TY - JOUR ID - 19436 TI - Intratympanic Steroid for the Management of Sudden Hearing Loss: Introduction of a Tapering Method JO - Iranian Journal of Otorhinolaryngology JA - IJORL LA - en SN - 2251-7251 AU - Rajati, Mohsen AU - Ghasemi, Mohammad Mehdi AU - Sharifian, Mohammad Reza AU - Nourizadeh, Navid AU - Yousefi, Razieh AU - Hosseinpoor, Masoomeh AD - Sinus and Surgical Endoscopic Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Biostatistics, Health School, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2022 PY - 2022 VL - 34 IS - 1 SP - 9 EP - 16 KW - Intratympanic KW - steroid KW - Sudden sensorineural hearing loss DO - 10.22038/ijorl.2021.57477.2977 N2 - Introduction:Sudden sensorineural hearing loss (SSNHL) is a therapeutic challenge. There are several controversies regarding the management protocol of SSNHL. This study aimed to present the results of a novel treatment algorithm, which is a combination of systemic steroids and a tapering intratympanic (IT) dexamethasone regimen.Materials and Methods:The past 10 years’ medical records of idiopathic SSNHL cases in Ghaem and Emamreza hospital, Mashhad University of Medical Sciences were evaluated. Patients were assessed using standardized methods for pure-tone threshold audiometry. The management method of SSNHL treatment included oral steroids combined with IT administration of dexamethasone once a day for 7 days and continuing it on an alternate day and then weekly basis. Patients’ recovery was assessed using Siegel’s criteria.Results:This study included a total of 248 cases of idiopathic sudden hearing loss, with a mean age of 40.63±16.19 years. In total, 105 (42.3%) and 143 (57.7%) patients were female and male, respectively. The most common associated symptoms included tinnitus (86.9%, n=205) followed by vertigo (52.1%, n=122). The final hearing outcome of patients showed that 39 (15.7%), 38(15.3%), 86 (34.7%), and 85 (34.3%) patients underwent a complete recovery, partial recovery, slight recovery, and no recovery, based on Siegel’s criteria.Conclusions:The dose, interval, and duration of IT steroid treatment were not universally approved. The treatment method designed based on a tapering of IT steroid injection in combination with already known systemic administration of steroids can be a treatment option in SSNHL patients.  UR - https://ijorl.mums.ac.ir/article_19436.html L1 - https://ijorl.mums.ac.ir/article_19436_50801a7c0a92f73ae73065f3cdd2a06c.pdf ER -