Introduction: Thyroid cancers constitute 0.5%- 1% of all cancers of which differentiated cancers are most common. Mixed thyroid carcinomas are rare entities comprising only 0.5% of thyroid cancers. These tumours pose challenges in diagnosis by fine needle aspiration cytology.
Case Report: Here, we present two rare cases of these mixed thyroid carcinomas. The first is that of a 21 year old female diagnosed with medullary thyroid carcinoma by the method of fine needle aspiration cytology (FNAC). She underwent definitive surgical treatment. Final histopathology revealed diagnosis of a nodular tumour with mixed features predominantly medullary carcinoma with areas of follicular carcinoma, confirmed on immunohistochemistry. Second report is that of a 45-year- old female diagnosed as medullary thyroid carcinoma on fine needle aspiration cytology (FNAC). Definitive surgical treatment was performed. Histopathology showed a mixed tumour with medullary and papillary components as confirmed through the process of immunohistochemistry. Conclusions: The knowledge of these rare carcinomas is important in avoiding a dilemma in management of this condition. Detection of these mixed tumours is difficult by FNAC. The definitive treatment essentially requires recognition of medullary component. We re-emphasize the importance of immune-histochemistry in arriving at an accurate diagnosis.
Subramanian, N., Agarwal, S., Agarwal, A., Gupta, P. (2022). Rare Mixed Thyroid Carcinomas: A Report of Two Cases. Iranian Journal of Otorhinolaryngology, 34(1), 55-57. doi: 10.22038/ijorl.2021.48526.2614
MLA
Nitya Subramanian; Sangeet Kumar Agarwal; Alok Agarwal; Pallav Gupta. "Rare Mixed Thyroid Carcinomas: A Report of Two Cases". Iranian Journal of Otorhinolaryngology, 34, 1, 2022, 55-57. doi: 10.22038/ijorl.2021.48526.2614
HARVARD
Subramanian, N., Agarwal, S., Agarwal, A., Gupta, P. (2022). 'Rare Mixed Thyroid Carcinomas: A Report of Two Cases', Iranian Journal of Otorhinolaryngology, 34(1), pp. 55-57. doi: 10.22038/ijorl.2021.48526.2614
VANCOUVER
Subramanian, N., Agarwal, S., Agarwal, A., Gupta, P. Rare Mixed Thyroid Carcinomas: A Report of Two Cases. Iranian Journal of Otorhinolaryngology, 2022; 34(1): 55-57. doi: 10.22038/ijorl.2021.48526.2614