Auditory and Vestibular Assessment of Patients with Type Two Diabetes Mellitus: A Case-Control Study

Document Type : Original

Authors

1 Sinus and Surgical Endoscopic Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Department of Otolaryngology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Audiology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction:
Type two diabetes mellitus may relate to auditory and vestibular dysfunction. This relationship was frequently observed in elders. The present study aimed to evaluate the auditory and vestibular function of diabetic patients and compare the results with those of a healthy adult control group.
 
Materials and Methods:
Patients were asked to complete demographic characteristics form. Moreover, fasting blood sugar, as well as hemoglobin A1C tests, were carried out on them. Both the patients and control group were evaluated using several auditory and vestibular tests including Pure Tone Audiometry (PTA), video Head Impulse Test (v-HIT), ocular Vestibular Evoked Myogenic Potential (o-VEMP), and cervical Vestibular Evoked Myogenic Potential (c-VEMP).
 
Results:
The PTA showed a significant difference in some frequencies between the two groups. These differences were minimal in lower frequencies and become greater at 8000Hz. The v-HIT was abnormal for some patients and also showed a significant difference between the two groups. The o-VEMP and c-VEMP results were normal in most patients.
 
Conclusion:
Based on the obtained results, auditory and vestibular dysfunctions are related to Diabetes. Patients with type two diabetes mellitus showed mild auditory and vestibular dysfunctions compared to the healthy control group.

Keywords

References

  1. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives. Nature reviews Endocrinology. 2011;8(4):228-36.
  2. Lam DW, LeRoith D. The worldwide diabetes epidemic. Current opinion in endocrinology, diabetes, and obesity. 2012;19(2): 93-6.
  3. Faraji O, Etemad K, Akbari Sari A, Ravaghi H. Policies and Programs for Prevention and Control of Diabetes in Iran: A Document Analysis. Glob J Health Sci. 2015;7(6):44051.
  4. Peykari N, Djalalinia S, Qorbani M, Sobhani S, Farzadfar F, Larijani B. Socioeconomic inequalities and diabetes: A systematic review from Iran. J Diabetes Metab Disord. 2015;14:8.
  5. Katibeh M, Hosseini S, Soleimanizad R, Manaviat MR, Kheiri B, Khabazkhoob M, et al. Prevalence and risk factors of diabetes mellitus in a central district in Islamic Republic of Iran: a population-based study on adults aged 40-80 years. East Mediterr Health J. 2015;21(6):412-9.
  6. Saydah S, Lochner K. Socioeconomic status and risk of diabetes-related mortality in the U.S. Public health reports (Washington, DC: 1974). 2010; 125(3):377-88.
  7. Bourdel-Marchasson I, Helmer C, Fagot-Campagna A, Dehail P, Joseph PA. Disability and quality of life in elderly people with diabetes. Diabetes & metabolism. 2007;33 Suppl 1:S66-74.
  8. Wandell PE, Tovi J. The quality of life of elderly diabetic patients. Journal of diabetes and its complications. 2000;14(1):25-30.
  9. Fagot-Campagna A, Bourdel-Marchasson I, Simon D. Burden of diabetes in an aging population: prevalence, incidence, mortality, characteristics and quality of care. Diabetes & metabolism. 2005;31 Spec No 2:5S35-5S52.
  10. Dall TM, Zhang Y, Chen YJ, Quick WW, Yang WG, Fogli J. The economic burden of diabetes. Health affairs (Project Hope). 2010; 29(2): 297-303.
  11. Agrawal Y, Carey JP, Della Santina CC, Schubert MC, Minor LB. Diabetes, vestibular dysfunction, and falls: analyses from the National Health and Nutrition Examination Survey. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2010;31(9):1445-50.
  12. Li J, Zhang T, Shen J, Gong J, Wang H, Zhang J, et al. [The changes in vestibular function in patients with diabetes mellitus and its clinical significance]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2008;22(1):10-3.
  13. Ward BK, Agrawal Y, Hoffman HJ, Carey JP, Della Santina CC. Prevalence and impact of bilateral vestibular hypofunction: results from the 2008 US National Health Interview Survey. JAMA otolaryng- ology-head & neck surgery. 2013; 139(8): 803-10.
  14. Srinivas CV, Shyamala V, Shiva Kumar BR. Clinical Study to Evaluate the Association Between Sensorineural Hearing Loss and Diabetes Mellitus in Poorly Controlled Patients Whose HbA1c >8. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India. 2016;68(2):191-5.
  15. Kamali B, Hajiabolhassan F, Fatahi J, Nasli Esfahani E, Sarrafzadeh J, Faghihzadeh S. Effects of diabetes mellitus type Iota with or without neuropathy on vestibular evoked myogenic potentials. Acta medica Iranica. 2013; 51(2): 107-12.
  16. Morrison S, Colberg SR, Parson HK, Vinik AI. Relation between risk of falling and postural sway complexity in diabetes. Gait & posture. 2012; 35(4): 662-8.
  17. Haas L. Functional decline in older adults with diabetes. The American journal of nursing. 2007; 107(6 Suppl):50-4; quiz 4.
  18. Ghazizadeh Hashemi SA, Jafarzadeh S, Haddadi Aval M, Hosseinabadi R. Ocular Motor Function in Patients with Bilateral Vestibular Weakness. Iran J Otorhinolaryngol. 2016; 28(86): 177-81.
  19. Patel JC. Falls in elderly. Indian journal of medical sciences. 2000;54(8):350-2.
  20. Jacobson GP, McCaslin DL, Grantham SL, Piker EG. Significant vestibular system impairment is common in a cohort of elderly patients referred for assessment of falls risk. Journal of the American Academy of Audiology. 2008;19(10):799-807.
  21. Tilling LM, Darawil K, Britton M. Falls as a complication of diabetes mellitus in older people. Journal of diabetes and its complications. 2006;20(3):158-62.
  22. Frisina ST, Mapes F, Kim S, Frisina DR, Frisina RD. Characterization of hearing loss in aged type II diabetics. Hearing research. 2006;211(1-2):103-13.
  23. Ren H, Wang Z, Mao Z, Zhang P, Wang C, Liu A, et al. Hearing Loss in Type 2 Diabetes in Association with Diabetic Neuropathy. Archives of medical research. 2017;48(7):631-7.
  24. Bainbridge KE, Hoffman HJ, Cowie CC. Diabetes and hearing impairment in the United States: audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004. Annals of internal medicine. 2008;149(1): 1-10.
  25. Austin DF, Konrad-Martin D, Griest S, McMillan GP, McDermott D, Fausti S. Diabetes-related changes in hearing. The Laryngoscope. 2009;119(9):1788-96.
  26. Shargorodsky J, Curhan SG, Eavey R, Curhan GC. A prospective study of cardiovascular risk factors and incident hearing loss in men. The Laryngoscope. 2010;120(9):1887-91.
  27. Gupta S, Eavey RD, Wang M, Curhan SG, Curhan GC. Type 2 diabetes and the risk of incident hearing loss. Diabetologia. 2019;62(2):281-5.
  28. Nemati S, Hassanzadeh R, Mehrdad M, Sajedi Kia S. Hearing Status in Patients with Type 2 Diabetes Mellitus According to Blood-Sugar Control: A Comparative Study. Iran J Otorhinolaryngol. 2018;30(99):209-18.
  29. Konrad-Martin D, Austin DF, Griest S, McMillan GP, McDermott D, Fausti S. Diabetes-related changes in auditory brainstem responses. The Laryngoscope. 2010;120(1):150-8.
  30. Bayram A. Vestibular evoked myogenic potentials in patients with diabetes mellitus. Journal of otology. 2019;14(3):89-93.
  31. Cohen Atsmoni S, Brener A, Roth Y. Diabetes in the practice of otolaryngology. Diabetes & metabolic syndrome. 2019;13(2):1141-50.
  32. Albernaz PL. Hearing Loss, Dizziness, and Carbohydrate Metabolism. International archives of otorhinolaryngology. 2016;20(3):261-70.
  33. D'Silva LJ, Staecker H, Lin J, Maddux C, Ferraro J, Dai H, et al. Otolith Dysfunction in Persons With Both Diabetes and Benign Paroxysmal Positional Vertigo. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2017; 38(3): 379-85.
  34. Hoseinabadi R, Pourbakht A, Yazdani N, Kouhi A, Kamali M, Abdollahi FZ, et al. The Effects of the Vestibular Rehabilitation on the Benign Paroxysmal Positional Vertigo Recurrence Rate in Patients with Otolith Dysfunction. Journal of audiology & otology. 2018; 22(4):204-8.
  35. Walley M, Anderson E, Pippen MW, Maitland G. Dizziness and Loss of Balance in Individuals With Diabetes: Relative Contribution of Vestibular Versus Somatosensory Dysfunction. Clinical diabetes: a publication of the American Diabetes Association. 2014;32(2):76-7.
  36. Agrawal Y, Carey JP, Della Santina CC, Schubert MC, Minor LB. Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004. Archives of internal medicine. 2009; 169(10):938-44.
  37. D'Silva LJ, Lin J, Staecker H, Whitney SL, Kluding PM. Impact of Diabetic Complications on Balance and Falls: Contribution of the Vestibular System. Physical therapy. 2016;96(3):400-9.
  38. Kars HJ, Hijmans JM, Geertzen JH, Zijlstra W. The effect of reduced somatosensation on standing balance: a systematic review. Journal of diabetes science and technology. 2009;3(4):931-43.

 

 

Iranian Journal of Otorhinolaryngology
Volume 33, Issue 5
September and October 2021
Pages 263-269

Files

Share

How to cite

Statistics