Oral metastatic undifferentiated pleomorphic sarcoma: a case report

Document Type : Case Report

Authors

1 Graduated student, School of dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Associate professor, Department of Oral and Maxillofacial Pathology, School of dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

3 Assistant Professor, Department of Oral and Maxillofacial Pathology, School of dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Introduction:

Oral metastases are rare, nevertheless, they must be considered in the differential diagnosis of lesions in patients with a previous history of malignancy or older adults. The clinical signs of oral metastasis typically comprise pain, dysphagia, ulceration, bleeding, and paresthesia. Soft tissue sarcomas tend to affect the extremities and retroperitoneum. The most common metastases in the oral cavity are carcinomas, and sarcomas rarely metastasize to this area. Undifferentiated pleomorphic sarcoma is a mesenchymal malignancy that infrequently affects the head and neck site. It shows a male predilection and occurs in all age groups. The lung is the most common area of distant metastasis in undifferentiated pleomorphic sarcoma.

Case report:

This report presents a 61-year-old female patient with a painful bluish-purple mass of the posterior right mandibular alveolar mucosa. She had a history of thigh UPS about four years ago. Incisional biopsy was performed and the specimen was stained with hematoxylin and eosin. Immunohistochemical antibodies for CK, S100, desmin, myogenin, MDM2, SOX10, caldesmon were negative and focally positive for CD68. Ki-67 index was about 70%.

Conclusion:

This report aim is to increase awareness of this rare lesion by describing the clinical, histopathologic, and immunohistochemical findings of metastatic undifferentiated pleomorphic sarcoma of oral cavity.

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