Value of Platelet to Lymphocyte Ratio in Nasopharyngeal Carcinoma Various Stages

Document Type : Original

Authors

Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine Padjadjaran University/ Dr. Hasan Sadikin General Hospital Bandung, Indonesia.

10.22038/ijorl.2024.75070.3523

Abstract

Introduction:
Nasopharyngeal Carcinoma (NPC) is among the most common head and neck cancer, significantly affecting the growth of human tumors. Therefore, this study aimed to investigate platelet-to-lymphocyte ratio (PLR) as a measure of inflammation in patients with various stages of NPC.
Materials and Methods:
This retrospective case-control study was conducted on patients diagnosed with NPC between 2016 and 2020 in Dr. Hasan Sadikin Bandung Hospital, Indonesia. Based on NPC classification criteria, patients were classified into early and advanced groups. Subsequently, the PLR ratio was calculated as the number of platelet divided by the absolute number of lymphocytes in the two groups, and the results were statistically analyzed using Unpaired T-test, Pearson, and Chi-square test.
Results:
A total of 102 patients with an age range of 40 to 49 years were included in this study. A slight correlation of 0.272 (P<0.001) was observed between PLR and clinical stage, while NPC patients with PLR value > 188 had a 2.7 times higher risk of advanced stage (RR=2.702).
Conclusion:
The PLR was significantly related to the clinical stage of NPC cancer.

Keywords

Main Subjects

References

  1. Cen RX, Li YG, Li Y. Platelet-to-lymphocyte ratio as a potential prognostic factor in nasopharyngeal carcinoma: A meta-analysis. Med (United States). 2019;98(38):1–8.
  2. Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet [Internet]. 2019;394(10192):64–80. Available from: http://dx.doi.org/10.1016/S0140-6736(19)30956-0
  3. Moore, K. L.; Dalley, A. F.; Agur AMR. Moore Clinically Oriented Anatomy. 8th ed. Vol. 282, Wolters Kluwer. Wolters Kluwer Health; 2018. 1045–1059 p.
  4. Nathania N, Dewi YA, Permana AD. Profile of head neck cancer patients from 2013-2018 at Dr . Hasan Sadikin General Hospital Bandung. ORLI. 2020;51(2):141–5.
  5. Chang ET, Ye W, Zeng YX, Adami HO. The evolving epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2021;30(6):1035–47.
  6. Handayani R, Afriani Dewi Y, Madani DZ. Prevalence of Nasopharyngeal Carcinoma Patients in Departement of Orl-Hns Hasan Sadikin General Hospital 2010 -2017. Int J Nasopharyngeal Carcinoma. 2020;2(01):01–3.
  7.                Komite Penanggulangan Kanker. Kanker Nasofarig. Indonesia KKR, editor. 2017. 68–70 p.
  8. Achmad AF, Hutajulu S, Kurnianda J. Peripheral neutrophil to lymphocyte ratio as independent prognostic factors in patients with nasopharyngeal carcinoma. Ann Oncol. 2017;28:x106.
  9. Zeng X, Liu G, Pan Y, Li Y. Development and validation of immune inflammation–based index for predicting the clinical outcome in patients with nasopharyngeal carcinoma. J Cell Mol Med. 2020; 24(15): 8326–49.
  10.                Cui X, Jia Z, Chen D, Xu C, Yang P. The prognostic value of the C-reactive protein to albumin ratio in cancer: An updated meta-analysis. Med (United States). 2020;99(14).
  11. Li B, Zhou P, Liu Y, Wei H, Yang X, Chen T, et al. Platelet-to-lymphocyte ratio in advanced Cancer: Review and meta-analysis. Vol. 483, Clinica Chimica Acta. Elsevier B.V.; 2018. p. 48–56.
  12.                Mounce LTA, Hamilton W, Bailey SER. Cancer incidence following a high-normal platelet count: cohort study using electronic healthcare records from English primary care. Br J Gen Pract. 2020; 70(698): E622–8.
  13. Rüegg C. Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions. J Leukoc Biol. 2006;80(4):682–4.
  14.                Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3): 209–49.
  15. Okekpa SI, Mydin RBSMN, Mangantig E, Azmi NSA, Zahari SNS, Kaur G, et al. Nasopharyngeal carcinoma (NPC) risk factors: A systematic review and meta-analysis of the association with lifestyle, diets, socioeconomic and sociodemographic in asian region. Asian Pacific J Cancer Prev. 2019; 20(11): 3505–14.
  16.                Barrett D, Ploner A, Chang ET, Liu Z, Zhang CX, Liu Q, et al. Past and recent salted fish and preserved food intakes are weakly associated with nasopharyngeal carcinoma risk in adults in southern China. J Nutr. 2019;149(9):1596–605.
  17. Hardianti RA, Dewi YA, Utami RD. Risk Factor of Nasopharyngeal Carcinoma Dr. Hasan Sadikin General Hospital Bandung. Int J Nasopharyngeal Carcinoma. 2019;1(03):110–1.
  18. Mydin RBSMN, Okekpa SI. Molecular Pathways for Nasopharyngeal Carcinoma focused on Acetaldehyde, Nitrosamines and Nicotine Exposures. Malaysian J Med Heal Sci. 2019; 15(July): 64–70.
  19. Long M, Fu Z, Li P, Nie Z. Cigarette smoking and the risk of nasopharyngeal carcinoma: A meta-analysis of epidemiological studies. BMJ Open. 2017; 7(10):14–7.
  20. Li WZ, Lv SH, Liu GY, Liang H, Xia WX, Xiang YQ. Age-dependent changes of gender disparities in nasopharyngeal carcinoma survival. Biol Sex Differ. 2021;12(1):1–10.
  21.                Zuo XY, Feng QS, Sun J, Wei PP, Chin YM, Guo YM, et al. X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma. Biol Sex Differ. 2019;10(1):1–11.
  22.                Ko JMY, Tsang KHK, Dai W, Choi SSA, Leong MML, Ngan RKC, et al. Leukocyte telomere length associates with nasopharyngeal carcinoma risk and survival in Hong Kong Chinese. Int J Cancer. 2018; 143(9):2289–98.
  23.                Berele BA, Cai Y, Yang G. Prognostic Value of Tumor Infiltrating Lymphocytes in Nasopharyngeal Carcinoma Patients: Meta-Analysis. Technol Cancer Res Treat. 2021;20:1–13.
  24.                Zhang X, Zhao W, Yu Y, Qi X, Song L, Zhang C, et al. Clinicopathological and prognostic significance of platelet-lymphocyte ratio (PLR) in gastric cancer: An updated meta-Analysis. World J Surg Oncol. 2020;18(1):1–12.
  25.                Yang S, Zhao K, Ding X, Jiang H, Lu H. Prognostic significance of hematological markers for patients with nasopharyngeal carcinoma: A meta-analysis. J Cancer. 2019;10(11):2568–77.
  26.                Diana D, Kusmardi. Tumor-infiltrating lymphocytes dan Peranannya pada Karsinoma Payudara. Maj Patol Indones. 2020;29(1):30–40.
  27.                Majumdar S, Pathak S, Nandi D. Thymus: The Site for Development of Cellular Immunity. Resonance. 2018;23(2):197–217.
  28.                Chen Y, Sun J, Hu D, Zhang J, Xu Y, Feng H, et al. Predictive value of pretreatment lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio in the survival of nasopharyngeal carcinoma patients. Cancer Manag Res. 2021;13(November):8767–79.
  29.                Takenaka Y, Oya R, Kitamiura T, Ashida N, Shimizu K, Takemura K, et al. Platelet count and platelet-lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta-analysis. Head Neck. 2018;40(12):2714–23.
  30.                Xingming Y, Lu T, Bai W, Jia J, Wang L, Zong J, et al. Association of Neutrophil-to-Lymphocyte Ratio, Neutrophil Count, and VEGF on Metastasis in Patients with Nasopharyngeal Carcinoma. 2020;1–12.
  31.                Fang T, Wang Y, Yin X, Zhai Z, Zhang Y, Yang Y, et al. Diagnostic Sensitivity of NLR and PLR in Early Diagnosis of Gastric Cancer. J Immunol Res. 2020;2020.
  32.                Tu XP, Tian T, Chen LS, Luo XN, Lu ZM, Zhang SY, et al. Prognostic values of preoperative NLR and PLR in patients with laryngeal squamous cell carcinoma. Transl Cancer Res. 2018;7(2):301-9.
  33.                Kadir A, Perkasa MF, Punagi AQ. Comparison of Platelet-Lymphocyte Ratio Before and After Chemotherapy in Histopathology Type of Nasopharyngeal Carcinoma. 2022;7(1):1–11.
  34.                Peng RR, Liang ZG, Chen KH, Li L, Qu S, Zhu XD. Nomogram based on lactate dehydrogenase-to-albumin ratio (Lar) and platelet-to-lymphocyte ratio (plr) for predicting survival in nasopharyngeal carcinoma. J Inflamm Res. 2021;14(June):4019–33.
Iranian Journal of Otorhinolaryngology
Volume 36, Issue 3
May and June 2024
Pages 467-473

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