TY - JOUR ID - 1232 TI - Giant Keratocystic Odontogenic Tumor: Three Cases and a Literature Review JO - Iranian Journal of Otorhinolaryngology JA - IJORL LA - en SN - 2251-7251 AU - Caixeta Guimarães, Alexandre AU - Dutra de Cassia Ferreira Santos, Mariana AU - de Carvalho, Guilherme Machado AU - Takahiro Chone, Carlos AU - Nizam Pfeilsticker, Leopoldo AD - Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil. Y1 - 2013 PY - 2013 VL - 25 IS - 4 SP - 245 EP - 251 KW - Keratocystic tumor KW - Jaw KW - Mandible KW - odontogenic tumor DO - 10.22038/ijorl.2013.1232 N2 - Introduction: A keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. It represents 2–11% of jaw cysts, and has a slow but aggressive growth. The evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesions.   Materials and Methods: This is a clinical retrospective study with a full analysis of patient history regarding physical evaluation, radiologic images, pathology results, and surgical resection. We performed a major literature review concerning current concepts relating to its biological characterization.   Results: Three cases of keratocystic odontogenic tumor were identified. Two of the cases were large, with aggressive behavior and significant bone destruction and recurrence, which had been overlooked for more than a decade. The third case had an early diagnosis, and the treatment led to full recovery and complete healing. Conclusion:  The keratocystic odontogenic tumor is a benign lesion with slow growth, which lends itself to a more conservative treatment, even in cases of large lesions. A better understanding of these tumors, both at the biological and molecular level, could lead to guidelines for treatment and prognosis of such patients. UR - https://ijorl.mums.ac.ir/article_1232.html L1 - https://ijorl.mums.ac.ir/article_1232_4928c457c46e4ac7831ccbbc0ac12599.pdf ER -