Laryngeal Carcinoma in a Pediatric Patient - A Case Report

Document Type : Case Report

Authors

1 Department of Otorhinolaryngology, IMS and SUM Hospital, Siksha“O”Anusandhan University (Deemed to be), K8, Kalinganagar, Bhubaneswar-751003, Odisha, India.

2 Directorate of Medical Research, IMS and SUM Hospital, Siksha“O” Anusandhan University (Deemed to be), K8, Kalinganagar, Bhubaneswar-751003, Odisha, India.

Abstract

Introduction:
 Carcinoma of the larynx is an extremely uncommon clinical entity in pediatric age. The diagnosis of the laryngeal carcinoma is often delayed due to the low index of suspicion. The factors contributing to delayed diagnosis include the similarity of its symptoms to common benign lesions of the larynx in childhood and difficult examination of the larynx in pediatric patients. The treatment of laryngeal carcinoma is still a challenge due to the lack of available guidelines among pediatric patients.
 
Case Report:
 An 11-year-old male presented with hoarseness of voice over the last 3 month and was diagnosed with laryngeal carcinoma based on the fiberoptic nasopharyngolaryngoscopy examinations and biopsy. He was treated with a complete course of radiotherapy.
 
Conclusion:
This case is reported due to the paucity of the laryngeal carcinoma cases among pediatric patients in medical literature. The obtained results will create awareness among clinician to rule out laryngeal carcinoma in pediatric patients with laryngeal symptoms, such as the hoarseness of voice which will help early diagnosis and treatment.

Keywords

Main Subjects


1. Almadori G, Cadoni G, Cattani P, Galli J, Bussu F, Ferrandina G, et al. Human papillomavirus infection and epidermal growth factor receptor expression in pri- mary laryngeal squamous cell carcinoma. Clin Cancer Res 2001;12: 3988-93.
2. Rinaldo A, Ferrito A, Healy GB. Cancer of the larynx in children and adolescents: a neoplastic lesion with a different etiology. Acta Otolaryngol 2004; 124:992-94.
3. Gindhart TD, Johnston WH, Chism SE, Dedo HH. Carcinoma of the larynx in childhood. Cancer 1980;46:1683-87.
4. McGuirt JWF, Little JP. Laryngeal cancer in children and adolescents. Otolaryngol Clin North Am 1997; 30 (2): 207-14.
5. Palenzuela G, Bernard F, Gardiner Q, Mondain M. Malignant B cell non-Hodgkin’s lymphoma of the larynx in children with Wiskott Aldrich syndrome. International Journal of Pediatric Otorhinolaryngology 2003; 67: 989-93.
6. Majoros M, Devine KD, Parhill EM. Malignant transformation of benign laryngeal papillomatosis in children after radiation therapy. Surg Clin North Am 1963; 43:1049.
7. Simon M, Kahn T, Schneider A, Pirsig W. Laryngeal carcinoma in a 12 year old child. Association with human papilloma virus 18 and 33. Arch Otolaryngol Head and Neck Surg 1994; 120: 277-82.
8.Vargas SO, French CA, Faul PN, Fletcher JA, Davis IJ, Dal Cin P, et al. Upper respiratory tract carcinoma with chromosomal translocation 15; 19:Evidence for a distinct disease entity of young patients with a rapidly fatal course. Cancer 2001; 92:1195-203.
9. Rastogi M, Srivastava M, Bhatt MLB, Srivastava K, Bhatia N. Laryngeal carcinoma in a 13 year old child. oral oncology EXTRA 2005;41:207-10.
10. Whyte A, Boeddinghaus R, Matias MA. Diagnostic Imaging Principles and Applications in Head and Neck Pathology. Contemporary Oral Medicine: A Comprehensive Approach to Clinical Practice 2019:173-253.
11. Paulino AC, Simon JH, Zhen W, Wen B. Long term effects in children treated with radiotherapy for head and neck rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 2000;48:1489-95.
12. Manish J, Pankaj C, Prathamesh P, Devendra C, Gauri P, Anil PGD. Carcinoma larynx in children. Int J Head Neck Surg 2010; 1: 49-51.
13. Prasad KC, Abraham P, Peter R. Malignancy of the larynx in a child, Ear Nose Throat J 2001; 80 (8): 508-11.
14. Siddiqui F, Sarin R, Agarwal JP, Thotathil Z, Mistry R, Dinshaw K. Squamous cell carcinoma of the larynx and hypopharynx in children: A distinct  clinical entity? Med Pediatr Oncol 2003;40:322-24.
15. Goyal P, Kellman RM. Frontolateral hemilaryngectomy for the management of a case of pediatric squamous cell carcinoma of the larynx. Laryngoscope 2005;115: 965-67.