Ipsilateral Oropharyngeal and Cervical Lymph Node Tuberculosis Simulating Oropharyngeal Malignancy with Regional Lymph Node Metastasis: A Case Report

Document Type : Case Report

Authors

1 Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Lahad Datu, Peti Surat 60065, 91110 Lahad Datu, Sabah, Malaysia.

2 Department of Pathology, Hospital Queen Elizabeth 1, Karung Berkunci No. 2029, 88586 Kota Kinabalu, Sabah, Malaysia.

10.22038/ijorl.2025.85739.3877

Abstract

Introduction:
Tuberculosis (TB) is an important contagious disease and a major public health problem globally. It may manifest as pulmonary TB or primary or secondary extrapulmonary TB. Primary oropharyngeal TB is very rare and may mimic presentation of oropharyngeal malignancy especially in the negative initial TB workup.
 Case Report:
We would like to highlight a case of an elderly man presented with ipsilateral oropharyngeal mass and cervical lymph node (LN) enlargement, mimicking oropharyngeal malignancy with regional LN metastasis.
Conclusion:
History of TB contact, poor oral hygiene, and poor immunity should alert the possibility of oropharyngeal TB. Involvement of ipsilateral oropharyngeal structure and cervical LN may simulate presentation of oropharyngeal malignancy with regional LN metastasis. Tissue biopsy for histopathological examination and appropriate staining is considered gold standard for diagnosis of TB and excluding malignancy. It is an important communicable disease, thus notification and referral to infectious disease team should be done without delay.

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Main Subjects

References

  1. Global tuberculosis report 2024. Geneva: World Health Organization; 2024. Licence: CC BY-NC-SA 3.0 IGO.
  2. Barss L. Connors WJA., Fisher D. Chapter 7: Extra-pulmonary tuberculosis. Can J Respir Crit Care Sleep Med. 2022; 6(sup1):87–108. doi: 10.1080/24745332.2022.2036073.
  3. Sidam S, Sahoo AK, Gupta V, Khurana U. Varied presentation of oropharyngeal tuberculosis: Review of cases. 2023;15(8):e43636. doi: 10.7759/cureus.43636. PMID: 37719636; PMCID: PMC10504869.
  4. Dadgarnia M, Baradaranfar M, Yazdani N, Kouhi A. Oropharyngeal tuberculosis: An unusual presentation. Acta Med Iran. 2008;46(6):521-524.
  5. Lambor SD, Lambor DV, Nayak SSR, Naik AD. Primary oropharyngeal tuberculosis—A differential diagnosis to malignancy. Int J Otorhinolaryngol Head Neck Surg. 2014; 3(3):128-132. doi: 10.4236/ ijohns.2014.33023.
  6. Kakisi OK, Kechagia AS, Kakisis IK, Rafailidis PI, Falagas ME. Tuberculosis of the oral cavity: a systematic review. Eur J Oral Sci. 2010;118(2):103-9. doi: 10.1111/j.1600-0722.2010.00725. x. PMID: 20486998.
  7. Ghatak S, Jana T, Bandyopadhyaya S, Biswas SK. Primary oropharyngeal tuberculosis causing destruction of uvula-A rare presentation. Int J Pediatr Otorhinolaryngol. 2020;5(2):91-92. doi: 10.1016/j.pedex.2009.04.001.
  8. Arora N, Brar T, Passey JC, Agarwal AK. Oropharyngeal tuberculosis-Mimicking oral cavity carcinoma. Int J Head Neck Surg. 2014;5(2):94-95. doi: 10.5005/jp-journals-10001-1190.
  9. Dhanasekar T, Inba Shyamala R, Arshad AM, Rajagopalan. An interesting case of tonsillar tuberculosis in a 10-year-old boy. J Clin Tuberc Other Mycobact Dis. 2020; 20:100162. doi: 10. 1016/j.jctube.2020.100162.
  10. Das A, Das SK, Pandit S, Basuthakur S. Tonsillar tuberculosis: A forgotten clinical entity. J Family Med Prim Care. 2015;4(1):124-6. doi: 10.4103/2249-4863.152268.
Iranian Journal of Otorhinolaryngology
Volume 37, Issue 5
September and October 2025
Pages 287-290

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