Evaluation of SubcutaneousRush Immunotherapy Effectiveness in Perennial Allergic Rhinitis after a Year from Treatment

Document Type: Original


1 Department of Pediatric , Faculty of Medicine, Zahedan University of Medical Sciences Zahedan, Iran.

2 Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Pediatric , Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.

4 Department of Biomedical Informatics, Facultyof Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Allergen immunotherapy is an effective treatment for allergic rhinitis. Conventional immunotherapy takesat least 5 to 6 months to reach the maintenance dosage; nonetheless, rush immunotherapy accelerates to reach the maintenance dose several months earlier. However, the safety and efficacy of this treatment has not been widely investigated. The objective of the present study was to determine the efficacy of subcutaneous rush immunotherapy in the patients with perennial allergic rhinitis after a year from treatment.
Materials and Methods:
This study was carried out on a total of 15 patients with allergic rhinitis who received rush immunotherapy and were evaluated for the quality of life and clinical symptoms improvement with Sino-Nasal Outcome Test Questionnaire (SNOT-22) and Mini Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) before and after a year from treatment. Moreover, specific weed mix Immunoglobulin E (IgE) was measured before and after a year from treatment. Statistical analysis was performed using SPSS software (version 16) (P0.001).
Rush immunotherapy is an effective treatment in the patients with allergic rhinitis. It seems to be an alternative treatment in cases that need more rapid treatment. However, it is recommended to carry out other studiesonthe control group.


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