Iranian Journal of Otorhinolaryngology

Iranian Journal of Otorhinolaryngology

Tonsillar Lymphoma in Children According to Age Group: A Systematic Review

Document Type : Systematic Review

Authors
Guilherme-Machado de Carvalho
Henrique-Furlan Pauna
Agrício- Nubiato Crespo
Reinaldo- Jordão Gusmão
Alexandre-Caixeta Guimarães
Department of Otorhinolaryngology- Head and Neck Surgery, University of Campinas, Campinas, São Paulo, Brazil.
10.22038/ijorl.2018.25481.1833
Abstract
Introduction:
Lymphoma is a common malignant tumor of the head and neck occurring during childhood. Early diagnosis is very important in terms of prognosis in patients with tonsillar lymphoma.Our objective was to evaluate the clinical manifestations of pediatric tonsillar lymphoma according to different age groups.
 Materials and Methods:
A systematic review of available English, Spanish, or Portuguese literature from January 1996 to June 2012 was performedin the BIREME, Cochrane, IBECS, Lilacs, PubMed/Medline, SCIELO, and Scopus databases, using “tonsillar lymphoma” and “children” as keywords. Inclusion criteria were pediatric case reports, patients aged up to 18 years, and information on clinical features at the time of diagnosis.
 Results:
Out of 87 identified publications, 13 articles were selected describing 53 patients. Tonsillar asymmetry was the most common sign. Snoring is a common sign in patients aged under 5 years; clinical lymphadenopathy is frequent among patients aged between 6 and 10 years; and dysphagia is a common sign in patients between 11 and 18 years of age. Burkitt’s lymphoma is the most common form among all ages studied, followed by B-cell lymphoma.
 Conclusion:
Clinical manifestations differ according to age group. However, tonsillar asymmetry is the most frequent sign regardless of age group.
Keywords
Children
Lymphoma
Tonsillar neoplasm
Lymphadenopathy
Tonsillar asymmetry
Subjects
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Iranian Journal of Otorhinolaryngology
Volume 30, Issue 2
March and April 2018
Pages 69-75