012;50(10):704-6.
21
22. Jamilian A, Nayeri F, Babayan A. Incidence of cleft lip and palate in Tehran. J Indian Soc Pedod Prev Dent 2007;25:174-6.
22
23. Taher AA. Cleft lip and palate in Tehran. Cleft Palate Craniofac J 1992; 29(1):15-6.
23
24. Jahanbin A, Kianifar H, Yaghoubi-Al Z, Malekian A, Keikhaee B, Hasanzadeh N, et al. Had prevalence of cleft lip and palate differed during the Iran-Iraq war? J Craniofac Surg. 2013 May; 24(3):826-9.
24
25. Murray JC, Daack-Hirsch S, Buetow KH, Munger R, Espina L, Paglinawan N, et al. Clinical and epidemiologic studies of cleft lip and palate in the Philippines. Cleft Palate Craniofac J 1997; 34 (1):7-10.
25
26. Kim S, Kim WJ, Oh C, Kim JC. Cleft lip and palate incidence among the live births in the Republic of Korea. J Korean Med Sci 2002;17:49-52.
26
27. Elahi MM, Jacson IT, Elahi O, Khan AH, Mubarak F, Tariq GB, et al. Epidemiology of cleft
27
lip and palate in Pakistan. Plast Reconstr Surg 2004;113:1548-55.
28
28. Al Omari F, Al-Omari IK. Cleft lip and palate in Jordan: birth prevalence rate. Cleft Palate Craniofac J 2004;41(6):609-12.
29
29. FitzPatrick DR, Raine PA, Boorman JG. Facial clefts in the west of Scotland in the period 1980-1984: epidemiology and genetic diagnoses. J Med Genet 1994; 31(2):126-9.
30
30. Iregbulem LM. The incidence of cleft lip and palate in Nigeria. Cleft Palate J 1982;19(3):201-5.
31
31. Yazdee AK, Saedi B, Sazegar AA, Mehdipour P. Epidemiological aspects of cleft lip and palate in Iran. 2011; 49(1):54-8.
32
32. Jahanbin A, Eslami N. Seasonal and yearly trends in cleft lip and palate in northeast Iran, 1989-2011. J Craniofac Surg 2012; 23(5):e456-9.
33
33. Calzolari E, Pierini A, Astolfi G, Bianchi F, Neville AJ, Rivieri F. Associated anomalies in multi-malformed infants with cleft lip and palate: An epidemiologic study of nearly 6 million births in 23 EUROCAT registries. Am J Med Genet A 2007; 143: 528-37.
34
ORIGINAL_ARTICLE
Oral Manifestations of Human Immunodeficiency Virus-Infected Patients
Background: Oral lesions are among the earliest clinical manifestations of human immunodeficiency (HIV) infection and are important in early diagnosis and for monitoring the progression to acquired immunodeficiency syndrome (AIDS). The purpose of this study was to determine the prevalence of oral lesions and their relationship with a number of factors in HIV/AIDS patients attending an HIV center. Methods: A total of 110 HIV-positive patients were examined to investigate the prevalence of oral lesions according to the criteria established by the European Community Clearing House on Oral Problems Related to HIV Infection. An independent T-test was used for correlation of oral lesions with CD4+ count and a χ2 test was used for analysis of the relationship of co-infection with hepatitis B virus (HBV), sexual contact, route of transmission, history of drug abuse, and history of incarceration. Results: Most of the cases were male patients (82.7%). The mean age across all participants was 36.2±8.1 years. Rampant carries, severe periodontitis and oral candidiasis were the most notable oral lesions. Oral lesions were more prevalent in patients between 26–35 years of age. There was a significant difference between patients with and without pseudomembranous candidiasis and angular cheilitis according to mean level of CD4+. Conclusion: The most common oral presentations were severe periodontitis, pseudomembranous candidiasis and xerostomia.
https://ijorl.mums.ac.ir/article_3222_7559d7a49db7f65140f4b5513c963459.pdf
2015-01-01
43
54
10.22038/ijorl.2015.3222
HIV
Aids
oral manifestations
Atessa
Pakfetrat
atessapakfetrat@yahoo.com
1
Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Farnaz
Falaki
falakifalaki@yahoo.com
2
Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Zohreh
Dalirsani
zdalirsani@gmail.com
3
Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Zahra
Delavarian
delavarian41@yahoo.com
4
Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Majid
Sanatkhani
sanatkhanim@mums.ac.ir
5
Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mahsa
Zabihi Marani
zabihi11@yahoo.com
6
General Dentist, Mashhad, Iran
AUTHOR
1. Patton LL, McKaig RG, Strauss RP, Eron JJ, Jr. Oral manifestations of HIV in a southeast USA population. Oral Dis. 1998;4(3):164-9. Epub 1999/ 02/11.
1
2. Patton LL, McKaig R, Strauss R, Rogers D, Eron JJ, Jr. Changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89(3):299-304. Epub 2000/03/10.
2
3. Arendorf TM, Bredekamp B, Cloete CA, Sauer G. Oral manifestations of HIV infection in 600 South African patients. J Oral Pathol Med. 1998;27(4):176-9. Epub 1998/05/01.
3
4. Patton LL, Phelan JA, Ramos-Gomez FJ, Nittayananta W, Shiboski CH, Mbuguye TL. Prevalence and classification of HIV-associated oral lesions. Oral Dis. 2002;8 Suppl 2:98-109. Epub 2002/08/08.
4
5. Coogan MM, Greenspan J, Challacombe SJ. Oral lesions in infection with human immunodeficiency virus. Bull World Health Organ. 2005;83(9):700-6. Epub 2005/10/08.
5
6. Palmer GD, Robinson PG, Challacombe SJ, Birnbaum W, Croser D, Erridge PL, et al. Aetiological factors for oral manifestations of HIV. Oral Dis. 1996;2(3):193-7. Epub 1996/09/01.
6
7. Beyer T, Czernin J, Freudenberg LS. Variations in clinical PET/CT operations: results of an international survey of active PET/CT users. J Nucl Med. 2011;52(2):303-10. Epub 2011/01/15.
7
8. Hjerppe A, Saarinen JP, Venermo MA, Huhtala HS, Vaalasti A. Prolonged healing of venous leg ulcers: the role of venous reflux, ulcer characteristics and mobility. J Wound Care. 2010;19(11):474, 6, 8 passim. Epub 2010/12/08.
8
9. Classification and diagnostic criteria for oral lesions in HIV infection. EC-Clearinghouse on Oral Problems Related to HIV Infection and WHO Collaborating Centre on Oral Manifestations of the Immunodeficiency Virus. J Oral Pathol Med. 1993;22(7):289-91. Epub 1993/08/01.
9
10. Khatibi M, Moshari AA, Jahromi ZM, Ramezankhani A. Prevalence of oral mucosal lesions and related factors in 200 HIV+/AIDS Iranian patients. J Oral Pathol Med. 2011;40(8):659-64. Epub 2011/02/24.
10
11. Coulter ID HK, Marcus M, Hays RD, Freed J, Der-Martirosia C, et al. Associations of self-reported oral health with physical and mental health in a nationally representative sample of HIV persons receiving medical care. Quality of Life Research 2002;11:57-60.
11
12. Kim LS, Stansell J, Cello JP, Koch J. Discrepancy between sex- and water-associated risk behaviors for cryptosporidiosis among HIV-infected patients in San Francisco. J Acquir Immune Defic Syndr Hum Retrovirol. 1998; 19(1): 44-9. Epub 1998/09/10.
12
13. Ravikumar VN, Rudresh K, Jalihal U, Satish R, Manjunath R. Clinical and endoscopic spectrum of upper gastrointestinal manifestations in HIV patients. Kathmandu Univ Med J (KUMJ). 2010; 8(29):25-8. Epub 2011/01/07.
13
14. Li ZC, Zhao Y, Dou ZH, Yu L, Wu H, Zhang FJ. [Clinical features of 66 children with acquired immunodeficiency syndrome]. Zhongguo Dang Dai Er Ke Za Zhi. 2009;11(2):93-5. Epub 2009/02/19.
14
15. Bendlick C SC, Relchart P.A. Oral Manifestations in 10 Combodian Patients with HIV infection avd AIDS. J Oral Pathol Med. 2002;31:1-4.
15
16. Sharma G, Pai KM, Setty S, Ramapuram JT, Nagpal A. Oral manifestations as predictors of immune suppression in a HIV-/AIDS-infected population in south India. Clin Oral Investig. 2009; 13(2):141-8. Epub 2008/08/01.
16
17. Greenwood I ZJ, Robinson PG. changes in the pevalence of HIV-associated mucosal disease at a dedicated clinic over 7 years. Oral Dis. 2002; 8(2):90-4.
17
18. Glick M, Muzyka BC, Lurie D, Salkin LM. Oral manifestations associated with HIV-related disease as markers for immune suppression and AIDS. Oral Surg Oral Med Oral Pathol. 1994; 77(4):344-9. Epub 1994/04/01.
18
19. Coates E, Slade GD, Goss AN, Gorkic E. Oral conditions and their social impact among HIV dental patients. Australian dental journal. 1996;41(1):33-6. Epub 1996/02/01.
19
20. Chidzonga MM. HIV/AIDS orofacial lesions in 156 Zimbabwean patients at referral oral and maxillofacial surgical clinics. Oral Dis. 2003;9(6):317-22. Epub 2003/11/25.
20
21. Tirwomwe JF, Rwenyonyi CM, Muwazi LM, Besigye B, Mboli F. Oral manifestations of HIV/AIDS in clients attending TASO clinics in Uganda. Clin Oral Investig. 2007;11(3):289-92. Epub 2007/05/04.
21
22. Hodgson TA. HIV-associated oral lesions: prevalence in Zambia. Oral Dis. 1997;3 Suppl 1:S46-50. Epub 1997/05/01.
22
23. Tukutuku K, Muyembe-Tamfum L, Kayembe K, Odio W, Kandi K, Ntumba M. Oral manifestations of AIDS in a heterosexual population in a Zaire hospital. J Oral Pathol Med. 1990; 19(5):232-4. Epub 1990/05/01.
23
24. Kerdpon D, Pongsiriwet S, Pangsomboon K, Iamaroon A, Kampoo K, Sretrirutchai S, et al. Oral manifestations of HIV infection in relation to clinical and CD4 immunological status in northern and southern Thai patients. Oral Dis. 2004; 10(3): 138-44. Epub 2004/04/20.
24
25. Khongkunthian P, Grote M, Isaratanan W, Piyaworawong S, Reichart PA. Oral manifestations in 45 HIV-positive children from Northern Thailand. J Oral Pathol Med. 2001;30(9):549-52. Epub 2001/09/14.
25
26. Gabler IG, Barbosa AC, Velela RR, Lyon S, Rosa CA. Incidence and anatomic localization of oral candidiasis in patients with AIDS hospitalized in a public hospital in Belo Horizonte, MG, Brazil. J Appl Oral Sci. 2008;16(4):247-50. Epub 2008/ 12/18.
26
27. Holmes HK SL. Oral lesions of HIV infection in developing countries. Oral Dis. 2002;8(suppl 2): 40-3.
27
28. Nittayananta W, Chanowanna N, Winn T. Mode of HIV transmission associated with risk of oral lesions in HIV-infected subjects in Thailand. J Oral Pathol Med. 2010;39(2):195-200. Epub 2009/ 12/17.
28
29. Sen S MS, Bhattacharya S, Halder S, Bhaumik P. Oral manifestations in humn immunodeficiency virus infected patients. Indian J Dermatol. 2010;55(1):116-8.
29
30. Ramírez-Amador V E-PL, Sierra-Madero J, Anaya-Saavedra G, González-Ramírez I, Ponce-de-León S. The changing clinical spectrum of human immunodeficiency virus (HIV)-related oral lesions in 1,000 consecutive patients. A twelve-year study in a referral center in Mexico. Medicine. 2003; 82:39-50.
30
31. Flaitz CM, Nichols CM, Hicks MJ. Oral malignancies diagnosed in an HIV-dedicated dental clinic. Texas dental journal. 1996;113(6):49-57. Epub 1996/06/01.
31
32. Shiboski CH, Neuhaus JM, Greenspan D, Greenspan JS. Effect of receptive oral sex and smoking on the incidence of hairy leukoplakia in HIV-positive gay men. J Acquir Immune Defic Syndr. 1999;21(3):236-42. Epub 1999/07/27.
32
33. Pedreira EN CC, Barroso EC, Santos JA, Fonseca FP, Taveira LA. Epidemiology and oral manifestations of HIV-positive patients in specialized service in Brazil. Journal of Appllied Oral Sci. 2008;16(6).
33
34. Babamahmoodi F, Heidari Gorji MA, Mahdi Nasehi M, Delavarian L. The prevalence rate of hepatitis B and hepatitis C co-infection in HIV positive patients in Mazandaran province, Iran. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina. 2012;9(2):299-303. Epub 2012/08/29.
34
ORIGINAL_ARTICLE
A New Clinical Scoring System for Adenoid Hypertrophy in Children
Introduction: Chronic nasal obstruction due to adenoid hypertrophy is a very common disorder. Although the clinical assessment of adenoid hypertrophy is essential, its real value in young children is difficult to evaluate. The purpose of this prospective study was to validate a simple clinical score to predict the severity of adenoid obstruction and to evaluate the relationship between this method of clinical scoring with radiography and nasopharyngeal endoscopy. Materials and Methods: Ninety symptomatic children were enrolled into this study. The clinical score included difficulty of breathing during sleep, apnea, and snoring. We investigated the relationship between clinical scoring, nasal endoscopy, and radiographic findings. Results: The clinical score correlated very well with endoscopic findings (P<0.000), but the correlation between the clinical score and radiologic findings (P>0.05) and endoscopic findings and imaging (P>0.05) was weak. Conclusion: Clinical findings could be used to select children for adenoidectomy, especially when endoscopic examination is not available or cannot be performed.
https://ijorl.mums.ac.ir/article_3435_c0195188f40b90595041cd0a244a0775.pdf
2015-01-01
55
61
10.22038/ijorl.2015.3435
Adenoids
Endoscopy
Radiography
Signs and symptoms
Sleep apnea syndromes
Snoring
Shervin
Sharifkashani
sharifkashani@tums.ac.ir
1
Department of Radiology, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Payman
Dabirmoghaddam
dabirmoghadam@sina.tums.ac.ir
2
Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
Maryam
Kheirkhah
mkheirkhah@mail.com
3
Postgraduate, Tehran University of Medical Sciences.
AUTHOR
Rima
Hosseinzadehnik
rima_h55@yahoo.com
4
Azad University of Dentistry. Tehran, Iran.
AUTHOR
1. Mlynarek A, Tewfik MA, Hager A, Manoukian JJ, Schloss FMD, Tewfik FTL,et al. Lateral neck radiography versus direct video rhinoscopy in assessing adenoid size. J Otolaryngol 2004; 33(6):360–5.
1
2. Lourenco EA, Lopes Kde C, Pontes A Jr, Oliveira MHde, Umemura A, Vargas L, et al. Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children. Braz J Otorhinolaryngol 2005; 71(1):23–7.
2
3. Saedi B, Sadeghi M, Mojtahedi M, Mahboubi H. Diagnostic efficacy of different methods in the assessment of adenoid hypertrophy. Am J Otolaryngol 2011; 32(2):147–51.
3
4. Lertsburapa K, Schroeder JW, Sullivan C. Assessment of adenoid size: A comparison of lateral radiographic measurements, radiologist assessment, and nasal endoscopy. Int J Pediatr Otorhinolaryngol 2010; 74(11):1281–5.
4
5. Brouilette R, Hanson D, David R, Klemka L, Anna S, Fernbach S, et al. A diagnostic approach to suspected obstructive sleep apnea in children. J Pediatr 1984;105(1):10–14.
5
6. Cohen D, Konak S. The evaluation of radiographs of the nasopharynx. Clin Otolaryngol Allied Sci 1985; 10(2):73–8.
6
7. Bitar MA, Rahi A, et al. A suggested clinical score to predict the severity of adenoid obstruction in children. Eur Arch Otorhinolaryngol 2006; 263 (10):924–8.
7
8. Major MP, Flores-Mir c, Major PW. Assessment of lateral cephalometric diagnosis of adenoid hypertrophy and posterior upper airway obstruction: a systematic review. Am J Orthod Dentofacial Orthop 2006; 130(6):700–8.
8
9. Caylakli F, Hizal E, Yilmaz I. Correlation between adenoid-nasopharynx ratio and endoscopic examination of adenoid hypertrophy: a blind, prospective clinical study. Int J Pediatr Otorhinolaryngol 2009; 73(11):1532–5.
9
10. Wormald PJ, Prescott CA. Adenoids: comparison of radiological assessment methods with clinical and endoscopic findings. J Laryngol Otol 1992; 106(04):342–4.
10
11. Ysunza A, Pamplona MC, Ortega JM, Prado H, et al. Video fluoroscopy for evaluating adenoid hypertrophy in children. Int J Pediatr Otorhino- laryngol 2008; 72(8):1159–65.
11
12. Pardise JL, Bernard BS, Colborn DK, et al. Assessment of adenoidal obstruction in children: clinical signs versus roentgenographic findings. Pediatrics 1998; 101(6):979–86.
12
13. Chisholm EJ, Lew-Gor S, Hajioff D, et al. Adenoid size assessment: a comparison of palpation, nasendoscopy and mirror examination. Clin Otolaryngol 2005; 30(1):39–41.
13
14. Kubba H, Bingham BJ. Endoscopy in the assessment of children with nasal obstruction. J Laryngol Otol 2001; 115(05):380–4.
14
15. Cassano P, Gelardi M, Cassano M, Fiorella ML, Fiorella R. Adenoid tissue rhinopharyngeal obstruction grading based on fiberendoscopic findings: a novel approach to therapeutic management. Int J Pediatr. Otorhinolaryngol 2003; 67(12):1303–9.
15
ORIGINAL_ARTICLE
Sleep Apnea Syndrome after Posterior Fossa Surgery: A Case of Acquired Ondine's Curse
Introduction: Ondine’s Curse is a catastrophic but rare condition in adults. It is referred to as a congenital or acquired condition, in which the patient cannot breathe automatically while asleep. Acquired causes of this disease can be any cause affecting the ventrolateral part of the medulla, which is considered to be the breathing center in humans. Case Report: A 51-year-old woman, with ataxia and the symptoms and signs of rising Intra-Cranial Pressure, who underwent ventriculoperitoneal shunting and removal of tumour, developed episodic apnea during sleep after surgery and hypercapnia when awake. In her post-operative CT scan, some fine spots of hypodensity in the left lateral part of the medulla were observed. She was managed pharmacologically and underwent tracheotomy. After 50 days, she was discharged from the hospital when she was able to breathe normally. Conclusion: Having experience with this condition after resection of a fourth ventricle tumor, it was found that Ondine’s Curse can be considered as one of the complications of posterior fossa surgery and is curable by proper management.
https://ijorl.mums.ac.ir/article_3463_8ba1e5b7c715fd684075e93333ac791c.pdf
2015-01-01
63
67
10.22038/ijorl.2015.3463
Central hypoventilation syndrome
Ondine’s Curse
Posterior fossa surgery
Elnaz
Faraji rad
farajil@mums.ac.ir
1
Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
mohammad
faraji rad
farajim@mums.ac.ir
2
Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Shahram
Amini
aminish@mums.ac.ir
3
Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Reza
zare
zarer@mums.ac.ir
4
Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
1. Chin, Terry. Congenital Central Hypoventilation Syndrome. EMedicine 27 Nov. 2006. 17 Sept. 2008.Available from: URL: http://www.emedicine. Com/ ped/topic1645.htm
1
2. Takeda S, Fujii Y, Matsuda H, Kawahara h, Nakahara K. Central alveolar hypoventilation syndrome with gastroesophageal reflux. Chest 1996; 110(3):850-2.
2
3. Juan G, Ramon M, Ciscar MA, Garcia B, Lloret T, Cervello MA, et al. Acute respiratory insufficiency as initial manifestation of brainstem lesion. Arch Bronconeum 1999; 35(11):560-3.
3
4. Bullemer F, Heindl S, Karg O. Ondines curse in adults. Pneumologie 1999;53:s91-92
4
5. Sadler M, Wiles CM, stoodley N, Linnane S J, Smith A P. Ondine's curse in a woman with leber's hereditary optic neuropathy. J Neurol neurosurg psychiatry 2002; 73(3):347-8.
5
6. Nannapaneni R, Behari S, Todd NV, Mendelow AD. Retracing "Undine's curse". Neurosurgery 2005; 57(2): 354–63
6
7. Hui-Tzu H, peterus T, Ching-Chi L. Ondines Curse in a patient With unilateral medullary and bilateral erebellar infarctions. j chin med assoc 2005: 68(11): 531-4.
7
8. Trang H, Dehan M, Beaufils F, Zaccaria I, Amiel J, Gaultier C. The French Congenital Central Hypoventilation Syndrome Registry: general data, phenotype, and genotype. Chest 2005;127 (1):72-9.
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9. Schestatsky P, Nelson Teixeira Fernandes L. Aquired ondine's curse. Arq Neuro-psiquiatr 2004; 62(2b):523-7.
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16
ORIGINAL_ARTICLE
Coexistence of Granular Cell Tumor with Squamous Cell Carcinoma on the Tongue: A Case Report
Introduction: Granular cell tumors (GCTs) are rare and mostly benign soft tissue tumors. Though they have been reported in all parts of body, they are generally located in the head and neck region, especially on the tongue. Some malign forms exist, but these have been rarely reported. Granular cell tumors have a neural origin and, in immunohistochemical evaluations, they express S-100 and neuron specific enolase (NSE). The treatment of these tumors is bulky surgical excision. Case Report: In this case, a cauliflower shaped lesion with a 1 cm diameter was excised from the midline tongue of a 65 year old woman. The histopathological evaluation indicated that it was squamous cell carcinoma (SCC) covering GCT. Herein, the coexistence of GCT and SCC we describe on the same region of the tongue, in accordance with literature review, since this is a very rare condition. Conclusion: Pseudoepitheliomatous hyperplasia may accompany GCTs on the tongue and this condition may mimic well-differentiated SCC. For this reason, with the help of Ki-67 and p63 expression, in addition to immunohistochemical markers, well-differentiated SCC should be differentiated from pseudoepitheliomatous hyperplasia through careful investigation.
https://ijorl.mums.ac.ir/article_3460_c92c7c3c564f4b9c622aa1f4b51e50ee.pdf
2015-01-01
69
74
10.22038/ijorl.2015.3460
immunohistochemistry
Granular cell tumor
Squamous cell carcinoma
Tongue
Recep
Bedir
bedirrecep@gmail.com
1
Department of Pathology, Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey.
LEAD_AUTHOR
Rukiye
Yilmaz
rukiyeyılmaz@gmail.com
2
Department of Pathology, Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey.
AUTHOR
Ibrahim
Sehitoglu
sehitogluibrahim@gmail.com
3
Department of Pathology, Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey.
AUTHOR
Abdulkadir
Ozgur
akozgur53@mynet.com
4
Department of Otorhinolaryngology,Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey.
AUTHOR
1. Abrikossoff AI. About Fibromas of the striated muscles. Wirchow Arch Pathol Anat 1926; 260: 215-33.
1
2. Kesici U, Mataraci E, Kesici S, Sezgin Z. Granular cell tumor on perianal region. Acta Medica Iranica 2013;51:509-11.
2
3. Son HY, Kim JP, Ko GH, Lee EJ, Woo SH. Lingual squamous cell carcinoma surrounded by granular cell tumor. Chonnam Med J 2012;48: 65-8.
3
4. Dive A, Dhobley A, Fande PZ, Dixit S. Granuler cell tumor of the tongue: report of a case. J Oral Maxillofac Pathol 2013;17:148.
4
5. Saito K, Kato H, Fukai Y, Kimura H, Miyazaki T, Kashiwabara K, et al. Esophageal granular cell tumor covered by intramucosal squamous cell carcinoma: report of a case. Surg Today 2008; 38(7):651-5.
5
6. Vinco A, Vettoretto N, Cervi E, Villanacci V, Baronchelli C, Giulini SM, et al. Association of multiple granular cell tumors and squamous carcinoma of the esophagus: case report and review of the literature. Dis Esophagus. 2001;14:262-4.
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7. Al-Ahmadie H, Hasselgren PO, Yassin R, Mutema G. Colocalized granular cell tumor and infiltrating ductal carcinoma of the breast. Arch Pathol Lab Med 2002;126:731-3.
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9. Caltabiano R, Cappellani A, Di Vita M, Lanzafame S. The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohisto- chemical study. J Craniofac Surg 2008; 19:1691-4
9
ORIGINAL_ARTICLE
Subjective Visual Vertical and Horizontal Abnormalities in a Patient with Lateral Medullary Syndrome-A Case Report
Introduction: Evaluation of persistent vertigo in post infarct patients is very important as the management depends on whether the cause is purely of central origin or due to associated vestibular affliction. Case Report: A patient with left sided dorsolateral medullary syndrome and persistent vestibular symptoms was evaluated. Vestibular test battery showed abnormal smooth pursuit, bilateral hyperactive caloric responses, and abnormal dynamic subjective visual vertical and dynamic subjective visual horizontal tests. Conclusion: Dorsolateral medullary infarctions (Wallenberg’s syndrome) typically cause a central vestibular tonus imbalance in the roll plane with ipsilateral deviations of perceived vertical orientation. The SVV and SVH tests may have a role in localizing the pathology in a patient with lateral medullary syndrome.
https://ijorl.mums.ac.ir/article_3440_649762359970db5a5037d484c591f175.pdf
2015-01-01
75
80
10.22038/ijorl.2015.3440
Cerebrovascular Accident (CVA)
Caloric Tests
Lateral Medullary Syndrome
Vestibular Function Tests
Amit
Tyagi
ashuu.06@gmail.com
1
AVC Department, Christian Medical College,Vellore,India.
AUTHOR
Gaurav
Ashish
gauravashish05@hotmail.com
2
AVC Department, Christian Medical College,Vellore,India.
LEAD_AUTHOR
Anjali
Lepcha
anjalilepcha@gmail.com
3
AVC Department, Christian Medical College,Vellore,India.
AUTHOR
Achamma
Balraj
abalraj@cmcvellore.ac.in
4
AVC Department, Christian Medical College,Vellore,India.
AUTHOR
1. Sacco RL, Freddo L, Bello JA, Odel JG, Onesti ST, Mohr JP. Wallenberg’s lateral medullary syndrome: Clinical-magnetic resonance imaging correlations. Arch Neurol 1993;50(6):609–14.
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2. Cipparrone L, Fratiglioni L, Siracusa G, Amato MP, Amaducci L, Pagnini P, et al. Electronysta- gmography in the diagnosis of multiple sclerosis. Acta Neurol Scand 1989;80(3):193–200.
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3. Funabashi M, Santos-Pontelli TEG, Colafemina JF, Pavan TZ, Carneiro AAO, Takayanagui OM. A new method to analyze the subjective visual vertical in patients with bilateral vestibular dysfunction. Clinics 2012 ;67(10):1127–31.
3
4. Schubert MC, Minor LB. Vestibulo-ocular Physiology Underlying Vestibular Hypofunction. Phys Ther 2004 ;84(4):373–85.
4
5. Akin FW, Murnane OD, Pearson A, Byrd S, Kelly KJ. Normative data for the subjective visual vertical test during centrifugation. J Am Acad Audiol.2011;22(7):460–8.
5
6. Pavan TZ, Funabashi M, Carneiro JAO, Pontelli TEG dos S, Tedeschi W, Colafêmina JF, et al. Software for subjective visual vertical assessment: an observational cross-sectional study. Braz J Otorhinolaryngol 2012;78(5):51–8.
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7. Barnett HJM, Mohr JP, Stein BM, Yatsu FM. New York: Churchill Livingstone; 1998.
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8. Cass SP. Vestibular Disorders: A Case-study Approach. Oxford University Press; 2003. 440 p.
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9. Kato I, Ogino S, Okada T, Koizuka I, Kanayama R, Nakamura T. Wallenberg’s syndrome: neurotological classification. Auris Nasus Larynx. 2003; Suppl: S13–18.
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10. Brandt T, Bronstein AM. Cervical vertigo. J Neurol Neurosurg Psychiatry 2001;71(1):8–12.
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11. CURRIER RD, GILES CL, DEJONG RN. Some comments on Wallenberg’s lateral medullary syndrome. Neurology 1961;11:778–91.
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12. Kim JS. Pure lateral medullary infarction: clinical-radiological correlation of 130 acute, consecutive patients. Brain J Neurol 2003;126 (8):1864–72.
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13. Kerber KA, Brown DL, Lisabeth LD, Smith MA, Morgenstern LB. Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke J Cereb Circ 2006;37(10):2484–7.
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15. Lee H, Cho Y-W. A case of isolated nodulus infarction presenting as a vestibular neuritis. J Neurol Sci 2004;221(1-2):117–9.
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17. Kim JS. Pure lateral medullary infarction: clinical–radiological correlation of 130 acute, consecutive patients. Brain 2003;126(8):1864–72.
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22.Tomaz A, Borges FN, Ganança CF, Campos CAH de, Tilbery CP. [Signs and symptoms associated to otoneurologic alterations diagnosed on computerized vestibular exam of patients with multiple sclerosis]. Arq Neuropsiquiatr 2005; 63(3B):837–42.
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23. Funabashi M, Santos-Pontelli TEG, Colafêmina JF, Pavan TZ, Carneiro AAO, Takayanagui OM. A new method to analyze the subjective visual vertical in patients with bilateral vestibular dysfunction. Clin São Paulo Braz 2012; 67(10): 1127–31.
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24. Tribukait A, Eiken O. Changes in the perceived head transversal plane and the subjective visual horizontal induced by Coriolis stimulation during gondola centrifugation. J Vestib Res Equilib Orientat 2006;16(3):105–16.
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25. Akin FW, Murnane OD, Pearson A, Byrd S, Kelly KJ. Normative data for the subjective visual vertical test during centrifugation. J Am Acad Audiol 2011;22(7):460–8.
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