Coexistence of Granular Cell Tumor with Squamous Cell Carcinoma on the Tongue: A Case Report

Document Type : Case Report


1 Department of Pathology, Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey.

2 Department of Otorhinolaryngology,Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey.


Granular cell tumors (GCTs) are rare and mostly benign soft tissue tumors. Though they have been reported in all parts of body, they are generally located in the head and neck region, especially on the tongue. Some malign forms exist, but these have been rarely reported. Granular cell tumors have a neural origin and, in immunohistochemical evaluations, they express S-100 and neuron specific enolase (NSE). The treatment of these tumors is bulky surgical excision.
Case Report:  
In this case, a cauliflower shaped lesion with a 1 cm diameter was excised from the midline tongue of a 65 year old woman. The histopathological evaluation indicated that it was squamous cell carcinoma (SCC) covering GCT. Herein, the coexistence of GCT and SCC we describe on the same region of the tongue, in accordance with literature review, since this is a very rare condition.
Pseudoepitheliomatous hyperplasia may accompany GCTs on the tongue and this condition may mimic well-differentiated SCC. For this reason, with the help of Ki-67 and p63 expression, in addition to immunohistochemical markers, well-differentiated SCC should be differentiated from pseudoepitheliomatous hyperplasia through careful investigation.


Main Subjects

1. Abrikossoff AI. About Fibromas of the striated muscles. Wirchow Arch Pathol Anat 1926; 260: 215-33.
2. Kesici U, Mataraci E, Kesici S, Sezgin Z. Granular  cell tumor on perianal region. Acta Medica Iranica 2013;51:509-11.
3. Son HY, Kim JP, Ko GH, Lee EJ, Woo SH. Lingual squamous cell carcinoma surrounded by granular cell tumor. Chonnam Med J 2012;48:        65-8.
4. Dive A, Dhobley A, Fande PZ, Dixit S. Granuler cell tumor of the tongue: report of a case. J Oral Maxillofac Pathol 2013;17:148.
5. Saito K, Kato H, Fukai Y, Kimura H, Miyazaki T, Kashiwabara K, et al. Esophageal granular cell tumor covered by intramucosal squamous cell carcinoma: report of a case. Surg Today 2008; 38(7):651-5.
 6. Vinco A, Vettoretto N, Cervi E, Villanacci V, Baronchelli C, Giulini SM, et al. Association of multiple granular cell tumors and squamous carcinoma of the esophagus: case report and review of the literature. Dis Esophagus. 2001;14:262-4.
 7. Al-Ahmadie H, Hasselgren PO, Yassin R, Mutema G. Colocalized granular cell tumor and infiltrating ductal carcinoma of the breast. Arch Pathol Lab Med 2002;126:731-3.
 8. Tai G, D'Costa H, Lee D, Watkins RM, Jones P. Case report: coincident granular cell tumour of the breast with invasive ductal carcinoma. Br J Radiol. 1995;68:1034-6.
9. Caltabiano R, Cappellani A, Di Vita M, Lanzafame S. The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohisto- chemical study. J Craniofac Surg 2008; 19:1691-4