The long-term Effects of the Coronavirus Disease (COVID-19) on Auditory Thresholds: A Case-Control Study

Document Type : Original

Authors

1 Department of Audiology, School of Paramedical and rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/ijorl.2024.80236.3698

Abstract

Introduction:
The available evidence about hearing loss in Coronavirus disease (COVID-19) patients mostly show sensorineural hearing loss, and the long-term effects of COVID-19 on auditory thresholds are unknown. This study aimed to compare the auditory threshold results in COVID-19 patients (several months after infection) with a control group.
 
Materials and Methods:
The clinical diagnosis of COVID-19 was confirmed with positive polymerase chain reaction findings and radiology images. Hearing evaluation was performed with an audiometry test and a calibrated audiometer in a sound-treated room. The results of 177 patients were compared with those of the 589 matched control group. In both groups, subjects over 50 years old or with any history of ear disease were excluded from the study.
Results:
The time interval between infection with COVID-19 and hearing tests was 170.51±98.38 days. There was no significant difference between the auditory thresholds in different frequencies in both groups. Also, no significant difference was observed between the auditory thresholds of the two groups in the first, second, and third trimesters after being infected.
Conclusion:
This study did not show the long-term effects of COVID-19 on auditory thresholds, and the findings do not support hearing loss as a long-term COVID symptom.

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Main Subjects


  1. Sriwijitalai W, Wiwanitkit V. Hearing loss and COVID-19: A note. Am J Otolaryngol. 2020;41(3):102473.
  2. Payus AO, Liew Sat Lin C, Mohd Noh M, Jeffree MS, Ali RA, Kilic O, et al. SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19)Could sudden sensorineural hearing loss be the sole manifestation of COVID-19? An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss. Bosn J Basic Med Sci. 2020;20(3):283-92.
  3. Maharaj SA-O, Bello Alvarez M, Mungul S, Hari K. Otologic dysfunction in patients with COVID-19: A systematic review. (2378-8038 (Print)).
  4. Jafari Z, Kolb BE, Mohajerani MA-O. Hearing Loss, Tinnitus, and Dizziness in COVID-19: A Systematic Review and Meta-Analysis. 2021(0317-1671 (Print)).
  5. Almufarrij I, Uus K, Munro KJ, Norman RE, Stall NM, Sinha SK. Does coronavirus affect the audio-vestibular system? A rapid systematic review Typically Atypical: COVID-19 Presenting as a all in an Older Adult. Int J Audiol. 2020;59(7):487-91.
  6. Kilic O, Kalcioglu MT, Cag Y, Tuysuz O, Pektas E, Caskurlu H, et al. Could sudden sensorineural hearing loss be the sole manifestation of COVID-19? An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss. Int J Infect Dis. 2020;97:208-11.
  7. Takahashi N, Abe R, Hattori N, Matsumura Y, Oshima T, Taniguchi T, et al. Clinical course of a critically ill patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). J Artif Organs. 2020.
  8. Fidan V. New type of corona virus induced acute otitis media in adult. Am J Otolaryngol. 2020;41(3):102487.
  9. Mustafa MWM. Audiological profile of asymptomatic Covid-19 PCR-positive cases. Am J Otolaryngol. 2020;41(3):102483.
  10. Freni F, Meduri A, Gazia F, Nicastro V, Galletti C, Aragona P, et al. Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2. Am J Otolaryngol. 2020;41(5):102612.
  11. Borre ED, Kaalund K, Frisco N, Zhang G, Ayer A, Kelly-Hedrick M, et al. The Impact of Hearing Loss and Its Treatment on Health-Related Quality of Life Utility: a Systematic Review with Meta-analysis. Journal of General Internal Medicine. 2023;38(2):456-79.
  12. Satar B. Criteria for establishing an association between Covid-19 and hearing loss. (1532-818X (Electronic)).
  13. McIntyre KM, Favre NM, Kuo CC, Carr MM. Systematic Review of Sensorineural Hearing Loss Associated With COVID-19 Infection. (2168-8184 (Print)).
  14. Mehraeen E, Afzalian A, Afsahi AM, Shahidi R, Fakhfouri A, Karimi K, et al. Hearing loss and COVID-19: an umbrella review. (1434-4726 (Electronic)).
  15. Cure E, Cumhur Cure M. Comment on "Hearing loss and COVID-19: A note". Am J Otolaryngol. 2020;41(4):102513.
  16. Saniasiaya JA-O. Hearing Loss in SARS-CoV-2: What Do We Know? 2021(1942-7522 (Electronic)).
  17. Silva Andrade BA-O, Siqueira S, de Assis Soares WA-O, de Souza Rangel F, Santos NA-O, Dos Santos Freitas A, et al. Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms. LID - 10.3390/v13040700 [doi] LID - 700. 2021(1999-4915 (Electronic)).
  18. Yong SA-O. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. (2374-4243 (Electronic)).
  19. Koc HC, Xiao J, Liu W, Li Y, Chen G. Long COVID and its Management. (1449-2288 (Electronic)).
  20. Davis HA-O, McCorkell LA-O, Vogel JA-O, Topol EA-O. Long COVID: major findings, mechanisms and recommendations. (1740-1534 (Electronic)).
  21. Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re'em Y, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. (2589-5370 (Electronic)).
  22. Almufarrij IA-O, Munro KA-O. One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms. (1708-8186 (Electronic)).