A Prospective Observational Study on the Accuracy of Transcutaneous Laryngeal Ultrasonography in Assessing Vocal Cord Mobility before and after Thyroid Surgery

Document Type : Original

Authors

1 Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.

2 Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.

3 Department of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi, India.

4 Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India

5 Department of Biostastics, All India Institute of Medical Sciences, New Delhi, India.

6 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

10.22038/ijorl.2025.86965.3949

Abstract

Introduction:
Recurrent Laryngeal Nerve (RLN) injury remains one of the significant complications associated with thyroidectomy, occurring in approximately 1% to 9% of cases. Vocal Cord (VC) function is typically assessed before surgery using laryngoscopy. However, Transcutaneous Laryngeal Ultrasonography (TLUS) has become a non-invasive alternative for evaluating VC mobility. This study was performed to compare the diagnostic accuracy of TLUS with traditional laryngoscopy in assessing vocal cord function in patients undergoing thyroid surgery.
Materials and Methods:
A total of 105 patients undergoing hemi- or total thyroidectomy were enrolled in a prospective observational study at a tertiary healthcare facility from October 2022 to June 2024. TLUS was conducted by endocrine surgeons using a Mindray UGW 11 device. VC mobility was categorised as usual (spontaneous, rhythmic, symmetrical movement) or unilateral VC paralysis (asymmetrical or absent movement on the affected side).
Results:
In the preoperative setting, TLUS achieved 100% sensitivity, Positive Predictive Value (PPV), and overall diagnostic accuracy. Postoperatively, it maintained a high sensitivity of 99.02%, with specificity reaching 100% and an area under the curve (AUC) of 0.99. The PPV remained at 100%, while the Negative Predictive Value (NPV) was 75%, and the diagnostic accuracy declined slightly to 99.05%. These findings highlight TLUS as a reliable, economical, and patient-friendly modality for evaluating vocal cord mobility in thyroid surgery.
Conclusion:
TLUS is an effective non-invasive method for assessing VC function, with high diagnostic accuracy. With further advancements in ultrasound technology and standardized protocols, TLUS can be incorporated into routine clinical practice as a supplement to traditional laryngoscopy techniques. This study supports the use of TLUS as a viable alternative for preoperative and postoperative VC assessment in thyroid surgery patients.
 

Keywords

Main Subjects


  1. Musholt TJ, Clerici T, Dralle H, Frilling A, Goretzki PE, Hermann MM, et al. Interdisciplinary Task Force Guidelines of the German Association of Endocrine Surgeons. German Association of Endocrine Surgeons practice guidelines for the surgical treatment of benign thyroid disease. Langenbecks Arch Surg. 2011 Jun; 396(5): 639-49. doi: 10.1007/s00423-011-0774-y. Epub 2011 Mar 22. PMID: 21424798.
  2. Hegedüs L. Clinical practice. The thyroid nodule. N Engl J Med. 2004 Oct 21;351(17):1764-71. doi: 10.1056/NEJMcp031436. PMID: 15496625.
  3. Randolph GW, Kamani D. The importance of preoperative laryngoscopy in patients undergoing thyroidectomy: voice, vocal cord function, and the preoperative detection of invasive thyroid malignancy. Surgery. 2006 Mar;139(3):357-62. doi: 10.1016/j.surg.2005.08.009. PMID: 16546500
  4. Stojadinovic A, Shaha AR, Orlikoff RF, Nissan A, Kornak MF, Singh B, et al. Prospective functional voice assessment in patients undergoing thyroid surgery. Ann Surg. 2002 Dec;236(6):823-32. doi: 10.1097/ 00000658-200212000-00015. PMID: 12454521; PMCID: PMC1422649.
  5. Bergenfelz A, Jansson S, Kristoffersson A, Mårtensson H, Reihnér E, Wallin G, et al. Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients. Langenbecks Arch Surg. 2008 Sep; 393(5):667-73. doi: 10.1007/s00423-008-0366-7. Epub 2008 Jul 17. PMID: 18633639.
  6. Dedecjus M, Adamczewski Z, Brzeziński J, Lewiński A. Real-time, high-resolution ultrasonography of the vocal folds--a prospective pilot study in patients before and after thyroidectomy. Langenbecks Arch Surg. 2010 Sep;395(7):859-64. doi: 10.1007/s00423-010-0694-2. Epub 2010 Jul 20. PMID: 20640934; PMCID: PMC2947713.
  7. Wong KP, Lang BH, Ng SH, Cheung CY, Chan CT, Lo CY. A prospective, assessor-blind evaluation of surgeon-performed transcutaneous laryngeal ultrasonography in vocal cord examination before and after thyroidectomy. Surgery. 2013 Dec; 154(6):1158-64; discussion 1164-5. doi: 10.1016/j. surg.2013.04.063. Epub 2013 Aug 19. PMID: 23969288.
  8. Gambardella C, Offi C, Romano RM, De Palma M, Ruggiero R, Candela G, et al. Transcutaneous laryngeal ultrasonography: a reliable, non-invasive and inexpensive preoperative method in the evaluation of vocal cords motility-a prospective multicentric analysis on a large series and a literature review. Updates Surg. 2020 Sep;72(3):885-892. doi: 10.1007/s13304-020-00728-3. Epub 2020 Mar 2. PMID: 32124271.
  9. Sciancalepore PI, Anzivino R, Petrone P, Petrone D, Quaranta N. Transcutaneous laryngeal ultrasonography: A promising tool for otolaryngologists during COVID-19. Am J Otolaryngol. 2021 Jan-Feb;42(1):102772. doi: 10.1016/j.amjoto.2020.102772. Epub 2020 Oct 20. PMID: 33099229; PMCID: PMC7574724.
  10. Ooi LL. B-mode real-time ultrasound assessment of vocal cord function in recurrent laryngeal nerve palsy. Ann Acad Med Singap. 1992 Mar;21(2):214-6. PMID: 1519889.
  11. Shah MK, Ghai B, Bhatia N, Verma RK, Panda NK. Comparison of transcutaneous laryngeal ultrasound with video laryngoscope for assessing the vocal cord mobility in patients undergoing thyroid surgery. Auris Nasus Larynx. 2019 Aug;46(4):593-598. doi: 10.1016/j.anl.2018.12.007. Epub 2018 Dec 19. PMID: 30577987.
  12. Kumar A, Sinha C, Kumar A, Singh AK, Vardhan H, Bhavana K, et al. Assessment of functionality of vocal cords using ultrasound before and after thyroid surgery: An observational study. Indian J Anaesth. 2018 Aug;62(8):599-602. doi: 10.4103/ija.IJA_197_18. PMID: 30166654; PMCID: PMC6100273.
  13. Kandil E, Deniwar A, Noureldine SI, Hammad AY, Mohamed H, Al-Qurayshi Z, et al. Assessment of vocal fold function using transcutaneous laryngeal ultrasonography and flexible laryngoscopy. JAMA Otolaryngol Head Neck Surg. 2016 Jan;142(1):74–78. doi: 10.1001/jamaoto.2015.2795. PMID: 26632676
  14. Wong CK, Wheeler MH. Thyroid nodules: rational management. World J Surg2000;24:934-41.
  15. Wolff S, Gałązka A, Dedecjus M. Transcutaneous laryngeal ultrasonography in vocal fold assessment before and after thyroid surgery in light of recent studies. Pol J Radiol. 2022 Mar 31;87:e195-e201. doi: 10.5114/pjr.2022.115154. PMID: 35505855; PMCID: PMC9047790.
  16. Masood MM, Huang B, Goins A, Hackman TG. Anatomic factors affecting the use of ultrasound to predict vocal fold motion: A pilot study. Am J Otolaryngol. 2018 Jul-Aug;39(4):413-417. doi: 10.1016/j.amjoto.2018.04.005. Epub 2018 Apr 13. PMID: 29678501.
  17. Friesen TL, Cahill GL, Brigger MT, Naheedy J, Zhang X, Jiang W. Feasibility and accuracy of laryngeal ultrasound for the assessment of vocal cord mobility in children. Int J Pediatr Otorhinolaryngol. 2022 Aug; 159:111193. doi: 10.1016/j. ijporl. 2022.111193. Epub 2022 Jun 2. PMID: 35724492.
  18. da Costa BOI, Rodrigues DSB, Santos AS, Pernambuco L. Transcutaneous Laryngeal Ultrasonography for the Assessment of Laryngeal Function After Thyroidectomy: A Review. Ear Nose Throat J. 2021 Jul;100(6):439–446. doi: 10.1177/ 0145561319870487 PMID: 31578107
  19. Lang BH, Wong CK, Tsang RK, Wong KP, Wong BY. Evaluating the cost-effectiveness of laryngeal examination after elective total thyroidectomy. Ann Surg Oncol. 2014 Oct; 21(11): 3548-56. doi: 10.1245/s10434-014-3770-y. Epub 2014 May 28. PMID: 24866435.
  20. Blum M. Ultrasonography of the Thyroid. 2020 Apr 11. In: Feingold KR, Ahmed SF, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext (Internet). South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905410.
  21. Rossi L, Papini P, De Palma A, Fregoli L, Becucci C, Ambrosini CE, Morganti R, Materazzi G. Surgeon-performed transcutaneous laryngeal ultrasound for vocal cord assessment after total thyroidectomy: a prospective study: Original article. Langenbecks Arch Surg. 2024 Jun 11;409(1):183. doi: 10.1007/ s00423- 024- 03362-4. PMID: 38861184; PMCID: PMC11166737.
  22. de Miguel M, Peláez EM, Caubet E, González Ó, Velasco M, Rigual L. Accuracy of transcutaneous laryngeal ultrasound for detecting vocal cord paralysis in the immediate postoperative period after total thyroidectomy. Minerva Anestesiol. 2017 Dec; 83(12):1239-1247. doi: 10.23736/S0375-9393. 17.11755-4. Epub 2017 Jun 14. PMID: 28631451.

 

 

 

  1. Wong KP, Lang BH, Lam S, Au KP, Chan DT, Kotewall NC. Determining the Learning Curve of Transcutaneous Laryngeal Ultrasound in Vocal Cord Assessment by CUSUM Analysis of Eight Surgical Residents: When to Abandon Laryngoscopy. World J Surg. 2016 Mar;40(3):659-64. doi: 10.1007/s00268-015-3348-2. PMID: 26585950.
  2. Woo JW, Park I, Choe JH, Kim JH, Kim JS. Comparison of ultrasound frequency in laryngeal ultrasound for vocal cord evaluation. Surgery. 2017 Apr;161(4):1108-1112. doi: 10.1016/j. surg.2016. 10.013. Epub 2016 Nov 18. PMID: 27871685.