The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients

Document Type : Original

Authors

1 Otorhinolaryngology Research Center, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

2 Otorhinolaryngology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

3 Maternal, Fetal and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Introduction:
This study was conducted to evaluate the effect of Doluperine® capsule (curcumin, piperine, and gingerol) on hearing recovery in diabetic patients with Sudden Sensorineural Hearing Loss (SSNHL).
Materials and Methods:
Fifty-one diabetic patients with SSNHL were randomized to receive two placebo capsules (group 1), a Doluperine® plus one placebo capsule (group 2), or two Doluperine® capsules (group 3). Moreover, all patients had an injection of dexamethasone in the middle ear.
Results:
The proportion of significant positive changes in PTA, SDS, and SRT was 45.4%, 45.4%, and 36.37% in group1, 84.6%, 84.6%, and 76.92% in group 2, and 70%, 50.0%, and 80.0% in group 3, respectively. Many patients in group 3 did not respond to treatment in the first month, while they recovered at the end of the second month. The chance of recovery reduced with increased time between the onset of symptoms and treatment (delayed visitation) in group 1; however, this finding was not seen in groups 2 and 3.
Conclusion:
Doluperine® is recommended as a complementary medicine along with steroid therapy for hearing loss improvement in diabetic patients; moreover, this herbal medicine seems to play an important role in recovery in patients with delayed visitation.

Keywords

Main Subjects

References

  1. Chandrasekhar S, Do B, Schwartz S, Bontempo L, Faucett E, Finestone S, et al. Clinical Practice Guideline: Sudden Hearing Loss (Update). Otolaryngology Head and Neck Surgery. 2019; 161: S1-S45.
  2. Huy PTB, Sauvaget E. Idiopathic Sudden Sensorineural Hearing Loss Is Not an Otologic Emergency. Otology & Neurotology. 2005; 26(5).
  3. Mattox DE, Lyles CA. Idiopathic sudden sensorineural hearing loss. Am J Otol. 1989; 10(3): 242-7.
  4. Son EJ, Bang JH, Kang J-G. Anterior Inferior Cerebellar Artery Infarction Presenting With Sudden Hearing Loss and Vertigo. The Laryngoscope. 2007; 117(3):556-8.
  5. Rudack C, Langer C, Stoll W, Rust S, Walter M. Vascular risk factors in sudden hearing loss. Thrombosis and haemostasis.2006;95(03): 454-61.
  6. Capaccio P, Ottaviani F, Cuccarini V, Bottero A, Schindler A, Cesana BM, et al. Genetic and acquired prothrombotic risk factors and sudden hearing loss. The Laryngoscope. 2007; 117(3):547-51.
  7. Finger RP, Gostian AO. Apheresis for idiopathic sudden hearing loss: reviewing the evidence. Journal of clinical apheresis. 2006; 21(4):241-5.
  8. O'Malley MR, Haynes DS. Sudden hearing loss. Otolaryngologic Clinics of North America. 2008; 41(3):633-49.
  9. Haynes DS, O'Malley M, Cohen S, Watford K, Labadie RF. Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy. The Laryngoscope. 2007; 117(1):3-15.
  10. Gianoli GJ, Li JC. Transtympanic steroids for treatment of sudden hearing loss. Otolaryngology-Head and Neck Surgery. 2001; 125(3):142-6.
  11. Herr BD, Marzo SJ. Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss. Otolaryngology-head and neck surgery. 2005; 132(4):527-31.
  12. Gao Y, Liu D. Combined intratympanic and systemic use of steroids for idiopathic sudden sensorineural hearing loss: a meta-analysis. European Archives of Oto-Rhino-Laryngology. 2016; 273(11): 3699-711.
  13. Arastou S, Tajedini A, Borghei P. Combined intratympanic and systemic steroid therapy for poor-prognosis sudden sensorineural hearing loss. Iran J Otorhinolaryngol. 2013;25(70):23-8.
  14. Han C-S, Park J-R, Boo S-H, Jo J-M, Park K-W, Lee W-Y, et al. Clinical efficacy of initial intratympanic steroid treatment on sudden sensorineural hearing loss with diabetes. Otolaryngology-head and neck surgery. 2009; 141(5):572-8.
  15. Kakehata S, Sasaki A, Oji K, Futai K, Ota S, Makinae K, et al. Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing loss with diabetes. Otology & Neurotology. 2006;27(5):604-8.
  16. Moon IS, Kim J, Lee S-Y, Choi H, Lee W-S. How long should the sudden hearing loss patients be followed after early steroid combination therapy? European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2009; 266:1391-5.
  17. Hara J, Zhang J, Gandhi K, Flaherty A, Barber W, Leung M, et al. Oral and intratympanic steroid therapy for idiopathic sudden sensorineural hearing loss: Steroid Therapy for Sudden Hearing Loss. Laryngoscope Investigative Otolaryngology. 2018;3.
  18. International diabetes federation 2020 [Available from: https://idf.org/our-network/ regions-members/ middle-east-and-north-africa/members/35-iran.html.
  19. Fetoni AR, Paciello F, Rolesi R, Eramo SLM, Mancuso C, Troiani D, et al. Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea. Free Radical Biology and Medicine. 2015;85:269-81.
  20. Haryuna TSH, Riawan W, Nasution A, Ma'at S, Harahap J, Adriztina I. Curcumin reduces the noise-exposed cochlear fibroblasts apoptosis. International archives of otorhinolaryngology. 2016;20(04):370-6.

 

  1. Scarpidis U, Madnani D, Shoemaker C, Fletcher CH, Kojima K, Eshraghi AA, et al. Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation. Otology & Neurotology. 2003; 24(3):409-17.
  2. Bucak A, Ozdemir C, Ulu S, Gonul Y, Aycicek A, Uysal M, et al. Investigation of protective role of curcumin against paclitaxel‐induced inner ear damage in rats. The Laryngoscope. 2015; 125(5): 1175-82.
  3. Yamaguchi T, Yoneyama M, Onaka Y, Imaizumi A, Ogita K. Preventive effect of curcumin and its highly bioavailable preparation on hearing loss induced by single or repeated exposure to noise: A comparative and mechanistic study. Journal of Pharmacological Sciences. 2017;134(4):225-33.
  4. Haryuna TSH, Riawan W, Reza M, Saragih AR. Modulation of antioxidant status by curcumin prevents cochlear damage after noise exposure. J Chem Pharm Res. 2015;7(11):593-7.
  5. Fani A, Ghasedi M, Esmaeeliun F, Alizadeh B. The effect of curcuma on improvement of clinical symptoms of patients with irritable bowel syndrome. HBI_Journals. 2010; 13(3): 109-15.
  6. Suresh D, Srinivasan K. Studies on the in vitro absorption of spice principles – Curcumin, capsaicin and piperine in rat intestines. Food and Chemical Toxicology. 2007;45(8):1437-42.
  7. Μ A, Al-Hadidi D, Menon M, Pesek J, Dhami MSI. Ginger: An Ethnomedical, Chemical and Pharmacological Review. Drug Metabolism and Personalized Therapy. 2001; 18(3-4):159-90.
  8. Sottejeau Y, Patel AM, Gerber G, Pierre SV, Maixent J-M. Effect of a novel Omegacoeur®/Doluperine® nutritional combination on human embryonic kidney cell viability. The FASEB Journal. 2011;25(1_supplement):981.14-.14.
  9. Battaglia A, Burchette R, Cueva R. Combination therapy (intratympanic dexamethasone+ high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss. Otology & Neurotology. 2008;29(4):453-60.
  10. Soyalıç H, Gevrek F, Koç S, Avcu M, Metin M, Aladağ İ. Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats. Int J Pediatr Otorhinolaryngol. 2016;89:173-8.

 

Iranian Journal of Otorhinolaryngology
Volume 35, Issue 4
July and August 2023
Pages 207-215

Files

Share

How to cite

Statistics