The Prevalence of Hearing Loss in Patients with Hepatitis B Infection Compared with Healthy Volunteers

Gholami Parizad, Elaheh; Gerami Matin, Houshang; Gholami Parizad, Eskandar; Khosravi, Afra

doi:10.22038/ijorl.2017.17478.1591

The Prevalence of Hearing Loss in Patients with Hepatitis B Infection Compared with Healthy Volunteers

Document Type : Original

Authors

¹ Clinical Microbiology Research Centre, Ilam University of Medical Sciences, Ilam, Iran.

² Nose and Sinus Disease Research Canter, Amiralmomenin Hospital, Guilan University of Medical Science, Rasht, Iran.

³ Psychosocial Injuries Prevention Research Centre, Ilam University of Medical Sciences, Ilam, Iran.

10.22038/ijorl.2017.17478.1591

Abstract

Introduction:
Hepatitis B virus is a virus that creates significant hepatic and extra-hepatic complications, with widespread prevalence across the community and body systemic involvement, and can impact on hearing performance. This study aims to evaluate hearing loss among individuals with hepatitis B compared with healthy subjects.

Materials and Methods:
In this case-control study, 83 HBsAg-positive patients with a 1-year history of disease were selected for pure tone audiometry (PTA) testing, while 108 HBsAg-negative patients were selected as the control group. Subjects in both groups were aged 20–40 years. The threshold was set at 25 db for hearing loss. Final data were analyzed using SPSS software.

Results:
Significant differences were found between the case group and control group in average PTA and hearing loss. There was also a significant difference between the two groups in average PTA at frequencies of 250, 4,000, and 8,000 Hz, but not at speech frequencies of 500, 1,000 and 2,000 Hz, despite the difference in average PTA.

Conclusion:
According to significant differences in average PTA between patients with hepatitis B virus and healthy subjects in this study, hearing loss may be attributed to the presence HBV of in the patient group.

Keywords

Main Subjects

References

1. Tajiri K, Shimizu Y. Unsolved problems and future perspectives of hepatitis B virus vaccination. World J Gastroenterol 2015; 21(23): 7074–83.

2. Churin Y, Roderfeld M, Roeb E. Hepatitis B virus large surface protein:function and fame. Hepato Biliary Nutr 2015; 4(1):1–10.

3. Locarnini S, Hatzakis A, Chen DS, Lok A. Strategies to control hepatitis B: Public policy, epidemiology, vaccine and drugs. J Hepatol 2015; 62(1): 76–86.

4. Gholami parizad E, Khosravi A, Gholami parizad E, Sadeghifard N, Ghafourian S. Evaluation of Chronic Hepatitis B Infection in Patients with Seronegative HbsAg. Iran J Public Health 2012; 41(2): 100–4.

5. Alter SJ, Bennett JS, Koranyi K, Krepple A, Simon R. Common Childhood Viral Infections. Curr Probl Pediatr Adolesc Health Care 2015; 45(2): 21–53.

6. Wen YH, Chen PR, Wu HP. Prognostic factors of idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 2014; 241:1423–9.

7. Sara SA. Teh BM, Friedland P. Bilateral sudden sensorineural hearing loss: review. Jf Laryngol Otol 2014; 128(1): 8–15.

8. Cox E, Kleiman M, Gelfand I.Acute Deafness as the Presenting Symptom of Bacterial Meningitis. Pediatr Infect Dis J 2009; 28(4): 342–3

9. Cohen BE, Durstenfeld A, Roehm PC. Viral Causes of Hearing Loss: A Review for Hearing Health Professionals. Trends Hear 2014; 18: 1–17.

10. Greco A, Fusconi M, Gallo A, Marinelli C, Macri G.F, Vincentiis M. Sudden sensorineural hearing loss: An autoimmune disease? Autoimmun Rev 2011; 10: 756–61.

11. Masayuki N, Yuko S, Toshiyaki K, Michio H. Adult Human Parvovirus B19 Infection Presenting with Hearing Difficulty and Dizziness. Tohoku J Exp Med 2011; 224: 57–9.

12. Hernandez-Rodriguz J, Alba MA, Prieto-Gonzalez S, Cide MC. Diagnosis and classification of polyarteritis nodosa. J Autoimmune 2014; 48: 84–9.

13. JansSen H, Van Zonneveld M, Van Nunen A, Niesters H, Schalm S, de Man R. Polyartrit nodosa associated with hepatitis B virus infection, the role of antiviral treatment and mutations in the hepatitis B virus genome. Eur J Gastroenterol Hepatol 2004; 16 (8): 801–7.

14. Shayani Nasab M, Fathololoomi MR, Alizamir A. Association between Hepatitis B and Hearing Status. Oman Med J 2012; 27(5): 418–20.

15. Chao CK, Czechowicz JA, Messener AH, Roca KL, Rodrigus ML, Villafuerte CG, et al. High Prevalence of Hearing Impairment in HIV-Infected Peruvian Children. Otolaryngol Head Neck Surg 2012; 146(2): 259–65.

16. Sargent EW. Autoimmune inner ear disease (AIEDS): Autoimmune disease with audio-vestibular involvement 2002, www. Audiologyonline. com/ articles/autoimmune-inner-ear-disease-aieds-1160.

17. Chi C, Wei-Bin L, Po-Hung C,Kai-Chieh C, Ta-Jen L. Sudden deafness as a presenting symptom of chronic hepatitis B with acute exacerbation. Otolaryngol Head Neck Surg 2009; 141: 659–60.

18. Khosravi A, Hommel M, Sayemiri K. Age-dependent antibody response to Plasmodium falciparum merozoite surface protein 2 (MSP-2) Parasite Immunology, 2011, 33(3), pp. 145-157.

19. Hoseinzadeh M., Khosravi A, Sayemiri K, Rasol M.H, Mohaveri A.The antibody titers to helicobacter pylori in 7-12 year old iron deficiency anemic children, in Ilam. Journal of Research in Medical Sciences, 2010, 15(6), pp. 324-330.

20. Noorizadeh H, Farmany A, Khosravi A. Investigation of retention behaviors of essential oils by using QSRR . Journal of the Chinese Chemical Society, 2010 57(5 A), pp. 982-991.