Iranian Journal of Otorhinolaryngology

Iranian Journal of Otorhinolaryngology

The Effects of Aloe Vera Cream on the Alar Scar in Rhinoplasty, A Randomized Double-Blind Controlled Trial

Document Type : Original

Authors
Reza Kaboodkhani 1
Mohsen Sarikhani 1
Tayebeh Kazemi 1
Mohammad Mehdi Zarshenas 2
Mohammad Miaad Shahrizi 2
Maryam Sadat Sadati 3
Seyed Hossein Owji 4
1 Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Department of Phytopharmaceuticals (Traditional medicine), School of Pharmacy, Shiraz University of Medical sciences, Shiraz, Iran.
3 Molecular Dermatology Research Center, Shiraz University of Medical Sciences.
4 Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical sciences, Shiraz, Iran AND Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
10.22038/ijorl.2024.77572.3601
Abstract
Introduction:
Many studies have been done on the use of aloe vera in wound healing, but fewer studies were done on the influence of this material on the reduction of the alar scar. Therefore, we evaluated the effect of a newly made aloe vera cream on alar wound healing after rhinoplasty.
Materials and Methods:
This was a randomized, double-arm, parallel-group, double-blind controlled trial and was done from June 2021 to February 2022.  External wedge resection was done for all patients. The patients were randomly assigned to receive aloe vera cream (n=31) (intervention group) or Face Doux cream (comparison group) (n = 29). A pharmacist prepared the aloe vera cream. The primary outcome measure was the wound scar status which was assessed by two Questionnaires, including the mean Patient Scar Assessment Questionnaire (PSAQ) and Vancouver Scar Scale (VSS). Randomization and Blinding were done.
Results:
The mean PSAQ was significantly lower in group A after two weeks (26.9 versus 31.5, P<0.001), after two months (15.7 versus 19.6, P=0.04), and six months follow-up (8.8 versus 11.8, P=0.005). The mean VSS was significantly lower in group A after two weeks (5.6 versus 7.1, P=0.001), after two months (3.5 versus 4.9, P=0.002), and six months (1.2 versus 2.7, P<0.001). Repeated measurement analysis showed that both interventions significantly affected PSAQ and VSS.
Conclusion:
Although both interventions had a significant effect on PSAQ and VSS, compared to Face Duox, the topical use of Aloe Vera cream significantly reduced scar formation after alar resection, both statistically and clinically.
Keywords
Aloe vera
Cicatrix
Wound healing
Rhinoplasty
Subjects
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Iranian Journal of Otorhinolaryngology
Volume 36, Issue 3
May and June 2024
Pages 499-505