Mantle Cell Lymphoma of the Palatine Tonsil: A Rare Case Report

Document Type : Case Report

Authors

1 Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, India.

2 Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, India.

Abstract

Introduction:
Primary mantle cell lymphoma (MCL) of the palatine tonsil without involvement of the regional lymph nodes is rarely reported.
 Case Report:
A 52-year-old male presented with complaints of a change in his voice over 3 months, with neither sore throat nor fever. Physical examination revealed right-sided grade IV and left-sided grade III tonsillar enlargement with prominent vessels. The patient underwent bilateral tonsillectomy. An initial histopathological report revealed chronic tonsillitis on the left side and suspicion of atypical lymphoproliferative disorder on the right. Immunohistochemically, the neoplastic cells were positive for Bcl2, CD20, CD5 and Cyclin D1 and negative for CD10, Bcl6 and CD3; thus a diagnosis of MCL was confirmed.
 Conclusion:
MCL of the tonsil is rare. The microscopic diagnosis is challenging as the picture is very similar compared with other types of small cell lymphomas. A detailed immunohistochemistry panel is required for an accurate diagnosis.

Keywords

Main Subjects

References

1. Ferry J. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin. In: Jaffe MD E, ed. By. Hematopathology. 2nd ed. Philadelphia: Elsevier; 2017. P. 1133–65.
2. Leux C, Maynadié M, Troussard X, Cabrera Q, Herry A, Le Guyader-Peyrou S et al. Mantle cell lymphoma epidemiology: a population-based study in France. Ann Hematol. 2014;93(8):1327–33.
3. Wang T, Bartlett N. Lymphomas of the Head and Neck. In: Flint P, Cummings C, editors. Cummings otolaryngology head and neck surgery. 6th ed. Philadelphia, PA: Elsevier Saunders; 2017. p. 1805–15.
4. Miranda RN, Khoury JD, Medeiros LJ. Mantle Cell Lymphoma. In: Atlas of Lymph Node Pathology [Internet]. New York, NY: Springer New York; 2013. p. 229–35.
5. Nghelina LIA. Non-Hodgkin lymphomas of Waldeyer’s. 2012;53(4):1057–60.
6. Campo E, Jares P. Mantle cell lymphoma. In: Jaffe E, Arber D, Harris N, campo E, editors. Hematopathology. 2nd ed. Philadelphia, PA: Elsevier; 2017. p. 397–414.
7. Klapper W. Histopathology of Mantle Cell Lymphoma. Seminars in Hematology. 2011; 48(3):148–54.
8. Vasilakaki T, Tsavari A, Arkoumani E, Koulia K, Manoloudaki K, Marinis A, et al. Primary Mantle Cell Lymphoma of the Tonsil: An Uncommon Case. Hell J Surg. 2015;876:485–7.
9. Kumar V, Abbas A. Diseases of white blood cells, Lymph Nodes, Spleen and Thymus. In: Kumar V, Abbas A, Aster J, editors. Robbins and Cotran pathologic basis of disease. 9th ed. Philadelphia: Elsevier-Saunders; 2015. p. 579–628
10. Guggisberg K, Jordan RCK. Mantle cell lymphoma of the oral cavity: case series and comprehensive review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:98–104.
 
 
Iranian Journal of Otorhinolaryngology
Volume 30, Issue 5 - Serial Number 100
September and October 2018
Pages 297-300

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