Middle Ear Primary Oncocytic Schneiderian Papilloma: A Case Report

Document Type : Case Report


1 Sinus and Surgical Endoscopic Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Cutaneous Leishmaniosis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Chronic otitis media is a significant health problem, but middle ear and mastoid neoplasms, either benign or malignant, are extremely rare.
Case Report:
Here is a report from a 51-year-old female who presented persistent otorrhea with an aural polyp. The patient was operated on with the probable diagnosis of cholesteatoma. During surgery, a fragile mass was discovered, and histopathologic examination reported the diagnosis of a primary oncocytic Schneiderian papilloma. Microscopically it has pseudostratified epithelium of columnar cell epithelium with eosinophilic granular cytoplasm and hyperchromatic nuclei. The treatment of choice for Schneiderian papillomas is complete surgical removal.
Although very rare, oncocytic Schneiderian papilloma should be considered a differential diagnosis of ear neoplasms such as auditory canal polyps.


  1. Vorasubin N, Vira D, Suh JD, Bhuta S, Wang MB. Schneiderian papillomas: comparative review of exophytic, oncocytic, and inverted types. Am J Rhinol Allergy. 2013; 27(4):287-92.
  2. Nudell J, Chiosea S, Thompson LDR. Carcinoma ex-Schneiderian papilloma (malignant transformation): a clinicopathologic and immuno- phenotypic study of 20 cases combined with a comprehensive review of the literature. Head Neck Pathol. 2014;8(3):269-86.
  3. Nwaorgu OG, Onakoya PA. Inverted papilloma of the nose and paranasal sinuses: a fifteen-year review. Afr J Med Med Sci. 2002;31(3):191-4.
  4. Fu Z-M, Zhao L-P, Guo Y-Y, Guan G-F. A Rare Instance of Primary Oncocytic Schneiderian Papilloma of Middle Ear and Eustachian Tube With a Combined Trans Oto and Nasal Approach Resection. Journal of Craniofacial Surgery. 2020; 31(2).
  5. Stone DM, Berktold RE, Ranganathan C, Wiet RJ. Inverted Papilloma of the Middle Ear and Mastoid. Otolaryngology–Head and Neck Surgery. 1987; 97(4):416-8.
  6. Kaddour HS, Woodhead CJ. Transitional papilloma of the middle ear. The Journal of Laryngology & Otology. 2007;106(7):628-9.
  7. Roberts WH, Dinges DL, Hanly MG. Inverted Papilloma of the Middle Ear. Annals of Otology, Rhinology & Laryngology. 1993;102(11):890-2.


  1. Schaefer N, Chong J, Griffin A, Little A, Gochee P, Dixon N. Schneiderian-Type Papilloma of the Middle Ear: A Review of the Literature. Int Surg. 2015; 100(6):989-93.
  2. Shen J, Baik F, Mafee MF, Peterson M, Nguyen QT. Inverting Papilloma of the Temporal Bone: Case Report and Meta-Analysis of Risk Otology & Neurotology. 2011;32(7).
  3. Fletcher CD. Diagnostic histopathology of tumors: 2-volume set with CD-ROMs: Elsevier Health Sciences; 2007.
  4. Bishop JA. OSPs and ESPs and ISPs, Oh My! An Update on Sinonasal (Schneiderian) Papillomas. Head Neck Pathol. 2017;11(3):269-77.
  5. Thompson LDR. Middle Ear and Temporal Bone Papilloma: A Clinicopathologic Study and Comprehensive Literature Review of 57 Cases. Head Neck Pathol. 2021.