Simultaneous Therapy Approach: Systemic and Intratympanic Corticosteroid for Idiopathic Sudden Sensorineural Hearing Loss: A Clinical Study

Document Type : Original

Authors

1 Sinus and Surgical Endoscopic Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad.

4 Department of Audiology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/ijorl.2025.89180.3984

Abstract

Introduction:
Idiopathic Sudden sensorineural hearing loss (ISSNHL) can be treated with various methods. This study investigated the impact of combined systemic and intratympanic corticosteroid injections on hearing improvement and associated symptoms in patients with ISSNHL.Top of Form.
Materials and Methods:
The study investigated the recovery process of 73 patients with ISSNHL from Khorasan Razavi registry between the years 2022 to 2024. These patients received treatment involving both systemic and intratympanic corticosteroid.
Results:
One month after treatment, the study using Modified Siegel's criteria found complete, partial, and slight improvement in 30%, 14%, and 16% of patients, respectively. During this period, 24% of cases with tinnitus were completely treated, while 51% experienced partial relief. For cases with vertigo, 67% were completely treated, and 33% had partial improvement.
Conclusion:
Combined corticosteroid treatment is effective in approximately sixty percent of ISSNHL cases. This therapy also demonstrates success in alleviating related symptoms such as tinnitus and vertigo.

Keywords

Main Subjects

References

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Iranian Journal of Otorhinolaryngology
Volume 37, Issue 6
November and December 2025
Pages 327-334

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