TY - JOUR ID - 4247 TI - The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery JO - Iranian Journal of Otorhinolaryngology JA - IJORL LA - en SN - 2251-7251 AU - Rajabi Mashhadi, Mohammadtaghi AU - Bagheri, Reza AU - Abdollahi, Abbas AU - Ghamari, Mohammad Javad AU - shahidsales, soudabeh AU - Salehi, Maryam AU - Shahkaram, Reza AU - Majidi, Mohamad Reza AU - Sheibani, Shima AD - Endoscopic & Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Cardio-Thoracic Surgery & Transplant Research Center, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Radiotherapy & oncology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2015 PY - 2015 VL - 27 IS - 4 SP - 279 EP - 284 KW - Esophageal Cancer KW - Neoadjuvant Therapy KW - Surgery DO - 10.22038/ijorl.2015.4247 N2 - Introduction: Early diagnosis and appropriate treatment is required in esophageal cancer due to its invasive nature. The aim of this study was to evaluate early post-esophagectomy complications in patients with esophageal cancer who received neoadjuvant chemoradiotherapy (NACR).   Materials and Methods: This randomized clinical trial was carried out between 2009 and 2011. Patients with lower-third esophageal cancer were randomly assigned to one of two groups. The first group consisted of 50 patients receiving standard chemoradiotherapy (Group A) and then undergoing surgery, and the second group consisted of 50 patients undergoing surgery only (Group B). Patients were evaluated with respect to age, gender, clinical symptoms, type of pathology, time of surgery, perioperative blood loss, and number of lymph nodes resected as well as early post-operative complicate including leakage at the anastomosis site, chylothorax and pulmonary complications, hospitalization period, and mortality rate within the first 30 days after surgery.   Results: The mean age of patients was 55 years. Seventy-two patients had squamous cell carcinoma (SCC) and 28 patients had adenocarcinoma (ACC). There was no significant difference between the two groups with respect to age, gender, time of surgery, complications including anastomotic leakage, chylothorax, pulmonary complications, cardiac complications, deep venous thrombosis (DVT), or mortality. However, there was a significant difference between the two groups regarding hospital stay, time of surgery, perioperative blood loss, and number of lymph nodes resected.   Conclusion:  The use of NACR did not increase early post-operative complications or mortality among patients with esophageal cancer.  UR - https://ijorl.mums.ac.ir/article_4247.html L1 - https://ijorl.mums.ac.ir/article_4247_6b450631560dbcdf675037956258783c.pdf ER -