The Effect of Coenzyme Q10 on Tinnitus Severity and Sleep Quality in Patients with Presbycusis

Document Type : Original

Authors

1 Department of Otolaryngology Head and Neck Surgery, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

2 Department of Audiology, School of Rehabilitation, Hearing Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

3 Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

10.22038/ijorl.2024.79602.3681

Abstract

Introduction:
Tinnitus is one of the symptoms of presbycusis that affects patients' sleep and social life. This study aimed to determine the effect of coenzyme Q10 (CoQ10) on treating tinnitus due to presbycusis.
 
Materials and Methods:
In this double-blind, randomized clinical trial, 50 patients with tinnitus due to presbycusis were randomly divided into groups A and B, with 25 patients in each group. In addition to routine treatments, group A received 100 mg of CoQ10 daily, while group B received a placebo. Both groups were evaluated for tinnitus severity, loudness of tinnitus, quality of life, and sleep disturbance before and 6 weeks after starting the treatment.
 
Results:
In the intervention and control groups, the mean changes in score compared to before the treatment were as follows: quality of life (3.1 ± 1.67) and (1.28 ± 0.76) (P = 0.298), sleep disorder (-7.60 ± 1.38) and (-1.0 ± 8.55) (P<0.001), tinnitus disability (-17.2 ± 52.93) and (-4.56 ± 1.37) (P<0.001), tinnitus loudness of right ear (-1.68 ± 0.41) and (-0.95 ± 0.23) (P=0.11) and left ear (-2.2 ± 0.35) and (-0.54 ± 0.21) (P<0.001).
 
Conclusion:
This study indicated that adding CoQ10 to the routine regimen for patients with tinnitus due to presbycusis significantly decreases tinnitus disability, improves sleep disturbance, and reduces tinnitus loudness. However, more studies should be conducted in this regard.

Keywords

Main Subjects

References

  1. Priberam Dictionary of the Portuguese Language (2013). 2013.
  2. Roth TN, Hanebuth D, Probst R. Prevalence of age-related hearing loss in Europe: a review. Eur Arch Otorhinolaryngol. 2011;268(8):1101-7.
  3. Baraldi Gdos S, de Almeida LC, Borges AC. Hearing loss in aging. Braz J Otorhinolaryngol. 2007;73(1):58-64.
  4. Guerra TM EL, Cavalcante MdeÁ, Silva RCL, Miranda, ICC QVPoatat, 2010; coepBJO, 76(5):663–666.
  5. Ciorba A, Bianchini C, Pelucchi S, Pastore A. The impact of hearing loss on the quality of life of elderly adults. Clin Interv Aging. 2012;7:159-63.
  6. Assumption ARM ASTRPEU, 2012;11:19–22 HU.
  7. Schlee W, Mueller N, Hartmann T, Keil J, Lorenz I, Weisz N. Mapping cortical hubs in tinnitus. BMC biology. 2009;7(1):80.
  8. Hoffman HJ RGEotISJ, Editor. Tinnitus: Theory and Management. Shelton, CT: PMPH-USA; 2004. p. 16-41.
  9. Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among US adults. The American journal of medicine. 2010; 123(8): 711-8.
  10. Gilles A, De Ridder D, Van Hal G, Wouters K, Punte AK, Van de Heyning P. Prevalence of leisure noise-induced tinnitus and the attitude toward noise in university students. Otology & neurotology. 2012; 33(6):899-906.
  11. Marciano E, Carrabba L, Giannini P, Sementina C, Verde P, Bruno C, et al. Psychiatric comorbidity in a population of outpatients affected by tinnitus: Comorbilidad psiquiátrica en una población de pacientes de consulta externa afectados por tinnitus. International journal of audiology. 2003;42(1):4-9.
  12. Ahmad N, Seidman M. Tinnitus in the older adult. Drugs & aging. 2004;21(5):297-305.
  13. Crane FL. Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition. 2001;20(6):591-8.
  14. Khan M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngology—Head and Neck Surgery. 2007;136(1):72-7.
  15. Niklowitz P, Menke T, Andler W, Okun JG. Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults. Clinica chimica acta. 2004;342(1-2):219-26.
  16. Sohmiya M, Tanaka M, Tak NW, Yanagisawa M, Tanino Y, Suzuki Y, et al. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease. Journal of the neurological sciences. 2004;223(2):161-6.
  17. Müller T, Büttner T, Gholipour A-F, Kuhn W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease. Neuroscience letters. 2003;341(3):201-4.
  18. Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q 10 as a potential treatment. Journal of bioenergetics and biomembranes. 2004;36(4):381-6.
  19. Bhagavan HN, Chopra RK. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free radical research. 2006;40(5):445-53.
  20. Lenaz G, Fato R, Formiggini G, Genova ML. The role of Coenzyme Q in mitochondrial electron transport. Mitochondrion. 2007;7:S8-S33.
  21. Weber C, Arck P, Mazurek B, Klapp BF. Impact of a relaxation training on psychometric and immunologic parameters in tinnitus sufferers. Journal of Psychosomatic Research. 2002;52(1):29-33.
  22. Ahmadi S, Aghvamy M, Afshingoo M. The effect of endurance training and Coenzyme Q10 Supplementation on Sleep Quality in children with autism spectrum disorders. Preventive Care in Nursing & Midwifery Journal. 2020 Apr 10; 10(1): 56-61.
  23. Egilmez O, Kalcioglu M. Antioxidant therapy in tinnitus. British Journal of Medicine and Medical Research. 2015 Jan 10;10(7):1-7.
  24. Scasso F, Sprio AE, Canobbio L, Scanarotti C, Manini G, Berta GN, et al. Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study. Heliyon. 2017;3(2):e00251.
  25. Staffa P, Cambi J, Mezzedimi C, Passali D, Bellussi L. Activity of coenzyme Q 10 (Q-Ter multicomposite) on recovery time in noise-induced hearing loss. Noise & health. 2014;16(72):265-9.
  26. Polanski JF, Soares AD, de Mendonca Cruz OL. Antioxidant therapy in the elderly with tinnitus. Braz J Otorhinolaryngol. 2016;82(3):269-74.
  27. Mennink LM, Aalbers MW, van Dijk P, van Dijk JM. The role of inflammation in tinnitus: A systematic review and meta-analysis. Journal of Clinical Medicine. 2022 Feb 14;11(4):1000.
  28. Mehrabani S, Askari G, Miraghajani M, Tavakoly R, Arab A. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies. Complementary therapies in medicine. 2019;43:181-7.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  1. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008; 24(4):293-9.
  2. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: a double blind randomized clinical trial. Nutritional neuroscience. 2016;19(3):138-43.
  3. Gvozdjáková A, Kucharská J, Ostatníková D, Babinská K, Nakládal D, Crane FL. Ubiquinol improves symptoms in children with autism. Oxid Med Cell Longev. (2014) 2014:798957.
  4. Mousavinejad E, Ghaffari MA, Riahi F, Hajmohammadi M, Tiznobeyk Z, Mousavinejad M. Coenzyme Q(10) supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Psychiatry Res. (2018) 265:62–9.
  5. Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. Effectiveness of coenzyme Q10 supplementation for reducing fatigue: a systematic review and meta-analysis of randomized controlled trials. Frontiers in pharmacology. 2022;13:883251.
Iranian Journal of Otorhinolaryngology
Volume 37, Issue 1
January and February 2025
Pages 33-39

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