Inflammatory Myofibroblastic Tumor of the Larynx: A Case Report

Document Type : Case Report


1 Department of Otorhinolaryngology, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

2 ENT & HNS Research Center, Hazart Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

3 Pathologist, Shahriyar Hospital, Tehran, Iran.

4 General practitioner, Iran University of Medical Sciences, Tehran, Iran.

5 College of Dentistry, Ajman University of Science and Technology, Ajman, UAE.


Inflammatory myofibroblastic pseudotumors are initially described in the lung and various extrapulmonary sites such as the orbits, palatine tonsils, ears, gingiva, pterygomaxillary space, and periodontal tissues. These tumors rarely involve the larynx and predilection to the glottis occurs in an indolent manner.
Case Report
This case describes a laryngeal myofibroblastic tumor in a 46-year-old woman who presented with an aggressive tumor that extended to the floor of the mouth and the base of the tongue. Extended supraglottic laryngectomy was undertaken for the patient. The diagnosis was spindle cell proliferation with dense lymphoplasma cell infiltration compatible with inflammatory myofibroblastic tumor (Inflammatory pseudotumor or plasma cell granuloma). Definitive diagnosis was achieved with immunohistochemical (IHC) staining.
We believe that further IHC studies are required to define the true nature of these tumors especially for those that behave in an aggressive pattern.


Main Subjects

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