Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Does Malleolus non-Lifting Tympanoplasty have any Advantage Over Malleus Lifting Technique?711606610.22038/ijorl.2016.6066ENMohammad Reza VahidiOtorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Abolfazl MollasadeghiDepartment of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Honeyeh ShahbazianOtorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Nasim BehniafardOtorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Mohammad Hossein DadgarniaOtorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Journal Article20150328<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>In order to achieve a higher success rate for tympanoplasty, different techniques have been developed, and a wide variety of grafting materials have been developed. One of the techniques currently receiving considerable attention involves not lifting the remaining of eardrum from the malleus and embedding the graft underneath in order to repair the eardrum correctly in its original position, as well as minimizing graft lateralization leading to progression of hearing rehabilitation. We compared the effects of tympanoplasty with and without malleus lifting on hearing loss in patients with chronic otitis media. <br/><strong><em> </em></strong> <br/><strong><em>Materials and Methods</em></strong><strong><em>: </em></strong><br/>In this study, 30 consecutive patients diagnosed as having chronic otitis media without cholesteatoma were randomly assigned to two tympanoplasty groups; with or without malleus lifting. Air and bone conduction thresholds were recorded before and 45 days after the intervention. <br/> <br/><strong><em>Results:</em></strong> <br/>In groups, except for 8000 Hz, the air conduction was significantly improved following surgery. According to air conduction there was no difference between the groups before surgery at different frequencies, although it was improved to a greater degree in the group without lifting at 250 Hz postoperatively. The average post-operative air-bone gap (ABG) gain was significantly higher in all study frequencies in the target group. One of the effects of this technique is inner-ear protection from physical trauma to the ossicular chain, and prevention of damage to bone conduction. <br/><strong><em> </em></strong> <br/><strong><em>Conclusion:</em></strong><em> </em><br/>A higher hearing threshold and also higher ABG gain can be achieved by not lifting the remaining eardrum from the malleus and embedding the graft undereath it, especially at lower frequencies.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Effect of Early Intervention on Language Development in Hearing-Impaired Children1320603510.22038/ijorl.2016.6035ENElahe ShojaeiDepartment of Audiology, Rehabilitation Sciences Faculty, Iran University of Medicine Sciences, Tehran, Iran.Zahra JafariDepartment of Basic Sciences in Rehabilitation, Rehabilitation Sciences Faculty, Iran University of Medical Sciences, Tehran, Iran.Maryam GholamiClinical speech therapist, Social Welfare Organization, Tehran, Iran.Journal Article20150202<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>Hearing loss from birth up to the age of 3 years has a negative effect on speech/language development and results in sensory, cognitive, emotional, and academic defects in adulthood by causing delayed development of communicative-linguistic abilities. The present study was performed in order to assess the effect of early intervention on language development in Persian children aged 6-7 years with severe sensorineural hearing loss. <br/><strong><em> </em></strong> <br/><strong><em>Materials and Methods</em></strong><strong><em>: </em></strong><br/>Thirty boys and girls aged 6-7 years participated in this study, all of them had severe congenital sensorineural hearing loss in both ears. All children were using bilateral behind-the-ear hearing aid, and had similar economic/socio-cultural backgrounds. Subjects were categorized into two groups based on the age of identification/intervention of hearing loss (3-6 and 12-15 months of age). The Persian TOLD-P3 test was used to evaluate language development in all subjects. Data collection was accomplished by observation, completion of questionnaires, and speech recording. <br/> <br/><strong><em>Results:</em></strong> <br/>There was a significant difference in language development in 11 sub-tests and five lingual gains on the Persian TOLD-P3 test between early (3-6 months of age) and late identified/intervened (12-15 months of age) hearing-impaired children (P<0.05). Early identified/intervened hearing-impaired children had a notable preference in all assessed sub-tests and lingual gains. <br/><strong><em> </em></strong> <br/><strong><em>Conclusion:</em></strong><em> </em><br/>Early identification/intervention of hearing loss before the age of 6 months has a significant positive effect on a child’s language development in terms of picture/relational/oral vocabulary, grammatical comprehension, sentence combining, grammatical completion, phonologic analysis, word differentiation, word production, semantics, and syntax. Moreover, early identification/ intervention of hearing loss develops the hearing-impaired child’s lingual gains in visual vocabulary, grammatical completion, word differentiation, phonologic analysis, and word production.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Effects of Hyperbilirubinemia on Auditory Brainstem Response of Neonates Treated with Phototherapy2329607110.22038/ijorl.2016.6071ENNegin SalehiDepartment of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.Fereshte BagheriDepartment of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.Hamid Ramezani FarkhaniDepartment of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.Journal Article20150516<strong><em>Introduction</em></strong><strong><em>:</em></strong><br /> One of the most common pathologies in neonates is hyperbilirubinemia, which is a good marker for damage to the central nervous system. The sensitivity of the auditory system to bilirubin has been previously documented, with much discrepancy in its effects on Auditory Brainstem Response results. Thus the objective of this study was to evaluate the effects of hyperbilirubinemia on Auditory Brainstem Response of neonates treated with phototherapy.<br /> <strong><em> </em></strong><br /> <strong><em>Materials and Methods</em></strong><strong><em>: </em></strong><br /> Forty-two term neonates with hyperbilirubinemia, who underwent phototherapy participated in this cross sectional study. The recording of Auditory Brainstem Response was made shortly after confirming that the total serum bilirubin level was greater than 15 µg/dl. Latency of waves I, III, V and inter-peak latencies of the waves were measured. To test the hypothesis about the difference of means between the two groups, continuous variables were compared using either the t-test (normal distribution) or the Mann-Whitney test (non-normal distribution).<br /> <strong><em> </em></strong><br /> <strong><em>Results:</em></strong> <br /> There was a significant increase in the absolute latencies of waves III and V, and I-III and I-V inter-peak latencies of the sample group compared to the control group in both ears (P<0.05). However, wave I absolute latency and III-V inter-peak interval did not show a significant difference between the two study groups (P>0.05).<br /> <strong><em> </em></strong><br /> <strong><em>Conclusion:</em></strong><em> </em><br /> The results of this study underline the importance of the Auditory Brainstem Response Test as an efficient tool for monitoring the auditory brainstem pathway in neonates who are at risk of neurotoxicity and for diagnosing the earliest stages of auditory damage caused by high levels of bilirubin.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Audiological Outcome of Classical Adenoidectomy versus Endoscopically-Assisted Adenoidectomy using a Microdebrider3137603310.22038/ijorl.2016.6033ENVanita SarinDepartment of Otorhinolaryngology, Sri Guru Ram Das Institute of Medical Sciences & Research, Amritsar, Punjab, India.Vanika AnandDepartment of Otorhinolaryngology, Christian Medical College, Ludhiana, Punjab, India.Bhanu BhardwajDepartment of Otorhinolaryngology, Sri Guru Ram Das Institute of Medical Sciences & Research, Amritsar, Punjab, India.Journal Article20150108<strong><em>Introduction</em></strong><strong><em>:</em></strong>
The aim of this study was to evaluate audiological outcomes following adenoidectomy by the classical method and by endoscopically-assisted adenoidectomy using a powered instrument (microdebrider).
<strong><em> </em></strong>
<strong><em>Materials and Methods</em></strong><strong><em>: </em></strong>
This study was conducted in a tertiary care center. It included 40 patients divided into two equal groups of 20 each. Group-A patients underwent classical adenoidectomy, while Group-B patients were subjected to endoscopically-assisted adenoidectomy using a microdebrider. Hearing outcome was measured by post-operative pure-tone audiometry and tympanometry.
<strong><em>Results:</em></strong>
The post-operative average air-bone gap (ABG) was reduced from 19.6 dB to 11.8 dB in Group A and from 17.6 dB to 8.7 dB in Group B (P=0.010). There was reversal of tympanometric curves from type-B and type-C to type-A in 55% of the patients in Group A, while type-A curve was seen in 90% cases in Group B in the post-operative period.
<strong><em> </em></strong>
<strong><em>Conclusion:</em></strong><em> </em>
Audiological outcomes of endoscopically-assisted adenoidectomy using a microdebrider were superior compared with classical adenoidectomy.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Endoscopic Repair of CSF Rhinorrhea: An Institutional Experience3943603010.22038/ijorl.2016.6030ENSarita Kumari MisharaDepartment of Otorhinolaryngology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.George Ani MathewDepartment of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.Roshna Rose PaulDepartment of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.0000-0001-8133-3955Syed Kamran AsifDepartment of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.Mary JohnDepartment of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.Ajoy Mathew VargheseDepartment of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.Mary KurineDepartment of Otorhinolaryngology, Christian Medical College, Vellore, Tamilnadu, India.Journal Article20140420<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>Endoscopic repair is considered the treatment of choice in cerebrospinal fluid (CSF) rhinorrhea. The aim of our study was to analyze the etiopathogenesis of CSF rhinorrhea, the outcome of treatment and the causes of failure in a developing-country setting. <br/><em> </em> <br/><strong><em>Materials and Methods</em></strong><strong><em>: </em></strong><br/>A retrospective review of patients treated with endoscopic repair for CSF rhinorrhea at a tertiary care hospital in southern India from January 2002 to December 2009 identified 36 patients, the majority of them being women. The defects were closed in three layers using fat, fascia lata and nasal mucosa along with a fibrin sealant in the majority of the patients. Per-operatively, a subarachnoid drain was placed in all patients. Patients were followed up for 1 year. <br/><strong><em> </em></strong> <br/><strong><em>Results:</em></strong> <br/>Spontaneous onset of CSF rhinorrhea was noted in 61% of patients. The most common site of leak was found to be the left cribriform plate area. Hence the most common cause of CSF rhinorrhea in our study was spontaneous and the second most common was post-traumatic. Our success rate on the first attempt at endoscopic repair was 100%, with a recurrence rate of 6%. A large defect, failure of localization of the defect, or other co-morbid conditions such as chronic cough may be the most likely causes of recurrence of leak. <br/> <br/><strong><em>Conclusion:</em></strong> <br/>Accurate localization of the site of lesion using a high-resolution computed tomography (CT) scan with magnetic resonance imaging (MRI) and confirmation of the site of leak by intraoperative Valsalva maneuver along with multilayered closure of the dural defect and post-operative lumbar drain appear to be essential for the successful endoscopic repair of CSF rhinorrhea.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Effect of Topical Estrogen in the Mangement of Traumatic Facial Wounds4549603410.22038/ijorl.2016.6034ENSeyed Amirhosein Ghazizadeh HashemiDepartment of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Behrooz BaratiDepartment of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Hosein MohammadiDepartment of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Masumeh SaeidiStudent Research Commitee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Abbas BahreiniStudents Research Committee, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Mohammad Ali KianiDepartment of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranJournal Article20150222<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>Acute skin wound healing is a complicated process comprising various phases. Recent animal studies have shown that steroid sex hormones such as estrogen maybe helpful in the regulation of several pathophysiologic stages that are involved in wound healing. In this study we examined the effects of topical estrogen in the treatment of traumatic facial wounds. <br/><strong><em> </em></strong> <br/><strong><em>Materials and Methods</em></strong><strong><em>: </em></strong><br/>Patients referred to Luqman Hospital, Tehran with traumatic wounds were enrolled in this case-control study into two groups of equal size. From the second week of the study, topical estrogen (0.625 mg conjugated topical estrogen ointment) was administered in the case group, while the control group received a Eucerin dressing only. The two groups were then compared in terms of wound healing rate on Day 7,14, and 30. <br/><strong><em> </em></strong> <br/><strong><em>Results:</em></strong> <br/>Thirty patients with mean age of 16.02+36.23 years were compared in the control and estrogen-treated groups. After treatment, no scars or keloids were observed in either group. The wound area in the estrogen group was lower than that in the control group on Day 14 and 30, but the difference was not significant (P>0.05). Healing rates in the control group on Day 14 (7.1+42.3 vs.50.3+4.9 mm2) and Day 30 (1.9+93.5 vs. + 97.3<span style="text-decoration: underline;">+</span>0.6 mm2) (were lower than those in the estrogen group, but the differences were not significant (P>0.05). Findings show that the required time for wound healing in the estrogen-treated group was lower than that in the control group, but the difference was not significant (P>0.05). <br/><strong><em> </em></strong> <br/><strong><em>Conclusion:</em></strong><em> </em><br/>Based on this study, topical estrogen has no effect on the rate of wound healing or the rate of wound area .Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101MTA1 Expression in Benign and Malignant Salivary gland Tumors5159606510.22038/ijorl.2016.6065ENAzadeh Andisheh-TadbirPrevention of Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Ali Dehghani -NazhvaniDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Mohammad Javad AshrafDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Bijan KhademiDepartment of Otorhinolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.Hosein MirhadiDepartment of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Shima Torabi-ArdekaniDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Journal Article20150228<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>Salivary gland tumors (SGTs) are important parts of human neoplasms. The most common SGT is pleomorphic adenoma and the most common malignant SGTs are mucoepidermoid carcinoma and adenoid cystic carcinoma (ACC). Metastasis-associated genes 1 (MTA1), a member of the nucleosome remodeling and histone deacetylation complex, is one newly discovered gene which recruits histone deacetylation, causing ATP-dependent chromosome remodeling, and regulating transcription. MTA1 had been shown to be overexpressed in malignant tumors with the enhancement of invasion and metastasis. <br/><strong><em> </em></strong> <br/><strong><em>Materials and Methods</em></strong><strong><em>: </em></strong><br/>Fifty-six samples of salivary tumors from the Khalili Hospital archive, including 20 cases of pleomorphic adenoma, 17 cases of mucoepidermoid carcinoma, 19 cases of ACC, and 23 cases of normal salivary gland tissues were chosen for immunohistochemical analysis of MTA1. <br/> <br/><strong><em>Results:</em></strong> <br/>MTA1 expression in the malignant tumors was significantly higher than that in pleomorphic adenoma (P<0.001), and higher in pleomorphic adenoma than the normal salivary glands<br clear="all" />(P< 0.001). In total, 69.6% of normal salivary gland tissues showed MTA1, but all cases of salivary gland tumors were positive for MTA1. High nuclear expression of MTA1 was detected in 83.3% (30/36) of the malignant salivary gland tumors and 45% (9/20) of pleomorphic adenoma, while low MTA1 expression was seen in all of the normal salivary gland tissues. No statistically significant correlation was found between MTA1 protein expression and any clinicopathological features (P>0.05). <br/><strong><em> </em></strong> <br/><strong><em>Conclusion:</em></strong><em> </em><br/>Our findings demonstrate that MTA1 was significantly overexpressed in malignant salivary gland neoplasm in comparison to a lower level in benign pleomorphic adenoma, suggesting that MTA1 protein might be involved in carcinogenesis.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Effects of Tonsil size on Pulmonary Function test Results after Tonsillectomy in Children6166607210.22038/ijorl.2016.6072ENMitra Samareh FekriPhysiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.Aliasghar Arabi MianroodiDepartment of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.Hosein ShakeriDepartment of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.Narges KhanjaniDepartment of Epidemiology and Biostatistics, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.Journal Article20150408<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>Adenotonsillar hypertrophy is a typical cause of surgery in children. Evaluation and identification of patients as potential candidates tonsillectomy is a primary concern for otolaryngologists. This study focuses on the results of pulmonary function tests (PFTs) after tonsillectomy in children. <br/><strong><em>Materials and Methods</em></strong><strong><em>: </em></strong><br/>This cross-sectional study examined 50 patients suffering from tonsillar hypertrophy in 2013. Full details and results of otolaryngology examinations were recorded. Moreover, patients were examined with respect to forced inspiratory flow at 50% of vital capacity (FIF50%), forced expiratory flow at 50% of vital capacity (FEF50%), forced expiratory volume in 1 second (FEV1)/peak expiratory flow rate (PEFR), and FEV1/forced expired volume in 0.5 seconds (FEV0.5) before and after surgery using spirometry. All data were analyzed using SPSS Software (version 19), and central descriptive measures, and data were compared by performing T-test and Chi-square tests. <br/><strong><em>Results:</em></strong> <br/>According to tonsil size, patients were distributed as follows: 18 patients (36%) with +1 tonsil size, 18 patients (36%) with +2 tonsil size, and seven patients (14%) with +3 tonsil size, and seven patients (14%) with +4 tonsil size. Thirty-three (66%) and 17 patients (34%) were female and male, respectively, with a mean of age of 9.7 2.97 years (range, 7–18 years). Seventy-eight percent of patients were aged 10 years or less. Moreover, 25 patients (50%), 17 patients (34%), and eight patients (16%), respectively, reported obstructive symptoms, recurrent tonsillitis, and both symptoms. In patients with +3 and +4 tonsil size, spirometric parameters indicated relief of symptoms of obstruction. Only in patients with +4 tonsil size were the changes statistically significant. <br/><strong><em>Conclusion:</em></strong><em> </em><br/>Tonsillectomy can relieve obstructive symptoms in patients with tonsils larger than +3 to a great extent. Additionally, spirometry can identify patients with +3 and +4 tonsils who do not have clinical signs of an obstructive upper airway.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101An Unusual Case of Cauda Equina Secondary to Spinal Metastasis of Thyroid Cancer6771603210.22038/ijorl.2016.6032ENShabbir AkhtarDepartment of Otorhinolaryngology, Head and Neck Surgery, Aga Khan University Hospital, Karachi, Pakistan.Mohammad AdeelDepartment of Otorhinolaryngology, Head and Neck Surgery, Aga Khan University Hospital, Karachi, Pakistan.Journal Article20141001<strong><em>Introduction</em></strong><strong><em>:</em></strong>
Cauda equina secondary to metastatic follicular thyroid cancer of the lumbosacral area is a rare entity.
<strong><em> </em></strong>
<strong><em>Case Report:</em></strong>
We report an unusual case of a 52-year-old male who presented with backache, lower limb weakness, and perianal numbness. A CT-scan of the lumbosacral area showed an enhancing mass at the L4, L5 and S1 vertebrae. Histopathology after excision revealed a metastatic thyroid cancer. Hence, a CT scan of the neck and chest was performed which showed a nodule in the left lobe of the thyroid and a mass in the left chest wall. A total thyroidectomy and excision of the chest wall lesion was undergone, which was diagnosed as a follicular carcinoma of the thyroid.
<strong><em> </em></strong>
<strong><em>Conclusion:</em></strong><em> </em>
Metastatic workup of spinal metastasis should include evaluation of the thyroid gland.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Pleomorphic Adenoma of the Larynx: A Case Report7377606310.22038/ijorl.2016.6063ENSeyyed Jafar MotahariDepartment of Otorhinolaryngology, Mazandaran University of Medical Sciences, Sari, Iran.Fereshteh KhavarinejadDepartment of Research, Ghaemshahr Health Center, Mazandaran University Of Medical Sciences, Ghaemshahr , Iran.Shahram SalimiDepartment of Pathology, Mazandaran University of Medical Sciences, Ghaemshahr, Iran.Milad BahariMedical Student Research Center, Faculty of Medicine, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.Journal Article20150314<strong><em>Introduction</em></strong><strong><em>:</em></strong>
Pleomorphic adenomas are tumors mostly originating from salivary glands. These lesions in the larynx are very rare.
<strong><em>Case Report:</em></strong>
We report a rare case of pleomorphic adenoma that originated from the mucosal lining, just above the glottic area at the level of the laryngeal ventricle in a 55-year-old female patient. The tumor could not be palpated easily but was observed in the CT scan. We resected the large and firm tumor using trans hyoid pharyngotomy as the surgical approach.
<strong><em>Conclusion:</em></strong><em> </em>
Pleomorphic adenoma in the ventricle of the larynx is an extremely rare lesion. Trans-hyoid pharyngotomy can have good results as the surgical approach in removing such lesions.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Inflammatory Myofibroblastic Tumor of the Larynx: A Case Report7982603110.22038/ijorl.2016.6031ENFarzad IzadiDepartment of Otorhinolaryngology, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.Hadi GhanbariENT & HNS Research Center, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.0000-0001-9771-7697Mohammad AziziPathologist, Shahriyar Hospital, Tehran, Iran.Shahram GasembaglouDepartment of Otorhinolaryngology, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.Mohammad Javad ManteghiGeneral practitioner, Iran University of Medical Sciences, Tehran, Iran.Azadeh GhanbariCollege of Dentistry, Ajman University of Science and Technology, Ajman, UAE.Journal Article20140908<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>Inflammatory myofibroblastic pseudotumors are initially described in the lung and various extrapulmonary sites such as the orbits, palatine tonsils, ears, gingiva, pterygomaxillary space, and periodontal tissues. These tumors rarely involve the larynx and predilection to the glottis occurs in an indolent manner. <br/><strong><em> </em></strong> <br/><strong><em>Case Report</em></strong> <br/>This case describes a laryngeal myofibroblastic tumor in a 46-year-old woman who presented with an aggressive tumor that extended to the floor of the mouth and the base of the tongue. Extended supraglottic laryngectomy was undertaken for the patient. The diagnosis was spindle cell proliferation with dense lymphoplasma cell infiltration compatible with inflammatory myofibroblastic tumor (Inflammatory pseudotumor or plasma cell granuloma). Definitive diagnosis was achieved with immunohistochemical (IHC) staining. <br/> <br/><strong><em>Conclusion:</em></strong><em> </em><br/>We believe that further IHC studies are required to define the true nature of these tumors especially for those that behave in an aggressive pattern.Mashhad University of Medical Sciences (MUMS)Iranian Journal of Otorhinolaryngology2251-725128120160101Chronic Invasive Fungal Granuloma–A Diagnostic Dilemma in an Immunocompetent Host8388602910.22038/ijorl.2016.6029ENShrinivas ChavanDepartment of Otorhinolaryngology,
Government Medical College and Hospital, Jubilee Park, Aurangabad, Maharashtra State, India.0000-0003-3262-1496K BhopleDepartment of Pathology,
Government Medical College,
Aurangabad. Maharashtra State, India.Sunil DeshmukhDepartment of Otorhinolaryngology
Government Medical College,
Aurangabad, Maharashtra State, India.Prateek JainDepartment of otorhinolaryngology Government Medical College,
Aurangabad, Maharashtra State, India.0000000298298583Mangala SonavaniDepartment of Medicine Government Medical College, Aurangabad.
Maharashtra State, India.Journal Article20131012<strong><em>Introduction</em></strong><strong><em>:</em></strong> <br/>Invasive fungal sinusitis, though considered to be rare entity, is nowadays frequently encountered, not only in immunocompromised patients but also in immunocompetent patients. The changing prevalence towards immunocompetent hosts is due to the indiscriminate usage of broad spectrum antibiotics, steroids, and immunosuppressive drugs. Diagnosing invasive fungal sinusitis should not pose any difficulty to both the clinician [a whitish colour secretion in elderly Diabetics, and CT Scan PNS showing concretion in the sinus along with destruction of the surrounding bone] and to the pathologist; however, when the invasive fungal sinus infection presents in a form of a granuloma then its diagnosis imposes a challenge to medical professionals. <br/><strong><em> </em></strong><strong><em>Case Report</em></strong> <br/>We are presenting a case study,which consists of 3 cases of chronic invasive fungal sinus infection.Two patients were treated for tuberculoma and had completed a course of Anti Koch’s Treatment and one patient was given a trial of broad spectrum antibiotics and steroids.Eventually all cases were diagnosed as a chronic invasive form of fungal granuloma (CIFG). <br/><strong><em> </em></strong><strong><em>Conclusion:</em></strong> <br/>CIFG of the paranasal sinuses is seen in immunocompetent hosts, especially those that are in the 2nd and 3rd decades of their lives. Gradually progressive proptosis is the primary presenting symptom. MRI scanning is a better imaging modality compared to CT scanning. Routine H&E staining may prove inadequate and special stains such as the GMS stain should be employed in the slightest doubt of a fungal aetiology. A team approach towards patients is paramount for early diagnosis and timely medical and surgical intervention.