Iranian Journal of Otorhinolaryngology

Iranian Journal of Otorhinolaryngology

The prognostic value of Ki-67 immunostaining in meningioma

Authors
alireza birjandi
Hosein Mashhadinegad
AR Rafatee
10.22038/ijorl.2005.28685
Abstract
This study was designed to provide the relationship among labeling indices of ki-67, Helsinki grading, and tumor histopathology of meningiomas.
Method: ki-67 staining by polyclonal was performed on twenty-nine formalin- ixed/paraffin embedded tissues obtained from 29 meningiomas resected from 29 atients. The Helsinki grading and histopathology (classification of Russel and Lubistein) of tumour were reviewed by a pathologist.
Results: There were 21 women and 8 men. The mean age of patients was 49.1 with inge between 21 and 70 year. The most common presenting symptom was headache 16 patients, 55.1%). The most common presenting sign was papilledema patients, 27.5%). The tumor was located most commonly on convexity patients, 24.1%). There were 22 benign meningiomas (grade I Helsinki) and 7 ypical meningiomas (grade II Helsinki).
i-67 was stained in 12 specimens;(71.14%) benign meningiomas and 5 atypical eningiomas. There were no differences between the two groups (p=0.192).
he ki-67 labeling index was significantly lower in benign meningiomas than in ypical meningiomas (mean ki-67: 9.5 ±17.9 versus 31.8+28.4,p=0.02).
he ki-67labeling index was lower in meningothelial than transitional and fibroblastic eningiomas but it was not significant (the mean ki-67: 8.2 ±14.6versus 18.6±26.7 and 1± 28.8,p-0.27 and p=0.14). The log (ki-67) was higher than 1.2 in atypical eningiomas but was distributed evenly between 1.6 and 2.
Conclusion: The ki-67 labeling index was significantly higher in atypical