The Effect of Smoking on Mineral and Protein Composition of Saliva

Document Type : Original

Authors

Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Introduction:
To assess the salivary composition of proteins and minerals in smokers compared with non-smokers.
 
Materials and Methods:
In this study we compared the total protein and Ca, Na, K, Mg, Pb of whole saliva in two groups of men (28 smokers and 31nonsmokers) aged between 29-41years.
 
Results:
Fifty-nine participants were evaluated. The mean age was 33.14±5.32 years among smokers and 32.15±5.12 years among non-smokers (P>0.05). The mean concentration of total protein, Ca, Pb,and Zn of whole saliva in smokers was lower than that in non-smokers, but the difference was not statistically significant (P>0.05). The mean concentration of Na, K, Mg in whole saliva was not significantly different between smokers and non-smokers (P>0.05).
 
Conclusion: 
We specified that smoking reduced the value of total protein, Ca and Pb of saliva, however it did not havean impact on Na, K, and Mg of saliva.  

Keywords

Main Subjects

References

1. Wilmarth PA, Riviere MA, Rustvold DL, Lauten JD, Madden TE, David LL. Two-dimensional liquid chromatography of the human whole saliva proteome. J Proteome Res 2004; 3(5):1017–23.
2. Edgar M, Dawes C, O’Mullane D. Factors influencing salivary flow rate and composition. In: Saliva and dental health. 3rd ed. Br Dent J; 2004:
32-49.
3. Pink R, Simek J, Vondrakova J, Faber E, Michl P, Pazdera J, et al. Saliva as a diagnostic medium. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2009; 153(2):103–10.
4. Llena-Puy C. The role of saliva in maintaining oral health and as an aid to diagnosis. Med Oral Patol Oral Cir Bucal 2006; 11:449–55.
5. Khalili J. Oral cancer. Risk factors, prevention and diagnostic. Exp Oncol. 2008; 30:259–64.
6. Banoczy J, Gintner Z, Dombi C. Tobacco use and oral leukoplakia. J Dent Educ 2001; 65(4):322–7.
7. Battino M, Ferreiro MS, Gallardo I, Newman HN, Bullon P. The antioxidant capacity of saliva. J Clin Periodontol 2002; 29(3):189–94.
8. Avsar A, Darka O, Bodrumlu EH, Bek Y. Evaluation of the relationship between passive smoking and salivary electrolytes, protein, secretory IgA, sialic acid and amylase in young children. Arch Oral Biol 2009; 54(5):457–63.
9. Laine MA, Sewón LA, Karjalainen SM, Helenius H, Doroguinskaia A, Lehtonen-Veromaa M. Salivary variables in relation to tobacco smoking and female sex steroid hormone-use in 30 to 59-year-old women. Acta Odontol.Scand 2002; 60(4): 237–40.
10. Padmavathi P, Reddy VD, Kavitha G, Paramahamsa M, Varadacharyulu N. Chronic cigarette smoking alters erythrocyte membrane lipid composition and properties in male human volunteers. Nitric Oxide. 2010; 23(3):181–86.
11. Erdemir EO, Erdemir A. The detection of salivary minerals in smokers and non-smokers with chronic periodontitis by the inductively coupled plasma-atomic emission spectrophotometry technique. J Periodontol 2006; 7(6):990–5.
12. Pasupathi P, Rao YY, Farook J, Saravanan G, Bakthavathsalam G. Effect of cigarette smoking on lipids and oxidative stress biomarkers in patients with acute myocardial infarction. Res J Medicine Med Sci 2009; 4(2):151–9.
13. Pasupathi P, Saravanan G, Farook J. Oxidative stress bio markers and antioxidant status in cigarette
smokers compared to nonsmokers. J Pharm Sci Res 2009;1: 55–62.
14. Kolte AP,  Kolte RA,  Laddha K. Effect of smoking on salivary composition and periodontal status. 2012;16(3):350–3.
15. Zuabi O, Machtei EE, Ben Aryeh H, Ardekian L, Peled M, Laufer D. The effect of smoking and periodontal treatment on salivary composition in patients with established periodontitis. J Periodontal 1999; 70(10):1240–6.
16. Lawrence HP. Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health. J Can Dent Assoc 2002; 68(3):170–4.
17. Haake SK, Newman MG, Nisengard RJ, Sanz M. Periodontal Microbiology. In: Newman MG, Takei HH, Carranza FA.Carranza's Clinical Periodontology. 4th edition Philadelphia: WB Saunders; 2002: 96–112.
18. Nakonieczna-Rudnicka M,  Bachanek T,  Rogowska W. Concentration of calcium ions in the saliva and the value of the pH of the saliva in female and male smokers. Przegl Lek 2009; 66 (10): 652–4.
19. Sevón L, Laine MA, Karjalainen S, Doroguinskaia A, Helenius H, Kiss E, et al. Effect of Age on Flow-Rate, Protein and Electrolyte Composition of  Stimulated Whole Saliva in Healthy, Non-Smoking Women. Open Dentistry J 2008; 2:         89–92.
20. Luther T, Carrion CF, Cobb N, Le G, Edwards C, Schwartz S, et al. Methods for analyzing saliva proteins for systemic disease detection. Gen Dent 2010; 58(2):110–3.
21. Gursoy UK, Könönen E, Pradhan-Palikhe P, Tervahartiala T, Pussinen PJ, Suominen-Taipale L, et al. Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis. J Clin Periodontol. 2010; 37(6):487–93.
22.  Jessop DS, Turner-Cobb JM. Measurement and meaning of salivary cortisol: a focus on health and disease in children. Stress 2008; 11(1):1–14.
23. Hu S, Denny P, Denny P, Xie Y, Loo JA, Wolinsky LE, et al. Ogorzalek Loo RR, Navazesh M, Wong DT. Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol. 2004(5); 25:1423–30.
24.  Sato J, Goto J, Murata T, Kitamori S, Yamazaki Y, Satoh A, et al. Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110(3):330–6.
Iranian Journal of Otorhinolaryngology
Volume 27, Issue 4 - Serial Number 4
July and August 2015
Pages 301-305

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