ORIGINAL_ARTICLE
Does Malleolus non-Lifting Tympanoplasty have any Advantage Over Malleus Lifting Technique?
Introduction: In order to achieve a higher success rate for tympanoplasty, different techniques have been developed, and a wide variety of grafting materials have been developed. One of the techniques currently receiving considerable attention involves not lifting the remaining of eardrum from the malleus and embedding the graft underneath in order to repair the eardrum correctly in its original position, as well as minimizing graft lateralization leading to progression of hearing rehabilitation. We compared the effects of tympanoplasty with and without malleus lifting on hearing loss in patients with chronic otitis media. Materials and Methods: In this study, 30 consecutive patients diagnosed as having chronic otitis media without cholesteatoma were randomly assigned to two tympanoplasty groups; with or without malleus lifting. Air and bone conduction thresholds were recorded before and 45 days after the intervention. Results: In groups, except for 8000 Hz, the air conduction was significantly improved following surgery. According to air conduction there was no difference between the groups before surgery at different frequencies, although it was improved to a greater degree in the group without lifting at 250 Hz postoperatively. The average post-operative air-bone gap (ABG) gain was significantly higher in all study frequencies in the target group. One of the effects of this technique is inner-ear protection from physical trauma to the ossicular chain, and prevention of damage to bone conduction. Conclusion: A higher hearing threshold and also higher ABG gain can be achieved by not lifting the remaining eardrum from the malleus and embedding the graft undereath it, especially at lower frequencies.
https://ijorl.mums.ac.ir/article_6066_87e10d68cfce4e24a1ab1b21beb3ff94.pdf
2016-01-01
7
11
10.22038/ijorl.2016.6066
Auditory Threshold
Hearing Loss
Lifting
Otitis media
Tympanoplasty
Mohammad Reza
Vahidi
vahidy_mr@yahoo.com
1
Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Abolfazl
Mollasadeghi
mollasadeghi@ssu.ac.ir
2
Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Honeyeh
Shahbazian
shahbazian.honeyeh@gmail.com
3
Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Nasim
Behniafard
nbehniafard@gmail.com
4
Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Mohammad Hossein
Dadgarnia
drdadgarnia@yahoo.com
5
Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
LEAD_AUTHOR
1. Bhutta MF. Epidemiology and pathogenesis of otitis media: construction of a phenotype landscape. Audiol Neurootol 2014;19(3):210–23.
1
2. Thomas NM, Brook I. Otitis media: an update on current pharmacotherapy and future perspectives. Expert Opin Pharmacother 2014;15(8):1069–83.
2
3. Qureishi A, Lee Y, Belfield K, Birchall JP, Daniel M. Update on otitis media - prevention and treatment. Infect Drug Resist 2014;7:15–24.
3
4. Monasta L, Ronfani L, Marchetti F, et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One 2012;7(4):e36226.
4
5. Berger G. Nature of spontaneous tympanic membrane perforation in acute otitis media in children. J Laryngol Otol 1989;103(12):1150–3.
5
6. Kitahara T, Kamakura T, Ohta Y, Morihana T, Horii A, Uno A, et al. Chronic otitis media with cholesteatoma with canal fistula and bone conduction threshold after tympanoplasty with mastoidectomy. Otol Neurotol 2014 ;35(6):981–8.
6
7. Wiatr M, Składzień J, Tomik J, Stręk P, Przeklasa-Muszyńska A. Type II tympanoplasty in chronic cholesteatoma and granulomatous otitis media - distant results of otosurgery. Adv Med Sci 2014; 59(1):44–6.
7
8. Xia Z, Wang Z, Xu Z, Zhang Y, Xu E, Chen X. The clinical analysis of tympanoplasty in treating children's chronic otitis media. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013;27(19):1051–4.
8
9. Tringali S, Dubreuil C, Bordure P. Tympanic membrane perforation and tympanoplasty. Ann Otolaryngol Chir Cervicofac 2008;125(5):261–72.
9
10. Gérard JM, Thill MP, Gersdorff M. The art of tympanoplasty and its clinical illustration. Ann Otolaryngol Chir Cervicofac 2003;120(2):83–93.
10
11. Harris JP, Mehta RP, Nadol JB. Malleus fixation: clinical and histopathologic findings. Ann Otol Rhinol Laryngol 2002; 111(3):246–54.
11
12. Rogha M, Berjis N, Taherinia A, Eshaghian A. Comparison of tympanic membrane grafting medial or lateral to malleus handle. Adv Biomed Res 2014; 3:56.doi:10.4103/2277-9175.125804.eCollection 2014.
12
13. Johns III MM , Sataloff RT, Merati AL, Rosen CA. Shortfalls of the American Academy of Otolaryngology-Head and Neck Surgery's Clinical practice guideline. Otolaryngol Head Neck Surg 2010; 143(2):175-7.
13
14. Stage J, Bak-Pedersen K. Underlay tympanoplasty with the graft lateral to the malleus handle. Clin Otolaryngol Allied Sci 1992;17(1):6–9.
14
15. Kutluhan A, Yalçıner G, Güler G, Kösemehmetoğlu K, Bozdemir K, Bilgen AS. Shall we resect the tip of manubrium mallei in tympanoplasty? Clin Exp Otorhinolaryngol 2011; 4(1):24–6.
15
ORIGINAL_ARTICLE
Effect of Early Intervention on Language Development in Hearing-Impaired Children
Introduction: Hearing loss from birth up to the age of 3 years has a negative effect on speech/language development and results in sensory, cognitive, emotional, and academic defects in adulthood by causing delayed development of communicative-linguistic abilities. The present study was performed in order to assess the effect of early intervention on language development in Persian children aged 6-7 years with severe sensorineural hearing loss. Materials and Methods: Thirty boys and girls aged 6-7 years participated in this study, all of them had severe congenital sensorineural hearing loss in both ears. All children were using bilateral behind-the-ear hearing aid, and had similar economic/socio-cultural backgrounds. Subjects were categorized into two groups based on the age of identification/intervention of hearing loss (3-6 and 12-15 months of age). The Persian TOLD-P3 test was used to evaluate language development in all subjects. Data collection was accomplished by observation, completion of questionnaires, and speech recording. Results: There was a significant difference in language development in 11 sub-tests and five lingual gains on the Persian TOLD-P3 test between early (3-6 months of age) and late identified/intervened (12-15 months of age) hearing-impaired children (P<0.05). Early identified/intervened hearing-impaired children had a notable preference in all assessed sub-tests and lingual gains. Conclusion: Early identification/intervention of hearing loss before the age of 6 months has a significant positive effect on a child’s language development in terms of picture/relational/oral vocabulary, grammatical comprehension, sentence combining, grammatical completion, phonologic analysis, word differentiation, word production, semantics, and syntax. Moreover, early identification/ intervention of hearing loss develops the hearing-impaired child’s lingual gains in visual vocabulary, grammatical completion, word differentiation, phonologic analysis, and word production.
https://ijorl.mums.ac.ir/article_6035_e54925668c45d3dbbbb7e8e92417ecd2.pdf
2016-01-01
13
20
10.22038/ijorl.2016.6035
Child
Early identification
Early intervention
Hearing Loss
Language development
Elahe
Shojaei
elaheshojaei49@gmail.com
1
Department of Audiology, Rehabilitation Sciences Faculty, Iran University of Medicine Sciences, Tehran, Iran.
LEAD_AUTHOR
Zahra
Jafari
jafari . z @ iums.ac.ir
2
Department of Basic Sciences in Rehabilitation, Rehabilitation Sciences Faculty, Iran University of Medical Sciences, Tehran, Iran.
AUTHOR
Maryam
Gholami
arvinrezaei2013@yahoo.com
3
Clinical speech therapist, Social Welfare Organization, Tehran, Iran.
AUTHOR
1. Briscoe J, Norbury CF, Bishop DV. Phonological processing, language and literacy: A comparison of child with mild to moderate sensorineural hearing and those with specific language impairment. J Child Psycholpsychiat 2001; 42(3):329–40.
1
2. Chapman RS. Children's language learning: an intractionist prespective. J Child Pycholpsychiat 2000; 41(1):33–54.
2
3. Schimer BR. Language and literacy development in children who are deaf. 1st ed. Eric. 2000.
3
4. Sininger YS, Grimes A, Christensen E. Auditory development in early amplified children: Factors influencing auditory–based communication outcomes in children with hearing loss. Ear Hear 2010; 31(2):166–85.
4
5. Locke JL, Bogin B. Language and life history: A new perspective on development and evolution of human language. J Behav Brain Struct Sci 2006; 29(3):259–80.
5
6. Moeller MP, Mccleary T, Stelmachowicz P. Longitudinal development of phonology and morphology children with late-identified mild–moderate sensorineural hearing loss. Ear Hear 2010; 31(5):625–35.
6
7. Borg E, Quist G, Reinholdson AC. Speech and language development in a population of Swedish hearing impaired pre-school. Int J Pediatr Otorhinolaryngol 2007; 71(7):1061–77.
7
8. Kushalanagar P, Mathur G, Rathmann C. Infants and children with hearing loss need early language access. J Clin Ethics 2010;21(2):143–154.
8
9. Ching YC, Crowe K, Martin V, Day J, Mahler N, Youn S, et al. Language development and every day functioning of children with hearing loss assessed at 3 years of age. Int J Speech Lang Path 2010;12(2): 124–31.
9
10. Meinzen-Derr J, Wiley S, Choll ID. Impact of early intervention on expressive and receptive language development among young children with permanent hearing loss. Am Ann Deaf. 2011;155(5):580–91.
10
11. Ptok M. Early detection of hearing impairment in new born and infants. Dtsch Arztebl Int. 2011;108(25):426–431.
11
12. Pimperton H, Kennedy CK. The impact of early identification of permanent childhood hearing impairment on speech and language outcomes. Arch Dis Child 2012;97(7):648–53.
12
13. Olzinger HD, Felling J, Beitel C. Early onset of family centered intervention predicts language outcomes in children with hearing loss. Int J Pediat Otorhinolaryngol, 2011;75(2):256–260.
13
14. Northern JH, Down MP. Hearing in children. 4th ed. Baltimore: Williams&Willkins. 2000.
14
15. Kasai N, Fukushima K, Omori K, Sugaya A, Ojima T. Effects of early identification and intervention on language development in Japanese children with prelingual severe to profound hearing impairment. Ann Otol Rhinollaryngol. 2012; 121(4): 16–20.
15
16. Fulcher A, Purcell AA, Baker E, Mumron S. Listen up: children with early identified hearing loss achieve age- appropriate speech/ Language outcomes by 3 years of age. Int J Pediat Otorhinolaryngol 2012;76(12):1785–94.
16
17. Bush ML, Bianchi K, Lester C, Shinn JB, Gal TJ, Fardo DW, Schoenberg N. Delays in diagnosis of congenital hearing loss in Rural children. J Pediat 2014;164(2):393–7.
17
18. Mcleods CK. A systematic review of cross- linguistic and metalinguistic speech and language out comes for children with hearing loss. Int J Biling Edu. 2014;17(3):287–309.
18
19. Murria A, Guerzonia L, Fabrizib E, Marian V. Preschool children have better spoken language when early implanted. Int J Pediatoto Rhinoloryngol. 2014;78(8):1327–31.
19
20. Kasai N, Fukushima K, Omori K, Ojima T. Effects of early identification and intervention on language development in Japanese children with prelingual severe to profound hearing impairment. Ann Otol Rhinolaryngol. 2012;121(4):16–20.
20
21. Alpiner IG, McCarthy PA. Rehabilitative audiology: Children and adults. . 3rd ed. Lippincott Williams & Wilkins. 2000.
21
22. Hull RH .What Is AauralRehabilitation? Aural habilitation .3rd ed. San Diego, London: Singular publishing,INC . 1997 ; 1-18.
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23. Strommen E. The Good enough-Harris Draw-A-Person Test and Drawing Development. Vis Arts Res 1997;13(2):22–28.
23
24. Newcomer P, Hammill D. Test of languagedevelopment (TOLD- P3). Normalization in Persian: Hassanzades-Minayi A. Tehran. Research Institute of exceptional children. 2002.
24
25. Effects of hearing loss on development. American speech language hearing society. 2011.
25
26. Nemati P, Soleymani Z, Moradi A, Jalaei S. Comparison of some language characteristics between dyslexic children aged 7 & 8 years old and normal ones. Novin Reh.2009;2(3-4):40–46.
26
27. Zarifian T, Mohamadi R, Mahmoudi Bakhtiyari B. Syntactical Skills of Persian Hearing Impaired and typically normal children: A Comparative Research: University of Social Welfare & Rehabilitation Sciences. 2010
27
28. Yoshinaga-Itano C. From Screening to Early Identification and Intervention: Discovering Predictors to Successful Outcomes for Children With Significant Hearing Loss. J. Deaf Stud. Deaf Educ.2003;8(1):11–30.
28
29. Yoshinaga-Itano C, Apuzzo M, Coulter D, Stredler-Brown A. The effect of early identification of hearing loss on developmental outcomes. Annal Infant Hearing Screening Seminars. 1996.
29
30. Rinaldi P, Caselli C. Lexical and Grammatical Abilities in Deaf Italian Preschoolers: The Role of Duration of formal Language Experience. J Deaf Edu. 2009;14(1):63–75.
30
ORIGINAL_ARTICLE
Effects of Hyperbilirubinemia on Auditory Brainstem Response of Neonates Treated with Phototherapy
Introduction: One of the most common pathologies in neonates is hyperbilirubinemia, which is a good marker for damage to the central nervous system. The sensitivity of the auditory system to bilirubin has been previously documented, with much discrepancy in its effects on Auditory Brainstem Response results. Thus the objective of this study was to evaluate the effects of hyperbilirubinemia on Auditory Brainstem Response of neonates treated with phototherapy. Materials and Methods: Forty-two term neonates with hyperbilirubinemia, who underwent phototherapy participated in this cross sectional study. The recording of Auditory Brainstem Response was made shortly after confirming that the total serum bilirubin level was greater than 15 µg/dl. Latency of waves I, III, V and inter-peak latencies of the waves were measured. To test the hypothesis about the difference of means between the two groups, continuous variables were compared using either the t-test (normal distribution) or the Mann-Whitney test (non-normal distribution). Results: There was a significant increase in the absolute latencies of waves III and V, and I-III and I-V inter-peak latencies of the sample group compared to the control group in both ears (P<0.05). However, wave I absolute latency and III-V inter-peak interval did not show a significant difference between the two study groups (P>0.05). Conclusion: The results of this study underline the importance of the Auditory Brainstem Response Test as an efficient tool for monitoring the auditory brainstem pathway in neonates who are at risk of neurotoxicity and for diagnosing the earliest stages of auditory damage caused by high levels of bilirubin.
https://ijorl.mums.ac.ir/article_6071_7cadd2e330380ae83e392b1c71c24c46.pdf
2016-01-01
23
29
10.22038/ijorl.2016.6071
Auditory Brainstem Response
Hyperbilirubinemia
total serum bilirubin
neonate
Negin
Salehi
salehi_au@yahoo.com
1
Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
AUTHOR
Fereshte
Bagheri
f-bagheri@razi.tums.ac.ir
2
Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
Hamid
Ramezani Farkhani
salehi.heaven@yahoo.com
3
Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
AUTHOR
1. de Steuben C. Breast-feeding and jaundice: a review. Journal of nurse-midwifery 1992; 37(2): S59-S66.
1
2. Gubernick JA, Rosenberg HK, Ilaslan H, Kessler A. US Approach to Jaundice in Infants and Children 1. Radiographics 2000; 20(1):173-95.
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3. Fay DL, Schellhase KG, Suresh GK. Bilirubin screening for normal newborns: a critique of the hour-specific bilirubin nomogram. Pediatrics 2009; 124(4): 1203-5.
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4. Protocol A. ABM Clinical Protocol# 22: Guidelines for Management of Jaundice in the Breastfeeding Infant Equal to or Greater Than 35 Weeks’ Gestation. Breastfeeding Medicine 2010; 5(2): 87-93.
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5. Bhutani VK, Maisels MJ, Stark AR, Buonocore G. Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants≥ 35 weeks gestation. Neonatology 2008;94(1):63-7.
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6. Johnson L, Bhutani VK, editors. The clinical syndrome of bilirubin-induced neurologic dysfunction. Seminars in perinatology. 2011; 35(3): 101-13.
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7. Bhutani VK, Stevenson DK, editors. The need for technologies to prevent bilirubin-induced neurologic dysfunction syndrome. Seminars in perinatology; 2011: Elsevier.
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8. Boo N, Oakes M, Lye M, Said H. Risk factors associated with hearing loss in term neonates with hyperbilirubinaemia. 1994.
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9. Oh W, Tyson JE, Fanaroff AA, Vohr BR, Perritt R, Stoll BJ, et al. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics. 2003;112(4):773-9.
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10. Graziani LJ, Mitchell DG, Kornhauser M, Pidcock FS, Merton DA, Stanley C, et al. Neurodevelopment of preterm infants: neonatal neurosonographic and serum bilirubin studies. Pediatrics. 1992;89(2):229-34.
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11. Okhravi T, Eslami ST, Ahmadi AH, Nassirian H, Najibpour R. Evaluation of Auditory Brain Stems Evoked Response in Newborns With Pathologic Hyperbilirubinemia in Mashhad, Iran. Iranian Red Crescent Medical Journal. 2015;17(2).
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12. Zhang S, Wickesberg RE, Oertel D. Jaundiced Gunn rats have increased synaptic delays in the ventral cochlear nucleus. Brain research. 1989;501(1):194-7.
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13. Shaia WT, Shapiro SM, Spencer RF. The jaundiced Gunn rat model of auditory neuropathy/dyssynchrony. The Laryngoscope. 2005;115(12):2167-73.
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14. Nakamura H, Takada S, Shimabuku R, Matsuo M, Matsuo T, Negishi H. Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia. Pediatrics. 1985;75(4):703-8.
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15. Deorari A, Singh M, Ahuja G, Bisht M, Verma A, Paul V, et al. One year outcome of babies with severe neonatal hyperbilirubinemia and reversible abnormality in brainstem auditory evoked responses. Indian pediatrics. 1994;31(8):915-21.
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16. Agrawal V, Shukla R, Misra P, Kapoor R, Malik G. Brainstem auditory evoked response in newborns with hyperbilirubinemia. Indian pediatrics. 1998;35:513-8.
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17. Moeller MP. Early intervention and language development in children who are deaf and hard of hearing. Pediatrics. 2000;106(3):e43-e.
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18. Hall JW. New handbook of auditory evoked responses: ASHA; 2007.
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19. Wilkinson AR, Jiang ZD, editors. Brainstem auditory evoked response in neonatal neurology. Seminars in Fetal and Neonatal Medicine; 2006: Elsevier.
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20. Amin SB, Ahlfors C, Orlando MS, Dalzell LE, Merle KS, Guillet R. Bilirubin and serial auditory brainstem responses in premature infants. Pediatrics. 2001;107(4):664-70.
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21. Smith CM, Barnes GP, Jacobson CA, Oelberg DG. Auditory brainstem response detects early bilirubin neurotoxicity at low indirect bilirubin values. Journal of perinatology. 2004;24(11):730-2.
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22. Soares I, Collet L, Delorme C, Salle B, Morgon A. Are click-evoked BAEPs useful in case of neonate hyperbilirubinemia? International journal of pediatric otorhinolaryngology. 1989;17(3):231-7.
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23. Streletz L, Graziani L, Branca P, Desai H, Travis S, Mikaelian D. Brainstem auditory evoked potentials in fullterm and preterm newborns with hyperbili- rubinemia and hypoxemia. Neuropediatrics. 1986; 17(2):66-71.
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24. Wong V, Chen W-X, Wong K-Y. Short-and long-term outcome of severe neonatal nonhemolytic hyperbilirubinemia. Journal of child neurology. 2006;21(4):309-15.
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25. Watchko JF. Neonatal Hyperbilirubinemia-What Are the Risks? New England Journal of Medicine. 2006;354(18):1947-9.
25
26. Shapiro SM. Bilirubin toxicity in the developing nervous system. Pediatric neurology. 2003; 29(5): 410-21.
26
27. Fakhim SA, Naderpoor M, Shahidi N, Basharhashemi F, Nejati N, Sakha SH, et al. Study of prevalence and causes of hearing loss in high risk neonates admitted to neonatal ward and neonatal intensive care unit. Int Adv Otol. 2010;6:365-70.
27
28. Smitherman H, Stark AR, Bhutan VK, editors. Early recognition of neonatal hyperbilirubinemia and its emergent management. Seminars in Fetal and Neonatal Medicine; 2006: Elsevier.
28
29. Hansen TWR, editor Kernicterus: an international perspective. Seminars in neonatology; 2002: Elsevier.
29
30. Shapiro SM, Popelka GR, editors. Auditory impairment in infants at risk for bilirubin-induced neurologic dysfunction. Seminars in perinatology; 2011: Elsevier.
30
31. Sharma R, Grover N, Sankhyan N, Sharma M. Auditory brainstem responses in neonatal hyperbilirubinemia and effect of therapy. Indian Journal of Otolaryngology and Head and Neck Surgery. 2006; 58(4):340-2.
31
32. Rattay F, Danner SM. Peak I of the human auditory brainstem response results from the somatic
32
regions of type I spiral ganglion cells: Evidence from computer modeling. Hearing research. 2014;315: 67-79.
33
33. Jiang ZD, Chen C, Liu TT, Wilkinson AR. Changes in brainstem auditory evoked response latencies in term neonates with hyperbilirubinemia. Pediatric neurology. 2007;37(1):35-41.
34
34. Jiang ZD, Wilkinson AR. Impaired function of the auditory brainstem in term neonates with hyperbilirubinemia. Brain and Development. 2014; 36(3):212-8.
35
35. Ahlfors CE, Parker AE. Unbound bilirubin concentration is associated with abnormal automated auditory brainstem response for jaundiced newborns. Pediatrics. 2008;121(5):976-8.
36
36. Perlman M, Fainmesser P, Sohmer H, Tamari H, Wax Y, Pevsmer B. Auditory nerve-brainstem evoked responses in hyperbilirubinemic neonates. Pediatrics. 1983;72(5):658-64.
37
37. Shapiro SM. Acute brainstem auditory evoked potential abnormalities in jaundiced Gunn rats given sulfonamide. Pediatric research. 1988; 23(3):306-10.
38
38. Shapiro SM. Reversible brainstem auditory evoked potential abnormalities in jaundiced Gunn rats given sulfonamide. Pediatric research. 1993; 34(5): 629-33.
39
39. Mohammadi M, Ashrafi M, Shabanian R. Auditory brainstem responses (ABR) in hyperbilirubinemic newborns. Medical Journal of The Islamic Republic of Iran (MJIRI). 2002; 16(2): 63-6.
40
40. Sharma P, Chhangani N, Meena KR, Jora R, Sharma N, Gupta B. Brainstem evoked response audiometry (BAER) in neonates with hyperbili rubinemia. The Indian Journal of Pediatrics. 2006; 73(5):413-6.
41
ORIGINAL_ARTICLE
Audiological Outcome of Classical Adenoidectomy versus Endoscopically-Assisted Adenoidectomy using a Microdebrider
Introduction:
The aim of this study was to evaluate audiological outcomes following adenoidectomy by the classical method and by endoscopically-assisted adenoidectomy using a powered instrument (microdebrider).
Materials and Methods:
This study was conducted in a tertiary care center. It included 40 patients divided into two equal groups of 20 each. Group-A patients underwent classical adenoidectomy, while Group-B patients were subjected to endoscopically-assisted adenoidectomy using a microdebrider. Hearing outcome was measured by post-operative pure-tone audiometry and tympanometry.
Results:
The post-operative average air-bone gap (ABG) was reduced from 19.6 dB to 11.8 dB in Group A and from 17.6 dB to 8.7 dB in Group B (P=0.010). There was reversal of tympanometric curves from type-B and type-C to type-A in 55% of the patients in Group A, while type-A curve was seen in 90% cases in Group B in the post-operative period.
Conclusion:
Audiological outcomes of endoscopically-assisted adenoidectomy using a microdebrider were superior compared with classical adenoidectomy.
https://ijorl.mums.ac.ir/article_6033_18c4a4a751bb76782ab081a492cc2569.pdf
2016-01-01
31
37
10.22038/ijorl.2016.6033
Adenoidectomy
Audiological
Endoscopic
Microdebrider
Tympanometry
Vanita
Sarin
vanitasarin@yahoo.co.in
1
Department of Otorhinolaryngology, Sri Guru Ram Das Institute of Medical Sciences & Research, Amritsar, Punjab, India.
LEAD_AUTHOR
Vanika
Anand
vanika.anand@gmail.com
2
Department of Otorhinolaryngology, Christian Medical College, Ludhiana, Punjab, India.
AUTHOR
Bhanu
Bhardwaj
bhardwaj_bhanu123@yahoo.co.in
3
Department of Otorhinolaryngology, Sri Guru Ram Das Institute of Medical Sciences & Research, Amritsar, Punjab, India.
AUTHOR
1.Caylan R, Bektas D, Atalay C, Korkmaz O. Prevalence and risk factors of otitis media with effusion in Trabzon, a city in northeastern Turkey, with an emphasis on the recommendation of OME screening. Eur Arch Otorhinolaryngol. 2006; 263 (5):404–8.
1
2. Sarafoleanu C, Enache R, Sarafoleanu D. Eustachian Tube Dysfunction of Adenoid Origin. Therapeutics, Pharmacology and Clinical Toxicology. 2010;14(1):36–40.
2
3. Bluestone CD, Doyle WJ. Anatomy and physiology of Eustachian tube and middle ear related to otitis media. J Allergy Clin Immunol. 1988; 81: 997-1003.
3
4. Bross Soriano D, Schimelmitz-Idi J, Arrieta-Gomez JR. Endoscopic adenoidectomy; use or abuse of the technology? Cir. 2004;72(1):15–9.
4
5. Gelder LV. Open nasal speech following adenoidectomy and tonsillectomy. J Comm Dis. 1974;7(3):263–7.
5
6. Canon CR, Relogle WH, Schenk MP. Endoscopic assisted adenoidectomy. Otolaryngology Head and Neck Surgery. 1999;121(6):740–4.
6
7. Becker SP, Roberts N, Coglianese D. Endoscopic adenoidectomy for the relief of serous otitis media. Laryngoscope.1992;102:1379–84.
7
8. Rodriguez K, Murray N, Guarisco JL. Power assisted partial adenoidectomy. Laryngoscope. 2002; 112:26–8.
8
9. Fujioka M, Young LW, Girdang BR. Radiographic evaluation of adenoidal size in children: Adenoidal-nasopharyngeal ratio. Am J Radiol.1979;133:401.
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10. Clemens J, McMurray JS, Willging JP. Electrocautery versus curette adenoidectomy: comparison of postoperative results. Int J Pediatr Otorhinolaryngol.1998;43(2):115–22.
10
11. Grewal N, Godhane AV. Lateral cephalometry: A simple and economical clinical guide for assessment of nasopharyngeal free airway space in mouth breathers. Contemp Clin Dent. 2010;1(2):66–9.
11
12. Mlynarek A, Tewfik MA, Hagr A, Manoukian JJ, Schloss MD, Tewfik TL et al. Lateral neck radiography versus direct video rhinoscopy in assessing adenoid size. J Otolaryngol. 2004; 33(6):360–5.
12
13. Datta R, Singh VP, Deshpal. Conventional versus Endoscopic powered adenoidectomy: A Comparative Study. MJAFI. 2009;65:308–12.
13
14. Caylan R, Bektas D, Atalay C, Korkmaz O. Prevalence and risk factors of otitis media with effusion in Trabzon, a city in northeastern Turkey, with an emphasis on the recommendation of OME screening. Eur Arch Otorhinolaryngol. 2006; 263 (5):404–8.
14
15. Parsons DS. Rhinologic uses of powered instrumentation in children beyond sinus surgery. Otolaryngol Clin North Am.1996;29:105-14.
15
16. Murray N, Flitzpatrick P, Guarisco JL. Powered Partial Adenoidectomy. Arch Otolaryngol Head and Neck Surg. 2002;128(7):792-6.
16
17. Costantini F, Salamanca F, Amaina T, Zibordi F, Videoendoscopic adenoidectomy with microdebrider. Acta Otolaryngologica Italica. 2008, 28(1):26–9.
17
18. Somani SS, Naik CS, Bangad SV. Endoscopic adenoidectomy with microdebrider. Indian J Otolaryngol Head Neck Surg. 2010;64(4):427-31
18
19. Benito Orejas JI, Alonso Mesonero M, Almaraz Gomez A, Morais Perez D, Santos Perez J. Trend changes in adenotonsillar surgery. An Otorhinolaryngol Ibero Am. 2006;33(6):537-81.
19
20. Mori H, Kitahara K, Kita M, Takahashi H, Nakai Y. Analysis of tympanograms in relation to the treatment of adenoid vegetation. Nippon Jibiinkoka Gakkai Kaiho.1980;83(4):415-23.
20
1.Caylan R, Bektas D, Atalay C, Korkmaz O. Prevalence and risk factors of otitis media with effusion in Trabzon, a city in northeastern Turkey, with an emphasis on the recommendation of OME screening. Eur Arch Otorhinolaryngol. 2006; 263 (5):404–8.
21
2. Sarafoleanu C, Enache R, Sarafoleanu D. Eustachian Tube Dysfunction of Adenoid Origin. Therapeutics, Pharmacology and Clinical Toxicology. 2010;14(1):36–40.
22
3. Bluestone CD, Doyle WJ. Anatomy and physiology of Eustachian tube and middle ear related to otitis media. J Allergy Clin Immunol. 1988; 81: 997-1003.
23
4. Bross Soriano D, Schimelmitz-Idi J, Arrieta-Gomez JR. Endoscopic adenoidectomy; use or abuse of the technology? Cir. 2004;72(1):15–9.
24
5. Gelder LV. Open nasal speech following adenoidectomy and tonsillectomy. J Comm Dis. 1974;7(3):263–7.
25
6. Canon CR, Relogle WH, Schenk MP. Endoscopic assisted adenoidectomy. Otolaryngology Head and Neck Surgery. 1999;121(6):740–4.
26
7. Becker SP, Roberts N, Coglianese D. Endoscopic adenoidectomy for the relief of serous otitis media. Laryngoscope.1992;102:1379–84.
27
8. Rodriguez K, Murray N, Guarisco JL. Power assisted partial adenoidectomy. Laryngoscope. 2002; 112:26–8.
28
9. Fujioka M, Young LW, Girdang BR. Radiographic evaluation of adenoidal size in children: Adenoidal-nasopharyngeal ratio. Am J Radiol.1979;133:401.
29
10. Clemens J, McMurray JS, Willging JP. Electrocautery versus curette adenoidectomy: comparison of postoperative results. Int J Pediatr Otorhinolaryngol.1998;43(2):115–22.
30
11. Grewal N, Godhane AV. Lateral cephalometry: A simple and economical clinical guide for assessment of nasopharyngeal free airway space in mouth breathers. Contemp Clin Dent. 2010;1(2):66–9.
31
12. Mlynarek A, Tewfik MA, Hagr A, Manoukian JJ, Schloss MD, Tewfik TL et al. Lateral neck radiography versus direct video rhinoscopy in assessing adenoid size. J Otolaryngol. 2004; 33(6):360–5.
32
13. Datta R, Singh VP, Deshpal. Conventional versus Endoscopic powered adenoidectomy: A Comparative Study. MJAFI. 2009;65:308–12.
33
14. Caylan R, Bektas D, Atalay C, Korkmaz O. Prevalence and risk factors of otitis media with effusion in Trabzon, a city in northeastern Turkey, with an emphasis on the recommendation of OME screening. Eur Arch Otorhinolaryngol. 2006;263 (5):404–8.
34
15. Parsons DS. Rhinologic uses of powered instrumentation in children beyond sinus surgery. Otolaryngol Clin North Am.1996;29:105-14.
35
16. Murray N, Flitzpatrick P, Guarisco JL. Powered Partial Adenoidectomy. Arch Otolaryngol Head and Neck Surg. 2002;128(7):792-6.
36
17. Costantini F, Salamanca F, Amaina T, Zibordi F, Videoendoscopic adenoidectomy with microdebrider. Acta Otolaryngologica Italica. 2008, 28(1):26–9.
37
18. Somani SS, Naik CS, Bangad SV. Endoscopic adenoidectomy with microdebrider. Indian J Otolaryngol Head Neck Surg. 2010;64(4):427-31
38
19. Benito Orejas JI, Alonso Mesonero M, Almaraz Gomez A, Morais Perez D, Santos Perez J. Trend changes in adenotonsillar surgery. An Otorhinolaryngol Ibero Am. 2006;33(6):537-81.
39
20. Mori H, Kitahara K, Kita M, Takahashi H, Nakai Y. Analysis of tympanograms in relation to the treatment of adenoid vegetation. Nippon Jibiinkoka Gakkai Kaiho.1980;83(4):415-23.
40
ORIGINAL_ARTICLE
Endoscopic Repair of CSF Rhinorrhea: An Institutional Experience
Introduction: Endoscopic repair is considered the treatment of choice in cerebrospinal fluid (CSF) rhinorrhea. The aim of our study was to analyze the etiopathogenesis of CSF rhinorrhea, the outcome of treatment and the causes of failure in a developing-country setting. Materials and Methods: A retrospective review of patients treated with endoscopic repair for CSF rhinorrhea at a tertiary care hospital in southern India from January 2002 to December 2009 identified 36 patients, the majority of them being women. The defects were closed in three layers using fat, fascia lata and nasal mucosa along with a fibrin sealant in the majority of the patients. Per-operatively, a subarachnoid drain was placed in all patients. Patients were followed up for 1 year. Results: Spontaneous onset of CSF rhinorrhea was noted in 61% of patients. The most common site of leak was found to be the left cribriform plate area. Hence the most common cause of CSF rhinorrhea in our study was spontaneous and the second most common was post-traumatic. Our success rate on the first attempt at endoscopic repair was 100%, with a recurrence rate of 6%. A large defect, failure of localization of the defect, or other co-morbid conditions such as chronic cough may be the most likely causes of recurrence of leak. Conclusion: Accurate localization of the site of lesion using a high-resolution computed tomography (CT) scan with magnetic resonance imaging (MRI) and confirmation of the site of leak by intraoperative Valsalva maneuver along with multilayered closure of the dural defect and post-operative lumbar drain appear to be essential for the successful endoscopic repair of CSF rhinorrhea.
https://ijorl.mums.ac.ir/article_6030_e2d9abae08a354ea137a6d8b864938f2.pdf
2016-01-01
39
43
10.22038/ijorl.2016.6030
Cribriform plate
CSF rhinorrhea
Transnasal Endoscopic Surgery
Subarachnoid Space
Valsalva Maneuver
Sarita Kumari
Mishara
dr.sarita.m@gmail.com
1
Department of Otorhinolaryngology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
AUTHOR
George Ani
Mathew
georgemathew70@gmail.com
2
Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.
LEAD_AUTHOR
Roshna Rose
Paul
anhsor@gmail.com
3
Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.
AUTHOR
Syed Kamran
Asif
skamrann@gmail.com
4
Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.
AUTHOR
Mary
John
sunilandmary@gmail.com
5
Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.
AUTHOR
Ajoy Mathew
Varghese
ajoymathew@gmail.com
6
Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.
AUTHOR
Mary
Kurine
kurien_mary@hotmail.com
7
Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.
AUTHOR
1. Park J-I, Strelzow W, Friedman WH. Current management of cerebrospinal fluid rhinorrhoea. Laryngoscope1983; 93:1294–300.
1
2. Presutti L, Mattioli F, Villari D, Marchioni D, Alicandri-Ciufelli M. Transnasal endoscopic treatment of cerebrospinal fluid leak: 17 years’ experience. Acta Otorhinolaryngol Ital. 2009; 29(4): 191–6.
2
3. Banks CA, Palmer JN, Chiu AG, O'Malley BW Jr, Woodworth BA, Kennedy DW. Endoscopic closure
3
of CSF rhinorrhea: 193 cases over 21 years. Otolaryngol Head Neck Surg. 2009;140(6):826–33.
4
4. Eljamel MS, Foy PM. Non-traumatic CSF fistulae: Clinical history and management. Br J Neurosurg. 1991; 5:275–9.
5
5. Lund VJ, Savy L, Lloyd G, Howard D. Optimum imaging and diagnosis of cerebrospinal fluid rhinorrhea. J Laryngol Otol. 2000;114:988–92.
6
6. Seth R, Rajasekaran K, Benninger MS, Batra PS. The utility of intrathecal fluorescein in cerebrospinal fluid leak repair. Otolaryngol Head Neck Surg. 2010; 143(5):626–32.
7
7. Stankiewicz JA. Cerebrospinal fluid fistula and endoscopic sinus surgery. Laryngoscope 1991; 101: 250–6.
8
8. Kelly TF, Stankiewicz JA, Chow JM, Origitano TC, Shea J. Endoscopic closure of postsurgical anterior cranial fossa cerebrospinal fluid leaks. Neurosurgery.1996;106: 1080–3.
9
9. Ye H, Zuo J, Zhao H, Liu S, An H, Liu Y. Endonasal endoscopic repair of CSF rhinorrhea in a series of 69 patients. Br J Neurosurg. 2010;24(3): 244–8.
10
ORIGINAL_ARTICLE
Effect of Topical Estrogen in the Mangement of Traumatic Facial Wounds
Introduction: Acute skin wound healing is a complicated process comprising various phases. Recent animal studies have shown that steroid sex hormones such as estrogen maybe helpful in the regulation of several pathophysiologic stages that are involved in wound healing. In this study we examined the effects of topical estrogen in the treatment of traumatic facial wounds. Materials and Methods: Patients referred to Luqman Hospital, Tehran with traumatic wounds were enrolled in this case-control study into two groups of equal size. From the second week of the study, topical estrogen (0.625 mg conjugated topical estrogen ointment) was administered in the case group, while the control group received a Eucerin dressing only. The two groups were then compared in terms of wound healing rate on Day 7,14, and 30. Results: Thirty patients with mean age of 16.02+36.23 years were compared in the control and estrogen-treated groups. After treatment, no scars or keloids were observed in either group. The wound area in the estrogen group was lower than that in the control group on Day 14 and 30, but the difference was not significant (P>0.05). Healing rates in the control group on Day 14 (7.1+42.3 vs.50.3+4.9 mm2) and Day 30 (1.9+93.5 vs. + 97.3+0.6 mm2) (were lower than those in the estrogen group, but the differences were not significant (P>0.05). Findings show that the required time for wound healing in the estrogen-treated group was lower than that in the control group, but the difference was not significant (P>0.05). Conclusion: Based on this study, topical estrogen has no effect on the rate of wound healing or the rate of wound area .
https://ijorl.mums.ac.ir/article_6034_cd692feddef97ec905d6504c8d691d33.pdf
2016-01-01
45
49
10.22038/ijorl.2016.6034
Estrogen
Effect
Traumatic Wounds
Treatment
Seyed Amirhosein
Ghazizadeh Hashemi
1
Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Behrooz
Barati
baratib@tums.ac.ir
2
Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Hosein
Mohammadi
mohammadih@gmail.com
3
Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Masumeh
Saeidi
masumeh_saeedi@yahoo.com
4
Student Research Commitee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Abbas
Bahreini
5
Students Research Committee, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Mohammad Ali
Kiani
kianima@mums.ac.ir
6
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1. Simpson NB, Gunliff WJ. Rook S. Text book of dermatology. 7th ed. Oxford Blackwell Science; 2004:11–38.
1
2. Edwards R, Harding KG. Bacteria and wound healing. Curr Opin Infect Dis. 2004;17(2):91–6.
2
3. Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol. 2007;25(1):19–25.
3
4. Albsoul-Younes A, Younes NA, Badran DH. Topical phenytoin ointment increases autograft acceptance in rats. Saudi Med J. 2006;27(7):962–6.
4
5. Gal P, Toporcer T, Vidinsky B, Mokry M, Grendel T, Novotny M, et al. postsurgical administration of estradiol benzoate decreases tensil strength of skin wound in ovariectomized rats. J Surg Res. 2008;147(1):117–22.
5
6. Gilliver SC1, Ashcroft GS. Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens. See comment in PubMed Commons below Climacteric. 2007;10(4):276–88.
6
7. Hardman MJ, Emmerson E, Campbell L, Ashcroft GS. Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice. Endocrinology. 2008; 149(2):551–7.
7
8. Ou KY, Chen YC, Hsu SC, Tsai EM. Topical vaginal oestrogen cream used for treatment of burn injury of vaginal mucosa after misapplication of 100% acetic acid in a perimenopausal woman: a case report. Aust N Z J Obstet Gynaecol. 2007; 47(4):345–6.
8
9. Gilliver SC, Ashworth JJ, Mills SJ, Hardman MJ, Ashcroft GS. Androgens modulate the inflammatory response during acute wound healing. J Cell Sci. 2006;119(Pt 4):722–32.
9
10. Gilliver SC1, Wu F, Ashcroft GS. Regulatory roles of androgens in cutaneous wound healing. Thromb Haemost. 2003;90(6):978–85.
10
11. Gilliver SC, Ashworth JJ, Ashcroft GS. The hormonal regulation of cutaneous wound healing. Clin Dermatol. 2007;25(1):56–62.
11
12. Luu-The V, Labrie F. The intracrine sex steroid biosynthesis pathways. Prog Brain Res. 2010; 181:177–92.
12
13. Breuer B, Trungold S, Martucci C, Wallenstein S, Likourezos A, Libow LS, Zumoff B. Relationships of sex hormone levels to dependence in activities of daily living in the frail elderly. Maturitas. 2001;39(2):147–59.
13
14. Zmuda JM, Cauley JA, Kriska A, Glynn NW, Gutai JP, Kuller LH. Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. Am J Epidemiol. 1997; 146(8): 609–17.
14
15. Hardman MJ, Ashcroft GS. Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly. Genome Biology 2008;9(5):R80.
15
16. Abe R, Shimizu T, Ohkawara A, Nishihira J. Enhancement of macrophage migration inhibitory factor (MIF) expression in injured epidermis and cultured fibroblasts. Biochim Biophys Acta. 2000; 1500(1):1–9.
16
17. Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol. 1999;155(4):1137–46.
17
18. Khaksar S, Kesmati M, Rezaie A, Rasekh A. Topical Estrogen Accelerates Wound Healing in Diabetic Rats. Iranian Journal of Endocrinology and Metabolism. 2011;12 (5):544–51. 19. Shamseddini S, Yavar Zadeh M, Shamseddini A. Comparison of the healing effects of topical Phenytoin, Estrogen and Silver Sulfadiazine on skin wounds in male rats. Iranian J Dermatol 2006;8(6):482–86.
18
20. Mirnezami M, Ebrahimi Fakhar H, Rezaei K, Rahimi H. Comparing the healing effects of topical phenytoin, conjugated estrogen and silver sulfadiazine on skin wounds in male rats. KAUMS Journal(FEYZ ). 2011; 15(1):11–14.
19
21. Juckett G, Hartman-Adams H. Management of keloids and hypertrophic scars. Am Fam Physician. 2009; 80(3):253–60.
20
ORIGINAL_ARTICLE
MTA1 Expression in Benign and Malignant Salivary gland Tumors
Introduction: Salivary gland tumors (SGTs) are important parts of human neoplasms. The most common SGT is pleomorphic adenoma and the most common malignant SGTs are mucoepidermoid carcinoma and adenoid cystic carcinoma (ACC). Metastasis-associated genes 1 (MTA1), a member of the nucleosome remodeling and histone deacetylation complex, is one newly discovered gene which recruits histone deacetylation, causing ATP-dependent chromosome remodeling, and regulating transcription. MTA1 had been shown to be overexpressed in malignant tumors with the enhancement of invasion and metastasis. Materials and Methods: Fifty-six samples of salivary tumors from the Khalili Hospital archive, including 20 cases of pleomorphic adenoma, 17 cases of mucoepidermoid carcinoma, 19 cases of ACC, and 23 cases of normal salivary gland tissues were chosen for immunohistochemical analysis of MTA1. Results: MTA1 expression in the malignant tumors was significantly higher than that in pleomorphic adenoma (P<0.001), and higher in pleomorphic adenoma than the normal salivary glands(P< 0.001). In total, 69.6% of normal salivary gland tissues showed MTA1, but all cases of salivary gland tumors were positive for MTA1. High nuclear expression of MTA1 was detected in 83.3% (30/36) of the malignant salivary gland tumors and 45% (9/20) of pleomorphic adenoma, while low MTA1 expression was seen in all of the normal salivary gland tissues. No statistically significant correlation was found between MTA1 protein expression and any clinicopathological features (P>0.05). Conclusion: Our findings demonstrate that MTA1 was significantly overexpressed in malignant salivary gland neoplasm in comparison to a lower level in benign pleomorphic adenoma, suggesting that MTA1 protein might be involved in carcinogenesis.
https://ijorl.mums.ac.ir/article_6065_ed7dadb75844f9a916a80820fd7befd5.pdf
2016-01-01
51
59
10.22038/ijorl.2016.6065
Salivary gland tumour
Pleomorphic adenoma
Adenoid cystic carcinoma
Mucoepidermoid carcinoma
MTA1
Azadeh
Andisheh-Tadbir
andisheh202003@yahoo.com
1
Prevention of Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Ali
Dehghani -Nazhvani
dehghaninajvani@sums.ac.ir
2
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Mohammad Javad
Ashraf
mjashraf@sums.ac.ir
3
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Bijan
Khademi
khademib@yahoo.com
4
Department of Otorhinolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Hosein
Mirhadi
mirhadid@sums.ac.ir
5
Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Shima
Torabi-Ardekani
shima.torabi25@gmail.com
6
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
LEAD_AUTHOR
1. Alves FA, Pires FR, De Almeida OP, Lopes MA, Kowalski LP. PCNA, Ki-67 and p53 expressions in submandibular salivary gland tumours. International journal of oral and maxillofacial surgery 2004; 33(6):593-7.
1
2. Jones AV, Franklin CD. An analysis of oral and maxillofacial pathology found in adults over a 30-year period. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2006;35(7):392-401.
2
3. Speight PM, Barrett AW. Salivary gland tumours. Oral diseases. 2002;8(5):229-40. Epub 2002/10/05.
3
4. Ota T, Ota K, Jono H, Fujimori H, Ueda M, Shinriki S, et al. Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis. Oral oncology 2010;46(9):657-61.
4
5. Andisheh-Tadbir A, Ashraf MJ, Khademi B, Ahmadi Sh. Clinical implication of CD166 expression in salivary gland tumor.Tumor Biology 2015; 36(4): 2793-9.
5
6. Toh Y, Pencil SD, Nicolson GL. A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. The Journal of biological chemistry 1994;269(37):22958-63.
6
7. Toh Y, Nicolson GL. The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. Clinical & experimental metastasis 2009;26(3):215-27.
7
8. Bowen NJ, Fujita N, Kajita M, Wade PA. Mi-2/NuRD: multiple complexes for many purposes. Biochimica et biophysica acta. 2004;1677(1-3):52-7.
8
9. Nicolson GL, Nawa A, Toh Y, Taniguchi S, Nishimori K, Moustafa A. Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clinical & experimental metastasis 2003;20(1):19-24.
9
10. Ryu SH, Chung YH, Lee H, Kim JA, Shin HD, Min HJ, et al. Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma. Hepatology (Baltimore, Md) 2008; 47(3): 929-36.
10
11. Patel SG, Shah JP. TNM staging of cancers of the head and neck: striving for uniformity among diversity. CA: a cancer journal for clinicians 2005;55(4):242-58.
11
12. Seethala RR. An update on grading of salivary gland carcinomas. Head and neck pathology 2009; 3(1):69-77.
12
13. Prisco MG, Zannoni GF, De Stefano I, Vellone VG, Tortorella L, Fagotti A, et al. Prognostic role of metastasis tumor antigen 1 in patients with ovarian cancer: a clinical study. Human pathology 2012; 43(2): 282-8.
13
14. Eveson JW, Cawson RA. Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. Journal of oral pathology 1985;14(6): 500-9.
14
15. Eveson JW. Troublesome tumours 2: borderline tumours of salivary glands. Journal of clinical pathology 1992;45(5):369-77.
15
16. Luukkaa H, Klemi P, Hirsimaki P, Vahlberg T, Kivisaari A, Kahari VM, et al. Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer. Acta oto-laryngologica 2008;128(4):482-90.
16
17. Manavathi B, Singh K, Kumar R. MTA family of coregulators in nuclear receptor biology and pathology. Nuclear receptor signaling 2007;5:e010.
17
18. Toh Y, Ohga T, Endo K, Adachi E, Kusumoto H, Haraguchi M, et al. Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. International journal of cancer Journal international du cancer 2004;110(3): 362-7.
18
19. Geng L, Deepak PA, Aija L, Fuming C, Amanda M, Robert CR, et al. Identification of Metastasis Associated Antigen 1 (MTA1) by Serological Screening of Prostate Cancer cDNA Libraries. The open biochemistry journal 2008;2:100-7.
19
20. Moon HE, Cheon H, Lee MS. Metastasis-associated protein 1 inhibits p53-induced apoptosis. Oncology reports. 2007;18(5):1311-4.
20
21. Yoo YG, Kong G, Lee MO. Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. The EMBO journal 2006;25(6):1231-41.
21
22. Moon HE, Cheon H, Chun KH, Lee SK, Kim YS, Jung BK, et al. Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha. Oncology reports 2006;16(4):929-35.
22
23. Achen MG, Stacker SA. Molecular control of lymphatic metastasis. Annals of the New York Academy of Sciences 2008;1131:225-34.
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24. Royston D, Jackson DG. Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. The Journal of pathology 2009; 217(5):608-19.
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25. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nature reviews Cancer 2002; 2(6):442-54.
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26. Kawasaki G, Yanamoto S, Yoshitomi I, Yamada S, Mizuno A. Overexpression of metastasis-associated MTA1 in oral squamous cell carcinomas: correlation with metastasis and invasion. International journal of oral and maxillofacial surgery 2008; 37(11):1039-46.
26
27. Xu L, Mao XY, Fan CF, Zheng HC. MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer. Virchows Archiv : an international journal of pathology 2011;459(4):415-22.
27
28. Li SH, Wang Z, Liu XY. Metastasis-associated protein 1 (MTA1) overexpression is closely associated with shorter disease-free interval after complete resection of histologically node-negative esophageal cancer. World journal of surgery 2009;33(9):1876-81.
28
29. Moon WS, Chang K, Tarnawski AS. Overexpression of metastatic tumor antigen 1 in hepatocellular carcinoma: Relationship to vascular invasion and estrogen receptor-alpha. Human pathology 2004;35(4):424-9.
29
30. Balasenthil S, Broaddus RR, Kumar R. Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas. Human pathology 2006;37(6): 656-61.
30
31. Manavathi B, Kumar R. Metastasis tumor antigens, an emerging family of multifaceted master coregulators. The Journal of biological chemistry 2007;282(3):1529-33.
31
32. Andishehtadbir A, Najvani AD, Pardis S, Ashkavandi ZJ, Ashraf MJ, Khademi B, et al. Metastasis-Associated Protein 1 Expression in Oral Squamous Cell Carcinomas: Correlation with Metastasis and Angiogenesis. Turk patoloji dergisi. 2014. Epub 2014/10/11. Metastaz Iliskili Protein 1 Ekspresyonunun Oral Skuamoz Hucreli Karsinomlarda Metastaz ve Anjiyogenez ile Iliskisi.
32
33. Kumar R, Wang RA, Mazumdar A, Talukder AH, Mandal M, Yang Z, et al. A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature. 2002;418(6898):654-7.
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34. Li W, Zhu H, Bao W, Fu H, Li Z, Liu X, et al. Involvement of metastasis tumor antigen 1 in hepatic regeneration and proliferation. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology 2008;22(1-4):315-26.
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35. Li W, Ma L, Zhao J, Liu X, Li Z, Zhang Y. Expression profile of MTA1 in adult mouse tissues. Tissue & cell 2009;41(6):390-9.
35
36. Li G, Miles A, Line A, Rees RC. Identification of tumour antigens by serological analysis of cDNA expression cloning. Cancer immunology, immunotherapy : CII 2004;53(3):139-43.
36
ORIGINAL_ARTICLE
Effects of Tonsil size on Pulmonary Function test Results after Tonsillectomy in Children
Introduction: Adenotonsillar hypertrophy is a typical cause of surgery in children. Evaluation and identification of patients as potential candidates tonsillectomy is a primary concern for otolaryngologists. This study focuses on the results of pulmonary function tests (PFTs) after tonsillectomy in children. Materials and Methods: This cross-sectional study examined 50 patients suffering from tonsillar hypertrophy in 2013. Full details and results of otolaryngology examinations were recorded. Moreover, patients were examined with respect to forced inspiratory flow at 50% of vital capacity (FIF50%), forced expiratory flow at 50% of vital capacity (FEF50%), forced expiratory volume in 1 second (FEV1)/peak expiratory flow rate (PEFR), and FEV1/forced expired volume in 0.5 seconds (FEV0.5) before and after surgery using spirometry. All data were analyzed using SPSS Software (version 19), and central descriptive measures, and data were compared by performing T-test and Chi-square tests. Results: According to tonsil size, patients were distributed as follows: 18 patients (36%) with +1 tonsil size, 18 patients (36%) with +2 tonsil size, and seven patients (14%) with +3 tonsil size, and seven patients (14%) with +4 tonsil size. Thirty-three (66%) and 17 patients (34%) were female and male, respectively, with a mean of age of 9.7 2.97 years (range, 7–18 years). Seventy-eight percent of patients were aged 10 years or less. Moreover, 25 patients (50%), 17 patients (34%), and eight patients (16%), respectively, reported obstructive symptoms, recurrent tonsillitis, and both symptoms. In patients with +3 and +4 tonsil size, spirometric parameters indicated relief of symptoms of obstruction. Only in patients with +4 tonsil size were the changes statistically significant. Conclusion: Tonsillectomy can relieve obstructive symptoms in patients with tonsils larger than +3 to a great extent. Additionally, spirometry can identify patients with +3 and +4 tonsils who do not have clinical signs of an obstructive upper airway.
https://ijorl.mums.ac.ir/article_6072_547d35cc7869e02470bc8728db122837.pdf
2016-01-01
61
66
10.22038/ijorl.2016.6072
Children
Spirometry
Tonsillectomy
Mitra
Samareh Fekri
m_ samareh @kmu.ac.ir
1
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
AUTHOR
Aliasghar
Arabi Mianroodi
mrarabi@yahoo.com
2
Department of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
LEAD_AUTHOR
Hosein
Shakeri
hosein_shakeri61@yahoo.com
3
Department of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
AUTHOR
Narges
Khanjani
nargeskhanjani@yahoo.com
4
Department of Epidemiology and Biostatistics, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
AUTHOR
1. Baugh RF, Archer SM, Mitchell RB, Rosenfeld RM, Amin R, Burns JJ, et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011; 144(1) Suppl S1–S30.
1
2. Lescanne E, Chiron B, Constant I, Couloigner V, Fauroux B, Hassani Y, et al. Pediatric tonsillectomy: clinical practice guidelines. Eur Ann Otorhinolaryngol Head Neck Dis 2012; 129(5):264–71.
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3. Bellussi LM, Marchisio P, Materia E, Passali FM. Clinical guideline on adenotonsillectomy: the Italian experience. Adv Otorhinolaryngol 72:142–5.
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4. American Academy of Otolaryngology-Head and Neck Surgery; Clinical Indicators: Adenoidetomy http:// www.entnet. org/ Practice/ upload/ Adenoidectomy- CI_Final- May- 2012. pdf (Accessed on August 14, 2013).
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6. Brouillete RT, Fernbach SK, Hunt CE. Obstructive sleep Apnea in infants and children. J Pediatr 1982; 100(1): 31-40.
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10. Farber J. Clinical practice guideline: diagnosis and management of childhood obstructive sleep apnea syndrome Pediatrics 2002; 109:704–12.
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13. Yadav SPS, Dodeja OP, Gupta KB, Chanda R. Pulmonary function tests in children with adenotonsillar hypertrophy. Int J Pediatr Otorhinolaryngol 2003; 67(2):121–5.
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14. Kornblot A. A Traditional approach to surgery of the tonsils and adenoids. Otolaryngol Clin North Am 1987; 20(2):349–63.
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15. Van Den Akker EH, Hoes AW, Burton MJ, Schilder AG. Large international differences in (adeno) tonsillectomy rates. Clin Otolaryngol Allied Sci 2004; 29:161–4.
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16. Blair RL, McKerrow WS, Carter NW, Fenton A. The Scottish tonsillectomy audit. Audit Sub-Committee of the Scottish Otolaryngological Society. J Laryngol Otol 1996; 110 Suppl 20:1–25.
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17. Boss EF, Marsteller JA, Simon AE. Outpatient tonsillectomy in children: demographic and geographic variation in the United States, 2006. J Pediatr 2012;160:814–9.
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18. Capper R, Canter RJ. Is there agreement among general practitioners, paediatricians and otolaryngologists about the management of children with recurrent tonsillitis? Clin Otolaryngol Allied Sci 2001; 26(5):371–8.
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19. Lock C, Wilson J, Steen N, Eccles M, Brittain K, Carrie S, et al. Childhood tonsillectomy: who is referred and what treatment choices are made? Baseline findings from the North of England and Scotland Study of Tonsillectomy and Adenotonsillectomy in Children (NESSTAC). Arch Dis Child 2010;95:203–8.
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20. Cullen KA, Hall MJ, Golosinskiy A. Ambulatory surgery in the United States, 2006. Natl Health Stat Report 2009;(11):1–25.
20
21. Baugh RF, Archer SM, Mitchell RB, Rosenfeld RM, Amin R, Burns JJ, et al. Am Acad Otolaryngol Head Neck Surg Found. Clinical Practice Guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011;144(1 Suppl):S1–30.
21
22. Ramos SD, Mukerji S, Pine HS. Tonsillectomy and adenoidectomy. Pediatr Clin North Am 2013; 60(4):793–807.
22
23. Clayburgh D, Milczuk H, Gorsek S, Sinden N, Bowman K, MacArthur C. Efficacy of tonsillectomy for pediatric patients with dysphagia and tonsillar hypertrophy. Arch Otolaryngol Head Neck Surg 2011;137(12):1197–202.
23
24. Belyea J, Chang Y, Rigby MH, Corsten G, Hong P. Post-tonsillectomy complications in children less than three years of age: A case-control study. Int J Pediatr Otorhinolaryngol 2014;78(5):871–4.
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25. Ruppel GL, Enright PL. Pulmonary function testing. Respir Care 2012;57(1):165–75.
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26. Roland PS, Rosenfeld RM, Mitchell RB, Friedman NR, Jones J, Kim TW, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Practice Guideline: Polysomnography Before Tonsillectomy in Children. Otolaryngol Head Neck Surg 2011;145(2 Suppl): S1–15.
26
27. J.Epstein L, Kristo D, J.Strollo P, Friedman N, Malhotra A, Patil SP, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 2009; (5)3:263–76.
27
ORIGINAL_ARTICLE
An Unusual Case of Cauda Equina Secondary to Spinal Metastasis of Thyroid Cancer
Introduction:
Cauda equina secondary to metastatic follicular thyroid cancer of the lumbosacral area is a rare entity.
Case Report:
We report an unusual case of a 52-year-old male who presented with backache, lower limb weakness, and perianal numbness. A CT-scan of the lumbosacral area showed an enhancing mass at the L4, L5 and S1 vertebrae. Histopathology after excision revealed a metastatic thyroid cancer. Hence, a CT scan of the neck and chest was performed which showed a nodule in the left lobe of the thyroid and a mass in the left chest wall. A total thyroidectomy and excision of the chest wall lesion was undergone, which was diagnosed as a follicular carcinoma of the thyroid.
Conclusion:
Metastatic workup of spinal metastasis should include evaluation of the thyroid gland.
https://ijorl.mums.ac.ir/article_6032_b4336778ced1ad0b85dc2b04ce34aedf.pdf
2016-01-01
67
71
10.22038/ijorl.2016.6032
Differentiated thyroid cancer
Follicular thyroid cancer
Metastasis
spine
Vertebrae
Shabbir
Akhtar
shabbir.akhtar@aku.edu
1
Department of Otorhinolaryngology, Head and Neck Surgery, Aga Khan University Hospital, Karachi, Pakistan.
AUTHOR
Mohammad
Adeel
doc.adeel.khan@gmail.com
2
Department of Otorhinolaryngology, Head and Neck Surgery, Aga Khan University Hospital, Karachi, Pakistan.
LEAD_AUTHOR
1. Sherma SI. Thyroid carcinoma. The Lancet 2003; 361(9356):501-11.
1
2. Muresan M, Olivier P, Leclère J, Sirveaux F, Brunaud L, Klein M, Zarnegar R, Weryha G. Bone metastases from differentiated thyroid carcinoma. Endocrine-related cancer2008;15(1):37-49.
2
3. Wilson P, Millar B, Brierley J. The management of advanced thyroid cancer. Clinical Oncology 2004; 16(8):561-8.
3
4. Sciubba DM, Petteys RJ, Kang S, Than KD, Gokaslan ZL, Gallia GL, Wolinsky J-P. Solitary spinal metastasis of Hürthle cell thyroid carcinoma. Journal of Clinical Neuroscience 2010;17(6):797-801.
4
5. Rodrigues G, Ghosh A. Synchronous bony and soft tissue metastases from follicular carcinoma of the thyroid. Journal of Korean Medical Science 2003; 18(6):914-6.
5
6. R Shaha A, P Shah J, R Loree T. Differentiated thyroid cancer presenting initially with distant metastasis. The American journal of surgery 1997; 174(5):474-6.
6
7. Girelli M, Casara D, Rubello D, Piccolo M, Piotto A, Pelizzo M, Busnardo B. Metastatic thyroid carcinoma of the adrenal gland. Journal of endocrinological investigation1993;16(2):139-141.
7
8. Hindié E, Zanotti-Fregonara P, Keller I, Duron F, Devaux J-Y, Calzada-Nocaudie M, et al. Bone metastases of differentiated thyroid cancer: impact of early 131I-based detection on outcome. Endocrine-related cancer 2007;14(3):799-807.
8
9. Wexler JA. Approach to the thyroid cancer patient with bone metastases. Journal of Clinical Endocrinology and Metabolism 2011;96(8):2296-307.
9
10. Durante C, Haddy N, Baudin E, Leboulleux S, Hartl D, Travagli J, et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. Journal of Clinical Endocrinology & Metabolism 2006;91(8):2892-9.
10
11. Eustatia-Rutten C, Romijn J, Guijt M, Vielvoye G, Van den Berg R, Corssmit E, et al. Outcome of palliative embolization of bone metastases in differentiated thyroid carcinoma. Journal of Clinical Endocrinology & Metabolism 2003; 88(7): 3184-9.
11
12. Kiml Y-S. Metastatic follicular thyroid carcinoma to the thymus in a 35-year-old woman. Yonsei medical journal 2002;43(5):665-9.
12
13. McCormack KR. Bone metastases from thyroid carcinoma. Cancer 1966;19(2):181-4.
13
14. Demura S, Kawahara N, Murakami H, Abdel-Wanis ME, Kato S, Yoshioka K, et al. Total en bloc
14
spondylectomy for spinal metastases in thyroid carcinoma: Clinical article. Journal of Neurosurgery: Spine 2011; 14(2):172-6.
15
15. Bernier M-O, Leenhardt L, Hoang C, Aurengo A, Mary J-Y, Menegaux F, et al. Survival and therapeutic modalities in patients with bone metastases of differentiated thyroid carcinomas. Journal of Clinical Endocrinology & Metabolism 2001; 86(4):1568-73.
16
ORIGINAL_ARTICLE
Pleomorphic Adenoma of the Larynx: A Case Report
Introduction:
Pleomorphic adenomas are tumors mostly originating from salivary glands. These lesions in the larynx are very rare.
Case Report:
We report a rare case of pleomorphic adenoma that originated from the mucosal lining, just above the glottic area at the level of the laryngeal ventricle in a 55-year-old female patient. The tumor could not be palpated easily but was observed in the CT scan. We resected the large and firm tumor using trans hyoid pharyngotomy as the surgical approach.
Conclusion:
Pleomorphic adenoma in the ventricle of the larynx is an extremely rare lesion. Trans-hyoid pharyngotomy can have good results as the surgical approach in removing such lesions.
https://ijorl.mums.ac.ir/article_6063_7d5d30f69018c5b950d2fc33c83c1052.pdf
2016-01-01
73
77
10.22038/ijorl.2016.6063
Pleomorphic adenoma
Trans hyoid pharyngotomy
Ventricle of the larynx
Seyyed Jafar
Motahari
sjmotaharimd@yahoo.com
1
Department of Otorhinolaryngology, Mazandaran University of Medical Sciences, Sari, Iran.
AUTHOR
Fereshteh
Khavarinejad
fereshteh_khd@yahoo.com
2
Department of Research, Ghaemshahr Health Center, Mazandaran University Of Medical Sciences, Ghaemshahr , Iran.
AUTHOR
Shahram
Salimi
parslab.dr.salimi@gmail.com
3
Department of Pathology, Mazandaran University of Medical Sciences, Ghaemshahr, Iran.
AUTHOR
Milad
Bahari
miladbahari@ymail.com
4
Medical Student Research Center, Faculty of Medicine, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
LEAD_AUTHOR
1. Bill E, Becelli R, Iannetti G. A primary pleomorphic adenoma of the parapharyngeal space. Minerrachir 1998;53(6):543-7.
1
2. Berenholz L, Kessler A, Segal S. Massive pleomorphic adenoma of the maxillary sinus: A case report. In J OralMaxillofac Surg 1998;27(5): 372-3.
2
3. Hirabayashi S, Yanai A, Muraishi Y. Huge pleomorphic ademoma of the upper retromolar area. Ann Plast Surg 1997; 38(2):184-6.
3
4. Chen YK, Lin LM, Lin CC, Yan YH. Palatal pleomorphic adenoma in a child with osteoid formation: report of case. ASDC J Dent Child 1998; 65(3): 209-11.
4
5. Mercado GJ, Gunduz K, Shields CL. Pleomorphic adenoma of the lacrimal gland in a teenager. Arch Ophthalmol 1998; 116(7): 962-3.
5
6. Mochinaga N, Yatsugi T, Tomokawa S. Pleomorphic adenoma of the breast: report of a case. Surg Today 1997; 27(3):278-81.
6
7. Dubey SP, Banerjee S, Ghosh LM, Roy S. Benign pleomorphic adenoma of the larynx: report of a case and review and analysis of 20 additional cases in the literature. Ear Nose Throat J 1997;76(8):548-50,552, 554- 7.
7
8. Sawatsubashi M, Tada K, Tokunaga O. Pleomorphic adenoma of the larynx: a case and review of the literature in Japan. Otolaryngol Head Neck Surg 1997;117(4):415-7.
8
9. Rooper L, Sharma R, Bishop JA. Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40− Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. Head and Neck Pathology. June 2014.
9
10. Bazal JC, Righi PD, Kesler KA. Pleomorphic Adenoma of the trachea.Otolaryngol Head Neck Surg 1997;116(1):139-40.
10
11. Takeda Y, Sasou S, Obata K. Pleomorphic adenoma of the minor salivary gland with pseudoepitheliomatous. Hyperplagia of the overlying oral mucosa: report of two cases. Pathol Int 1998; 48(5): 389-95.
11
12. Haisch A, Knobber D, Lobeck H. Myoepithelial carcinoma (malignant myoepithelioma) of the salivary glands. A case report.HNO 1998;46 (1):66-9.
12
13. Ito A, Sone M, Kitamura Y, Fakuta S, Nakashima T, Yanagita N. A case of pleomorphic adenoma of the epiglottis.Bilateral vocal cord paralysis after YAG laser surgery.AnurisNasusLarymx 1997;24(3):303-7.
13
14. Hoorweg JJ, Hilgers FJ, Keus RB, Zoetmulder FA, Loftus BM. Metastasizing pleomorphic adenoma: a report of three casws. Eur J SurgOncol 1998;24(5): 452-5.
14
ORIGINAL_ARTICLE
Inflammatory Myofibroblastic Tumor of the Larynx: A Case Report
Introduction: Inflammatory myofibroblastic pseudotumors are initially described in the lung and various extrapulmonary sites such as the orbits, palatine tonsils, ears, gingiva, pterygomaxillary space, and periodontal tissues. These tumors rarely involve the larynx and predilection to the glottis occurs in an indolent manner. Case Report This case describes a laryngeal myofibroblastic tumor in a 46-year-old woman who presented with an aggressive tumor that extended to the floor of the mouth and the base of the tongue. Extended supraglottic laryngectomy was undertaken for the patient. The diagnosis was spindle cell proliferation with dense lymphoplasma cell infiltration compatible with inflammatory myofibroblastic tumor (Inflammatory pseudotumor or plasma cell granuloma). Definitive diagnosis was achieved with immunohistochemical (IHC) staining. Conclusion: We believe that further IHC studies are required to define the true nature of these tumors especially for those that behave in an aggressive pattern.
https://ijorl.mums.ac.ir/article_6031_e9912cc47530643cecb522c9fbb51478.pdf
2016-01-01
79
82
10.22038/ijorl.2016.6031
Head and neck tumor
Immunohistochemstry (IHC)
Inflammatory myofibroblastic tumor
Larynx
laryngeal pseudotumor
Laryngeal mass
Farzad
Izadi
izadimd@yahoo.com
1
Department of Otorhinolaryngology, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
AUTHOR
Hadi
Ghanbari
ghanbari_md@iums.ac.ir
2
ENT & HNS Research Center, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
Mohammad
Azizi
mohammad_azizi@yahoo.com
3
Pathologist, Shahriyar Hospital, Tehran, Iran.
AUTHOR
Shahram
Gasembaglou
shahram_gasembaglou@yahoo.com
4
Department of Otorhinolaryngology, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
AUTHOR
Mohammad Javad
Manteghi
mohammad_manteghi@yahoo.com
5
General practitioner, Iran University of Medical Sciences, Tehran, Iran.
AUTHOR
Azadeh
Ghanbari
dds_pink@yahoo.com
6
College of Dentistry, Ajman University of Science and Technology, Ajman, UAE.
AUTHOR
1. Sarker A, An C, Davis M, Praprotnik D, McCarthy LJ, Orazi A. Inflammatory pseudotumor
1
of the spleen in a 6-year-old child. Arch Pathol Lab Med 2003;127(3): e127-30.
2
2. Cessna MH, Zhou H, Sanger WG, Perkins SL, Tripp S, Pickering D, et al. Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol, 2002;15(9): 931-8.
3
3. Pettinato G, Manivel JC, De Rosa N, Dehner LP. Inflammatory myofibroblastic tumor (plasma cell granuloma): clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol 1990;94(5):538-46.
4
4. Freeman A, Geddes N, Munson P, Joseph J, Ramani P, Sandison A, et al. Anaplastic lymphoma kinase (ALK1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathologic study of nine cases and review of the literature. Mod Pathol 2004;17: 765-71.
5
5. Tang TT, Segura AD, Oechler HW, Harb JM, Adair SE, Gregg DC, et al. Inflammatory myofibrohistiocytic proliferation simulating sarcoma in children Cancer, 1990; 65(7):1626-34.
6
6. Sitton JE, Harkin JC, Greber MA. Intracranial inflammatory pseudotumor. Clin Neuropathol 1992;11(1): 36-40.
7
7. Kumar S, Gupta AK, Kakkar N. Inflammatory myofibroblastic tumor larynx mimicking laryngeal papillomatosis, International Journal of Pediatric Otorhinolaryngology Extra 2009; 4(1): 42-4.
8
8. Suh Si, Seol HY, Lee JH, Lee YH, Kim TK, Lee NJ, et al. Inflammatory myofibroplastic tumor of the larynx. Head Neck 2006; 28(4):369-72.
9
9.VellinJF, Canata CM, Kemeny JL, Llompar X, Russier M, Mom T, et al. Inflammatory myofibroblastic tumor of the larynx. Fr ORL 2005; 87 : 75 – 7.
10
ORIGINAL_ARTICLE
Chronic Invasive Fungal Granuloma–A Diagnostic Dilemma in an Immunocompetent Host
Introduction: Invasive fungal sinusitis, though considered to be rare entity, is nowadays frequently encountered, not only in immunocompromised patients but also in immunocompetent patients. The changing prevalence towards immunocompetent hosts is due to the indiscriminate usage of broad spectrum antibiotics, steroids, and immunosuppressive drugs. Diagnosing invasive fungal sinusitis should not pose any difficulty to both the clinician [a whitish colour secretion in elderly Diabetics, and CT Scan PNS showing concretion in the sinus along with destruction of the surrounding bone] and to the pathologist; however, when the invasive fungal sinus infection presents in a form of a granuloma then its diagnosis imposes a challenge to medical professionals. Case Report We are presenting a case study,which consists of 3 cases of chronic invasive fungal sinus infection.Two patients were treated for tuberculoma and had completed a course of Anti Koch’s Treatment and one patient was given a trial of broad spectrum antibiotics and steroids.Eventually all cases were diagnosed as a chronic invasive form of fungal granuloma (CIFG). Conclusion: CIFG of the paranasal sinuses is seen in immunocompetent hosts, especially those that are in the 2nd and 3rd decades of their lives. Gradually progressive proptosis is the primary presenting symptom. MRI scanning is a better imaging modality compared to CT scanning. Routine H&E staining may prove inadequate and special stains such as the GMS stain should be employed in the slightest doubt of a fungal aetiology. A team approach towards patients is paramount for early diagnosis and timely medical and surgical intervention.
https://ijorl.mums.ac.ir/article_6029_ceb6a9e7802cbee5349375bb876a69e4.pdf
2016-01-01
83
88
10.22038/ijorl.2016.6029
Chronic invasive granulomatous fungal sinusitis
Immunocompetent Host
Tuberculoma and Chronic Granulomatous disease
Shrinivas
Chavan
shrinivasc77@hotmail.com
1
Department of Otorhinolaryngology, Government Medical College and Hospital, Jubilee Park, Aurangabad, Maharashtra State, India.
LEAD_AUTHOR
K
Bhople
deangmca@gmail.com
2
Department of Pathology, Government Medical College, Aurangabad. Maharashtra State, India.
AUTHOR
Sunil
Deshmukh
dr_sunildeshmukh@rediffmail.com
3
Department of Otorhinolaryngology Government Medical College, Aurangabad, Maharashtra State, India.
AUTHOR
Prateek
Jain
prateekjain70@gmail.com
4
Department of otorhinolaryngology Government Medical College, Aurangabad, Maharashtra State, India.
AUTHOR
Mangala
Sonavani
karmangalam@gmail.com
5
Department of Medicine Government Medical College, Aurangabad. Maharashtra State, India.
AUTHOR