Effect of Exposure to a Mixture of Organic Solvents on Hearing Thresholds in Petrochemical Industry Workers

Document Type : Original

Authors

1 Industrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

2 Department of Occupational Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Abstract

Introduction:
Hearing loss is one of the most common occupational diseases. In most workplaces, workers are exposed to noise and solvents simultaneously, so the potential risk of hearing loss due to solvents may be attributed to noise.  In this study we aimed to assess the effect of exposure to mixed aromatic solvents on hearing in the absence of exposure to hazardous noise.
 
Materials and Methods:
In a cross-sectional study, 99 workers from the petrochemical industry with exposure to a mixture of organic solvents whose noise exposure was lower than 85 dBA were compared with 100 un-exposed controls. After measuring sound pressure level and mean concentration of each solvent in the workplace, pure-tone-audiometry was performed and the two groups were compared in terms of high-frequency and low-frequency hearing loss. T-tests and Chi-square tests were used to compare the two groups.
 
Results:
The mean hearing threshold at all frequencies among petrochemical workers was normal (below 25 dB). We did not observe any significant association between solvent exposure and high-frequency or low-frequency hearing loss.
 
Conclusion: 
This study showed that temporary exposure (less than 4 years) to a mixture of organic solvents, without exposure to noise, does not affect workers’ hearing threshold in audiometry tests.

Keywords

Main Subjects

References

1. Gopal KV. Audiological findings in individuals exposed to organic solvents: case studies. Noise Health. 2008; 10: 74-82.
2. Mohammadi S, Labbafinejad Y, Attarchi M. Combined effects of ototoxic solvents and noise on hearing in automobile plant workers in Iran. Arh Hig Rada Toksikol. 2010; 61: 267-74.
3. De Barba MC, Jurkiewicz AL, Zeigelboim BS, de Oliveira LA, Belle AP. Audiometric findings in petrochemical workers exposed to noise and chemical agents. Noise Health. 2005; 7: 7-11.
4. Prasher D, Morata T, Campo P, Fechter L, Johnson AC, Lund SP, et al. NoiseChem: an European Commission research project on the effects of exposure to noise and industrial chemicals on hearing and balance. Int J Occup Med Environ Health. 2002; 15: 5-11.
5. Mirmohamadi J BMF, Nourani F. Hearing threshold level in workers of meybod tile factory. JSSU. 2008; 16: 8-13.
6. Rebert CS, Sorenson SS. Concentration-related effects of hexane on evoked responses from brain and peripheral nerve of the rat. Neurobehav Toxicol Teratol. 1983; 5: 69-76.
7. Barregard L, Axelsson A. Is there an ototraumatic interaction between noise and solvents? Scand Audiol. 1984; 13: 151-5.
8. Makitie AA, Pirvola U, Pyykko I, Sakakibara H, Riihimaki V, Ylikoski J. The ototoxic interaction of styrene and noise. Hear Res. 2003; 179: 9-20.
9. Morata TC, Dunn DE, Sieber WK. Occupational exposure to noise and ototoxic organic solvents. Arch Environ Health. 1994; 49: 359-65.
10. Sliwinska-Kowalska M. Exposure to organic solvent mixture and hearing loss: literature overview. Int J Occup Med Environ Health. 2007; 20: 309-14.
11. Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, Kotylo P, Fiszer M, Dudarewicz A, et al. Hearing loss among workers exposed to moderate concentrations of solvents. Scand J Work Environ Health. 2001; 27: 335-42.
 12. Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, Kotylo P, Fiszer M, Wesolowski W, et al. Exacerbation of noise-induced hearing loss by co-exposure to workplace chemicals. Environ Toxicol Pharmacol. 2005; 19: 547-53.
 13. Sliwinska-Kowalska M. Organic solvent exposure and hearing loss. Occup Environ Med. 2008; 65: 222-3.
 14. Sliwinska-Kowalska M, Prasher D, Rodrigues CA, Zamyslowska-Szmytke E, Campo P, Henderson D, et al. Ototoxicity of organic solvents - from scientific evidence to health policy. Int J Occup Med Environ Health. 2007; 20: 215-22.
15. Determination of Occupational Noise Exposure and Estimation of Noise-Induced Hearing Impairment ANSI S3 (1996).
16. Criteria for a recommended standard occupational noise exposure (1998).
17. ISO. Acoustics - guidelines for the measurement and assessment of exposure to noise in a working environment (1997).
18. NIOSH Manual of Analytical Methods (1994).
19. Rom WNaM, Steven B. Environmental and occupational medicine: Wolters Kluwer Health; 2007.
20. TLV and BEIs based on the documentation of the Threshold Limit Values for the chemical substances and physical agents and biological exposure indices (2008).
21. Institute ANS. Specifications for audiometers. ANSI S36-2004. New York: American National Standard Institute (2004).
22. Janghorbani M, Sheikhi A, Pourabdian S. The prevalence and correlates of hearing loss in drivers in isfahan, Iran. Arch Iran Med. 2009; 12: 128-34.
23. International Classification of Impairments, Disabilities, and Handicap (1980).
24. Boogaard PJ, van Sittert NJ. Exposure to polycyclic aromatic hydrocarbons in petrochemical industries by measurement of urinary 1-hydroxypyrene. Occup Environ Med. 1994; 51: 250-8.
25. Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, Kotylo P, Fiszer M, Wesolowski W, et al. Effects of coexposure to noise and mixture of organic solvents on hearing in dockyard workers. J Occup Environ Med. 2004; 46: 30-8.
26.  Morata TC. Assessing occupational hearing loss: beyond noise exposures. Scand Audiol Suppl. 1998; 48: 111-6.
27. Johnson AaH, B and Lindbald, AC and Morata, T and Nylen, P and Svensson, EB. Epidemiological study of noise and styrene effects using a comprehensive audiological test battery, Abstract, Nordic Noise.  An International Symposium on Noise and Health (2002).
28. Jacobsen P, Hein HO, Suadicani P, Parving A, Gyntelberg F. Mixed solvent exposure and hearing impairment: an epidemiological study of 3284 men. The Copenhagen male study. Occup Med (Lond). 1993; 43: 180-4.
29. Hodgkinson L, Prasher D. Effects of industrial solvents on hearing and balance: a review. Noise Health. 2006; 8: 114-33.
30. Muijser H, Lammers JH, Kullig BM. Effects of exposure to trichloroethylene and noise on hearing in rats. Noise Health. 2000; 2: 57-66.
31. Sliwinska-Kowalska M, Bilski B, Zamyslowska-Szmytke E, Kotylo P, Fiszer M, Wesolowski W, et al. [Hearing impairment in the plastics industry workers exposed to styrene and noise]. Med Pr. 2001; 52: 297-303.
32. Campo P, Lataye R, Loquet G, Bonnet P. Styrene-induced hearing loss: a membrane insult. Hear Res. 2001; 154: 170-80.
33.Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Kotylo P, Wesolowski W, Dudarewicz A, Fiszer M, et al. [Assessment of hearing impairment in workers exposed to mixtures of organic solvents in the paint and lacquer industry]. Med Pr. 2000;      51: 1-10.
34.Sliwinska-Kowalska MaZ-S, E and Syzymczak, W and Kotylo, P and Bak, M and Wesolowski, W
and Fiszer, M and Dudarewicz, A. Pawlaczyk-Luszczynnska, Epidemiological study on the association between occupational exposure to organic solvent and hearing, Abstract, Nordic Noise.  An International Symposium on Noise and Health2002.
35. Ameno K, Kiriu T, Fuke C, Ameno S, Shinohara T, Ijiri I. Regional brain distribution of toluene in rats and in a human autopsy. Arch Toxicol. 1992; 66: 153-6.
36. Sass-Kortsak AM, Corey PN, Robertson JM. An investigation of the association between exposure to styrene and hearing loss. Ann Epidemiol. 1995; 5: 15-24.
 
 
Iranian Journal of Otorhinolaryngology
Volume 26, Issue 4 - Serial Number 4
September and October 2014
Pages 235-243

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