Chronic Invasive Fungal Granuloma–A Diagnostic Dilemma in an Immunocompetent Host

Document Type : Case Report


1 Department of Otorhinolaryngology, Government Medical College and Hospital, Jubilee Park, Aurangabad, Maharashtra State, India.

2 Department of Pathology, Government Medical College, Aurangabad. Maharashtra State, India.

3 Department of Otorhinolaryngology Government Medical College, Aurangabad, Maharashtra State, India.

4 Department of otorhinolaryngology Government Medical College, Aurangabad, Maharashtra State, India.

5 Department of Medicine Government Medical College, Aurangabad. Maharashtra State, India.


Invasive fungal sinusitis, though considered to be rare entity, is nowadays frequently encountered, not only in immunocompromised patients but also in immunocompetent patients. The changing prevalence towards immunocompetent hosts is due to the indiscriminate usage of broad spectrum antibiotics, steroids, and immunosuppressive drugs. Diagnosing invasive fungal sinusitis should not pose any difficulty to both the clinician [a whitish colour secretion in elderly Diabetics, and CT Scan PNS showing concretion in the sinus along with destruction of the surrounding bone] and to the pathologist; however, when the invasive fungal sinus infection presents in a form of a granuloma then its diagnosis imposes a challenge to medical professionals.
 Case Report
We are presenting a case study,which consists of 3 cases of chronic invasive fungal sinus infection.Two patients were treated for tuberculoma and had completed a course of Anti Koch’s Treatment and one patient was given a trial of broad spectrum antibiotics and steroids.Eventually all cases were diagnosed as a chronic invasive form of fungal granuloma (CIFG).
CIFG of the paranasal sinuses is seen in immunocompetent hosts, especially those that are in the 2nd and 3rd decades of their lives. Gradually progressive proptosis is the primary presenting symptom. MRI scanning is a better imaging modality compared to CT scanning. Routine H&E staining may prove inadequate and special stains such as the GMS stain should be employed in the slightest doubt of a fungal aetiology. A team approach towards patients is paramount for early diagnosis and timely medical and surgical intervention.


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