Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Effects of Vestibular Rehabilitation Interventions in the Elderly with Chronic Unilateral Vestibular Hypofunction183188891210.22038/ijorl.2017.18825.1629ENArash BayatMusculoskletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.0000-0002-9393-2426Nader SakiHearing Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.0000-0003-4564-6406Journal Article20160928Introduction:<br /> Although vestibular rehabilitation therapy (VRT) methods are relatively popular in treating patients with body balance deficits of vestibular origin, only limited studies have been conducted into customized exercises for unilateral vestibular hypofunction (UVH). Furthermore, very little evidence is available on the outcomes of VRT in the elderly population with chronic UVH.<br /> Materials and Methods:<br /> A total of 21 patients, aged 61 to 74 years, with UVH participated in this study. The dizziness handicap inventory (DHI) was performed immediately before, and 2 and 8 weeks after treatment.<br /> Results:<br /> All patients showed a reduction in DHI scores during the study. The average decrease in DHI score was 25.98 points after 2 weeks’ intervention (P<0.001) and 32.54 points at the end of the study. This improvement was observed in all DHI subscores, and was most profound in the functional aspect. The correlation between the degree of final recovery and canal paresis was not significant (P>0.05). There were no relationships between the scores and gender.<br /> Conclusion:<br /> Our study demonstrates that VRT is an effective method for the management of elderly patients with UVH, and shows maximal effect on functional aspects.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Maternal Risk Factors Associated with the Development of Cleft Lip and Cleft Palate in Mexico: A Case-Control Study189195892510.22038/ijorl.2017.19302.1650ENEmmanuel Angulo-CastroDepartment of Perinatology, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, Mexico.Luis F Acosta-AlfaroDepartment of Perinatology, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, Mexico.Alma MGuadron-LlanosCIASaP, School of Medicine, Autonomous University of Sinaloa, 80246, Culiacan, Sinaloa, MexicoAdrian Canizalez-RomanResearch Department, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, MexicoFernando Gonzalez-IbarraDepartment of Internal Medicine, Gulf Coast Medical Center, Panama City, 32405, Florida, USA.Ignacio Osuna-RamirezFaculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, 80000 Culiacán, SIN, Mexico.Joel Murillo-LLanesResearch Department, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, MexicoJournal Article20161003Introduction:<br /> Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate.<br /> Materials and Methods:<br /> We conducted a case control study at the Women’s Hospital in Culiacan, Mexico. Medical records were analyzed, including patients who delivered babies with and without cleft lip and cleft palate from January 2010 to December 2015. Multiple variables were analyzed, including gestational age, weight at birth, the use of folic acid and multivitamins during pregnancy, smoking, alcohol abuse, the use of recreational drugs, history of sexually transmitted infections, marital status, socioeconomic status, education, and nutritional status.<br /> Results:<br /> We found that the maternal risk factors with the strongest association for the development of cleft lip and cleft palate were the following: patients who were not taking folic acid during pregnancy [OR 3.27, 95% CI 1.32-8.09], P=0.00; patients who were not taking vitamin supplementation during pregnancy [OR 2.6, 95% CI 1.19-7.27], P=0.02; smoking during pregnancy [OR 2.05, 95% CI 1.23-3.41], P=0.01; and alcohol abuse during pregnancy [OR 1.90, 95% CI 1.17-3.08], P=0.03.<br /> Conclusions:<br /> The main risk factors associated with the development of cleft lip and cleft palate in a Mexican population at the Women’s hospital in Culiacan, Sinaloa, Mexico were smoking, alcohol abuse, and patients not taking folic acid and multivitamins during pregnancy.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701The Antioxidant Effect of Curcumin on Cochlear Fibroblasts in Rat Models of Diabetes Mellitus197202892610.22038/ijorl.2017.19603.1660ENTengku- Siti- Hajar HaryunaDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia0000-0003-2779-3285Delfitri MunirDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia0000-0002-8526-6398Ana MariaDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, IndonesiaJenny BashiruddinDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaJournal Article20161023Introduction:<br /> The aim of this study was to investigate the potential of curcumin as an antioxidant to increase the expression of superoxide dismutase (SOD) in fibroblasts of the cochlear lateral wall in rat models of diabetes mellitus.<br /> Materials and Methods:<br /> Twenty-four male Wistar rats Rattus norvegicus were randomly divided into six groups: group 1 as the control group; group 2 as the diabetic group; group 3 and 4 as the diabetic groups that received curcumin therapy of 200 and 400 mg/kg b.w. for 3 days, respectively; and group 5 and 6 as the diabetic groups that received curcumin therapy of 200 and 400 mg/kg b.w. for 8 days, respectively. All rats underwent termination and necropsy procedure on their temporal bones for immunohistochemical assay to determine the expression of SOD.<br /> Results:<br /> The decreased expression of SOD was detected in the diabetic group (without curcumin treatment). The treatment of curcumin at doses of 200 and 400 mg/kg b.w. for 3 and 8 days led to significant differences (P<0.05) in the expression of the SOD compared to diabetic group (without curcumin treatment). No significant differences were found in terms of dose and duration of curcumin administration on the expression of SOD.<br /> Conclusion:<br /> Curcumin may act as an antioxidant against oxidative stress due to diabetes mellitus via increased expression of SOD on cochlear fibroblasts in rat models of diabetes mellitus.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Serum Levels of Cyfra 21 in Patients with Benign and Malignant Salivary Gland Tumors203208894610.22038/ijorl.2017.21085.1699ENNaghmeh JeiroodiDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Seyed Mohammad- Javad AslaniStudent Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Bijan KhademiOtolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.0000-0002-8303-6126Mahyar MalekzadehInstitute of Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Zohreh Jaafari- AshkavandiDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.0000-0003-4440-7083Journal Article20170101Introduction:<br /> Cyfra 21 is a serum-soluble fragment of cytokeratin19. Increased Cyfra 21 serum levels and their benefit as a tumor marker have been shown in some malignancies. This study aimed to evaluate the serum levels of Cyfra 21 in patients with benign and malignant salivary gland tumors.<br /> Materials and Methods:<br /> In this cross-sectional study, the serum level of Cyfra 21 in 44 patients with malignant salivary gland tumors and 16 cases of pleomorphic adenoma were compared with 28 healthy controls using enzyme-linked immunosorbent assay (ELISA). Data were analyzed statistically using the Kruskal Wallis test, analysis of variance (ANOVA) and Spearman’s correlation tests.<br /> Results:<br /> Mean serum levels of Cyfra 21 were 0.135 ± 0.285 ng/ ml in the control group, 0.167 ± 0.142 ng/ ml in patients with pleomorphic adenoma and 1.059 ± 3.251 ng/ml in patients with malignant salivary gland tumors. There was no significant difference among groups. Cyfra 21 levels did not correlate with location of tumor, clinical stage or cigarette smoking.<br /> Conclusion:<br /> Results of the present study showed no significant difference in Cyfra 21 serum level in salivary gland tumors compared with normal individuals. In addition, Cyfra 21 serum level was not sufficiently sensitive to function as a tumor marker in salivary gland tumors.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Is the Persian Version of the “Olfactory Disorder Questionnaire” Reliable and Valid?209213894210.22038/ijorl.2017.22436.1739ENMaryam JalessiSkull Base Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS ), Tehran, Iran.0000-0001-6081-0353Seyed Kamran KamravaENT and Head & Neck Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS ), Tehran, Iran.https://orcid.org/00Elahe AminiENT and Head & Neck Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS ), Tehran, Iran.Farhad RafieiENT and Head & Neck Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS ), Tehran, Iran.Mohammad Amin NasoutiSkull Base Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS ), Tehran, Iran.Naeimeh MoosaviSkull Base Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS ), Tehran, Iran.Mohammad FarhadiENT and Head & Neck Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS ), Tehran, Iran.Journal Article20170308Introduction:<br /> The Questionnaire for Olfactory Dysfunction (QOD) is a self-reporting olfactory-related quality of life questionnaire. The aim of this study was to determine the reliability and validity of the Persian version of this questionnaire.<br /> Materials and Methods:<br /> One hundred and thirteen patients with olfactory problems were enrolled in this study. The English version of the QOD was first translated into Persian. The reliability was then tested by determining the Cronbach alpha coefficient to assess internal consistency. The QOD was reviewed by a panel of experts, followed by calculating the content validity index to determine the content validity.<br /> Results:<br /> Based on the reliability analysis, the total Cronbach alpha was 0.88. The items in the “life quality” and “parosmia” domains had a good internal consistency in total, as well as in both genders and in different age subgroups. For the “sincerity” domain, however, low internal consistency was revealed (Cronbach alpha = 0.25). When questions related to the sincerity domain were omitted, the Cronbach alpha reached 0.89. The overall scale validity index for clarity and relevance were 0.88 and 0.87, respectively.<br /> Conclusion:<br /> The Persian version of the QOD seems to be a reliable and valid tool for the assessment of quality of life in patients with olfactory dysfunction. The “sincerity” domain cannot be used separately or should be substantially modified in order to be applicable to the Iranian population. However, there is no need to change the whole format of the questionnaire.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Fishbones in the Upper Aerodigestive Tract: A Review of 24 Cases of Adult Patients215219905610.22038/ijorl.2017.21440.1718ENStanislas Ballivet- De -RegloixDepartment of ENT – Head and Neck Surgery, Military Training Hospital Percy,101, Avenue Henri Barbusse
92140, Clamart, France.Anna CrambertDepartment of ENT – Head and Neck Surgery, Military Training Hospital Percy,101, Avenue Henri Barbusse
92140, Clamart, France.Olga MaurinEmergency Department, Fire Fighting Brigade of Paris, Place Jules Renard 75017, Paris, France.Gratien BonfortDepartment of ENT – Head and Neck Surgery, Military Training Hospital Percy,101, Avenue Henri Barbusse
92140, Clamart, France.Salome MartyDepartment of ENT – Head and Neck Surgery, Military Training Hospital Percy,101, Avenue Henri Barbusse
92140, Clamart, France.Yoann PonsDepartment of ENT – Head and Neck Surgery, Military Training Hospital Percy,101, Avenue Henri Barbusse
92140, Clamart, France.Journal Article20170118Introduction:
We present a retrospective study series and discussion of the current literature to discuss the management of fishbones in the upper aerodigestive tract.
Materials and Methods:
From January 2013 to July 2016, all patients referred to our referral center because of a fishbone in the upper aerodigestive tract were analysed.
Results:
Of the 24 patients, 95% of them reported discomfort in the throat. It was noted that 58% of physical examinations and nasofibroscopy results were normal. Ten fishbones were found in the upper aerodigestive tract. They were removed by foreign body forceps or by endoscopy depending on the location. Foreign body-related complications were not observed. Ten patients with no identifiable fishbone had no symptoms after 48 hours. Other patients, including the 10 patients with the fishbone removed, were asymptomatic after 10 days.
Conclusion:
From our experience, we recommend a systematic nasofibroscopy. If it is normal, the patient is assessed at 48h. The complementary investigation by CT scan and/or oesophagoscopy must be reserved in cases of suspicion of oesophageal localization or complication. Otherwise, rigid or flexible endoscopy may be performed when laryngoscopy is unsuccessful or for the treatment of foreign bodies lodged below this area.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701An Unusual Cause of Postaural Swelling: Kimura’s Disease221224893010.22038/ijorl.2017.8930ENPurodha PrasadDepartment of Otorhinolaryngology, Maulana Azad Medical College, New Delhi, India.Swati TandonDepartment of Otorhinolaryngology, Maulana Azad Medical College, New Delhi, India.Vasun BatraDepartment of Otorhinolaryngology, Maulana Azad Medical College, New Delhi, India.Ishwar SinghDepartment of Otorhinolaryngology, Maulana Azad Medical College, New Delhi, India.Journal Article20160503Introduction:<br /> Kimura’s disease (KD) is an allergic inflammatory disorder of unknown etiology endemic in Orientals. Kimura’s disease was first mentioned by Kimm and Szeto in China in 1937. Kimura’s disease is commonly encountered in Asia and is mostly reported in Japan, China, Singapore and Honkong. However, only a few cases have been reported in the Indian subcontinent.<br /> Case Report:<br /> A case of Kimura’s disease in a young male managed by surgery is reported in addition to a literature review.<br /> Conclusion:<br /> Diagnosis is made on the basis of histopathological analysis, clinical presentation, and laboratory investigations. Long term follow-up is required as Kimura’s disease is prone for recurrence.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Mixed Pyolaryngocele: A Rare Case of Deep Neck Infection225228893110.22038/ijorl.2017.8931ENRachid MahdoufiDepartment of Otorhinolaryngology-Head and Neck Surgery, Service d’ORL-CCF, Hospital 20 Aout 1953, CHU IBN ROCHD, Casablanca, Maroc.Ismail BarhmiDepartment of Otorhinolaryngology-Head and Neck Surgery, Service d’ORL-CCF, Hospital 20 Aout 1953, CHU IBN ROCHD, Casablanca, Maroc.Nabil TaziDepartment of Otorhinolaryngology-Head and Neck Surgery, Service d’ORL-CCF, Hospital 20 Aout 1953, CHU IBN ROCHD, Casablanca, Maroc.Redallah AbadaDepartment of Otorhinolaryngology-Head and Neck Surgery, Service d’ORL-CCF, Hospital 20 Aout 1953, CHU IBN ROCHD, Casablanca, Maroc.Mohamed RoubalDepartment of Otorhinolaryngology-Head and Neck Surgery, Service d’ORL-CCF, Hospital 20 Aout 1953, CHU IBN ROCHD, Casablanca, Maroc.Mohamed MahtarDepartment of Otorhinolaryngology-Head and Neck Surgery, Service d’ORL-CCF, Hospital 20 Aout 1953, CHU IBN ROCHD, Casablanca, Maroc.Journal Article20160121Introduction:<br /> Pyolaryngocele is a very rare and serious complication of laryngocele. It can present as deep neck space infection and mislead the diagnosis. Our aim is to bring this unusual entity to the attention of surgeons and describe its clinical features.<br /> Case Report:<br /> We report a case of a 45-year-old male patient with a five-week history of neck swelling, dysphonia, dyspnea and odynophagia. An urgent CT scan showed a mixed pyolaryngocele. The management consisted of a high dose antibiotic and an excision of the residual laryngocele via an external approach.<br /> Conclusion:<br /> A pyolaryngocele is an unusual complication of laryngocele, which becomes secondarily infected, causing many symptoms. Removing the laryngocele is still the best treatment option to prevent this complication and recurrence.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Pharyngocutaneous Fistula as a Rare Late Postoperative Complication Following Submandibulectomy: A Case Report229231897110.22038/ijorl.2016.14532.1519ENLeila MashaliDepartment of Otolaryngology Head and Neck Surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Somayeh AraghiDepartment of Otolaryngology Head and Neck Surgery, Tehran University of Medical Sciences, Tehran , Iran.Journal Article20160204Introduction:<br /> Submandibular gland excision is the gold standard treatment for submandibular gland disease. Although submandibulectomy is a relatively standardized surgical procedure, complications are frequently reported. These complications include nerve paralysis or paresis, aesthetic sequelae, hematoma, salivary fistulas or sialoceles, wound infections, hypertrophic scars and inflammations caused by residual lithiasis in the salivary duct.<br /> Case Report:<br /> We report a case of a rare complication of submandibular gland excision, pharyngocutaneous fistula, which appeared 6 years after previous surgery. The patient underwent surgery, during which a fistula tract from the skin to the pharynx was found and excised.<br /> Conclusion:<br /> The authors believe that inappropriate execution of the surgical procedure could result in postoperative complications.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725129420170701Diffuse Idiopathic Skeletal Hyperostosis Involving Cervical and Lumbar Spine Presenting with Dysphagia: A Case Report233236897210.22038/ijorl.2017.8972ENRamanuj SinhaDepartment of Otorhinolaryngology, Medical College, Kolkata, India.Neeraj AggarwalDepartment of Otorhinolaryngology, Medical College, Kolkata, India.Sirshak DuttaDepartment of Otorhinolaryngology, Medical College, Kolkata, India.Avijit ChoudhuryDepartment of Otorhinolaryngology, Medical College, Kolkata, India.Sanjoy-Kumar GhoshDepartment of Otorhinolaryngology, Medical College, Kolkata, India.Debasis GuhaSenior Divisional Medical Officer, B R Singh Hospital (Eastern Railways), Kolkata, IndiaJournal Article20160411Introduction:<br /> Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a very rare cause of dysphagia when it occurs in the cervical spine. It can also affect the lumbar region where it causes deformity.<br /> Case Report:<br /> In this article, a rare case of Diffuse Idiopathic Skeletal Hyperostosis involving both the cervical and lumbar spine, presenting with dysphagia and spinal stiffness leading to a stooping posture, is reported.<br /> Conclusion:<br /> Cases of simultaneous involvement of cervical and lumbar vertebrae by Diffuse Idiopathic Skeletal Hyperostosis, presenting with symptoms of both area involvement, are rarely reported in the English literature. When investigating a case of dysphagia, a high level of suspicion is required to diagnose such a condition.