Verruciform Xanthoma of the Ventral Surface of the Tongue: A Rare Case Report and Literature Review

Document Type : Case Report

Authors

1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

4 Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Introduction:
Verruciform xanthoma (VX) is an uncommon benign lesion with the subepithelial accumulation of foamy histiocytes and superficial papillary proliferations with a bright orange hue. This lesion exhibits an oral region predilection.Its clinical differential diagnosis includes verrucous leukoplakia, verrucous carcinoma, squamous papilloma, verruca vulgaris, condyloma accuminatum, squamous cell carcinoma, and fibroepithelial polyp.
 
Case Report:
This report presents a case of VX of the ventral surface of the tongue afflicting a 33-year-old otherwise healthy male.
Conclusion:
This case report can be valuable as a consequence of VX rarity and the similarity of its clinical features to papillary lesions. A biopsy is required for its definite diagnosis particularly when it occurs at sites with a high-risk of squamous cell carcinoma development, such as the lateral border and ventral surface of the tongue.

Keywords

References

  1. Oliveira PT, Jaeger RG, Cabral LA, Carvalho YR, Costa AL, Jaeger MM. Verruciform xanthoma of the oral mucosa. Report of four cases and a review of the literature. Oral Oncol. 2001; 37(3):326-31.
  2. Tamiolakis P, Theofilou VI, Tosios KI, Sklavounou-Andrikopoulou A. Oral verruciform xanthoma: Report of 13 new cases and review of the literature. Med Oral Patol Oral Cir Bucal. 2018 1; 23 (4): e429-e435.
  3. Shahrabi Farahani S, Treister NS, Khan Z, Woo SB. Oral verruciform xanthoma associated with chronic graft-versus-host disease: a report of five cases and a review of the literature. Head Neck Pathol. 2011; 5(2): 193-8.
  4. Yu CH, Tsai TC, Wang JT, Liu BY, Wang YP, Sun A, et al. Oral verruciform xanthoma: a clinicopathologic study of 15 cases. J Formos Med Assoc. 2007; 106(2):141-7.
  5. Hu JA, Li Y, Li S. Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis. Report of three cases. 2005;113(9):629-34.
  6. Belknap AN, Islam MN, Bhattacharyya I, Cohen DM, Fitzpatrick SG. Oral verruciform xanthoma: A series of 212 cases and review of the literature. Head Neck Pathol. 2020: 2.
  7. Theofilou VI, Sklavounou A, Argyris PP, Chrysomali E. ral Verruciform Xanthoma within Lichen Planus: A Case Report and Literature Review. Case Rep Dent.

2018 22; 2018:1615086.

  1. Getz GI, Parag-Sharma K, Reside J, Padilla RJ, Amelio AL. Identification of NSDHL mutations associated with CHILD syndrome in oral verruciform xanthoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019; 128(1): 60-69.
  2. Ide F, Obara K, Yamada H, et al. Cellular basis of verruciform xanthoma: immunohistochemical and ultrastructural characterization.Oral Disease. 2008; 14: 150–7.
  3. Barrett AW, Boyapati RP, Bisase BS, Norris PM, Shelley MJ, Collyer J, et al. Verruciform xanthoma of the oral mucosa: A series of eight typical and three anomalous cases. Int J Surg Pathol. 2019; 27(5): 492-498.
  4. Tang R, Kopp SA, Cobb C, Halpern AV. Disseminated verruciform xanthoma: a case report. Cutis.2014; 93(6): 307-10.
  5. Baig FAH, Luqman M, Vij H, Ibrahim M. Oral verruciform xanthoma of lateral border of tongue- a sheep in wolf’s clothing. J Stomatol Oral Maxillofac Surg. 2019;120(5):480-482. 
  6. Hiraishi Y, Tojyo I, Kiga N, Tanimoto K, Fujita S. A case of verruciform xanthoma arising in the tongue.J Clin Diagn Res. 2016;10(12):ZD07-ZD08.
  7. Marques YM, de Andrade CR, Machado de Sousa SC, Navarro CM. Oral verruciform xanthoma: a case report and literature review. Case Rep Pathol. 2014:2014; 641015.
  8. Joshi R, Ovhal A. Verruciform xanthoma: report of five cases. Indian J Dermatol. 2012;57:479–82.
  9. Stoopler ET, Desai B. A tongue mass in a patient with oral lichen planus. J Can Dent Assoc. 2012;
    78: c60. 
  10. Mete O, Kurklu E, Bilgic B, Beka H, Unur M. Flat-type verruciform xanthoma of the tongue and its differential diagnosis. Dermatol Online J.2009 15; 15(9): 5.
  11. Visintini E, Rizzardi C, Chiandussi S, Biasotto M, Melato M, Di Lenarda R. Verruciform xanthoma of the oral mucosa. Report of a case. Minerva Stomatol.2006; 55(11-12):639-45.
  12. Akbari ME, Atarbashi Moghadam S, Atarbashi Moghadam F, Bastani Z. Malignant tumors of tongue in Iranian population. Iran J Cancer Prev. 2016; 9:e4467. 
  13. Capocasale G, Panzarella V, Tozzo P, Mauceri R, Rodolico V, Lauritano D, Campisi G. Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature. BMC Res Notes. 2017: 10(1):1-6.
  14. Qi Y, Sun Q, Yang P, Song A. A case of multiple verruciform xanthoma in gingiva. Br J Oral Maxillofac Surg. 2014;52(1):e1-3.

 

Iranian Journal of Otorhinolaryngology
Volume 33, Issue 1
January and February 2021
Pages 55-59

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