Correlation between Allergic Rhinitis and Otitis Media with Effusion

Document Type : Original

Authors

1 Department of Otorhinolaryngology-Head & Neck Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Immunology Research Centre, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical

3 Cancer Molecular Pathology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction:
Otitis media with effusion (OME) is prevalent among children in such a way that it is the most common cause of hearing loss and surgery in childhood. Immunoglobulin E (IgE) mediated hypersensitivity has been proposed as a causative factor in the development of OME; however, there has been contrasting data in this regard. Therefore, the present study aimed to detect the possibilities of interconnection.
Materials and Methods:
In this study, 37 OME children were selected as the case group and 52 children were randomly chosen as the control group. Allergic rhinitis prevalence, serum total IgE concentration, serum eosinophil count, and nasal scraping cytology were evaluated in all the children. Furthermore, the skin prick test was performed in the OME group and suspected allergic rhinitis patients in the control group.
Results:
Allergic rhinitis prevalence was notably higher among OME patients than in the control group (P=0.01). There were no remarkable differences in eosinophil counts and serum IgE concentrations in the two groups. Nasal smear eosinophils did not show any significant difference between the two groups; however, Appreciable difference was observed in the allergic rhinitis patients, compared to other OME patients (P=0.004).
Conclusion:
There may be a correlation between allergic rhinitis and development of OME. Therefore, it seems reasonable to examine allergic rhinitis patients for OME.

Keywords

Main Subjects


1. Maw AR. Glue Ear in Childhood. A Prospective Study of Otitis Media with Effusion. Clinics in Developmental Medicine no. 135. London: MacKeith Press; 1995.
2. Zielhius GA, Rach GH, Bosch AV, Broek PV. The prevalence of otitis media with effusion : a critical review of the literature . Clin Otolaryngol 1990;15:283-8.
3. Anonymous. Glue ear guidelines:time to act on the evidence . Lancet 1992;340:1324-5.
4. Black NA. Is glue ear a modern phenomenon? A historical review of the medical literature . Clin Otolaryngol 1984; 9:155-63
5. Drake-Lee AB, Hughes RG,  Dunn C. Serum IgA and IgG functional antibodies and their subclasses to Streptococcus pneumonia capsular antigen found in two aged-matched cohorts of children with and without otitis media with effusion.Clin Otolaryngol 2003;28:335-40
6. Van Cauwenberge PB.  Relevant and irrelevant predisposing factors in secretary otitis media.  Acta Otolaryngol Suppl  1984;414: 147–153.
7. Alles R, Parikh A, Hawk L, Darby Y, Romero JN, Scadding G. The prevalence of atopic disorders in children with chronic otitis media with effusion. Pediatr Allergy Immunol 2001; 12: 102-6.
8. Mogi G, Tomonaga K, Watanabe T, Chaen T. The role of type 1 allergy in secretory otitis media and mast cells in the middle ear mucosa. Acta Otolaryngol(Supple)(Stockh)1992;493:155-63
9. Hall LJ, Asunction J, Lukat H. Allergy skin testing under general anesthesia with treatment response in ninety-two patients with chronic serous otitis media . Am J Otol 1980;2:150-7.
10. Sorenson CH, Holm-Jensen S. Middle ear effusion and risk factors. J Otolaryngol 1982;11:46-51.
11. Bernstein JM. The role of IgE-mediated hypersensitivity in the development of otitis media with effusion: a review.Otolaryngol Head Neck Surg 1993;109:611-20
12. Bernstein JM, Lee J , Conboy K , Ellis E, Li P. The role of IgE mediated hypersensitivity in recurrent otitis media with effusion. Am J Otol 1983;5:66-9
13. Bernstein JM, Lee J , Conboy K , Ellis E, Li P. Further observations on the role of IgE mediated hypersensitivity in recurrent otitis media with effusion. Otolaryngol Head Neck Surg 1985; 93:611-5
14. McMahan JT, Calenoff E, Croft DJ, Bareholtz L, Weber LD. Chronic otitis media with effusion and allergy. Modified Rast analysis in 119 cases. Otolaryngol Head Neck Surg 1981;89:427-31
15. Doyle WJ, Takahara T, Firema P. The role of allergy in the pathogenesis of otitis media with effusion. Arch Otolaryngol 1985;111:502-6
16. Liu Y, Lim DJ, Lang R. Chronic middle ear effusion immunological and bacteriological investigation. Arch Otolaryngol 1975;101:278-86
17. Mogi G, Hoys S, Maeda S. Immunoglobulin E(IgE) in middle ear effusion. Ann Otol Rhinol Laryngol 1974;83:393-6
18. Martines F, Martinciglio G, Martines E, Bentivegna D. The role of atopy in otitis media with effusion among primary school children: audiological investigation. Eur Arch Otorhinolaryngol. 2010; 267:1673–78.
19. Martines F, Bentivegna D, Maira E, Sciacca V, Martines E. Risk factors for otitis media with effusion: case–control study in Sicilian schoolchildren. Int J  Pediatr Otorhinolaryngol 2011;75:754–59
20. Hurst DS. Allergy management of refractory otitis media. Otolaryngol Head Neck Surg 1990;102:664–9.
21. Ellwood P, Asher MI, Beasley R, Clayton TO, Stewart AW. International study of asthma and allergies in childhood. Auckland: ISAAC International Data Centre; July 2000.
22. Meltzer EO, Jalowayski AA. Nasal cytology in clinical practice. Am J Rhinol 1988; 2:47–54..
23. Yeo SG, Park DC, Eun YG, Cha Cl. The role of allergic rhinitis in the development of otitis media with effusion: effect on eustachian tube function . Am J Otolaryngol 2007 May-Jun;28: 148–52.
24. Caffarelli C, Savini E, Giordano S, Gianlupi G, Cavagni G. Atopy in children with  otitis media with effusion. Clin Exp Allergy 1998;28: 591–596.
25. Casselbrandt ML, Mandel EM.Acute otitis media and otitis media with effusion. In:Flint P, Haughey B, Lund V, Niparko J, Robbins KT, Thomas JR, et al. editors.Cummings Otolaryngology Head and Neck Surgery. 6th ed. Philadelphia: Saunders;2015.Vol.4 p.3023,24.
26. Caffarelli C, Cavangi G, Giordano S, Savini E, Piacentini G.Incresed nasal eosinophils in children with otitis media with effusion.Otolaryngol Head Neck Surg 1996 Nov;115(5):454-7.
27. Baroody F, Naclerio R. Allergy and immunology of the upper airway. In: Flint P, Haughey B, Lund V, Niparko J, Robbins KT, Thomas JR, et al. editors. Cummings Otolaryngology Head and Neck Surgery.6th ed.Philadelphia:Saunders;2015.Vol.1 p.618.
28. Discombe G. Criteria of eosinophilia. Lancet 1946; 1:195-6.
29. Krause JR, Boggs DR. Search for eosinophilia in hospitalized patients with normal blood leukocyte concentration. Am J Hematol 1987; 24: 55-63.