ntroduction: From the most important laryngeal and hypopharyngeal cancer risk factors are smoking, alcohol and anemia. But reflux is one of the suggested etiologies. Pregnancy, Nonstroidal anti inflammation drugs and drugs decreasing the lower esophageal sphincter pressure will increase the reflux. Helicobacter pylories role in reflux formation is different due to the involved region and can also have a decreasing role and decline the rate of a series of esophageal and upper aero digestive system disease. Materials and Methods: This cross – sectional and case – control study was done in Qaem medical hospital, Mashhad during the years 1384 and 1385, for serum level detection of anti – H.pylori IgG and IgA antibodies in blood samples of both control and case groups. The variables were age, sex and serum test results. Results: 45 patients (39 male and 6 female) and 42 controls (33 male and 9 female) were evaluated. 2 groups were matched for age and sex. Positive IgG and IgA results in patients in order was 3 person (6.6 percent) and 3 person (6.6 person) and in control group 26 person (61.9%) and 12 person (28.5%). Result (P>0.001) was for healthy group showing the protective effect of H. Pylori against laryngeal cancer.
Conclusion: In our study, control group with a meaningful difference was affected by H.Pylori infection. This can be due to a protective effect for H. Pylori against the laryngeal and
I
hypopharyngeal malignancies. Prospective studies and simultaneously evaluation of reflux, H. Pylori infection and the regain of gastric location are suggested.