Iranian Journal of Otorhinolaryngology

Iranian Journal of Otorhinolaryngology

Effect of Topical Estrogen in the Mangement of Traumatic Facial Wounds

Document Type : Original

Authors
Seyed Amirhosein Ghazizadeh Hashemi 1
Behrooz Barati 1
Hosein Mohammadi 1
Masumeh Saeidi 2
Abbas Bahreini 3
Mohammad Ali Kiani 4
1 Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Student Research Commitee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Students Research Committee, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijorl.2016.6034
Abstract
Introduction:
Acute skin wound healing is a complicated process comprising various phases. Recent animal studies have shown that steroid sex hormones such as estrogen maybe helpful in the regulation of several pathophysiologic stages that are involved in wound healing. In this study we examined the effects of topical estrogen in the treatment of traumatic facial wounds.
 
Materials and Methods:
Patients referred to Luqman Hospital, Tehran with traumatic wounds were enrolled in this case-control study into two groups of equal size. From the second week of the study, topical estrogen (0.625 mg conjugated topical estrogen ointment) was administered in the case group, while the control group received a Eucerin dressing only. The two groups were then compared in terms of wound healing rate on Day 7,14, and 30.
 
Results:
Thirty patients with mean age of 16.02+36.23 years were compared in the control and estrogen-treated groups. After treatment, no scars or keloids were observed in either group. The wound area in the estrogen group was lower than that in the control group on Day 14 and 30, but the difference was not significant (P>0.05). Healing rates in the control group on Day  14 (7.1+42.3 vs.50.3+4.9 mm2) and Day 30 (1.9+93.5 vs. + 97.3+0.6 mm2) (were lower than those in the estrogen group, but the differences were not significant (P>0.05). Findings show that the required time for wound healing in the estrogen-treated group was lower than that in the control group, but the difference was not significant (P>0.05).
 
Conclusion: 
Based on this study, topical estrogen has no effect on the rate of wound healing or the rate of wound area .
Keywords
Estrogen
Effect
Traumatic Wounds
Treatment
Subjects
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Iranian Journal of Otorhinolaryngology
Volume 28, Issue 1 - Serial Number 1
January and February 2016
Pages 45-49