Acute Lymphoblastic Leukemia Following Nasopharyngeal Carcinoma: Report of an Unusual Case

Document Type : Case Report


1 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Department of Radiotherapy and Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Nasopharyngeal carcinoma (NPC) is a rare malignancy in children. Nasal obstruction, otitis media with effusion, pain in the ear, hearing problems, and unusual neck mass are among the signs and symptoms of this malignancy.
Case Report:
We report the case of a 13-year-old girl with NPC who later developed acute lymphoblastic leukemia (ALL) through the course of her disease. To our knowledge, this is the first report of ALL following childhood nasopharyngeal carcinoma in the English-language literature.
Reports of secondary malignancies at the site of radiotherapy for NPC exist, but this is the first report of ALL following NPC.


Main Subjects


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