TY - JOUR ID - 19435 TI - Overexpression of Lysosome-Associated Membrane Protein 1 in Oral Squamous Cell Carcinoma and its Correlation with Tumor Differentiation and Metastasis JO - Iranian Journal of Otorhinolaryngology JA - IJORL LA - en SN - 2251-7251 AU - Ranjbar, Mohammad Ali AU - Jamshidi, Maryam AD - Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Y1 - 2022 PY - 2022 VL - 34 IS - 1 SP - 3 EP - 8 KW - immunohistochemistry KW - LAMP1 KW - Oral squamous cell carcinoma DO - 10.22038/ijorl.2021.51683.2772 N2 - Introduction:The overexpression of lysosome-associated membrane protein 1 (LAMP1) has been demonstrated in different types of cancers, such as ovarian carcinoma, esophageal squamous cell carcinoma, breast cancer, and colorectal carcinoma. Nonetheless, the expression of LAMP1 in oral squamous cell carcinoma (OSCC) has not been investigated yet. Materials and Methods:This cross-sectional study was conducted on 65 patients with OSCC selected from the Department of Pathology of Shiraz University of Medical Sciences. The control group comprised 55 tissues of normal oral epithelium. The expression of LAMP1 in OSCC tissue samples was assessed using immunohistochemistry (IHC) analysis. The association between LAMP1 and clinicopathological features of patients with OSCC was also evaluated. Results:The expression of LAMP1 was significantly higher in OSCC tissues, as compared to that in normal tissues (P<0.001). The chi-square analysis indicated that the high LAMP1 expression was correlated with the degree of tumor differentiation and metastasis (P=0.014).Conclusions:The obtained results pointed to the overexpression of LAMP1 in OSCC, as well as its correlation with tumor grade and metastasis; therefore, LAMP1 might have a role to play in OSCC pathogenesis and could be regarded as an independent prognostic marker in oral squamous cell carcinoma. UR - https://ijorl.mums.ac.ir/article_19435.html L1 - https://ijorl.mums.ac.ir/article_19435_1dfbba5250a5928ee272a201198f924f.pdf ER -