Iranian Journal of Otorhinolaryngology

Iranian Journal of Otorhinolaryngology

Simultaneous Therapy Approach: Systemic and Intratympanic Corticosteroid for Idiopathic Sudden Sensorineural Hearing Loss: A Clinical Study

Document Type : Original

Authors
Mohsen Rajati 1
Imaneh Roshanzamir 1
Ermia Mousavi Mohammadi 2
Romina Tavasoli 3
Sadegh Jafarzadeh 4
1 Sinus and Surgical Endoscopic Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad.
4 Department of Audiology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ijorl.2025.89180.3984
Abstract
Introduction:
Idiopathic Sudden sensorineural hearing loss (ISSNHL) can be treated with various methods. This study investigated the impact of combined systemic and intratympanic corticosteroid injections on hearing improvement and associated symptoms in patients with ISSNHL.Top of Form.
Materials and Methods:
The study investigated the recovery process of 73 patients with ISSNHL from Khorasan Razavi registry between the years 2022 to 2024. These patients received treatment involving both systemic and intratympanic corticosteroid.
Results:
One month after treatment, the study using Modified Siegel's criteria found complete, partial, and slight improvement in 30%, 14%, and 16% of patients, respectively. During this period, 24% of cases with tinnitus were completely treated, while 51% experienced partial relief. For cases with vertigo, 67% were completely treated, and 33% had partial improvement.
Conclusion:
Combined corticosteroid treatment is effective in approximately sixty percent of ISSNHL cases. This therapy also demonstrates success in alleviating related symptoms such as tinnitus and vertigo.
Keywords
Sensorineural hearing loss
Sudden hearing loss
Corticosteroids
Vertigo
Tinnitus
Subjects
  1. Flint PW HB, ‎ Lund VJ,‎ Niparko JK,‎  Robbins KT,  Thomas JR,‎ et al. . Cummings Otolaryngology-Head and Neck Surgery. 7th Ed. . Philadelphia, PA: Saunders-Elsevier. 2020:P2323-27.
  2. Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2012;146(3 Suppl):S1-35. Epub 2012/03/14.
  3. Rajati M, Azarpajooh MR, Mouhebati M, Nasrollahi M, Salehi M, Khadivi E, et al. Is Sudden Hearing Loss Associated with Atherosclerosis? Iranian journal of otorhinolaryngology. 2016; 28(86):189-95. Epub 2016/07/19.
  4. Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. The Laryngoscope. 2010;120(5):1011-21. Epub 2010/04/28.
  5. Rajati M, Ghasemi MM, Sharifian MR, Nourizadeh N, Yousefi R, Hosseinpoor M. Intratympanic Steroid for the Management of Sudden Hearing Loss: Introduction of a Tapering Method. Iranian journal of otorhinolaryngology. 2022;34(120):9-16. Epub 2022/02/12.
  6. Cheng YF, Chu YC, Tu TY, Shiao AS, Wu SL, iao WH. Modified Siegel's criteria for sudden sensorineural hearing loss: Reporting recovery outcomes with matched pretreatment hearing grades. Journal of the Chinese Medical Association : JCMA. 2018;81(11):1008-12. Epub 2018/06/23.
  7. Yu H, Li H. Association of Vertigo With Hearing Outcomes in Patients With Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA otolaryngology-- head & neck surgery. 2018;144(8):677-83. Epub 2018/ 06/23.
  8. Plontke SK, Meisner C, Agrawal S, Cayé-Thomasen P, Galbraith K, Mikulec AA, et al. Intratympanic corticosteroids for sudden sensorineural hearing loss. The Cochrane database of systematic reviews. 2022;7(7):Cd008080. Epub 2022/07/23.

 

Iranian Journal of Otorhinolaryngology
Volume 37, Issue 6
November and December 2025
Pages 327-334